Author: Erik Ingelsson

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Preprints

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,383 times
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  • Site-wide: 5,649
  • In genetics: 184
• Year to date:
  • Site-wide: 78,198
• Since beginning of last month:
  • Site-wide: 71,714

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,354 times
• Download rankings, all-time:
  • Site-wide: 5,722
  • In genomics: 494
• Year to date:
  • Site-wide: 133,993
• Since beginning of last month:
  • Site-wide: 109,738

Large-scale non-targeted metabolomic profiling in three human population-based studies

• Downloaded 3,238 times
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  • Site-wide: 6,023
  • In bioinformatics: 495
• Year to date:
  • Site-wide: 111,536
• Since beginning of last month:
  • Site-wide: 71,373

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 3,073 times
• Download rankings, all-time:
  • Site-wide: 6,514
  • In genetics: 253
• Year to date:
  • Site-wide: 12,230
• Since beginning of last month:
  • Site-wide: 13,748

Identification of rare-disease genes in diverse undiagnosed cases using whole blood transcriptome sequencing and large control cohorts

• Downloaded 2,545 times
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  • Site-wide: 8,558
  • In genomics: 770
• Year to date:
  • Site-wide: 121,729
• Since beginning of last month:
  • Site-wide: None

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 2,360 times
• Download rankings, all-time:
  • Site-wide: 9,559
  • In genetic and genomic medicine: 50
• Year to date:
  • Site-wide: 6,801
• Since beginning of last month:
  • Site-wide: 28,054

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,937 times
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  • Site-wide: 12,858
  • In genetics: 468
• Year to date:
  • Site-wide: 163,277
• Since beginning of last month:
  • Site-wide: 178,517

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight novel adipocyte biology

• Downloaded 1,911 times
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  • Site-wide: 13,125
  • In genetics: 487
• Year to date:
  • Site-wide: 87,386
• Since beginning of last month:
  • Site-wide: 82,999

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,862 times
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  • Site-wide: 13,614
  • In genetics: 524
• Year to date:
  • Site-wide: 72,961
• Since beginning of last month:
  • Site-wide: 58,696

Genetic analyses in UK Biobank identifies 78 novel loci associated with urinary biomarkers providing new insights into the biology of kidney function and chronic disease

• Downloaded 1,703 times
• Download rankings, all-time:
  • Site-wide: 15,629
  • In genetics: 610
• Year to date:
  • Site-wide: 92,021
• Since beginning of last month:
  • Site-wide: 58,706

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,612 times
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  • Site-wide: 16,993
  • In genetics: 648
• Year to date:
  • Site-wide: 121,962
• Since beginning of last month:
  • Site-wide: 109,453

Zebrafish larvae as a model system for systematic characterization of drugs and genes in dyslipidemia and atherosclerosis

• Downloaded 1,590 times
• Download rankings, all-time:
  • Site-wide: 17,370
  • In genomics: 1,624
• Year to date:
  • Site-wide: 24,421
• Since beginning of last month:
  • Site-wide: 59,217

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

• Downloaded 1,284 times
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  • Site-wide: 24,247
  • In genomics: 2,592
• Year to date:
  • Site-wide: 8,499
• Since beginning of last month:
  • Site-wide: 10,118

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,260 times
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  • Site-wide: 24,999
  • In genetics: 979
• Year to date:
  • Site-wide: 92,425
• Since beginning of last month:
  • Site-wide: 54,326

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 1,216 times
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  • Site-wide: 26,412
  • In genetics: 1,113
• Year to date:
  • Site-wide: 56,141
• Since beginning of last month:
  • Site-wide: 27,570

Large-scale phenome-wide association study of PCSK9 loss-of-function variants demonstrates protection against ischemic stroke

• Downloaded 1,202 times
• Download rankings, all-time:
  • Site-wide: 26,922
  • In genetics: 1,002
• Year to date:
  • Site-wide: 187,472
• Since beginning of last month:
  • Site-wide: 178,468

Fitness, Physical Activity, And Cardiovascular Disease: Longitudinal And Genetic Analyses In The UK Biobank Study

• Downloaded 1,050 times
• Download rankings, all-time:
  • Site-wide: 33,028
  • In epidemiology: 1,714
• Year to date:
  • Site-wide: 162,372
• Since beginning of last month:
  • Site-wide: 94,447

Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9/based approach

• Downloaded 987 times
• Download rankings, all-time:
  • Site-wide: 36,301
  • In genomics: 2,841
• Year to date:
  • Site-wide: 83,245
• Since beginning of last month:
  • Site-wide: 92,327

Genetic dysregulation of gene expression and splicing during a ten-year period of human aging

• Downloaded 959 times
• Download rankings, all-time:
  • Site-wide: 37,936
  • In genomics: 2,912
• Year to date:
  • Site-wide: 95,114
• Since beginning of last month:
  • Site-wide: 132,126

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 924 times
• Download rankings, all-time:
  • Site-wide: 40,134
  • In genetics: 1,539
• Year to date:
  • Site-wide: 141,664
• Since beginning of last month:
  • Site-wide: 109,995

