Author: Erik Ingelsson

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Preprints

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 4,769
  • In genomics: 470
• Year to date:
  • Site-wide: 114,889
• Since beginning of last month:
  • Site-wide: 160,058

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 4,804
  • In genetics: 181
• Year to date:
  • Site-wide: 42,864
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  • Site-wide: 60,287

Large-scale non-targeted metabolomic profiling in three human population-based studies

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  • Site-wide: 5,063
  • In bioinformatics: 475
• Year to date:
  • Site-wide: 50,336
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  • Site-wide: 38,285

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • Site-wide: 6,377
  • In genetics: 258
• Year to date:
  • Site-wide: 10,067
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  • Site-wide: 13,298

Identification of rare-disease genes in diverse undiagnosed cases using whole blood transcriptome sequencing and large control cohorts

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  • Site-wide: 7,220
  • In genomics: 744
• Year to date:
  • Site-wide: 40,630
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  • Site-wide: 77,460

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 10,693
  • In genetics: 453
• Year to date:
  • Site-wide: 130,725
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  • Site-wide: 156,019

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight novel adipocyte biology

• Downloaded 1,833 times
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  • Site-wide: 11,353
  • In genetics: 478
• Year to date:
  • Site-wide: 65,436
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  • Site-wide: 101,293

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Site-wide: 11,831
  • In genetic and genomic medicine: 54
• Year to date:
  • Site-wide: 5,732
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  • Site-wide: 5,175

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 11,925
  • In genetics: 509
• Year to date:
  • Site-wide: 78,897
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  • Site-wide: 131,797

Genetic analyses in UK Biobank identifies 78 novel loci associated with urinary biomarkers providing new insights into the biology of kidney function and chronic disease

• Downloaded 1,633 times
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  • Site-wide: 13,450
  • In genetics: 589
• Year to date:
  • Site-wide: 62,360
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  • Site-wide: 78,091

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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  • Site-wide: 14,497
  • In genetics: 633
• Year to date:
  • Site-wide: 104,946
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  • Site-wide: 86,525

Zebrafish larvae as a model system for systematic characterization of drugs and genes in dyslipidemia and atherosclerosis

• Downloaded 1,345 times
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  • Site-wide: 18,197
  • In genomics: 1,734
• Year to date:
  • Site-wide: 32,067
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  • Site-wide: 21,854

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 21,961
  • In genetics: 959
• Year to date:
  • Site-wide: 13,374
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  • Site-wide: 94,305

Large-scale phenome-wide association study of PCSK9 loss-of-function variants demonstrates protection against ischemic stroke

• Downloaded 1,184 times
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  • Site-wide: 22,069
  • In genetics: 966
• Year to date:
  • Site-wide: 122,530
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  • Site-wide: 158,311

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 25,433
  • In genetics: 1,118
• Year to date:
  • Site-wide: 29,853
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  • Site-wide: 61,025

Fitness, Physical Activity, And Cardiovascular Disease: Longitudinal And Genetic Analyses In The UK Biobank Study

• Downloaded 1,013 times
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  • Site-wide: 27,962
  • In epidemiology: 1,602
• Year to date:
  • Site-wide: 146,915
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  • Site-wide: 151,423

Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9/based approach

• Downloaded 907 times
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  • Site-wide: 32,886
  • In genomics: 2,775
• Year to date:
  • Site-wide: 97,500
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  • Site-wide: 131,607

Genetic dysregulation of gene expression and splicing during a ten-year period of human aging

• Downloaded 890 times
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  • Site-wide: 33,827
  • In genomics: 2,849
• Year to date:
  • Site-wide: 132,117
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  • Site-wide: 117,935

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 887 times
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  • Site-wide: 34,010
  • In genetics: 1,490
• Year to date:
  • Site-wide: 113,463
• Since beginning of last month:
  • Site-wide: 139,313

Birthweight, Type 2 Diabetes and Cardiovascular Disease: Addressing the Barker Hypothesis with Mendelian randomization

• Downloaded 833 times
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  • Site-wide: 37,248
  • In genetics: 1,622
• Year to date:
  • Site-wide: 112,049
• Since beginning of last month:
  • Site-wide: 149,932

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 799 times
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  • Site-wide: 39,499
  • In genomics: 3,189
• Year to date:
  • Site-wide: 140,384
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  • Site-wide: 146,441

