Author: Emad Tajkhorshid

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Preprints

Mechanism of gating and partial agonist action in the glycine receptor

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Activation and desensitization mechanism of AMPA receptor-TARP complex by cryo-EM

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CryoFold: Ab-initio structure determination from electron density maps using molecular dynamics

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Aβ(1-42) tetramer and octamer structures reveal edge pores as a mechanism for membrane damage

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The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells

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The Structures of Secretory and Dimeric Immunoglobulin A

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Glutamate transporters contain a conserved chloride channel with two hydrophobic gates

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A Network of Phosphatidylinositol 4,5-bisphosphate Binding Sites Regulate Gating of the Ca2+-activated Cl− Channel ANO1 (TMEM16A)

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Selective Permeability of Carboxysome Shell Pores to Anionic Molecules

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Structural characterization of an intermediate reveals a unified mechanism for the CLC Cl−/H+ transport cycle

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Phosphatidic acid inhibits SNARE priming by inducing conformational changes in Sec18 protomers

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Overexpression of a non-muscle RBFOX2 isoform triggers cardiac conduction defects in myotonic dystrophy

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Non-Canonical Binding of a Small Molecule to Sortilin Alters Cellular Trafficking of ApoB and PCSK9 in Liver Derived Cells

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A statistical physics based approach to capture spurious solutions in AI-enhanced molecular dynamics

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Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter

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Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel

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Computational Recipe for Designing Antibodies against the Ebola Virus

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