Birthweight, Type 2 Diabetes and Cardiovascular Disease: Addressing the Barker Hypothesis with Mendelian randomization

• Downloaded 864 times
• Download rankings, all-time:
  • Site-wide: 44,350
  • In genetics: 1,691
• Year to date:
  • Site-wide: 154,247
• Since beginning of last month:
  • Site-wide: 128,351

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 848 times
• Download rankings, all-time:
  • Site-wide: 45,713
  • In genomics: 3,242
• Year to date:
  • Site-wide: 119,184
• Since beginning of last month:
  • Site-wide: 155,007

Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank

• Downloaded 808 times
• Download rankings, all-time:
  • Site-wide: 49,037
  • In genomics: 3,476
• Year to date:
  • Site-wide: 122,044
• Since beginning of last month:
  • Site-wide: 83,107

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 778 times
• Download rankings, all-time:
  • Site-wide: 51,840
  • In genetics: 1,919
• Year to date:
  • Site-wide: 189,747
• Since beginning of last month:
  • Site-wide: 183,976

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 729 times
• Download rankings, all-time:
  • Site-wide: 56,917
  • In genetics: 2,095
• Year to date:
  • Site-wide: 185,141
• Since beginning of last month:
  • Site-wide: 128,340

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 694 times
• Download rankings, all-time:
  • Site-wide: 60,991
  • In genetics: 2,233
• Year to date:
  • Site-wide: 170,910
• Since beginning of last month:
  • Site-wide: 158,482

Bioimpedance and new onset heart failure: A longitudinal study of ~500,000 individuals from the general population

• Downloaded 670 times
• Download rankings, all-time:
  • Site-wide: 64,098
  • In epidemiology: 2,709
• Year to date:
  • Site-wide: 194,858
• Since beginning of last month:
  • Site-wide: 175,116

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

• Downloaded 648 times
• Download rankings, all-time:
  • Site-wide: 67,032
  • In genetics: 2,500
• Year to date:
  • Site-wide: 145,517
• Since beginning of last month:
  • Site-wide: 124,479

Loss of function, missense, and intronic variants in NOTCH1 confer different risks for left ventricular outflow tract obstructive heart defects in two European cohorts

• Downloaded 636 times
• Download rankings, all-time:
  • Site-wide: 68,785
  • In genetics: 2,562
• Year to date:
  • Site-wide: 141,714
• Since beginning of last month:
  • Site-wide: 89,844

Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes

• Downloaded 601 times
• Download rankings, all-time:
  • Site-wide: 74,083
  • In genetic and genomic medicine: 371
• Year to date:
  • Site-wide: 53,426
• Since beginning of last month:
  • Site-wide: 140,613

Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci

• Downloaded 591 times
• Download rankings, all-time:
  • Site-wide: 75,568
  • In genomics: 4,657
• Year to date:
  • Site-wide: 177,066
• Since beginning of last month:
  • Site-wide: 156,795

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 558 times
• Download rankings, all-time:
  • Site-wide: 81,174
  • In genetics: 2,981
• Year to date:
  • Site-wide: 165,143
• Since beginning of last month:
  • Site-wide: 178,412

A phenome-wide association study of four syndromic genes reveals pleiotropic effects of common and rare variants in the general population

• Downloaded 495 times
• Download rankings, all-time:
  • Site-wide: 93,491
  • In genetic and genomic medicine: 483
• Year to date:
  • Site-wide: 92,217
• Since beginning of last month:
  • Site-wide: 74,690

Urinary biomarkers and cardiovascular outcomes in the UK Biobank: observational and Mendelian randomization analyses

• Downloaded 474 times
• Download rankings, all-time:
  • Site-wide: 98,040
  • In epidemiology: 3,891
• Year to date:
  • Site-wide: 142,180
• Since beginning of last month:
  • Site-wide: 132,022

Prediction performance of a cardiovascular risk assessment tool using Stanford EHR data repository

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 105,714
  • In bioinformatics: 8,253
• Year to date:
  • Site-wide: 176,449
• Since beginning of last month:
  • Site-wide: 124,514

Development and validation of a next-gen health stratification engine to determine risk for multiple cardiovascular diseases

• Downloaded 432 times
• Download rankings, all-time:
  • Site-wide: 107,846
  • In bioinformatics: 8,432
• Year to date:
  • Site-wide: 158,218
• Since beginning of last month:
  • Site-wide: 176,038

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

• Downloaded 417 times
• Download rankings, all-time:
  • Site-wide: 111,657
  • In cardiovascular medicine: 231
• Year to date:
  • Site-wide: 161,316
• Since beginning of last month:
  • Site-wide: 106,817

Clinical conditions and their impact on utility of genetic scores for prediction of acute coronary syndrome

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 128,816
  • In cardiovascular medicine: 289
• Year to date:
  • Site-wide: 169,321
• Since beginning of last month:
  • Site-wide: 139,538

Alcohol use and cardiometabolic risk in the UK Biobank: a Mendelian randomization study

• Downloaded 348 times
• Download rankings, all-time:
  • Site-wide: 130,255
  • In genetics: 4,822
• Year to date:
  • Site-wide: 118,713
• Since beginning of last month:
  • Site-wide: 164,432