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Author: Bogdan Pasaniuc

Rankings

  • All-time downloads: 91,452 (rank: 2,476 )
  • Categories:
    • bioinformatics: 11,628 (rank: 993 )
    • cancer biology: 580 (rank: 25,973 (tie) )
    • epidemiology: 1,526 (rank: 11,269 (tie) )
    • genetic and genomic medicine: 5,180 (rank: 579 (tie) )
    • genetics: 42,516 (rank: 140 )
    • genomics: 15,049 (rank: 1,443 )
    • health informatics: 320 (rank: 4,355 (tie) )
    • infectious diseases: 3,850 (rank: 15,729 )
    • neuroscience: 3,452 (rank: 9,599 (tie) )
    • oncology: 508 (rank: 3,329 (tie) )

Downloads per author, site-wide

Preprints

Germline determinants of the prostate tumor genome

cancer biology more details view paper

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Transcriptome-wide association studies: opportunities and challenges

genetics more details view paper
  • Downloaded 5,370 times
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    • Site-wide: 3,104
    • In genetics: 84
  • Year to date:
    • Site-wide: 45,743
  • Since beginning of last month:
    • Site-wide: 36,855

Regulatory variants explain much more heritability than coding variants across 11 common diseases

genetics more details view paper
  • Downloaded 4,634 times
  • Download rankings, all-time:
    • Site-wide: 3,781
    • In genetics: 103
  • Year to date:
    • Site-wide: 104,312
  • Since beginning of last month:
    • Site-wide: 89,700

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

bioinformatics more details view paper
  • Downloaded 3,971 times
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    • Site-wide: 4,693
    • In bioinformatics: 467
  • Year to date:
    • Site-wide: 1,207
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    • Site-wide: 3,011

Haplotypes of common SNPs can explain missing heritability of complex diseases

genetics more details view paper
  • Downloaded 3,267 times
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    • Site-wide: 6,277
    • In genetics: 208
  • Year to date:
    • Site-wide: 150,275
  • Since beginning of last month:
    • Site-wide: 109,898

Dissecting the genetics of complex traits using summary association statistics

genetics more details view paper
  • Downloaded 3,129 times
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    • Site-wide: 6,700
    • In genetics: 236
  • Year to date:
    • Site-wide: 134,170
  • Since beginning of last month:
    • Site-wide: 89,820

Integrative approaches for large-scale transcriptome-wide association studies

genetics more details view paper
  • Downloaded 3,088 times
  • Download rankings, all-time:
    • Site-wide: 6,828
    • In genetics: 240
  • Year to date:
    • Site-wide: 101,336
  • Since beginning of last month:
    • Site-wide: 109,879

Prior diagnoses and medications as risk factors for COVID-19 in a Los Angeles Health System

infectious diseases more details view paper
  • Downloaded 2,692 times
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    • Site-wide: 8,303
    • In infectious diseases: 1,430
  • Year to date:
    • Site-wide: 18,291
  • Since beginning of last month:
    • Site-wide: 20,457

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

genomics more details view paper
  • Downloaded 2,684 times
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    • Site-wide: 8,345
    • In genomics: 770
  • Year to date:
    • Site-wide: 166,427
  • Since beginning of last month:
    • Site-wide: 126,123

A Bayesian Framework for Multiple Trait Colocalization from Summary Association Statistics

genomics more details view paper
  • Downloaded 2,629 times
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    • Site-wide: 8,610
    • In genomics: 813
  • Year to date:
    • Site-wide: 98,366
  • Since beginning of last month:
    • Site-wide: 91,942

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture

genomics more details view paper
  • Downloaded 2,461 times
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    • Site-wide: 9,490
    • In genomics: 880
  • Year to date:
    • Site-wide: 74,342
  • Since beginning of last month:
    • Site-wide: 48,637

Local genetic correlation gives insights into the shared genetic architecture of complex traits

genetics more details view paper
  • Downloaded 2,379 times
  • Download rankings, all-time:
    • Site-wide: 9,995
    • In genetics: 375
  • Year to date:
    • Site-wide: 146,828
  • Since beginning of last month:
    • Site-wide: 121,866

Large uncertainty in individual PRS estimation impacts PRS-based risk stratification

genomics more details view paper
  • Downloaded 2,370 times
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    • Site-wide: 10,054
    • In genomics: 941
  • Year to date:
    • Site-wide: 19,557
  • Since beginning of last month:
    • Site-wide: 15,828

