Author: Emad Tajkhorshid

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Preprints

Structure of C. elegans TMC-1 complex illuminates auditory mechanosensory transduction

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Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter

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Mechanism of gating and partial agonist action in the glycine receptor

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Intelligent Resolution: Integrating Cryo-EM with AI-driven Multi-resolution Simulations to Observe the SARS-CoV-2 Replication-Transcription Machinery in Action

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CryoFold: determining protein structures and ensembles from cryo-EM data

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How to build a water-splitting machine: structural insights into photosystem II assembly

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Capturing the interplay of membrane lipids and structural transitions in human ABCA7

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Activation and desensitization mechanism of AMPA receptor-TARP complex by cryo-EM

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Confronting pitfalls of AI-augmented molecular dynamics using statistical physics

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The Structures of Secretory and Dimeric Immunoglobulin A

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Binding Mode of SARS-CoV2 Fusion Peptide to Human Cellular Membrane

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Glutamate transporters contain a conserved chloride channel with two hydrophobic gates

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Post-Translational Modifications Optimize the Ability of SARS-CoV-2 Spike for Effective Interaction with Host Cell Receptors

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The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells

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Aβ(1-42) tetramer and octamer structures reveal edge pores as a mechanism for membrane damage

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Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel

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Phosphatidic acid inhibits SNARE priming by inducing conformational changes in Sec18 protomers

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Structural transitions permitting ligand entry and exit in bacterial fatty acid binding proteins.

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Structural characterization of an intermediate reveals a unified mechanism for the CLC Cl−/H+ transport cycle

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Overexpression of a non-muscle RBFOX2 isoform triggers cardiac conduction defects in myotonic dystrophy

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Selective Permeability of Carboxysome Shell Pores to Anionic Molecules

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Molecular Mechanism of Capsid Disassembly in Hepatitis B Virus

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A Network of Phosphatidylinositol 4,5-bisphosphate Binding Sites Regulate Gating of the Ca2+-activated Cl− Channel ANO1 (TMEM16A)

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Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter

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Non-Canonical Binding of a Small Molecule to Sortilin Alters Cellular Trafficking of ApoB and PCSK9 in Liver Derived Cells

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Proton-driven alternating access in a spinster transporter, an emerging family of broad-specificity efflux pumps

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Structural Basis of Complex Formation Between Mitochondrial Anion Channel VDAC1 and Hexokinase-II

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Active Participation of Membrane Lipids in Inhibition of Multidrug Transporter P-Glycoprotein

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Extended-Ensemble Docking to Probe Evolution of Ligand Binding Sites in Proteins Undergoing Large-Scale Structural Changes for Their Function

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Computational Recipe for Designing Antibodies against the Ebola Virus

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Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function

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Microscopic Characterization of the Chloride Permeation Pathway in the Human Excitatory Amino Acid Transporter 1 (EAAT1)

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Investigation of gating in outer membrane porins provides new perspectives on antibiotic resistance mechanisms

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Rationalizing generation of broad spectrum antibiotics with the addition of a primary amine

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Tuning aromatic contributions by site-specific encoding of fluorinated phenylalanine residues in bacterial and mammalian cells

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