Author: Myles Brown

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Preprints

In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target

• Downloaded 2,205 times
• Download rankings, all-time:
  • Site-wide: 9,893
  • In cancer biology: 177
• Year to date:
  • Site-wide: 13,550
• Since beginning of last month:
  • Site-wide: 10,725

MIRA: Joint regulatory modeling of multimodal expression and chromatin accessibility in single cells

• Downloaded 2,057 times
• Download rankings, all-time:
  • Site-wide: 11,027
  • In bioinformatics: 1,247
• Year to date:
  • Site-wide: 2,619
• Since beginning of last month:
  • Site-wide: None

Determinants of transcription factor regulatory range

• Downloaded 1,825 times
• Download rankings, all-time:
  • Site-wide: 13,154
  • In genomics: 1,203
• Year to date:
  • Site-wide: 155,746
• Since beginning of last month:
  • Site-wide: 128,492

Integrative analysis and refined design of CRISPR knockout screens

• Downloaded 1,161 times
• Download rankings, all-time:
  • Site-wide: 26,207
  • In bioinformatics: 2,737
• Year to date:
  • Site-wide: 141,229
• Since beginning of last month:
  • Site-wide: 177,896

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

• Downloaded 1,123 times
• Download rankings, all-time:
  • Site-wide: 27,581
  • In cancer biology: 662
• Year to date:
  • Site-wide: 90,151
• Since beginning of last month:
  • Site-wide: 75,706

MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

• Downloaded 1,037 times
• Download rankings, all-time:
  • Site-wide: 31,000
  • In genomics: 2,683
• Year to date:
  • Site-wide: 22,795
• Since beginning of last month:
  • Site-wide: 25,472

Genome-wide CRISPR screens identify essential cell growth mediators in BRAF-inhibitor resistant melanoma

• Downloaded 741 times
• Download rankings, all-time:
  • Site-wide: 50,672
  • In cancer biology: 1,371
• Year to date:
  • Site-wide: 113,835
• Since beginning of last month:
  • Site-wide: 106,154

The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells

• Downloaded 720 times
• Download rankings, all-time:
  • Site-wide: 52,794
  • In cancer biology: 1,443
• Year to date:
  • Site-wide: 107,729
• Since beginning of last month:
  • Site-wide: 160,670

CoBRA: Containerized Bioinformatics workflow for Reproducible ChIP/ATAC-seq Analysis - from differential peak calling to pathway analysis

• Downloaded 712 times
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  • Site-wide: 53,614
  • In bioinformatics: 5,436
• Year to date:
  • Site-wide: 38,592
• Since beginning of last month:
  • Site-wide: 34,971

Inferring transcriptional regulators through integrative modeling of public chromatin accessibility and ChIP-seq data

• Downloaded 620 times
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  • Site-wide: 64,569
  • In bioinformatics: 6,030
• Year to date:
  • Site-wide: 120,345
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  • Site-wide: 143,915

FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance

• Downloaded 580 times
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  • Site-wide: 70,309
  • In cancer biology: 2,118
• Year to date:
  • Site-wide: 39,027
• Since beginning of last month:
  • Site-wide: 36,623

CHIPS: A Snakemake pipeline for quality control and reproducible processing of chromatin profiling data

• Downloaded 569 times
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  • Site-wide: 71,819
  • In bioinformatics: 6,583
• Year to date:
  • Site-wide: 98,326
• Since beginning of last month:
  • Site-wide: 106,461

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

• Downloaded 566 times
• Download rankings, all-time:
  • Site-wide: 72,352
  • In cancer biology: 2,027
• Year to date:
  • Site-wide: 136,653
• Since beginning of last month:
  • Site-wide: 104,048

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress

• Downloaded 524 times
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  • Site-wide: 79,396
  • In cancer biology: 2,325
• Year to date:
  • Site-wide: 51,716
• Since beginning of last month:
  • Site-wide: 81,999

Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 113,715
  • In cancer biology: 3,664
• Year to date:
  • Site-wide: 27,878
• Since beginning of last month:
  • Site-wide: 53,814

Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer

• Downloaded 235 times
• Download rankings, all-time:
  • Site-wide: 151,844
  • In cancer biology: 4,545
• Year to date:
  • Site-wide: 76,345
• Since beginning of last month:
  • Site-wide: 59,378