Author: Erik Ingelsson

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Preprints

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 4,009
  • In genomics: 434
• Year to date:
  • Site-wide: 75,359
• Since beginning of last month:
  • Site-wide: 108,659

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 4,285
  • In genetics: 174
• Year to date:
  • Site-wide: 60,191
• Since beginning of last month:
  • Site-wide: 46,863

Large-scale non-targeted metabolomic profiling in three human population-based studies

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  • Site-wide: 4,363
  • In bioinformatics: 432
• Year to date:
  • Site-wide: 36,037
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  • Site-wide: 17,841

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 2,443 times
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  • Site-wide: 6,098
  • In genetics: 272
• Year to date:
  • Site-wide: 7,821
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  • Site-wide: 10,048

Identification of rare-disease genes in diverse undiagnosed cases using whole blood transcriptome sequencing and large control cohorts

• Downloaded 2,355 times
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  • Site-wide: 6,440
  • In genomics: 702
• Year to date:
  • Site-wide: 34,644
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  • Site-wide: 62,972

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,870 times
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  • Site-wide: 8,987
  • In genetics: 405
• Year to date:
  • Site-wide: 89,822
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  • Site-wide: 100,517

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight novel adipocyte biology

• Downloaded 1,748 times
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  • Site-wide: 9,969
  • In genetics: 455
• Year to date:
  • Site-wide: 48,081
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  • Site-wide: 46,663

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,696 times
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  • Site-wide: 10,419
  • In genetics: 478
• Year to date:
  • Site-wide: 60,169
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  • Site-wide: 53,523

Genetic analyses in UK Biobank identifies 78 novel loci associated with urinary biomarkers providing new insights into the biology of kidney function and chronic disease

• Downloaded 1,526 times
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  • Site-wide: 12,119
  • In genetics: 570
• Year to date:
  • Site-wide: 56,158
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  • Site-wide: 88,514

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,486 times
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  • Site-wide: 12,618
  • In genetics: 593
• Year to date:
  • Site-wide: 94,356
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  • Site-wide: 103,560

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 1,288 times
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  • Site-wide: 15,694
  • In genetic and genomic medicine: 60
• Year to date:
  • Site-wide: 6,597
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  • Site-wide: 6,203

Zebrafish larvae as a model system for systematic characterization of drugs and genes in dyslipidemia and atherosclerosis

• Downloaded 1,187 times
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  • Site-wide: 17,713
  • In genomics: 1,783
• Year to date:
  • Site-wide: 28,317
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  • Site-wide: 36,294

Large-scale phenome-wide association study of PCSK9 loss-of-function variants demonstrates protection against ischemic stroke

• Downloaded 1,154 times
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  • Site-wide: 18,457
  • In genetics: 877
• Year to date:
  • Site-wide: 71,061
• Since beginning of last month:
  • Site-wide: 69,332

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 990 times
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  • Site-wide: 23,094
  • In genetics: 1,082
• Year to date:
  • Site-wide: 9,364
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  • Site-wide: 5,995

Fitness, Physical Activity, And Cardiovascular Disease: Longitudinal And Genetic Analyses In The UK Biobank Study

• Downloaded 981 times
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  • Site-wide: 23,425
  • In epidemiology: 1,353
• Year to date:
  • Site-wide: 111,810
• Since beginning of last month:
  • Site-wide: 82,632

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 949 times
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  • Site-wide: 24,678
  • In genetics: 1,159
• Year to date:
  • Site-wide: 20,926
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  • Site-wide: 30,351

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 851 times
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  • Site-wide: 28,741
  • In genetics: 1,359
• Year to date:
  • Site-wide: 67,059
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  • Site-wide: 46,804

Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9/based approach

• Downloaded 850 times
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  • Site-wide: 28,807
  • In genomics: 2,604
• Year to date:
  • Site-wide: 67,480
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  • Site-wide: 90,310

Genetic dysregulation of gene expression and splicing during a ten-year period of human aging

• Downloaded 838 times
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  • Site-wide: 29,406
  • In genomics: 2,647
• Year to date:
  • Site-wide: 117,299
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  • Site-wide: 129,289

Birthweight, Type 2 Diabetes and Cardiovascular Disease: Addressing the Barker Hypothesis with Mendelian randomization

• Downloaded 783 times
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  • Site-wide: 32,255
  • In genetics: 1,520
• Year to date:
  • Site-wide: 79,018
• Since beginning of last month:
  • Site-wide: 36,520

