Author: Yu Chen

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Preprints

A unique class of Zn2+-binding PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

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Patient-derived mutations impact pathogenicity of SARS-CoV-2

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  • Site-wide: 105
  • In infectious diseases: 41
• Year to date:
  • Site-wide: 6,252
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  • Site-wide: 3,205

CoVID-19 in Japan: What could happen in the future?

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  • Site-wide: 191
  • In epidemiology: 47
• Year to date:
  • Site-wide: 21,669
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  • Site-wide: 7,083

Aerodynamic Characteristics and RNA Concentration of SARS-CoV-2 Aerosol in Wuhan Hospitals during COVID-19 Outbreak

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  • Site-wide: 220
  • In microbiology: 20
• Year to date:
  • Site-wide: 50,043
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  • Site-wide: 2,093

Serology characteristics of SARS-CoV-2 infection since the exposure and post symptoms onset

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  • Site-wide: 273
  • In infectious diseases: 105
• Year to date:
  • Site-wide: 3,706
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Functional SARS-CoV-2-specific immune memory persists after mild COVID-19

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  • Site-wide: 647
  • In infectious diseases: 244
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  • Site-wide: 285
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  • Site-wide: 1,620

Active or latent tuberculosis increases susceptibility to COVID-19 and disease severity

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  • Site-wide: 1,033
  • In infectious diseases: 338
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  • Site-wide: 1,990
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ddPCR: a more sensitive and accurate tool for SARS-CoV-2 detection in low viral load specimens

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  • Site-wide: 1,420
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• Year to date:
  • Site-wide: 7,366
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  • Site-wide: 13,246

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

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  • Site-wide: 3,418
  • In pharmacology and toxicology: 15
• Year to date:
  • Site-wide: 51,655
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  • Site-wide: 43,901

Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCoV, in the nasal tissue

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  • Site-wide: 3,939
  • In infectious diseases: 867
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  • Site-wide: 33,169

The level of plasma C-reactive protein is closely related to the liver injury in patients with COVID-19

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  • Site-wide: 3,951
  • In infectious diseases: 870
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  • Site-wide: 9,018
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  • Site-wide: 21,612

Co-infection of influenza A virus enhances SARS-CoV-2 infectivity

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  • Site-wide: 4,702
  • In microbiology: 314
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  • Site-wide: None
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  • Site-wide: 110,229

A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells

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  • Site-wide: 5,126
  • In cell biology: 95
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  • Site-wide: 28,176
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  • Site-wide: 24,229

TSA-Seq Mapping of Nuclear Genome Organization

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  • Site-wide: 6,506
  • In genomics: 637
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  • Site-wide: 81,290

Predictive engineering and optimization of tryptophan metabolism in yeast through a combination of mechanistic and machine learning models

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  • Site-wide: 11,229
  • In bioengineering: 178
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Evaluating brain cell marker genes based on differential gene expression and co-expression

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  • Site-wide: 12,301
  • In neuroscience: 1,272
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  • Site-wide: 107,849
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  • Site-wide: 81,199

Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells

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  • Site-wide: 14,370
  • In cell biology: 405
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  • Site-wide: 24,399

Many bat species are not potential hosts of SARS-CoV and SARS-CoV-2: Evidence from ACE2 receptor usage

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  • Site-wide: 14,825
  • In ecology: 198
• Year to date:
  • Site-wide: 26,338
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  • Site-wide: 44,066

Quality control-based signal drift correction and interpretations of metabolomics/proteomics data using random forest regression

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  • Site-wide: 14,856
  • In bioinformatics: 1,632
• Year to date:
  • Site-wide: 27,871
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  • Site-wide: 51,544

TSA-Seq reveals a largely hardwired genome organization relative to nuclear speckles with small position changes tightly correlated with gene expression changes

• Downloaded 1,468 times
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  • Site-wide: 16,648
  • In genomics: 1,579
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  • Site-wide: 69,951
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  • Site-wide: 57,635

Medical treatment of 55 patients with COVID-19 from seven cities in northeast China who fully recovered: a single-center, retrospective, observational study

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  • Site-wide: 18,454
  • In respiratory medicine: 63
• Year to date:
  • Site-wide: 66,961
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  • Site-wide: 135,017

Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L

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  • Site-wide: 22,448
  • In biophysics: 579
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  • Site-wide: 16,629
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  • Site-wide: 25,628

SPIN reveals genome-wide landscape of nuclear compartmentalization

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  • Site-wide: 24,185
  • In bioinformatics: 2,688
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  • Site-wide: 43,705

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilities

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  • Site-wide: 24,448
  • In cancer biology: 596
• Year to date:
  • Site-wide: 7,002
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  • Site-wide: 18,168

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

• Downloaded 1,136 times
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  • Site-wide: 24,544
  • In genomics: 2,208
• Year to date:
  • Site-wide: 122,260
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  • Site-wide: 47,156

Questionnaire assessment helps the self-management of patients with inflammatory bowel disease during the outbreak of Coronavirus Disease 2019