Genetic control of gene expression and splicing in the developing human brain

neuroscience more details view paper
  • Downloaded 2,347 times
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    • Site-wide: 10,202
    • In neuroscience: 948
  • Year to date:
    • Site-wide: 90,904
  • Since beginning of last month:
    • Site-wide: 123,209

Contrasting the genetic architecture of 30 complex traits from summary association data

bioinformatics more details view paper
  • Downloaded 2,080 times
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    • Site-wide: 12,257
    • In bioinformatics: 1,259
  • Year to date:
    • Site-wide: 179,167
  • Since beginning of last month:
    • Site-wide: 170,984

Probabilistic fine-mapping of transcriptome-wide association studies

genetics more details view paper
  • Downloaded 2,068 times
  • Download rankings, all-time:
    • Site-wide: 12,366
    • In genetics: 450
  • Year to date:
    • Site-wide: 129,166
  • Since beginning of last month:
    • Site-wide: 150,116

Integrating gene expression with summary association statistics to identify susceptibility genes for 30 complex traits

genetics more details view paper
  • Downloaded 2,002 times
  • Download rankings, all-time:
    • Site-wide: 12,974
    • In genetics: 486
  • Year to date:
    • Site-wide: 153,335
  • Since beginning of last month:
    • Site-wide: 89,821

Widespread allelic heterogeneity in complex traits

genetics more details view paper
  • Downloaded 1,962 times
  • Download rankings, all-time:
    • Site-wide: 13,389
    • In genetics: 507
  • Year to date:
    • Site-wide: 158,822
  • Since beginning of last month:
    • Site-wide: 89,849

Colocalization of GWAS and eQTL Signals Detects Target Genes

genetics more details view paper
  • Downloaded 1,815 times
  • Download rankings, all-time:
    • Site-wide: 15,059
    • In genetics: 600
  • Year to date:
    • Site-wide: 97,201
  • Since beginning of last month:
    • Site-wide: 92,195

Efficient variance components analysis across millions of genomes

bioinformatics more details view paper
  • Downloaded 1,641 times
  • Download rankings, all-time:
    • Site-wide: 17,591
    • In bioinformatics: 1,835
  • Year to date:
    • Site-wide: 107,477
  • Since beginning of last month:
    • Site-wide: 166,883

Transcriptome-wide association studies accounting for colocalization using Egger regression

epidemiology more details view paper
  • Downloaded 1,550 times
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    • Site-wide: 19,235
    • In epidemiology: 1,252
  • Year to date:
    • Site-wide: 137,065
  • Since beginning of last month:
    • Site-wide: 124,925

Leveraging polygenic functional enrichment to improve GWAS power

genetics more details view paper
  • Downloaded 1,440 times
  • Download rankings, all-time:
    • Site-wide: 21,628
    • In genetics: 850
  • Year to date:
    • Site-wide: 182,752
  • Since beginning of last month:
    • Site-wide: 198,724

Combining SNP-to-gene linking strategies to pinpoint disease genes and assess disease omnigenicity

genetic and genomic medicine more details view paper
  • Downloaded 1,406 times
  • Download rankings, all-time:
    • Site-wide: 22,495
    • In genetic and genomic medicine: 137
  • Year to date:
    • Site-wide: 7,336
  • Since beginning of last month:
    • Site-wide: 26,884

Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization

genetic and genomic medicine more details view paper
  • Downloaded 1,330 times
  • Download rankings, all-time:
    • Site-wide: 24,566
    • In genetic and genomic medicine: 145
  • Year to date:
    • Site-wide: 65,862
  • Since beginning of last month:
    • Site-wide: 56,056

Optimal design of single-cell RNA sequencing experiments for cell-type-specific eQTL analysis

bioinformatics more details view paper
  • Downloaded 1,318 times
  • Download rankings, all-time:
    • Site-wide: 24,910
    • In bioinformatics: 2,572
  • Year to date:
    • Site-wide: 185,387
  • Since beginning of last month:
    • Site-wide: None

