Author: Andrew P Morris

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Preprints

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 4,267
  • In genomics: 440
• Year to date:
  • Site-wide: 83,146
• Since beginning of last month:
  • Site-wide: 61,210

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 4,397
  • In genetics: 169
• Year to date:
  • Site-wide: 34,250
• Since beginning of last month:
  • Site-wide: 64,813

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • Site-wide: 6,252
  • In genetics: 270
• Year to date:
  • Site-wide: 9,116
• Since beginning of last month:
  • Site-wide: 23,106

Identification of type 2 diabetes loci in 433,540 East Asian individuals

• Downloaded 1,885 times
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  • Site-wide: 9,563
  • In genetics: 415
• Year to date:
  • Site-wide: 41,768
• Since beginning of last month:
  • Site-wide: 86,882

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,881 times
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  • Site-wide: 9,588
  • In genetics: 417
• Year to date:
  • Site-wide: 100,109
• Since beginning of last month:
  • Site-wide: 64,595

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,726 times
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  • Site-wide: 10,867
  • In genetics: 481
• Year to date:
  • Site-wide: 61,184
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  • Site-wide: None

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

• Downloaded 1,690 times
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  • Site-wide: 11,204
  • In genetics: 499
• Year to date:
  • Site-wide: 85,957
• Since beginning of last month:
  • Site-wide: 24,064

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

• Downloaded 1,662 times
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  • Site-wide: 11,493
  • In genetics: 515
• Year to date:
  • Site-wide: 65,599
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  • Site-wide: 65,332

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,626 times
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  • Site-wide: 11,887
  • In genomics: 1,220
• Year to date:
  • Site-wide: 78,346
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  • Site-wide: 70,928

Integrative cross tissue analysis of gene expression identifies novel type 2 diabetes genes

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  • Site-wide: 13,339
  • In genetics: 607
• Year to date:
  • Site-wide: 53,348
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  • Site-wide: 39,238

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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  • Site-wide: 13,383
  • In genetics: 611
• Year to date:
  • Site-wide: 107,111
• Since beginning of last month:
  • Site-wide: 58,816

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 1,440 times
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  • Site-wide: 14,194
  • In genetic and genomic medicine: 60
• Year to date:
  • Site-wide: 6,291
• Since beginning of last month:
  • Site-wide: 14,280

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,440 times
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  • Site-wide: 14,197
  • In genetics: 652
• Year to date:
  • Site-wide: 104,260
• Since beginning of last month:
  • Site-wide: 62,175

Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis

• Downloaded 1,309 times
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  • Site-wide: 16,430
  • In genomics: 1,626
• Year to date:
  • Site-wide: 59,706
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  • Site-wide: 44,197

The genetic architecture of sporadic and recurrent miscarriage

• Downloaded 1,187 times
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  • Site-wide: 18,958
  • In genetics: 883
• Year to date:
  • Site-wide: 62,836
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  • Site-wide: 84,063

Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis

• Downloaded 1,120 times
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  • Site-wide: 20,679
  • In genomics: 1,977
• Year to date:
  • Site-wide: 24,317
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  • Site-wide: 24,777

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,074 times
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  • Site-wide: 22,013
  • In genetics: 1,004
• Year to date:
  • Site-wide: 10,196
• Since beginning of last month:
  • Site-wide: 53,971

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 993 times
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  • Site-wide: 24,649
  • In genetics: 1,126
• Year to date:
  • Site-wide: 23,505
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  • Site-wide: 90,223

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 861 times
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  • Site-wide: 30,239
  • In genetics: 1,396
• Year to date:
  • Site-wide: 80,655
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  • Site-wide: 43,391

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

• Downloaded 830 times
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  • Site-wide: 31,802
  • In bioinformatics: 3,553
• Year to date:
  • Site-wide: 77,185
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  • Site-wide: 24,510

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 776 times
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  • Site-wide: 34,956
  • In genomics: 2,957
• Year to date:
  • Site-wide: 111,219
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  • Site-wide: 62,066

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 724 times
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  • Site-wide: 38,464
  • In genetics: 1,738
• Year to date:
  • Site-wide: 142,931
• Since beginning of last month:
  • Site-wide: 80,659

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 637 times
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  • Site-wide: 45,487
  • In genetics: 2,039
• Year to date:
  • Site-wide: 102,057
• Since beginning of last month:
  • Site-wide: None

Genome Wide Association Scan identifies new variants associated with a cognitive predictor of dyslexia.

• Downloaded 635 times
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  • Site-wide: 45,660
  • In genomics: 3,610
• Year to date:
  • Site-wide: 114,968
• Since beginning of last month:
  • Site-wide: 70,997

Hypertension and renin-angiotensin system blockers are not associated with expression of Angiotensin Converting Enzyme 2 (ACE2) in the kidney

• Downloaded 599 times
• Download rankings, all-time:
  • Site-wide: 49,132
  • In cardiovascular medicine: 72
• Year to date:
  • Site-wide: 80,184
• Since beginning of last month:
  • Site-wide: 55,632

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

• Downloaded 577 times
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  • Site-wide: 51,507
  • In infectious diseases: 3,059
• Year to date:
  • Site-wide: 6,922
• Since beginning of last month:
  • Site-wide: 16,897

Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

• Downloaded 528 times
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  • Site-wide: 57,382
  • In rheumatology: 38
• Year to date:
  • Site-wide: 11,130
• Since beginning of last month:
  • Site-wide: 46,736

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 483 times
• Download rankings, all-time:
  • Site-wide: 63,472
  • In genetics: 2,806
• Year to date:
  • Site-wide: 146,597
• Since beginning of last month:
  • Site-wide: None

Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans

• Downloaded 409 times
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  • Site-wide: 75,433
  • In genetics: 3,281
• Year to date:
  • Site-wide: 47,075
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  • Site-wide: None

methylSCOPA and META-methylSCOPA: software for the analysis and aggregation of epigenome-wide association studies of multiple correlated phenotypes

• Downloaded 343 times
• Download rankings, all-time:
  • Site-wide: 88,046
  • In bioinformatics: 7,911
• Year to date:
  • Site-wide: 134,898
• Since beginning of last month:
  • Site-wide: 86,004

Chromatin-based techniques map DNA interaction landscapes in psoriasis susceptibility loci and highlight KLF4 as a target gene in 9q31

• Downloaded 311 times
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  • Site-wide: 95,148
  • In genomics: 5,873
• Year to date:
  • Site-wide: 118,415
• Since beginning of last month:
  • Site-wide: 91,204

Obesity as a cause of kidney disease - insights from Mendelian randomisation studies

• Downloaded 188 times
• Download rankings, all-time:
  • Site-wide: 124,954
  • In endocrinology: 115
• Year to date:
  • Site-wide: 68,766
• Since beginning of last month:
  • Site-wide: 105,947