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 758 times
• Download rankings, all-time:
  • Site-wide: 42,638
  • In genetics: 1,844
• Year to date:
  • Site-wide: 149,583
• Since beginning of last month:
  • Site-wide: 130,102

Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank

• Downloaded 751 times
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  • Site-wide: 43,156
  • In genomics: 3,413
• Year to date:
  • Site-wide: 126,173
• Since beginning of last month:
  • Site-wide: 111,710

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 708 times
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  • Site-wide: 46,888
  • In genetics: 2,021
• Year to date:
  • Site-wide: 150,999
• Since beginning of last month:
  • Site-wide: 158,363

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 666 times
• Download rankings, all-time:
  • Site-wide: 51,015
  • In genetics: 2,178
• Year to date:
  • Site-wide: 129,053
• Since beginning of last month:
  • Site-wide: 143,302

Bioimpedance and new onset heart failure: A longitudinal study of ~500,000 individuals from the general population

• Downloaded 654 times
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  • Site-wide: 52,270
  • In epidemiology: 2,507
• Year to date:
  • Site-wide: 156,719
• Since beginning of last month:
  • Site-wide: 158,455

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

• Downloaded 614 times
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  • Site-wide: 56,927
  • In genetics: 2,412
• Year to date:
  • Site-wide: 137,344
• Since beginning of last month:
  • Site-wide: 156,159

Loss of function, missense, and intronic variants in NOTCH1 confer different risks for left ventricular outflow tract obstructive heart defects in two European cohorts

• Downloaded 598 times
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  • Site-wide: 58,788
  • In genetics: 2,490
• Year to date:
  • Site-wide: 109,645
• Since beginning of last month:
  • Site-wide: 121,161

Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci

• Downloaded 565 times
• Download rankings, all-time:
  • Site-wide: 63,091
  • In genomics: 4,500
• Year to date:
  • Site-wide: 148,864
• Since beginning of last month:
  • Site-wide: 146,520

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 529 times
• Download rankings, all-time:
  • Site-wide: 68,307
  • In genetics: 2,914
• Year to date:
  • Site-wide: 143,003
• Since beginning of last month:
  • Site-wide: 91,209

Urinary biomarkers and cardiovascular outcomes in the UK Biobank: observational and Mendelian randomization analyses

• Downloaded 437 times
• Download rankings, all-time:
  • Site-wide: 84,552
  • In epidemiology: 3,654
• Year to date:
  • Site-wide: 129,289
• Since beginning of last month:
  • Site-wide: 70,204

Prediction performance of a cardiovascular risk assessment tool using Stanford EHR data repository

• Downloaded 416 times
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  • Site-wide: 88,752
  • In bioinformatics: 7,857
• Year to date:
  • Site-wide: 118,526
• Since beginning of last month:
  • Site-wide: 111,745

A phenome-wide association study of four syndromic genes reveals pleiotropic effects of common and rare variants in the general population

• Downloaded 415 times
• Download rankings, all-time:
  • Site-wide: 88,931
  • In genetic and genomic medicine: 448
• Year to date:
  • Site-wide: 78,483
• Since beginning of last month:
  • Site-wide: 58,371

Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes

• Downloaded 412 times
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  • Site-wide: 89,588
  • In genetic and genomic medicine: 451
• Year to date:
  • Site-wide: 21,380
• Since beginning of last month:
  • Site-wide: 2,233

Development and validation of a next-gen health stratification engine to determine risk for multiple cardiovascular diseases

• Downloaded 401 times
• Download rankings, all-time:
  • Site-wide: 91,938
  • In bioinformatics: 8,059
• Year to date:
  • Site-wide: 131,616
• Since beginning of last month:
  • Site-wide: 102,233

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 97,535
  • In cardiovascular medicine: 214
• Year to date:
  • Site-wide: 99,795
• Since beginning of last month:
  • Site-wide: 74,550

Clinical conditions and their impact on utility of genetic scores for prediction of acute coronary syndrome

• Downloaded 325 times
• Download rankings, all-time:
  • Site-wide: 109,970
  • In cardiovascular medicine: 249
• Year to date:
  • Site-wide: 77,021
• Since beginning of last month:
  • Site-wide: 105,486

Alcohol use and cardiometabolic risk in the UK Biobank: a Mendelian randomization study

• Downloaded 300 times
• Download rankings, all-time:
  • Site-wide: 116,329
  • In genetics: 4,747
• Year to date:
  • Site-wide: 71,563
• Since beginning of last month:
  • Site-wide: 88,746