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Author: Emad Tajkhorshid

Rankings

  • All-time downloads: 24,457 (rank: 11,013 )
  • Categories:
    • biochemistry: 2,509 (rank: 2,135 (tie) )
    • biophysics: 13,686 (rank: 111 )
    • cancer biology: 705 (rank: 18,383 (tie) )
    • genetics: 523 (rank: 30,183 (tie) )
    • immunology: 1,292 (rank: 11,999 (tie) )
    • neuroscience: 2,716 (rank: 10,984 (tie) )
    • plant biology: 1,281 (rank: 4,081 (tie) )

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Preprints

Structure of C. elegans TMC-1 complex illuminates auditory mechanosensory transduction

biochemistry more details view paper

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Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter

biophysics more details view paper

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Mechanism of gating and partial agonist action in the glycine receptor

neuroscience more details view paper
  • Downloaded 2,406 times
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    • Site-wide: 8,764
    • In neuroscience: 775
  • Year to date:
    • Site-wide: 85,139
  • Since beginning of last month:
    • Site-wide: 122,866

Intelligent Resolution: Integrating Cryo-EM with AI-driven Multi-resolution Simulations to Observe the SARS-CoV-2 Replication-Transcription Machinery in Action

biophysics more details view paper
  • Downloaded 2,040 times
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    • Site-wide: 11,182
    • In biophysics: 306
  • Year to date:
    • Site-wide: 2,367
  • Since beginning of last month:
    • Site-wide: 2,498

CryoFold: determining protein structures and ensembles from cryo-EM data

biophysics more details view paper
  • Downloaded 1,700 times
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    • Site-wide: 14,621
    • In biophysics: 326
  • Year to date:
    • Site-wide: 49,590
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How to build a water-splitting machine: structural insights into photosystem II assembly

plant biology more details view paper
  • Downloaded 1,323 times
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    • Site-wide: 21,397
    • In plant biology: 282
  • Year to date:
    • Site-wide: 36,868
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    • Site-wide: 37,481

Capturing the interplay of membrane lipids and structural transitions in human ABCA7

biophysics more details view paper
  • Downloaded 1,220 times
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    • Site-wide: 24,319
    • In biophysics: 1,267
  • Year to date:
    • Site-wide: 4,730
  • Since beginning of last month:
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Activation and desensitization mechanism of AMPA receptor-TARP complex by cryo-EM

biophysics more details view paper
  • Downloaded 1,167 times
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    • Site-wide: 26,000
    • In biophysics: 652
  • Year to date:
    • Site-wide: 141,359
  • Since beginning of last month:
    • Site-wide: 135,646

Confronting pitfalls of AI-augmented molecular dynamics using statistical physics

biophysics more details view paper
  • Downloaded 1,154 times
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    • Site-wide: 26,482
    • In biophysics: 692
  • Year to date:
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The Structures of Secretory and Dimeric Immunoglobulin A

immunology more details view paper
  • Downloaded 1,003 times
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    • Site-wide: 32,628
    • In immunology: 1,097
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    • Site-wide: 85,374
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    • Site-wide: 54,476

Binding Mode of SARS-CoV2 Fusion Peptide to Human Cellular Membrane

biophysics more details view paper
  • Downloaded 957 times
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    • Site-wide: 35,020
    • In biophysics: 1,022
  • Year to date:
    • Site-wide: 73,076
  • Since beginning of last month:
    • Site-wide: 84,593

Glutamate transporters contain a conserved chloride channel with two hydrophobic gates

biophysics more details view paper
  • Downloaded 949 times
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    • Site-wide: 35,422
    • In biophysics: 1,035
  • Year to date:
    • Site-wide: 95,678
  • Since beginning of last month:
    • Site-wide: 76,615

Post-Translational Modifications Optimize the Ability of SARS-CoV-2 Spike for Effective Interaction with Host Cell Receptors

biophysics more details view paper
  • Downloaded 746 times
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    • Site-wide: 50,294
    • In biophysics: 1,702
  • Year to date:
    • Site-wide: 33,108
  • Since beginning of last month:
    • Site-wide: 35,104

The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells

cancer biology more details view paper
  • Downloaded 720 times
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    • Site-wide: 52,872
    • In cancer biology: 1,443
  • Year to date:
    • Site-wide: 108,769
  • Since beginning of last month:
    • Site-wide: 165,007

Aβ(1-42) tetramer and octamer structures reveal edge pores as a mechanism for membrane damage

biophysics more details view paper
  • Downloaded 671 times
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    • Site-wide: 58,188
    • In biophysics: 1,831
  • Year to date:
    • Site-wide: 172,744
  • Since beginning of last month:
    • Site-wide: 158,686

Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel

biochemistry more details view paper
  • Downloaded 570 times
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    • Site-wide: 71,779
    • In biochemistry: 1,856
  • Year to date:
    • Site-wide: 121,824
  • Since beginning of last month:
    • Site-wide: 149,178

Phosphatidic acid inhibits SNARE priming by inducing conformational changes in Sec18 protomers

biochemistry more details view paper
  • Downloaded 563 times
  • Download rankings, all-time:
    • Site-wide: 72,902
    • In biochemistry: 1,898
  • Year to date:
    • Site-wide: 125,055
  • Since beginning of last month:
    • Site-wide: 121,922

Structural transitions permitting ligand entry and exit in bacterial fatty acid binding proteins.

biophysics more details view paper
  • Downloaded 560 times
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    • Site-wide: 73,282
    • In biophysics: 2,499
  • Year to date:
    • Site-wide: 94,988
  • Since beginning of last month:
    • Site-wide: 89,600