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 760 times
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  • Site-wide: 33,643
  • In genomics: 2,914
• Year to date:
  • Site-wide: 109,602
• Since beginning of last month:
  • Site-wide: 100,414

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 718 times
• Download rankings, all-time:
  • Site-wide: 36,361
  • In genetics: 1,702
• Year to date:
  • Site-wide: 134,338
• Since beginning of last month:
  • Site-wide: 112,677

Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank

• Downloaded 709 times
• Download rankings, all-time:
  • Site-wide: 37,023
  • In genomics: 3,119
• Year to date:
  • Site-wide: 89,406
• Since beginning of last month:
  • Site-wide: 47,002

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 685 times
• Download rankings, all-time:
  • Site-wide: 38,771
  • In genetics: 1,786
• Year to date:
  • Site-wide: 105,705
• Since beginning of last month:
  • Site-wide: 141,208

Bioimpedance and new onset heart failure: A longitudinal study of ~500,000 individuals from the general population

• Downloaded 629 times
• Download rankings, all-time:
  • Site-wide: 43,273
  • In epidemiology: 2,078
• Year to date:
  • Site-wide: 128,113
• Since beginning of last month:
  • Site-wide: 122,845

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 625 times
• Download rankings, all-time:
  • Site-wide: 43,583
  • In genetics: 2,012
• Year to date:
  • Site-wide: 91,596
• Since beginning of last month:
  • Site-wide: 108,224

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

• Downloaded 594 times
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  • Site-wide: 46,490
  • In genetics: 2,131
• Year to date:
  • Site-wide: 76,932
• Since beginning of last month:
  • Site-wide: 100,481

Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci

• Downloaded 536 times
• Download rankings, all-time:
  • Site-wide: 52,611
  • In genomics: 4,045
• Year to date:
  • Site-wide: 111,129
• Since beginning of last month:
  • Site-wide: 112,438

Loss of function, missense, and intronic variants in NOTCH1 confer different risks for left ventricular outflow tract obstructive heart defects in two European cohorts

• Downloaded 534 times
• Download rankings, all-time:
  • Site-wide: 52,795
  • In genetics: 2,396
• Year to date:
  • Site-wide: 94,194
• Since beginning of last month:
  • Site-wide: 74,101

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 482 times
• Download rankings, all-time:
  • Site-wide: 59,494
  • In genetics: 2,700
• Year to date:
  • Site-wide: 130,331
• Since beginning of last month:
  • Site-wide: 132,966

Urinary biomarkers and cardiovascular outcomes in the UK Biobank: observational and Mendelian randomization analyses

• Downloaded 381 times
• Download rankings, all-time:
  • Site-wide: 75,332
  • In epidemiology: 3,186
• Year to date:
  • Site-wide: 119,867
• Since beginning of last month:
  • Site-wide: 92,511

Prediction performance of a cardiovascular risk assessment tool using Stanford EHR data repository

• Downloaded 366 times
• Download rankings, all-time:
  • Site-wide: 78,098
  • In bioinformatics: 7,193
• Year to date:
  • Site-wide: 88,035
• Since beginning of last month:
  • Site-wide: 111,572

Development and validation of a next-gen health stratification engine to determine risk for multiple cardiovascular diseases

• Downloaded 348 times
• Download rankings, all-time:
  • Site-wide: 81,546
  • In bioinformatics: 7,416
• Year to date:
  • Site-wide: 117,529
• Since beginning of last month:
  • Site-wide: 89,340

A phenome-wide association study of four syndromic genes reveals pleiotropic effects of common and rare variants in the general population

• Downloaded 315 times
• Download rankings, all-time:
  • Site-wide: 88,411
  • In genetic and genomic medicine: 366
• Year to date:
  • Site-wide: 79,429
• Since beginning of last month:
  • Site-wide: 67,420

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

• Downloaded 309 times
• Download rankings, all-time:
  • Site-wide: 89,724
  • In cardiovascular medicine: 166
• Year to date:
  • Site-wide: 81,033
• Since beginning of last month:
  • Site-wide: 67,820

Clinical conditions and their impact on utility of genetic scores for prediction of acute coronary syndrome

• Downloaded 239 times
• Download rankings, all-time:
  • Site-wide: 105,437
  • In cardiovascular medicine: 219
• Year to date:
  • Site-wide: 63,227
• Since beginning of last month:
  • Site-wide: 50,833

Alcohol use and cardiometabolic risk in the UK Biobank: a Mendelian randomization study

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 110,577
  • In genetics: 4,750
• Year to date:
  • Site-wide: 53,751
• Since beginning of last month:
  • Site-wide: 37,778