Author: Andrew P Morris

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Preprints

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,416 times
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  • Site-wide: 5,887
  • In genetics: 194
• Year to date:
  • Site-wide: 85,665
• Since beginning of last month:
  • Site-wide: 45,968

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,375 times
• Download rankings, all-time:
  • Site-wide: 6,000
  • In genomics: 541
• Year to date:
  • Site-wide: 149,620
• Since beginning of last month:
  • Site-wide: 101,678

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 3,247 times
• Download rankings, all-time:
  • Site-wide: 6,361
  • In genetics: 239
• Year to date:
  • Site-wide: 9,869
• Since beginning of last month:
  • Site-wide: 4,666

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 2,495 times
• Download rankings, all-time:
  • Site-wide: 9,321
  • In genetic and genomic medicine: 55
• Year to date:
  • Site-wide: 7,231
• Since beginning of last month:
  • Site-wide: 7,332

Identification of type 2 diabetes loci in 433,540 East Asian individuals

• Downloaded 2,081 times
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  • Site-wide: 12,282
  • In genetics: 448
• Year to date:
  • Site-wide: 94,996
• Since beginning of last month:
  • Site-wide: 50,217

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,963 times
• Download rankings, all-time:
  • Site-wide: 13,420
  • In genetics: 506
• Year to date:
  • Site-wide: 162,188
• Since beginning of last month:
  • Site-wide: 79,461

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,909 times
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  • Site-wide: 13,994
  • In genetics: 549
• Year to date:
  • Site-wide: 73,045
• Since beginning of last month:
  • Site-wide: None

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

• Downloaded 1,819 times
• Download rankings, all-time:
  • Site-wide: 15,063
  • In genetics: 597
• Year to date:
  • Site-wide: 81,927
• Since beginning of last month:
  • Site-wide: 75,154

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

• Downloaded 1,813 times
• Download rankings, all-time:
  • Site-wide: 15,156
  • In genetics: 599
• Year to date:
  • Site-wide: 124,448
• Since beginning of last month:
  • Site-wide: 125,060

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,810 times
• Download rankings, all-time:
  • Site-wide: 15,189
  • In genomics: 1,361
• Year to date:
  • Site-wide: 79,208
• Since beginning of last month:
  • Site-wide: 105,595

Integrative cross tissue analysis of gene expression identifies novel type 2 diabetes genes

• Downloaded 1,727 times
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  • Site-wide: 16,296
  • In genetics: 666
• Year to date:
  • Site-wide: 64,499
• Since beginning of last month:
  • Site-wide: 14,632

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

• Downloaded 1,714 times
• Download rankings, all-time:
  • Site-wide: 16,474
  • In infectious diseases: 2,195
• Year to date:
  • Site-wide: 5,209
• Since beginning of last month:
  • Site-wide: 27,142

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,640 times
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  • Site-wide: 17,683
  • In genetics: 693
• Year to date:
  • Site-wide: 126,936
• Since beginning of last month:
  • Site-wide: 59,209

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,520 times
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  • Site-wide: 19,900
  • In genetics: 795
• Year to date:
  • Site-wide: 161,822
• Since beginning of last month:
  • Site-wide: 132,481

Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis

• Downloaded 1,447 times
• Download rankings, all-time:
  • Site-wide: 21,552
  • In genomics: 1,842
• Year to date:
  • Site-wide: 141,778
• Since beginning of last month:
  • Site-wide: None

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 1,329 times
• Download rankings, all-time:
  • Site-wide: 24,703
  • In genetics: 1,079
• Year to date:
  • Site-wide: 36,932
• Since beginning of last month:
  • Site-wide: 20,959

The genetic architecture of sporadic and recurrent miscarriage

• Downloaded 1,302 times
• Download rankings, all-time:
  • Site-wide: 25,512
  • In genetics: 993
• Year to date:
  • Site-wide: 143,711
• Since beginning of last month:
  • Site-wide: None

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,285 times
• Download rankings, all-time:
  • Site-wide: 26,053
  • In genetics: 1,018
• Year to date:
  • Site-wide: 105,640
• Since beginning of last month:
  • Site-wide: 108,748

Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis

• Downloaded 1,282 times
• Download rankings, all-time:
  • Site-wide: 26,161
  • In genomics: 2,196
• Year to date:
  • Site-wide: 122,197
• Since beginning of last month:
  • Site-wide: None

MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways

• Downloaded 971 times
• Download rankings, all-time:
  • Site-wide: 40,229
  • In bioinformatics: 4,053
• Year to date:
  • Site-wide: 141,992
• Since beginning of last month:
  • Site-wide: 174,193

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 948 times
• Download rankings, all-time:
  • Site-wide: 41,731
  • In genetics: 1,636
• Year to date:
  • Site-wide: 149,485
• Since beginning of last month:
  • Site-wide: 60,367

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 859 times
• Download rankings, all-time:
  • Site-wide: 48,550
  • In genomics: 3,491
• Year to date:
  • Site-wide: 155,859
• Since beginning of last month:
  • Site-wide: None

Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

• Downloaded 830 times
• Download rankings, all-time:
  • Site-wide: 51,154
  • In rheumatology: 37
• Year to date:
  • Site-wide: 66,008
• Since beginning of last month:
  • Site-wide: 53,992

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 797 times
• Download rankings, all-time:
  • Site-wide: 54,253
  • In genetics: 2,091
• Year to date:
  • Site-wide: 198,952
• Since beginning of last month:
  • Site-wide: 101,304

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 715 times
• Download rankings, all-time:
  • Site-wide: 63,634
  • In genetics: 2,424
• Year to date:
  • Site-wide: 179,540
• Since beginning of last month:
  • Site-wide: 84,315

Genome Wide Association Scan identifies new variants associated with a cognitive predictor of dyslexia.

• Downloaded 715 times
• Download rankings, all-time:
  • Site-wide: 63,622
  • In genomics: 4,334
• Year to date:
  • Site-wide: 162,410
• Since beginning of last month:
  • Site-wide: 125,214

Hypertension and renin-angiotensin system blockers are not associated with expression of Angiotensin Converting Enzyme 2 (ACE2) in the kidney

• Downloaded 711 times
• Download rankings, all-time:
  • Site-wide: 64,096
  • In cardiovascular medicine: 131
• Year to date:
  • Site-wide: 133,110
• Since beginning of last month:
  • Site-wide: 109,976

Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease

• Downloaded 695 times
• Download rankings, all-time:
  • Site-wide: 66,214
  • In genetic and genomic medicine: 527
• Year to date:
  • Site-wide: 6,267
• Since beginning of last month:
  • Site-wide: 5,098

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 577 times
• Download rankings, all-time:
  • Site-wide: 84,612
  • In genetics: 3,184
• Year to date:
  • Site-wide: 179,908
• Since beginning of last month:
  • Site-wide: 79,496

Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans

• Downloaded 474 times
• Download rankings, all-time:
  • Site-wide: 106,406
  • In genetics: 3,873
• Year to date:
  • Site-wide: 209,459
• Since beginning of last month:
  • Site-wide: 111,562

methylSCOPA and META-methylSCOPA: software for the analysis and aggregation of epigenome-wide association studies of multiple correlated phenotypes

• Downloaded 464 times
• Download rankings, all-time:
  • Site-wide: 108,743
  • In bioinformatics: 8,936
• Year to date:
  • Site-wide: 128,763
• Since beginning of last month:
  • Site-wide: 174,696

Chromatin-based techniques map DNA interaction landscapes in psoriasis susceptibility loci and highlight KLF4 as a target gene in 9q31

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 118,941
  • In genomics: 6,635
• Year to date:
  • Site-wide: 154,885
• Since beginning of last month:
  • Site-wide: 123,446

Trans-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

• Downloaded 422 times
• Download rankings, all-time:
  • Site-wide: 119,356
  • In endocrinology: 131
• Year to date:
  • Site-wide: 36,103
• Since beginning of last month:
  • Site-wide: 134,434

Obesity as a cause of kidney disease - insights from Mendelian randomisation studies

• Downloaded 373 times
• Download rankings, all-time:
  • Site-wide: 132,946
  • In endocrinology: 154
• Year to date:
  • Site-wide: 91,282
• Since beginning of last month:
  • Site-wide: 143,928