Author: Yang Luo

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Preprints

Exploring the genetic architecture of inflammatory bowel disease by whole genome sequencing identifies association at ADCY7

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  • Site-wide: 887
  • In genetics: 28
• Year to date:
  • Site-wide: 94,919
• Since beginning of last month:
  • Site-wide: 78,721

A reference panel of 64,976 haplotypes for genotype imputation

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  • Site-wide: 1,960
  • In genetics: 79
• Year to date:
  • Site-wide: 81,235
• Since beginning of last month:
  • Site-wide: 53,989

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

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  • Site-wide: 5,276
  • In genetics: 258
• Year to date:
  • Site-wide: 4,548
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  • Site-wide: 5,362

Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike

• Downloaded 2,287 times
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  • Site-wide: 5,370
  • In microbiology: 309
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 26,277

Population-specific causal disease effect sizes in functionally important regions impacted by selection

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  • Site-wide: 8,613
  • In genetics: 440
• Year to date:
  • Site-wide: 5,777
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  • Site-wide: 16,802

A positively selected, common, missense variant in FBN1 confers a 2.2 centimeter reduction of height in the Peruvian population

• Downloaded 1,480 times
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  • Site-wide: 10,219
  • In genomics: 1,167
• Year to date:
  • Site-wide: 48,897
• Since beginning of last month:
  • Site-wide: 42,923

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

• Downloaded 1,430 times
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  • Site-wide: 10,740
  • In genomics: 1,225
• Year to date:
  • Site-wide: 72,266
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  • Site-wide: 80,298

Fine-mapping identifies causal variants for RA and T1D in DNASE1L3, SIRPG, MEG3, TNFAIP3 and CD28/CTLA4 loci

• Downloaded 1,427 times
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  • Site-wide: 10,787
  • In genetics: 549
• Year to date:
  • Site-wide: 90,840
• Since beginning of last month:
  • Site-wide: 55,347

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,112 times
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  • Site-wide: 15,696
  • In genetics: 816
• Year to date:
  • Site-wide: 45,352
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  • Site-wide: 63,754

Discovering in vivo cytokine eQTL interactions from a lupus clinical trial

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  • Site-wide: 15,732
  • In genomics: 1,697
• Year to date:
  • Site-wide: 83,280
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  • Site-wide: 103,866

IMPACT: Genomic annotation of cell-state-specific regulatory elements inferred from the epigenome of bound transcription factors

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  • Site-wide: 15,747
  • In genetics: 819
• Year to date:
  • Site-wide: 84,536
• Since beginning of last month:
  • Site-wide: 58,286

SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease

• Downloaded 1,005 times
• Download rankings, all-time:
  • Site-wide: 18,286
  • In microbiology: 1,024
• Year to date:
  • Site-wide: 11,518
• Since beginning of last month:
  • Site-wide: 30,280

Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci

• Downloaded 943 times
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  • Site-wide: 20,042
  • In genomics: 2,059
• Year to date:
  • Site-wide: 68,708
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  • Site-wide: 47,692

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

• Downloaded 889 times
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  • Site-wide: 21,836
  • In hiv aids: 9
• Year to date:
  • Site-wide: 13,256
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  • Site-wide: 5,816

Progression of recent Mycobacterium tuberculosis exposure to active tuberculosis is a highly heritable complex trait driven by 3q23 in Peruvians

• Downloaded 635 times
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  • Site-wide: 34,762
  • In genetics: 1,742
• Year to date:
  • Site-wide: 101,977
• Since beginning of last month:
  • Site-wide: 46,815

Multimodal memory T cell profiling identifies a reduction in a polyfunctional Th17 state associated with tuberculosis progression

• Downloaded 574 times
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  • Site-wide: 39,553
  • In immunology: 1,030
• Year to date:
  • Site-wide: 18,527
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  • Site-wide: 31,165

Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

• Downloaded 529 times
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  • Site-wide: 43,652
  • In genomics: 3,597
• Year to date:
  • Site-wide: 16,182
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  • Site-wide: 7,182

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

• Downloaded 526 times
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  • Site-wide: 43,944
  • In genetics: 2,157
• Year to date:
  • Site-wide: 40,194
• Since beginning of last month:
  • Site-wide: 49,975

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

• Downloaded 322 times
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  • Site-wide: 72,202
  • In genetic and genomic medicine: 201
• Year to date:
  • Site-wide: 9,402
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  • Site-wide: 5,763

Paired heavy and light chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses

• Downloaded 318 times
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  • Site-wide: 73,003
  • In immunology: 1,929
• Year to date:
  • Site-wide: 315
• Since beginning of last month:
  • Site-wide: None

Outer Membrane Vesicles Mediated Horizontal Transfer of an Aerobic Denitrification Gene between Escherichia coli

• Downloaded 262 times
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  • Site-wide: 83,860
  • In microbiology: 5,984
• Year to date:
  • Site-wide: 78,830
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  • Site-wide: 34,918

Higher Native Peruvian ancestry proportion is associated with tuberculosis progression risk

• Downloaded 243 times
• Download rankings, all-time:
  • Site-wide: 87,906
  • In genetic and genomic medicine: 276
• Year to date:
  • Site-wide: 39,125
• Since beginning of last month:
  • Site-wide: 26,206

Cyclin G2 inhibits oral squamous cell carcinoma growth and metastasis by binding to insulin-like growth factor binding protein 3 and regulating the FAK-SRC-STAT signaling pathway

• Downloaded 52 times
• Download rankings, all-time:
  • Site-wide: 121,958
  • In cancer biology: 3,859
• Year to date:
  • Site-wide: 75,716
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  • Site-wide: 62,598