Author: Yukinori Okada

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Preprints

Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults

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Partitioning heritability by functional category using GWAS summary statistics

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Current clinical use of polygenic scores will risk exacerbating health disparities

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A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

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Japan COVID-19 Task Force: a nation-wide consortium to elucidate host genetics of COVID-19 pandemic in Japan

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Genetic analyses identify widespread sex-differential participation bias

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A global atlas of genetic associations of 220 deep phenotypes

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Large scale genome-wide association study in a Japanese population identified 45 novel susceptibility loci for 22 diseases

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Multi-Ancestry Meta-Analysis yields novel genetic discoveries and ancestry-specific associations

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Leveraging fine-mapping and non-European training data to improve cross-population polygenic risk scores

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Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

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Insights from complex trait fine-mapping across diverse populations

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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan

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A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

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The Polygenic and Monogenic Basis of Blood Traits and Diseases

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Identification of type 2 diabetes loci in 433,540 East Asian individuals

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Population-specific causal disease effect sizes in functionally important regions impacted by selection

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Tractor: A framework allowing for improved inclusion of admixed individuals in large-scale association studies.

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Global biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

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A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

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Leveraging supervised learning for functionally-informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs

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A practical guideline of genomics-driven drug discovery in the era of global biobank meta-analysis

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Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis

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IMPACT: Genomic annotation of cell-state-specific regulatory elements inferred from the epigenome of bound transcription factors

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A multi-task convolutional deep learning method for HLA allelic imputation and its application to trans-ethnic MHC fine-mapping of type 1 diabetes

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Protective effects of HLA-DRB1*04 subtypes in Parkinson's and Alzheimer's diseases implicate acetylated Tau PHF6 sequences

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Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference

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Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity

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Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing

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Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease

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Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control.

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Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative

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Genome-wide association meta-analysis identifies novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation

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Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

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Loss-of-function of MFGE8 and protection against coronary atherosclerosis

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A community driven GWAS summary statistics standard

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Evidence of polygenic adaptation at height-associated loci in mainland Europeans and Sardinians

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Meta-analysis of 208,370 East Asians identifies 113 genomic loci and yields new non-immune cell relevant biological insights for systemic lupus erythematosus

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The association between the HLA-DRB1 shared epitope alleles and the risk of rheumatoid arthritis is influenced by massive gene-gene interactions.

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Regulatory T-cells are central hubs for age-, sex- and severity-associated cellular networks during COVID-19

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Genome-wide association meta-analysis identifies novel GP2 gene risk variants for pancreatic cancer in the Japanese population

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Mechanistic characterization of RASGRP1 variants identifies an hnRNP K-regulated transcriptional enhancer contributing to SLE susceptibility

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Structural basis of ethnic-specific variants of PAX4 associated with type 2 diabetes

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Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology

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A genome-wide association analysis of 2,622,830 individuals reveals new pathogenic pathways in gout.

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