Author: Erik Ingelsson

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Preprints

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,206 times
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  • Site-wide: 3,244
  • In genomics: 387
• Year to date:
  • Site-wide: 62,049
• Since beginning of last month:
  • Site-wide: 71,198

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,027 times
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  • Site-wide: 3,510
  • In genetics: 165
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 56,528

Large-scale non-targeted metabolomic profiling in three human population-based studies

• Downloaded 2,931 times
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  • Site-wide: 3,643
  • In bioinformatics: 405
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 107,678

Identification of rare-disease genes in diverse undiagnosed cases using whole blood transcriptome sequencing and large control cohorts

• Downloaded 2,216 times
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  • Site-wide: 5,515
  • In genomics: 667
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 53,340

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 1,995 times
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  • Site-wide: 6,406
  • In genetics: 324
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 11,828

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,833 times
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  • Site-wide: 7,287
  • In genetics: 364
• Year to date:
  • Site-wide: 25,701
• Since beginning of last month:
  • Site-wide: 74,003

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight novel adipocyte biology

• Downloaded 1,640 times
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  • Site-wide: 8,621
  • In genetics: 443
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 49,895

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,627 times
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  • Site-wide: 8,711
  • In genetics: 450
• Year to date:
  • Site-wide: 37,300
• Since beginning of last month:
  • Site-wide: 26,637

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,455 times
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  • Site-wide: 10,284
  • In genetics: 525
• Year to date:
  • Site-wide: 18,650
• Since beginning of last month:
  • Site-wide: 49,836

Genetic analyses in UK Biobank identifies 78 novel loci associated with urinary biomarkers providing new insights into the biology of kidney function and chronic disease

• Downloaded 1,451 times
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  • Site-wide: 10,325
  • In genetics: 533
• Year to date:
  • Site-wide: 36,696
• Since beginning of last month:
  • Site-wide: 23,991

Large-scale phenome-wide association study of PCSK9 loss-of-function variants demonstrates protection against ischemic stroke

• Downloaded 1,083 times
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  • Site-wide: 16,064
  • In genetics: 836
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 97,537

Zebrafish larvae as a model system for systematic characterization of drugs and genes in dyslipidemia and atherosclerosis

• Downloaded 1,039 times
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  • Site-wide: 17,084
  • In genomics: 1,820
• Year to date:
  • Site-wide: 21,752
• Since beginning of last month:
  • Site-wide: 17,599

Fitness, Physical Activity, And Cardiovascular Disease: Longitudinal And Genetic Analyses In The UK Biobank Study

• Downloaded 955 times
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  • Site-wide: 19,398
  • In epidemiology: 1,084
• Year to date:
  • Site-wide: 39,948
• Since beginning of last month:
  • Site-wide: 60,395

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 853 times
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  • Site-wide: 22,840
  • In genetic and genomic medicine: 61
• Year to date:
  • Site-wide: 5,316
• Since beginning of last month:
  • Site-wide: 3,970

Genetic dysregulation of gene expression and splicing during a ten-year period of human aging

• Downloaded 805 times
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  • Site-wide: 24,749
  • In genomics: 2,404
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 80,623

Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9/based approach

• Downloaded 793 times
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  • Site-wide: 25,284
  • In genomics: 2,440
• Year to date:
  • Site-wide: 25,702
• Since beginning of last month:
  • Site-wide: 26,311

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 785 times
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  • Site-wide: 25,659
  • In genetics: 1,308
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 91,319

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 764 times
• Download rankings, all-time:
  • Site-wide: 26,566
  • In genetics: 1,354
• Year to date:
  • Site-wide: 10,349
• Since beginning of last month:
  • Site-wide: 16,761

Birthweight, Type 2 Diabetes and Cardiovascular Disease: Addressing the Barker Hypothesis with Mendelian randomization

• Downloaded 727 times
• Download rankings, all-time:
  • Site-wide: 28,574
  • In genetics: 1,452
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 111,036

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 726 times
• Download rankings, all-time:
  • Site-wide: 28,644
  • In genomics: 2,659
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 109,612

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 695 times
• Download rankings, all-time:
  • Site-wide: 30,387
  • In genetics: 1,541
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 99,702

Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank

• Downloaded 662 times
• Download rankings, all-time:
  • Site-wide: 32,402
  • In genomics: 2,913
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 113,404

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 652 times
• Download rankings, all-time:
  • Site-wide: 33,129
  • In genetics: 1,668
• Year to date:
  • Site-wide: 70,352
• Since beginning of last month:
  • Site-wide: 73,005

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 645 times
• Download rankings, all-time:
  • Site-wide: 33,574
  • In genetics: 1,694
• Year to date:
  • Site-wide: 10,726
• Since beginning of last month:
  • Site-wide: 7,745

Bioimpedance and new onset heart failure: A longitudinal study of ~500,000 individuals from the general population

• Downloaded 608 times
• Download rankings, all-time:
  • Site-wide: 36,195
  • In epidemiology: 1,693
• Year to date:
  • Site-wide: 68,996
• Since beginning of last month:
  • Site-wide: 110,874

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 587 times
• Download rankings, all-time:
  • Site-wide: 37,895
  • In genetics: 1,877
• Year to date:
  • Site-wide: 43,490
• Since beginning of last month:
  • Site-wide: 46,474

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

• Downloaded 544 times
• Download rankings, all-time:
  • Site-wide: 41,648
  • In genetics: 2,058
• Year to date:
  • Site-wide: 38,692
• Since beginning of last month:
  • Site-wide: 57,843

Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci

• Downloaded 508 times
• Download rankings, all-time:
  • Site-wide: 45,188
  • In genomics: 3,694
• Year to date:
  • Site-wide: 60,814
• Since beginning of last month:
  • Site-wide: 82,936

Loss of function, missense, and intronic variants in NOTCH1 confer different risks for left ventricular outflow tract obstructive heart defects in two European cohorts

• Downloaded 490 times
• Download rankings, all-time:
  • Site-wide: 47,116
  • In genetics: 2,303
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 76,194

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 460 times
• Download rankings, all-time:
  • Site-wide: 50,563
  • In genetics: 2,470
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 107,537

Urinary biomarkers and cardiovascular outcomes in the UK Biobank: observational and Mendelian randomization analyses

• Downloaded 356 times
• Download rankings, all-time:
  • Site-wide: 65,486
  • In epidemiology: 2,682
• Year to date:
  • Site-wide: 64,381
• Since beginning of last month:
  • Site-wide: 88,246

Prediction performance of a cardiovascular risk assessment tool using Stanford EHR data repository

• Downloaded 325 times
• Download rankings, all-time:
  • Site-wide: 70,631
  • In bioinformatics: 6,700
• Year to date:
  • Site-wide: 40,898
• Since beginning of last month:
  • Site-wide: 100,909

Development and validation of a next-gen health stratification engine to determine risk for multiple cardiovascular diseases

• Downloaded 319 times
• Download rankings, all-time:
  • Site-wide: 71,730
  • In bioinformatics: 6,780
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 102,196

A phenome-wide association study of four syndromic genes reveals pleiotropic effects of common and rare variants in the general population

• Downloaded 263 times
• Download rankings, all-time:
  • Site-wide: 82,496
  • In genetic and genomic medicine: 253
• Year to date:
  • Site-wide: 68,758
• Since beginning of last month:
  • Site-wide: 67,546

Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study

• Downloaded 263 times
• Download rankings, all-time:
  • Site-wide: 82,557
  • In cardiovascular medicine: 126
• Year to date:
  • Site-wide: 37,226
• Since beginning of last month:
  • Site-wide: 59,921

Clinical conditions and their impact on utility of genetic scores for prediction of acute coronary syndrome

• Downloaded 174 times
• Download rankings, all-time:
  • Site-wide: 100,905
  • In cardiovascular medicine: 200
• Year to date:
  • Site-wide: 41,692
• Since beginning of last month:
  • Site-wide: 47,480

Alcohol use and cardiometabolic risk in the UK Biobank: a Mendelian randomization study

• Downloaded 119 times
• Download rankings, all-time:
  • Site-wide: 111,183
  • In genetics: 4,930
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 52,034