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Author: Patrick R Griffin

Rankings

  • All-time downloads: 15,231 (rank: 20,146 (tie) )
  • Categories:
    • biochemistry: 6,157 (rank: 651 )
    • biophysics: 2,803 (rank: 1,930 )
    • cancer biology: 1,329 (rank: 8,443 (tie) )
    • cell biology: 350 (rank: 35,534 (tie) )
    • molecular biology: 1,029 (rank: 7,997 (tie) )
    • pharmacology and toxicology: 186 (rank: 9,149 (tie) )
    • physiology: 272 (rank: 9,961 (tie) )

Downloads per author, site-wide

Preprints

Structural basis for the RNA-guided ribonuclease activity of CRISPR-Cas13d

biochemistry more details view paper
  • Downloaded 4,734 times
  • Download rankings, all-time:
    • Site-wide: 3,493
    • In biochemistry: 49
  • Year to date:
    • Site-wide: 63,004
  • Since beginning of last month:
    • Site-wide: 46,638

Molecular glue CELMoD compounds are allosteric regulators of cereblon conformation

molecular biology more details view paper
  • Downloaded 1,684 times
  • Download rankings, all-time:
    • Site-wide: 15,835
    • In molecular biology: None
  • Year to date:
    • Site-wide: 1,013
  • Since beginning of last month:
    • Site-wide: 50

Defining a canonical ligand-binding pocket in the orphan nuclear receptor Nurr1

biophysics more details view paper
  • Downloaded 1,217 times
  • Download rankings, all-time:
    • Site-wide: 26,304
    • In biophysics: 635
  • Year to date:
    • Site-wide: 125,697
  • Since beginning of last month:
    • Site-wide: 104,229

Structures of the Human LONP1 Protease Reveal Regulatory Steps Involved in Protease Activation

molecular biology more details view paper
  • Downloaded 1,092 times
  • Download rankings, all-time:
    • Site-wide: 31,086
    • In molecular biology: 786
  • Year to date:
    • Site-wide: 74,110
  • Since beginning of last month:
    • Site-wide: 133,281

Dual mechanism estrogen receptor inhibitors

cancer biology more details view paper
  • Downloaded 806 times
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    • Site-wide: 49,091
    • In cancer biology: 1,736
  • Year to date:
    • Site-wide: 28,853
  • Since beginning of last month:
    • Site-wide: 13,098

Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics

biophysics more details view paper
  • Downloaded 801 times
  • Download rankings, all-time:
    • Site-wide: 49,489
    • In biophysics: 2,190
  • Year to date:
    • Site-wide: 22,217
  • Since beginning of last month:
    • Site-wide: 11,741

The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells

cancer biology more details view paper
  • Downloaded 732 times
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    • Site-wide: 56,418
    • In cancer biology: 1,443
  • Year to date:
    • Site-wide: 133,036
  • Since beginning of last month:
    • Site-wide: 103,450

Structural basis of altered potency and efficacy displayed by a major in vivo metabolite of the anti-diabetic PPARγ drug pioglitazone

biochemistry more details view paper
  • Downloaded 572 times
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    • Site-wide: 78,444
    • In biochemistry: 1,903
  • Year to date:
    • Site-wide: 138,950
  • Since beginning of last month:
    • Site-wide: 99,365

Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calmodulin (CaM) Effector in Mouse Brain

biochemistry more details view paper
  • Downloaded 496 times
  • Download rankings, all-time:
    • Site-wide: 93,026
    • In biochemistry: 2,309
  • Year to date:
    • Site-wide: 178,160
  • Since beginning of last month:
    • Site-wide: 180,150

Quantitative Structural Assessment of Graded Receptor Agonism

biophysics more details view paper
  • Downloaded 469 times
  • Download rankings, all-time:
    • Site-wide: 98,986
    • In biophysics: 3,214
  • Year to date:
    • Site-wide: 187,024
  • Since beginning of last month:
    • Site-wide: 149,945

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

biophysics more details view paper
  • Downloaded 430 times
  • Download rankings, all-time:
    • Site-wide: 108,110
    • In biophysics: 3,605
  • Year to date:
    • Site-wide: 155,251
  • Since beginning of last month:
    • Site-wide: 162,124

A Simple and Robust Cell Based Assay for the Discovery of Novel Cytokinesis Inhibitors

cell biology more details view paper
  • Downloaded 385 times
  • Download rankings, all-time:
    • Site-wide: 119,526
    • In cell biology: 5,202
  • Year to date:
    • Site-wide: 128,585
  • Since beginning of last month:
    • Site-wide: 136,831

Structural insights into the role of Dicer-related helicase 3 in RNAi in Caenorhabditis elegans.

biochemistry more details view paper
  • Downloaded 316 times
  • Download rankings, all-time:
    • Site-wide: 139,082
    • In biochemistry: 4,177
  • Year to date:
    • Site-wide: 85,291
  • Since beginning of last month:
    • Site-wide: 26,282

PPARG in osteocytes is essential for sclerostin expression, bone mass, marrow adiposity and TZD-induced bone loss

physiology more details view paper
  • Downloaded 310 times
  • Download rankings, all-time:
    • Site-wide: 140,911
    • In physiology: 1,333
  • Year to date:
    • Site-wide: 108,721
  • Since beginning of last month:
    • Site-wide: 108,657

Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro

biochemistry more details view paper
  • Downloaded 303 times
  • Download rankings, all-time:
    • Site-wide: 143,004
    • In biochemistry: None
  • Year to date:
    • Site-wide: 15,338
  • Since beginning of last month:
    • Site-wide: 16,470

RIG-I uses its intrinsically disordered CARDs-Helicase linker in RNA proofreading functions

biochemistry more details view paper
  • Downloaded 263 times
  • Download rankings, all-time:
    • Site-wide: 154,611
    • In biochemistry: 4,602
  • Year to date:
    • Site-wide: 82,896
  • Since beginning of last month:
    • Site-wide: 177,738

Discovery of a Novel, Selective and Short-Acting Skeletal Myosin II Inhibitor

pharmacology and toxicology more details view paper
  • Downloaded 213 times
  • Download rankings, all-time:
    • Site-wide: 168,262
    • In pharmacology and toxicology: 1,317
  • Year to date:
    • Site-wide: 133,930
  • Since beginning of last month:
    • Site-wide: 91,158

Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement.

biophysics more details view paper
  • Downloaded 194 times
  • Download rankings, all-time:
    • Site-wide: 172,866
    • In biophysics: 6,238
  • Year to date:
    • Site-wide: 125,175
  • Since beginning of last month:
    • Site-wide: 142,029

Structural basis of interdomain communication in PPARγ

biochemistry more details view paper
  • Downloaded 169 times
  • Download rankings, all-time:
    • Site-wide: 178,435
    • In biochemistry: None
  • Year to date:
    • Site-wide: 36,926
  • Since beginning of last month:
    • Site-wide: 1,628

RORβ modulates a gene program that is protective against articular cartilage damage

cell biology more details view paper
  • Downloaded 45 times
  • Download rankings, all-time:
    • Site-wide: 195,760
    • In cell biology: None
  • Year to date:
    • Site-wide: 118,046
  • Since beginning of last month:
    • Site-wide: 107,205

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