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Author: Bogdan Pasaniuc

Rankings

  • All-time downloads: 67,748 (rank: 2,405 )
  • Categories:
    • bioinformatics: 7,356 (rank: 1,520 )
    • cancer biology: 525 (rank: 19,245 (tie) )
    • epidemiology: 1,434 (rank: 8,399 (tie) )
    • genetic and genomic medicine: 1,014 (rank: 3,759 (tie) )
    • genetics: 38,503 (rank: 147 )
    • genomics: 13,372 (rank: 1,400 )
    • infectious diseases: 2,622 (rank: 14,694 (tie) )
    • neuroscience: 2,922 (rank: 8,139 (tie) )

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Preprints

Leveraging genomic diversity for discovery in an EHR-linked biobank: the UCLA ATLAS Community Health Initiative

genetic and genomic medicine more details view paper

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Transcriptome-wide association studies: opportunities and challenges

genetics more details view paper
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    • Site-wide: 2,356
    • In genetics: 75
  • Year to date:
    • Site-wide: 11,541
  • Since beginning of last month:
    • Site-wide: 9,335

Regulatory variants explain much more heritability than coding variants across 11 common diseases

genetics more details view paper
  • Downloaded 4,487 times
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    • Site-wide: 2,796
    • In genetics: 91
  • Year to date:
    • Site-wide: 113,967
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Haplotypes of common SNPs can explain missing heritability of complex diseases

genetics more details view paper
  • Downloaded 3,159 times
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    • Site-wide: 4,612
    • In genetics: 180
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Dissecting the genetics of complex traits using summary association statistics

genetics more details view paper
  • Downloaded 2,952 times
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    • In genetics: 208
  • Year to date:
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Integrative approaches for large-scale transcriptome-wide association studies

genetics more details view paper
  • Downloaded 2,950 times
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    • Site-wide: 5,061
    • In genetics: 209
  • Year to date:
    • Site-wide: 62,740
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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

genomics more details view paper
  • Downloaded 2,611 times
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    • Site-wide: 6,023
    • In genomics: 626
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A Bayesian Framework for Multiple Trait Colocalization from Summary Association Statistics

genomics more details view paper
  • Downloaded 2,512 times
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    • Site-wide: 6,409
    • In genomics: 678
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    • Site-wide: 65,353
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Local genetic correlation gives insights into the shared genetic architecture of complex traits

genetics more details view paper
  • Downloaded 2,296 times
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    • Site-wide: 7,302
    • In genetics: 324
  • Year to date:
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Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture

genomics more details view paper
  • Downloaded 2,266 times
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    • Site-wide: 7,443
    • In genomics: 775
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Genetic control of gene expression and splicing in the developing human brain

neuroscience more details view paper
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    • In neuroscience: 747
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    • Site-wide: 79,922

Prior diagnoses and medications as risk factors for COVID-19 in a Los Angeles Health System

infectious diseases more details view paper
  • Downloaded 2,173 times
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    • Site-wide: 7,910
    • In infectious diseases: 1,210
  • Year to date:
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Contrasting the genetic architecture of 30 complex traits from summary association data

bioinformatics more details view paper
  • Downloaded 2,013 times
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    • Site-wide: 8,855
    • In bioinformatics: 1,001
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    • Site-wide: 46,241

Probabilistic fine-mapping of transcriptome-wide association studies

genetics more details view paper
  • Downloaded 1,924 times
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    • Site-wide: 9,451
    • In genetics: 402
  • Year to date:
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Integrating gene expression with summary association statistics to identify susceptibility genes for 30 complex traits

genetics more details view paper
  • Downloaded 1,899 times
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    • Site-wide: 9,642
    • In genetics: 417
  • Year to date:
    • Site-wide: 121,809
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Widespread allelic heterogeneity in complex traits

genetics more details view paper
  • Downloaded 1,875 times
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    • Site-wide: 9,809
    • In genetics: 428
  • Year to date:
    • Site-wide: 99,917
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Large uncertainty in individual PRS estimation impacts PRS-based risk stratification

genomics more details view paper
  • Downloaded 1,713 times
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    • Site-wide: 11,222
    • In genomics: 1,158
  • Year to date:
    • Site-wide: 3,123
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    • Site-wide: 2,160

