Author: Jonathan Mill

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Preprints

Quantification of the pace of biological aging in humans through a blood test: the DunedinPACE DNA methylation algorithm

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Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

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Sex differences in gene expression in the human fetal brain

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Leveraging DNA methylation quantitative trait loci to characterize the relationship between methylomic variation, gene expression and complex traits.

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Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

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A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex

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A histone acetylome-wide association study of Alzheimer's disease: neuropathology-associated regulatory variation in the human entorhinal cortex

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Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex

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Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

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Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism

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Properties of the epigenetic clock and age acceleration

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Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.

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Schizophrenia is characterized by age- and sex-specific effects on epigenetic aging

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Elevated polygenic burden for autism is associated with differential DNA methylation at birth.

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Transcriptional signatures of progressive neuropathology in transgenic tau and amyloid mouse models.

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5-Hydroxymethylcytosine Is Highly Dynamic Across Human Fetal Brain Development

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Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic forms of autism in postmortem human brain tissue.

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Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging

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Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human Cortex

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Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.

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Assessing the co-variability of DNA methylation across peripheral cells and tissues: implications for the interpretation of findings in epigenetic epidemiology

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Genome-wide study of DNA methylation in Amyotrophic Lateral Sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol pathways

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DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

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Major surgery induces acute changes in DNA methylation associated with activation of the immune response.

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Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation

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DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy

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Genetic risk for Alzheimer's disease influences neuropathology via multiple biological pathways

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Whole transcriptome in-silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects

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A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

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Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders

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