Subtle stratification confounds estimates of heritability from rare variants

genetics more details view paper
  • Downloaded 1,316 times
  • Download rankings, all-time:
    • Site-wide: 24,981
    • In genetics: 982
  • Year to date:
    • Site-wide: 136,175
  • Since beginning of last month:
    • Site-wide: 151,021

Improved methods for multi-trait fine mapping of pleiotropic risk loci

genetics more details view paper
  • Downloaded 1,279 times
  • Download rankings, all-time:
    • Site-wide: 26,181
    • In genetics: 1,008
  • Year to date:
    • Site-wide: 190,269
  • Since beginning of last month:
    • Site-wide: 151,221

Fast estimation of genetic correlation for Biobank-scale data

bioinformatics more details view paper
  • Downloaded 1,267 times
  • Download rankings, all-time:
    • Site-wide: 26,592
    • In bioinformatics: 2,850
  • Year to date:
    • Site-wide: 68,829
  • Since beginning of last month:
    • Site-wide: 89,573

Broad transcriptomic dysregulation across the cerebral cortex in ASD

neuroscience more details view paper
  • Downloaded 1,248 times
  • Download rankings, all-time:
    • Site-wide: 27,190
    • In neuroscience: 3,605
  • Year to date:
    • Site-wide: 17,182
  • Since beginning of last month:
    • Site-wide: 12,426

Spatial localization of recent ancestors for admixed individuals

genetics more details view paper
  • Downloaded 1,208 times
  • Download rankings, all-time:
    • Site-wide: 28,578
    • In genetics: 1,109
  • Year to date:
    • Site-wide: 192,646
  • Since beginning of last month:
    • Site-wide: 169,426

Leveraging genomic diversity for discovery in an EHR-linked biobank: the UCLA ATLAS Community Health Initiative

genetic and genomic medicine more details view paper
  • Downloaded 1,119 times
  • Download rankings, all-time:
    • Site-wide: 32,275
    • In genetic and genomic medicine: 201
  • Year to date:
    • Site-wide: 14,883
  • Since beginning of last month:
    • Site-wide: 35,721

Localizing components of shared transethnic genetic architecture of complex traits from GWAS summary data

genomics more details view paper
  • Downloaded 1,118 times
  • Download rankings, all-time:
    • Site-wide: 32,319
    • In genomics: 2,623
  • Year to date:
    • Site-wide: 139,621
  • Since beginning of last month:
    • Site-wide: 141,515

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals

genetic and genomic medicine more details view paper
  • Downloaded 1,117 times
  • Download rankings, all-time:
    • Site-wide: 32,332
    • In genetic and genomic medicine: None
  • Year to date:
    • Site-wide: 2,853
  • Since beginning of last month:
    • Site-wide: 894

Polygenic scoring accuracy varies across the genetic ancestry continuum in all human populations

genetics more details view paper
  • Downloaded 1,115 times
  • Download rankings, all-time:
    • Site-wide: 32,470
    • In genetics: None
  • Year to date:
    • Site-wide: 2,859
  • Since beginning of last month:
    • Site-wide: 157

Multi-Tissue Transcriptome-Wide Association Studies Identify 21 Novel Candidate Susceptibility Genes for High Grade Serous Epithelial Ovarian Cancer

genomics more details view paper
  • Downloaded 1,077 times
  • Download rankings, all-time:
    • Site-wide: 34,216
    • In genomics: 2,734
  • Year to date:
    • Site-wide: 139,249
  • Since beginning of last month:
    • Site-wide: 79,904

Best practices for multi-ancestry, meta-analytic transcriptome-wide association studies: lessons from the Global Biobank Meta-analysis Initiative

genetic and genomic medicine more details view paper
  • Downloaded 1,057 times
  • Download rankings, all-time:
    • Site-wide: 35,163
    • In genetic and genomic medicine: 260
  • Year to date:
    • Site-wide: 7,639
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    • Site-wide: 5,852

Leveraging eQTLs to identify individual-level tissue of interest for a complex trait

genetics more details view paper
  • Downloaded 1,006 times
  • Download rankings, all-time:
    • Site-wide: 37,954
    • In genetics: 1,471
  • Year to date:
    • Site-wide: 166,124
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    • Site-wide: 130,843

A method to map and interpret pleiotropic loci using summary statistics of multiple traits

bioinformatics more details view paper
  • Downloaded 959 times
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    • Site-wide: 40,894
    • In bioinformatics: 4,165
  • Year to date:
    • Site-wide: 125,140
  • Since beginning of last month:
    • Site-wide: 76,758