Colocalization of GWAS and eQTL Signals Detects Target Genes

genetics more details view paper
  • Downloaded 1,665 times
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    • Site-wide: 11,694
    • In genetics: 524
  • Year to date:
    • Site-wide: 90,523
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    • Site-wide: 24,476

Efficient variance components analysis across millions of genomes

bioinformatics more details view paper
  • Downloaded 1,471 times
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    • Site-wide: 14,028
    • In bioinformatics: 1,615
  • Year to date:
    • Site-wide: 50,517
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    • Site-wide: 107,774

Transcriptome-wide association studies accounting for colocalization using Egger regression

epidemiology more details view paper
  • Downloaded 1,434 times
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    • Site-wide: 14,605
    • In epidemiology: 1,004
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    • Site-wide: 97,953
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Leveraging polygenic functional enrichment to improve GWAS power

genetics more details view paper
  • Downloaded 1,361 times
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    • Site-wide: 15,802
    • In genetics: 727
  • Year to date:
    • Site-wide: 135,202
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Optimal design of single-cell RNA sequencing experiments for cell-type-specific eQTL analysis

bioinformatics more details view paper
  • Downloaded 1,246 times
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    • Site-wide: 18,044
    • In bioinformatics: 2,069
  • Year to date:
    • Site-wide: 76,697
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    • Site-wide: 57,268

Subtle stratification confounds estimates of heritability from rare variants

genetics more details view paper
  • Downloaded 1,212 times
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    • Site-wide: 18,789
    • In genetics: 863
  • Year to date:
    • Site-wide: 80,466
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    • Site-wide: 37,157

Improved methods for multi-trait fine mapping of pleiotropic risk loci

genetics more details view paper
  • Downloaded 1,211 times
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    • Site-wide: 18,818
    • In genetics: 864
  • Year to date:
    • Site-wide: 132,807
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    • Site-wide: 73,731

Spatial localization of recent ancestors for admixed individuals

genetics more details view paper
  • Downloaded 1,145 times
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    • Site-wide: 20,436
    • In genetics: 936
  • Year to date:
    • Site-wide: 144,725
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    • Site-wide: 120,031

Localizing components of shared transethnic genetic architecture of complex traits from GWAS summary data

genomics more details view paper
  • Downloaded 1,039 times
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    • Site-wide: 23,594
    • In genomics: 2,220
  • Year to date:
    • Site-wide: 128,081
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    • Site-wide: 118,954

Fast estimation of genetic correlation for Biobank-scale data

bioinformatics more details view paper
  • Downloaded 1,008 times
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    • Site-wide: 24,619
    • In bioinformatics: 2,796
  • Year to date:
    • Site-wide: 31,735
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    • Site-wide: 107,796

Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization

genetic and genomic medicine more details view paper
  • Downloaded 992 times
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    • Site-wide: 25,208
    • In genetic and genomic medicine: 105
  • Year to date:
    • Site-wide: 9,467
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    • Site-wide: 42,319

Multi-Tissue Transcriptome-Wide Association Studies Identify 21 Novel Candidate Susceptibility Genes for High Grade Serous Epithelial Ovarian Cancer

genomics more details view paper
  • Downloaded 960 times
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    • Site-wide: 26,453
    • In genomics: 2,425
  • Year to date:
    • Site-wide: 110,300
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    • Site-wide: 116,088

Leveraging eQTLs to identify individual-level tissue of interest for a complex trait

genetics more details view paper
  • Downloaded 920 times
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    • Site-wide: 28,114
    • In genetics: 1,284
  • Year to date:
    • Site-wide: 67,985
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A method to map and interpret pleiotropic loci using summary statistics of multiple traits

bioinformatics more details view paper
  • Downloaded 818 times
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    • Site-wide: 33,114
    • In bioinformatics: 3,634
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    • Site-wide: 35,383
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Massively parallel reporter assays combined with cell-type specific eQTL informed multiple melanoma loci and identified a pleiotropic function of HIV-1 restriction gene, MX2, in melanoma promotion