• Downloaded 1,089 times
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  • Site-wide: 26,205
  • In gastroenterology: 26
• Year to date:
  • Site-wide: 94,000
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  • Site-wide: 50,385

Arabidopsis ATHB17 coordinates nuclear and plastidic photosynthesis gene expression in response to abiotic stress

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  • Site-wide: 33,750
  • In plant biology: 585
• Year to date:
  • Site-wide: 78,228
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  • Site-wide: 101,751

Uveal Melanoma Oncogene CYSLTR2 Encodes a Constitutively Active GPCR Highly Biased Toward Gq Signaling

• Downloaded 903 times
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  • Site-wide: 34,577
  • In cancer biology: 917
• Year to date:
  • Site-wide: 136,456
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  • Site-wide: 69,619

Role of Specialized mSWI/SNF Complexes in Prostate Cancer Lineage Plasticity

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  • Site-wide: 36,864
  • In cancer biology: 988
• Year to date:
  • Site-wide: 97,821
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  • Site-wide: 58,307

Deep learning based kcat prediction enables improved enzyme constrained model reconstruction

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  • Site-wide: 38,762
  • In systems biology: 785
• Year to date:
  • Site-wide: 2,240
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  • Site-wide: 11,546

A systematic dissection of human primary osteoblasts in vivo at single-cell resolution

• Downloaded 791 times
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  • Site-wide: 41,765
  • In bioinformatics: 4,363
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  • Site-wide: 49,605
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  • Site-wide: 33,051

Age groups that sustain resurging COVID-19 epidemics in the United States

• Downloaded 790 times
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  • Site-wide: 41,832
  • In epidemiology: 2,164
• Year to date:
  • Site-wide: 52,428
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  • Site-wide: 42,088

Transcriptional Inactivation of TP53 and the BMP Pathway Mediates Therapy-induced Dedifferentiation and Metastasis in Prostate Cancer

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  • Site-wide: 41,842
  • In cancer biology: 1,148
• Year to date:
  • Site-wide: 59,986
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  • Site-wide: 23,005

Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay

• Downloaded 758 times
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  • Site-wide: 44,435
  • In pharmacology and toxicology: 258
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  • Site-wide: 28,826
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  • Site-wide: 32,294

A novel xenograft model of human HCC in immunocompetent mouse

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  • Site-wide: 50,924
  • In cancer biology: 1,431
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  • Site-wide: 44,598
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  • Site-wide: 35,329

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

• Downloaded 675 times
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  • Site-wide: 52,223
  • In microbiology: 3,176
• Year to date:
  • Site-wide: 32,916
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  • Site-wide: 111,522

Characterization and Variation of the Rhizosphere Fungal Community Structure of Cultivated Tetraploid Cotton

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  • Site-wide: 52,967
  • In ecology: 1,216
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  • Site-wide: 155,650

An expedited approach towards the rationale design of non-covalent SARS-CoV-2 main protease inhibitors with in vitro antiviral activity

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  • Site-wide: 54,617
  • In pharmacology and toxicology: 321
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  • Site-wide: 21,103

ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming

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  • Site-wide: 58,572
  • In cancer biology: 1,688
• Year to date:
  • Site-wide: 96,704
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  • Site-wide: 166,175

A short prokaryotic argonaute cooperates with membrane effector to confer antiviral defense

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  • Site-wide: 59,889
  • In microbiology: 3,694
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  • Site-wide: 507

SCReadCounts: Estimation of cell-level SNVs from scRNA-seq data

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  • Site-wide: 66,197
  • In bioinformatics: 6,304
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  • Site-wide: 39,712

Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments

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  • Site-wide: 69,445
  • In systems biology: 1,515
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  • Site-wide: 71,913

Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo

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  • Site-wide: 69,747
  • In cell biology: 3,076
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  • Site-wide: 127,487

Mechanisms Governing Target Search and Binding Dynamics of Hypoxia-Inducible Factors

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  • Site-wide: 72,060
  • In molecular biology: 2,073
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  • Site-wide: 6,974

Structure and function of accessory Sec proteins involved in the adhesin export pathway of Streptococcus gordonii

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  • Site-wide: 72,921
  • In biochemistry: 1,986
• Year to date:
  • Site-wide: 112,906
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  • Site-wide: 101,684

Antibody neutralization to SARS-CoV-2 and variants after one year in Wuhan

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  • Site-wide: 75,713
  • In infectious diseases: 4,223
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  • Site-wide: 78,729

Selection and structural characterisation of anti-TREM2 scFvs that reduce levels of shed ectodomain

• Downloaded 493 times
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  • Site-wide: 77,087
  • In molecular biology: 2,223
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  • Site-wide: 53,819

Identification of decondensed large-scale chromatin regions by TSA-seq and their localization to a subset of chromatin domain boundaries

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  • Site-wide: 86,332
  • In genomics: 5,526
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  • Site-wide: 48,459

Poly(A) binding protein is required for mRNP remodeling to form P-bodies in mammalian cells

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  • Site-wide: 95,276
  • In biochemistry: 2,725
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  • Site-wide: 141,006

Bacillus cereus HS24 Suppresses Conidia Germination of Magnaporthe oryzae by Inhibiting the Ca2+ Signaling Pathway