Multi-ancestry fine-mapping improves precision to identify causal genes in transcriptome-wide association studies

genetics more details view paper
  • Downloaded 910 times
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    • Site-wide: 44,191
    • In genetics: 1,996
  • Year to date:
    • Site-wide: 3,937
  • Since beginning of last month:
    • Site-wide: 18,793

Massively parallel reporter assays combined with cell-type specific eQTL informed multiple melanoma loci and identified a pleiotropic function of HIV-1 restriction gene, MX2, in melanoma promotion

genomics more details view paper
  • Downloaded 878 times
  • Download rankings, all-time:
    • Site-wide: 46,768
    • In genomics: 3,500
  • Year to date:
    • Site-wide: 105,897
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    • Site-wide: 60,445

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative

infectious diseases more details view paper
  • Downloaded 835 times
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    • Site-wide: 50,407
    • In infectious diseases: 4,378
  • Year to date:
    • Site-wide: 4,547
  • Since beginning of last month:
    • Site-wide: 9,585

H3k27ac-HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility

genomics more details view paper
  • Downloaded 777 times
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    • Site-wide: 56,090
    • In genomics: 3,943
  • Year to date:
    • Site-wide: 78,085
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    • Site-wide: 161,861

Powerful eQTL mapping through low coverage RNA sequencing

genomics more details view paper
  • Downloaded 740 times
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    • Site-wide: 60,228
    • In genomics: 4,171
  • Year to date:
    • Site-wide: 69,285
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    • Site-wide: 84,694

A scalable method for estimating the regional polygenicity of complex traits

genetics more details view paper
  • Downloaded 731 times
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    • Site-wide: 61,313
    • In genetics: 2,330
  • Year to date:
    • Site-wide: 196,812
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    • Site-wide: 160,613

Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI

genetics more details view paper
  • Downloaded 727 times
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    • Site-wide: 61,812
    • In genetics: 2,351
  • Year to date:
    • Site-wide: 183,786
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    • Site-wide: 186,867

Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus

genomics more details view paper
  • Downloaded 712 times
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    • Site-wide: 63,677
    • In genomics: None
  • Year to date:
    • Site-wide: 5,889
  • Since beginning of last month:
    • Site-wide: 237

Isoform-level transcriptome-wide association uncovers extensive novel genetic risk mechanisms for neuropsychiatric disorders in the human brain

genetic and genomic medicine more details view paper
  • Downloaded 686 times
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    • Site-wide: 67,121
    • In genetic and genomic medicine: None
  • Year to date:
    • Site-wide: 6,277
  • Since beginning of last month:
    • Site-wide: 1,138

Haplotype-based eQTL mapping finds evidence for complex gene regulatory regions poorly tagged by marginal SNPs

genetics more details view paper
  • Downloaded 639 times
  • Download rankings, all-time:
    • Site-wide: 74,023
    • In genetics: 2,846
  • Year to date:
    • Site-wide: 174,299
  • Since beginning of last month:
    • Site-wide: 78,541

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

genetics more details view paper
  • Downloaded 638 times
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    • Site-wide: 74,255
    • In genetics: 2,805
  • Year to date:
    • Site-wide: 190,430
  • Since beginning of last month:
    • Site-wide: 150,182

Shared heritability and functional enrichment across six solid cancers

genomics more details view paper
  • Downloaded 638 times
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    • Site-wide: 74,232
    • In genomics: 4,896
  • Year to date:
    • Site-wide: 153,602
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    • Site-wide: 44,319

Credible learning of hydroxychloroquine and dexamethasone effects on COVID-19 mortality outside of randomized trials

infectious diseases more details view paper
  • Downloaded 613 times
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    • Site-wide: 78,138
    • In infectious diseases: 4,612
  • Year to date:
    • Site-wide: 103,881
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    • Site-wide: 173,605

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

cancer biology more details view paper
  • Downloaded 599 times
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    • Site-wide: 80,313
    • In cancer biology: 2,272
  • Year to date:
    • Site-wide: 164,857
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    • Site-wide: 180,235