genomics more details view paper
  • Downloaded 744 times
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    • Site-wide: 37,902
    • In genomics: 3,134
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Broad transcriptomic dysregulation across the cerebral cortex in ASD

neuroscience more details view paper
  • Downloaded 736 times
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    • In neuroscience: 5,196
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    • Site-wide: 10,463
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Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI

genetics more details view paper
  • Downloaded 667 times
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    • Site-wide: 43,833
    • In genetics: 1,964
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    • Site-wide: 142,898
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A scalable method for estimating the regional polygenicity of complex traits

genetics more details view paper
  • Downloaded 621 times
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    • Site-wide: 48,083
    • In genetics: 2,139
  • Year to date:
    • Site-wide: 100,887
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Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

genetics more details view paper
  • Downloaded 574 times
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    • Site-wide: 53,109
    • In genetics: 2,341
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Shared heritability and functional enrichment across six solid cancers

genomics more details view paper
  • Downloaded 557 times
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    • Site-wide: 55,113
    • In genomics: 4,139
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    • Site-wide: 127,289
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Haplotype-based eQTL mapping finds evidence for complex gene regulatory regions poorly tagged by marginal SNPs

genetics more details view paper
  • Downloaded 547 times
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    • Site-wide: 56,275
    • In genetics: 2,483
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    • Site-wide: 120,434

Leveraging ancestry to improve causal variant identification in exome sequencing for monogenic disorders

genetics more details view paper
  • Downloaded 546 times
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    • Site-wide: 56,320
    • In genetics: 2,491
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    • Site-wide: 153,718
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Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

cancer biology more details view paper
  • Downloaded 525 times
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    • Site-wide: 59,149
    • In cancer biology: 1,690
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H3k27ac-HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility

genomics more details view paper
  • Downloaded 521 times
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    • Site-wide: 59,620
    • In genomics: 4,377
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A unifying framework for joint trait analysis under a non-infinitesimal model

bioinformatics more details view paper
  • Downloaded 520 times
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    • Site-wide: 59,806
    • In bioinformatics: 5,888
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Powerful eQTL mapping through low coverage RNA sequencing

genomics more details view paper
  • Downloaded 449 times
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    • Site-wide: 70,261
    • In genomics: 4,863
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Credible learning of hydroxychloroquine and dexamethasone effects on COVID-19 mortality outside of randomized trials

infectious diseases more details view paper
  • Downloaded 449 times
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    • Site-wide: 70,256
    • In infectious diseases: 3,638
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Leveraging expression from multiple tissues using sparse canonical correlation analysis (sCCA) and aggregate tests improves the power of transcriptome-wide association studies (TWAS)

genetics more details view paper
  • Downloaded 436 times
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    • Site-wide: 72,328
    • In genetics: 3,175
  • Year to date:
    • Site-wide: 31,349
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    • Site-wide: 96,087

Quantifying the contribution of dominance effects to complex trait variation in biobank-scale data

genetics more details view paper
  • Downloaded 386 times
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    • Site-wide: 81,257
    • In genetics: 3,526
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    • Site-wide: 69,445
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    • Site-wide: 97,954

Gene expression imputation provides insight into the genetic architecture of frontotemporal dementia

genetics more details view paper
  • Downloaded 294 times
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    • Site-wide: 101,311
    • In genetics: 4,305
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    • Site-wide: 100,432

RAISS: Robust and Accurate imputation from Summary Statistics

bioinformatics more details view paper
  • Downloaded 280 times
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    • Site-wide: 104,708
    • In bioinformatics: 8,872
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    • Site-wide: 149,360
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    • Site-wide: 78,830

A two-step approach to testing overall effect of gene-environment interaction for multiple phenotypes

genetics more details view paper
  • Downloaded 274 times
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    • Site-wide: 105,973
    • In genetics: 4,492
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Combining SNP-to-gene linking strategies to pinpoint disease genes and assess disease omnigenicity

genetic and genomic medicine more details view paper
  • Downloaded 22 times
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    • Site-wide: 153,736
    • In genetic and genomic medicine: 936
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Partitioning gene-level contributions to complex-trait heritability by allele frequency identifies disease-relevant genes

genetics more details view paper
  • Downloaded 14 times
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    • Site-wide: 154,095
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