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  • Site-wide: 98,786
  • In microbiology: 6,752
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High temperature perception in leaves promotes vascular regeneration in distant tissues

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  • Site-wide: 99,395
  • In plant biology: 2,653
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  • Site-wide: 41,805

GpsB coordinates cell division and cell surface decoration by wall teichoic acids in Staphylococcus aureus

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  • Site-wide: 110,872
  • In microbiology: 7,743
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  • Site-wide: 17,512

Suppressors of YpsA-mediated cell division inhibition in Bacillus subtilis

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  • Site-wide: 113,296
  • In microbiology: 7,949
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  • Site-wide: 64,424
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  • Site-wide: 129,002

Cell group analysis reveals changes in upper-layer neurons associated with schizophrenia

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  • Site-wide: 115,707
  • In genomics: 6,585
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  • Site-wide: 85,062
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  • Site-wide: 73,758

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

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  • Site-wide: 116,645
  • In immunology: 3,537
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  • Site-wide: 109,010
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  • Site-wide: 154,797

Minor intron splicing efficiency increases with the development of lethal prostate cancer

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  • Site-wide: 118,935
  • In cancer biology: 3,590
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  • Site-wide: 3,834
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  • Site-wide: 1,343

Paip2 associates with PABPC1 on mRNA, and may facilitate PABPC1 dissociation from mRNA upon deadenylation

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  • Site-wide: 120,827
  • In biochemistry: 3,586
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  • Site-wide: 39,760
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  • Site-wide: 65,788

Hsa-mir-210 as a novel signature predicts survival in lung squamous cell carcinoma using bioinformatics analysis

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  • Site-wide: 123,944
  • In bioinformatics: 10,009
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  • Site-wide: 152,347

Genome scale modeling of the protein secretory pathway reveals novel targets for improved recombinant protein production in yeast

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  • Site-wide: 126,233
  • In systems biology: 2,710
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  • Site-wide: 5,187
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  • Site-wide: 27,571

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses

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  • Site-wide: 127,654
  • In immunology: 3,856
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  • Site-wide: 36,854
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  • Site-wide: 31,648

Construction of a potent pan-vaccine based on the evolutionary tendency of SARS-CoV-2 spike protein.

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  • Site-wide: 128,649
  • In microbiology: 9,268
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  • Site-wide: 1,722
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  • Site-wide: 2,167

Secreted and cell surface proteome analysis of pathogenic Corynebacterium diphtheriae reveals proteins relevant to virulence

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  • Site-wide: 132,165
  • In microbiology: 9,535
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  • Site-wide: None
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  • Site-wide: 71,661

KIT ligand protects against both light-induced and genetic photoreceptor degeneration

• Downloaded 253 times
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  • Site-wide: 133,766
  • In neuroscience: 19,986
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  • Site-wide: 33,972
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  • Site-wide: 118,786

Preliminary Study of the Potential Mechanism of CTSD in the Aging Process of Sepiella japonica: Fundamental Function Analysis

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  • Site-wide: 134,848
  • In genetics: 5,335
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  • Site-wide: 148,464

The volatile cedrene from plant beneficial Trichoderma guizhouense modulates Arabidopsis root development through auxin transport and signaling

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  • Site-wide: 139,138
  • In microbiology: 10,186
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  • Site-wide: 23,220

Broad neutralizing nanobody against SARS-CoV-2 engineered from pre-designed synthetic library

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  • Site-wide: 144,314
  • In microbiology: 10,614
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  • Site-wide: 93,839

Brain transcriptional regulatory architecture and schizophrenia etiology converge between East Asian and European ancestral populations

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  • Site-wide: 144,491
  • In genetics: 5,626
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  • Site-wide: 59,102

Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding

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  • Site-wide: 148,448
  • In biochemistry: 4,514
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  • Site-wide: 42,918

Analyses of the Autism-associated Neuroligin-3 R451C Mutation in Human Neurons Reveals a Gain-of-Function Synaptic Mechanism

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  • Site-wide: 151,793
  • In neuroscience: 22,549
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  • Site-wide: 2,153

Lin28a rejuvenates muscle stem cells via mitochondrial optimization

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  • Site-wide: 153,272
  • In cell biology: 7,028
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  • Site-wide: 59,626
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  • Site-wide: 32,431

Natural genetic diversity in the potato resistance gene RB confers suppression avoidance from Phytophthora effector IPI-O4

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  • Site-wide: 157,024
  • In plant biology: 4,401
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  • Site-wide: 132,880

Agonal factors distort gene-expression patterns in human postmortem brains

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  • Site-wide: 157,063
  • In bioinformatics: 11,913
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  • Site-wide: 131,252

SBP-SITA: A sequence-based prediction tools for S-itaconation

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  • Site-wide: 158,583
  • In bioinformatics: 12,008
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  • Site-wide: 3,394

Molecular dynamics simulations reveal the selectivity mechanism of structurally similar agonists to TLR7 and TLR8

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  • Site-wide: 168,483
  • In immunology: 5,231
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