Structural characterization of an intermediate reveals a unified mechanism for the CLC Cl−/H+ transport cycle

biophysics more details view paper
  • Downloaded 541 times
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    • Site-wide: 76,578
    • In biophysics: 2,600
  • Year to date:
    • Site-wide: 123,659
  • Since beginning of last month:
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Overexpression of a non-muscle RBFOX2 isoform triggers cardiac conduction defects in myotonic dystrophy

genetics more details view paper
  • Downloaded 537 times
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    • Site-wide: 77,251
    • In genetics: 3,089
  • Year to date:
    • Site-wide: 119,561
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    • Site-wide: 104,019

Selective Permeability of Carboxysome Shell Pores to Anionic Molecules

biochemistry more details view paper
  • Downloaded 517 times
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    • Site-wide: 80,666
    • In biochemistry: 2,129
  • Year to date:
    • Site-wide: 178,363
  • Since beginning of last month:
    • Site-wide: 153,916

Molecular Mechanism of Capsid Disassembly in Hepatitis B Virus

biophysics more details view paper
  • Downloaded 516 times
  • Download rankings, all-time:
    • Site-wide: 80,879
    • In biophysics: 2,795
  • Year to date:
    • Site-wide: 83,893
  • Since beginning of last month:
    • Site-wide: 110,048

A Network of Phosphatidylinositol 4,5-bisphosphate Binding Sites Regulate Gating of the Ca2+-activated Cl− Channel ANO1 (TMEM16A)

biophysics more details view paper
  • Downloaded 505 times
  • Download rankings, all-time:
    • Site-wide: 82,886
    • In biophysics: 2,846
  • Year to date:
    • Site-wide: 176,163
  • Since beginning of last month:
    • Site-wide: 169,715

Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter

biochemistry more details view paper
  • Downloaded 459 times
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    • Site-wide: 92,165
    • In biochemistry: 2,532
  • Year to date:
    • Site-wide: 140,726
  • Since beginning of last month:
    • Site-wide: 94,879

Non-Canonical Binding of a Small Molecule to Sortilin Alters Cellular Trafficking of ApoB and PCSK9 in Liver Derived Cells

biochemistry more details view paper
  • Downloaded 445 times
  • Download rankings, all-time:
    • Site-wide: 95,398
    • In biochemistry: 2,590
  • Year to date:
    • Site-wide: 172,542
  • Since beginning of last month:
    • Site-wide: 158,302

Proton-driven alternating access in a spinster transporter, an emerging family of broad-specificity efflux pumps

biophysics more details view paper
  • Downloaded 433 times
  • Download rankings, all-time:
    • Site-wide: 98,137
    • In biophysics: None
  • Year to date:
    • Site-wide: 4,494
  • Since beginning of last month:
    • Site-wide: 4,898

Structural Basis of Complex Formation Between Mitochondrial Anion Channel VDAC1 and Hexokinase-II

biophysics more details view paper
  • Downloaded 428 times
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    • Site-wide: 99,246
    • In biophysics: 3,542
  • Year to date:
    • Site-wide: 145,866
  • Since beginning of last month:
    • Site-wide: 116,488

Active Participation of Membrane Lipids in Inhibition of Multidrug Transporter P-Glycoprotein

biophysics more details view paper
  • Downloaded 376 times
  • Download rankings, all-time:
    • Site-wide: 111,954
    • In biophysics: 4,153
  • Year to date:
    • Site-wide: 134,542
  • Since beginning of last month:
    • Site-wide: 97,169

Extended-Ensemble Docking to Probe Evolution of Ligand Binding Sites in Proteins Undergoing Large-Scale Structural Changes for Their Function

biophysics more details view paper
  • Downloaded 349 times
  • Download rankings, all-time:
    • Site-wide: 119,103
    • In biophysics: 4,531
  • Year to date:
    • Site-wide: 58,593
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    • Site-wide: 98,103

Computational Recipe for Designing Antibodies against the Ebola Virus

immunology more details view paper
  • Downloaded 334 times
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    • Site-wide: 123,286
    • In immunology: 3,706
  • Year to date:
    • Site-wide: 116,398
  • Since beginning of last month:
    • Site-wide: 83,553

Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function

neuroscience more details view paper
  • Downloaded 334 times
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    • Site-wide: 123,158
    • In neuroscience: 17,824
  • Year to date:
    • Site-wide: 62,799
  • Since beginning of last month:
    • Site-wide: 173,963

Microscopic Characterization of the Chloride Permeation Pathway in the Human Excitatory Amino Acid Transporter 1 (EAAT1)

biophysics more details view paper
  • Downloaded 300 times
  • Download rankings, all-time:
    • Site-wide: 132,929
    • In biophysics: 4,974
  • Year to date:
    • Site-wide: 76,843
  • Since beginning of last month:
    • Site-wide: 114,473

Investigation of gating in outer membrane porins provides new perspectives on antibiotic resistance mechanisms

biophysics more details view paper
  • Downloaded 295 times
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    • Site-wide: 134,317
    • In biophysics: 5,141
  • Year to date:
    • Site-wide: 44,190
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    • Site-wide: 43,970

Rationalizing generation of broad spectrum antibiotics with the addition of a primary amine

biophysics more details view paper
  • Downloaded 215 times
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    • Site-wide: 157,567
    • In biophysics: 5,840
  • Year to date:
    • Site-wide: 126,691
  • Since beginning of last month:
    • Site-wide: 110,546

Tuning aromatic contributions by site-specific encoding of fluorinated phenylalanine residues in bacterial and mammalian cells

biochemistry more details view paper
  • Downloaded 124 times
  • Download rankings, all-time:
    • Site-wide: 178,105
    • In biochemistry: None
  • Year to date:
    • Site-wide: 25,702
  • Since beginning of last month:
    • Site-wide: 4,593

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