Author: Lars Lind

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Preprints

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

• Downloaded 6,160 times
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  • Site-wide: 2,573
  • In genetics: 83
• Year to date:
  • Site-wide: 244
• Since beginning of last month:
  • Site-wide: 654

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,416 times
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  • Site-wide: 5,874
  • In genetics: 194
• Year to date:
  • Site-wide: 84,265
• Since beginning of last month:
  • Site-wide: 61,063

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,375 times
• Download rankings, all-time:
  • Site-wide: 5,983
  • In genomics: 541
• Year to date:
  • Site-wide: 147,295
• Since beginning of last month:
  • Site-wide: 111,059

Large-scale non-targeted metabolomic profiling in three human population-based studies

• Downloaded 3,263 times
• Download rankings, all-time:
  • Site-wide: 6,291
  • In bioinformatics: 553
• Year to date:
  • Site-wide: 120,487
• Since beginning of last month:
  • Site-wide: 61,182

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 3,247 times
• Download rankings, all-time:
  • Site-wide: 6,337
  • In genetics: 239
• Year to date:
  • Site-wide: 9,665
• Since beginning of last month:
  • Site-wide: 5,542

Identification of rare-disease genes in diverse undiagnosed cases using whole blood transcriptome sequencing and large control cohorts

• Downloaded 2,588 times
• Download rankings, all-time:
  • Site-wide: 8,796
  • In genomics: 836
• Year to date:
  • Site-wide: 105,919
• Since beginning of last month:
  • Site-wide: 68,388

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 2,478 times
• Download rankings, all-time:
  • Site-wide: 9,394
  • In genetic and genomic medicine: 55
• Year to date:
  • Site-wide: 7,406
• Since beginning of last month:
  • Site-wide: 11,857

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,960 times
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  • Site-wide: 13,411
  • In genetics: 506
• Year to date:
  • Site-wide: 166,299
• Since beginning of last month:
  • Site-wide: 168,234

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,921 times
• Download rankings, all-time:
  • Site-wide: 13,832
  • In genetics: 549
• Year to date:
  • Site-wide: 66,034
• Since beginning of last month:
  • Site-wide: 27,909

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,810 times
• Download rankings, all-time:
  • Site-wide: 15,150
  • In genomics: 1,361
• Year to date:
  • Site-wide: 77,893
• Since beginning of last month:
  • Site-wide: 68,980

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

• Downloaded 1,714 times
• Download rankings, all-time:
  • Site-wide: 16,418
  • In infectious diseases: 2,195
• Year to date:
  • Site-wide: 5,121
• Since beginning of last month:
  • Site-wide: 8,261

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,640 times
• Download rankings, all-time:
  • Site-wide: 17,613
  • In genetics: 693
• Year to date:
  • Site-wide: 124,847
• Since beginning of last month:
  • Site-wide: 79,704

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

• Downloaded 1,369 times
• Download rankings, all-time:
  • Site-wide: 23,467
  • In genomics: 2,132
• Year to date:
  • Site-wide: 9,750
• Since beginning of last month:
  • Site-wide: 30,940

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 1,329 times
• Download rankings, all-time:
  • Site-wide: 24,585
  • In genetics: 1,079
• Year to date:
  • Site-wide: 36,093
• Since beginning of last month:
  • Site-wide: 22,025

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,280 times
• Download rankings, all-time:
  • Site-wide: 26,135
  • In genetics: 1,018
• Year to date:
  • Site-wide: 109,713
• Since beginning of last month:
  • Site-wide: 144,877

Genetic dysregulation of gene expression and splicing during a ten-year period of human aging

• Downloaded 998 times
• Download rankings, all-time:
  • Site-wide: 38,409
  • In genomics: 2,987
• Year to date:
  • Site-wide: 93,203
• Since beginning of last month:
  • Site-wide: 37,809

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 948 times
• Download rankings, all-time:
  • Site-wide: 41,600
  • In genetics: 1,636
• Year to date:
  • Site-wide: 147,233
• Since beginning of last month:
  • Site-wide: 91,644

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 871 times
• Download rankings, all-time:
  • Site-wide: 47,369
  • In genomics: 3,491
• Year to date:
  • Site-wide: 131,451
• Since beginning of last month:
  • Site-wide: 94,976

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 797 times
• Download rankings, all-time:
  • Site-wide: 54,101
  • In genetics: 2,091
• Year to date:
  • Site-wide: 196,556
• Since beginning of last month:
  • Site-wide: 150,136

An online atlas of human plasma metabolite signatures of gut microbiome composition

• Downloaded 785 times
• Download rankings, all-time:
  • Site-wide: 55,371
  • In epidemiology: 2,934
• Year to date:
  • Site-wide: 5,759
• Since beginning of last month:
  • Site-wide: 30,768

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

• Downloaded 743 times
• Download rankings, all-time:
  • Site-wide: 59,876
  • In genetics: 2,272
• Year to date:
  • Site-wide: 201,190
• Since beginning of last month:
  • Site-wide: 187,241

Mapping genetic determinants of 184 circulating proteins in 26,494 individuals to connect proteins and disease.

• Downloaded 713 times
• Download rankings, all-time:
  • Site-wide: 63,600
  • In genetic and genomic medicine: 423
• Year to date:
  • Site-wide: 19,757
• Since beginning of last month:
  • Site-wide: 14,766

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 712 times
• Download rankings, all-time:
  • Site-wide: 63,683
  • In genetics: 2,424
• Year to date:
  • Site-wide: 183,482
• Since beginning of last month:
  • Site-wide: 168,746

Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease

• Downloaded 668 times
• Download rankings, all-time:
  • Site-wide: 69,647
  • In genetic and genomic medicine: 527
• Year to date:
  • Site-wide: 6,592
• Since beginning of last month:
  • Site-wide: 9,493

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

• Downloaded 664 times
• Download rankings, all-time:
  • Site-wide: 70,283
  • In genetics: 2,656
• Year to date:
  • Site-wide: 167,139
• Since beginning of last month:
  • Site-wide: 148,285

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 577 times
• Download rankings, all-time:
  • Site-wide: 84,218
  • In genetics: 3,184
• Year to date:
  • Site-wide: 176,861
• Since beginning of last month:
  • Site-wide: 107,433

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

• Downloaded 470 times
• Download rankings, all-time:
  • Site-wide: 107,023
  • In genetic and genomic medicine: 729
• Year to date:
  • Site-wide: 22,582
• Since beginning of last month:
  • Site-wide: 116,707

Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders

• Downloaded 390 times
• Download rankings, all-time:
  • Site-wide: 127,757
  • In genetic and genomic medicine: 826
• Year to date:
  • Site-wide: 99,898
• Since beginning of last month:
  • Site-wide: 137,114

Streptococcus species abundance in the gut is linked to subclinical coronary atherosclerosis in 8,973 participants from the SCAPIS cohort

• Downloaded 187 times
• Download rankings, all-time:
  • Site-wide: 184,597
  • In epidemiology: 7,608
• Year to date:
  • Site-wide: 49,120
• Since beginning of last month:
  • Site-wide: 17,155

Obstructive sleep apnea is associated with specific gut microbiota species and functions in the population-based Swedish CardioPulmonary bioImage Study (SCAPIS)

• Downloaded 94 times
• Download rankings, all-time:
  • Site-wide: 201,779
  • In epidemiology: 7,823
• Year to date:
  • Site-wide: 99,485
• Since beginning of last month:
  • Site-wide: 65,770