Leveraging ancestry to improve causal variant identification in exome sequencing for monogenic disorders

genetics more details view paper
  • Downloaded 596 times
  • Download rankings, all-time:
    • Site-wide: 80,956
    • In genetics: 3,050
  • Year to date:
    • Site-wide: 199,410
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    • Site-wide: 169,442

Partitioning gene-level contributions to complex-trait heritability by allele frequency identifies disease-relevant genes

genetics more details view paper
  • Downloaded 594 times
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    • Site-wide: 81,148
    • In genetics: 3,102
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    • Site-wide: 48,622
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    • Site-wide: 115,828

Drug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer towards androgen-independence

oncology more details view paper
  • Downloaded 590 times
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    • Site-wide: 81,873
    • In oncology: 199
  • Year to date:
    • Site-wide: 16,119
  • Since beginning of last month:
    • Site-wide: 35,201

Leveraging expression from multiple tissues using sparse canonical correlation analysis (sCCA) and aggregate tests improves the power of transcriptome-wide association studies (TWAS)

genetics more details view paper
  • Downloaded 576 times
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    • Site-wide: 84,417
    • In genetics: 3,197
  • Year to date:
    • Site-wide: 164,236
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    • Site-wide: 141,821

A unifying framework for joint trait analysis under a non-infinitesimal model

bioinformatics more details view paper
  • Downloaded 561 times
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    • Site-wide: 87,239
    • In bioinformatics: 7,563
  • Year to date:
    • Site-wide: 206,366
  • Since beginning of last month:
    • Site-wide: 171,676

Optimized high-throughput screening of non-coding variants identified from genome-wide association studies

genetics more details view paper
  • Downloaded 513 times
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    • Site-wide: 97,133
    • In genetics: 3,808
  • Year to date:
    • Site-wide: 10,168
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    • Site-wide: 55,255

Quantifying the contribution of dominance effects to complex trait variation in biobank-scale data

genetics more details view paper
  • Downloaded 506 times
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    • Site-wide: 98,530
    • In genetics: 3,761
  • Year to date:
    • Site-wide: 151,162
  • Since beginning of last month:
    • Site-wide: 178,685

A two-step approach to testing overall effect of gene-environment interaction for multiple phenotypes

genetics more details view paper
  • Downloaded 449 times
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    • Site-wide: 111,787
    • In genetics: 4,393
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    • Site-wide: 108,008
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    • Site-wide: 38,887

Gene expression imputation provides insight into the genetic architecture of frontotemporal dementia

genetics more details view paper
  • Downloaded 396 times
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    • Site-wide: 125,881
    • In genetics: 4,673
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    • Site-wide: 191,820
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    • Site-wide: 161,785

Distal gene regulation mediated by non-coding RNAs contributes to germline risk for breast and prostate cancer

genetic and genomic medicine more details view paper
  • Downloaded 388 times
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    • Site-wide: 128,229
    • In genetic and genomic medicine: 895
  • Year to date:
    • Site-wide: 16,265
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    • Site-wide: 55,616

RAISS: Robust and Accurate imputation from Summary Statistics

bioinformatics more details view paper
  • Downloaded 388 times
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    • Site-wide: 128,068
    • In bioinformatics: 10,281
  • Year to date:
    • Site-wide: 180,496
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    • Site-wide: 106,930

The UCLA ATLAS Community Health Initiative: promoting precision health research in a diverse biobank

genetic and genomic medicine more details view paper
  • Downloaded 358 times
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    • Site-wide: 136,938
    • In genetic and genomic medicine: 1,016
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    • Site-wide: 18,499
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    • Site-wide: 23,233

Inferring disease architecture and predictive ability with LDpred2-auto

genetics more details view paper
  • Downloaded 311 times
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    • Site-wide: 150,738
    • In genetics: None
  • Year to date:
    • Site-wide: 23,140
  • Since beginning of last month:
    • Site-wide: 831

Health care utilization of fine-scale identity by descent clusters in a Los Angeles biobank

health informatics more details view paper
  • Downloaded 304 times
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    • Site-wide: 152,973
    • In health informatics: 894
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    • Site-wide: 23,982
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    • Site-wide: 4,899

Electronic health record signatures identify undiagnosed patients with Common Variable Immunodeficiency Disease

health informatics more details view paper
  • Downloaded 280 times
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    • Site-wide: 160,171
    • In health informatics: 845
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    • Site-wide: 27,291
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