Author: Alkes Price

Downloads per author, site-wide

Preprints

Quantitative analysis of population-scale family trees using millions of relatives

• Downloaded 20,180 times
• Download rankings, all-time:
  • Site-wide: 450
  • In genomics: 17
• Year to date:
  • Site-wide: 9,270
• Since beginning of last month:
  • Site-wide: 41,247

An Atlas of Genetic Correlations across Human Diseases and Traits

• Downloaded 14,875 times
• Download rankings, all-time:
  • Site-wide: 647
  • In genomics: 32
• Year to date:
  • Site-wide: 13,184
• Since beginning of last month:
  • Site-wide: 13,777

Partitioning heritability by functional category using GWAS summary statistics

• Downloaded 8,302 times
• Download rankings, all-time:
  • Site-wide: 1,374
  • In genetics: 33
• Year to date:
  • Site-wide: 12,328
• Since beginning of last month:
  • Site-wide: 13,524

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

• Downloaded 7,442 times
• Download rankings, all-time:
  • Site-wide: 1,574
  • In bioinformatics: 92
• Year to date:
  • Site-wide: 46,175
• Since beginning of last month:
  • Site-wide: 132,764

LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

• Downloaded 7,266 times
• Download rankings, all-time:
  • Site-wide: 1,613
  • In genomics: 123
• Year to date:
  • Site-wide: 93,913
• Since beginning of last month:
  • Site-wide: 123,544

LDpred-funct: incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

• Downloaded 5,258 times
• Download rankings, all-time:
  • Site-wide: 2,486
  • In genetics: 74
• Year to date:
  • Site-wide: 5,293
• Since beginning of last month:
  • Site-wide: 8,984

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

• Downloaded 4,944 times
• Download rankings, all-time:
  • Site-wide: 2,734
  • In genomics: 255
• Year to date:
  • Site-wide: 635
• Since beginning of last month:
  • Site-wide: 1,532

Distinguishing genetic correlation from causation across 52 diseases and complex traits

• Downloaded 4,764 times
• Download rankings, all-time:
  • Site-wide: 2,864
  • In genetics: 88
• Year to date:
  • Site-wide: 62,423
• Since beginning of last month:
  • Site-wide: 84,795

Regulatory variants explain much more heritability than coding variants across 11 common diseases

• Downloaded 4,541 times
• Download rankings, all-time:
  • Site-wide: 3,058
  • In genetics: 93
• Year to date:
  • Site-wide: 110,702
• Since beginning of last month:
  • Site-wide: 99,453

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

• Downloaded 4,412 times
• Download rankings, all-time:
  • Site-wide: 3,194
  • In genetics: 99
• Year to date:
  • Site-wide: 99,045
• Since beginning of last month:
  • Site-wide: 133,378

Mixed model association for biobank-scale data sets

• Downloaded 3,394 times
• Download rankings, all-time:
  • Site-wide: 4,613
  • In genetics: 164
• Year to date:
  • Site-wide: 85,358
• Since beginning of last month:
  • Site-wide: 140,977

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

• Downloaded 3,291 times
• Download rankings, all-time:
  • Site-wide: 4,827
  • In genetics: 179
• Year to date:
  • Site-wide: 75,808
• Since beginning of last month:
  • Site-wide: 66,468

Genome-wide maps of enhancer regulation connect risk variants to disease genes

• Downloaded 3,289 times
• Download rankings, all-time:
  • Site-wide: 4,833
  • In genetics: 180
• Year to date:
  • Site-wide: 3,882
• Since beginning of last month:
  • Site-wide: 44,012

Haplotypes of common SNPs can explain missing heritability of complex diseases

• Downloaded 3,203 times
• Download rankings, all-time:
  • Site-wide: 5,015
  • In genetics: 192
• Year to date:
  • Site-wide: 80,296
• Since beginning of last month:
  • Site-wide: 81,183

Fast principal components analysis reveals convergent evolution of ADH1B gene in Europe and East Asia

• Downloaded 3,091 times
• Download rankings, all-time:
  • Site-wide: 5,258
  • In bioinformatics: 499
• Year to date:
  • Site-wide: 77,217
• Since beginning of last month:
  • Site-wide: 127,100

Dissecting the genetics of complex traits using summary association statistics

• Downloaded 3,055 times
• Download rankings, all-time:
  • Site-wide: 5,343
  • In genetics: 210
• Year to date:
  • Site-wide: 38,127
• Since beginning of last month:
  • Site-wide: 30,941

Integrative approaches for large-scale transcriptome-wide association studies

• Downloaded 2,991 times
• Download rankings, all-time:
  • Site-wide: 5,536
  • In genetics: 218
• Year to date:
  • Site-wide: 78,875
• Since beginning of last month:
  • Site-wide: 85,026

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

• Downloaded 2,951 times
• Download rankings, all-time:
  • Site-wide: 5,650
  • In genetics: 225
• Year to date:
  • Site-wide: 9,915
• Since beginning of last month:
  • Site-wide: 26,800

Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

• Downloaded 2,925 times
• Download rankings, all-time:
  • Site-wide: 5,724
  • In genetics: 228
• Year to date:
  • Site-wide: 73,495
• Since beginning of last month:
  • Site-wide: 57,186

Functionally-informed fine-mapping and polygenic localization of complex trait heritability

• Downloaded 2,773 times
• Download rankings, all-time:
  • Site-wide: 6,168
  • In genetics: 251
• Year to date:
  • Site-wide: 11,749
• Since beginning of last month:
  • Site-wide: 40,939

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

• Downloaded 2,673 times
• Download rankings, all-time:
  • Site-wide: 6,503
  • In genetics: 261
• Year to date:
  • Site-wide: 76,494
• Since beginning of last month:
  • Site-wide: 76,869

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

• Downloaded 2,630 times
• Download rankings, all-time:
  • Site-wide: 6,648
  • In genomics: 669
• Year to date:
  • Site-wide: 137,201
• Since beginning of last month:
  • Site-wide: 137,519

Fast and accurate long-range phasing in a UK Biobank cohort

• Downloaded 2,432 times
• Download rankings, all-time:
  • Site-wide: 7,487
  • In genetics: 314
• Year to date:
  • Site-wide: 89,254
• Since beginning of last month:
  • Site-wide: 60,081

Efficient Bayesian mixed model analysis increases association power in large cohorts

• Downloaded 2,335 times
• Download rankings, all-time:
  • Site-wide: 7,962
  • In genetics: 336
• Year to date:
  • Site-wide: 120,544
• Since beginning of last month:
  • Site-wide: 136,734

Estimating the proportion of disease heritability mediated by gene expression levels

• Downloaded 2,327 times
• Download rankings, all-time:
  • Site-wide: 8,000
  • In genetics: 338
• Year to date:
  • Site-wide: 81,954
• Since beginning of last month:
  • Site-wide: 66,393

Polygenicity of complex traits is explained by negative selection

• Downloaded 2,014 times
• Download rankings, all-time:
  • Site-wide: 9,898
  • In genetics: 400
• Year to date:
  • Site-wide: 97,974
• Since beginning of last month:
  • Site-wide: 84,803

Abundant contribution of short tandem repeats to gene expression variation in humans

• Downloaded 1,965 times
• Download rankings, all-time:
  • Site-wide: 10,274
  • In genomics: 1,010
• Year to date:
  • Site-wide: 120,896
• Since beginning of last month:
  • Site-wide: 111,104

Reference-based phasing using the Haplotype Reference Consortium panel

• Downloaded 1,961 times
• Download rankings, all-time:
  • Site-wide: 10,297
  • In genetics: 423
• Year to date:
  • Site-wide: 95,904
• Since beginning of last month:
  • Site-wide: 89,748

Reconciling S-LDSC and LDAK models and functional enrichment estimates

• Downloaded 1,913 times
• Download rankings, all-time:
  • Site-wide: 10,682
  • In genetics: 450
• Year to date:
  • Site-wide: 43,711
• Since beginning of last month:
  • Site-wide: 73,546

Population-specific causal disease effect sizes in functionally important regions impacted by selection

• Downloaded 1,875 times
• Download rankings, all-time:
  • Site-wide: 11,023
  • In genetics: 466
• Year to date:
  • Site-wide: 44,115
• Since beginning of last month:
  • Site-wide: 107,302

Quantifying genetic effects on disease mediated by assayed gene expression levels

• Downloaded 1,875 times
• Download rankings, all-time:
  • Site-wide: 11,015
  • In genetics: 467
• Year to date:
  • Site-wide: 45,081
• Since beginning of last month:
  • Site-wide: 47,216

Multi-ethnic polygenic risk scores improve risk prediction in diverse populations.

• Downloaded 1,833 times
• Download rankings, all-time:
  • Site-wide: 11,399
  • In bioinformatics: 1,278
• Year to date:
  • Site-wide: 96,995
• Since beginning of last month:
  • Site-wide: 141,694

Transethnic genetic correlation estimates from summary statistics

• Downloaded 1,814 times
• Download rankings, all-time:
  • Site-wide: 11,570
  • In genetics: 488
• Year to date:
  • Site-wide: 111,919
• Since beginning of last month:
  • Site-wide: 129,268

Population structure of UK Biobank and ancient Eurasians reveals adaptation at genes influencing blood pressure

• Downloaded 1,785 times
• Download rankings, all-time:
  • Site-wide: 11,864
  • In genetics: 506
• Year to date:
  • Site-wide: 113,217
• Since beginning of last month:
  • Site-wide: 136,329

Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits

• Downloaded 1,769 times
• Download rankings, all-time:
  • Site-wide: 12,017
  • In genetics: 513
• Year to date:
  • Site-wide: 120,568
• Since beginning of last month:
  • Site-wide: 63,633

In silico integration of thousands of epigenetic datasets into 707 cell type regulatory annotations improves the trans-ethnic portability of polygenic risk scores

• Downloaded 1,502 times
• Download rankings, all-time:
  • Site-wide: 15,433
  • In genetics: 682
• Year to date:
  • Site-wide: 46,581
• Since beginning of last month:
  • Site-wide: 87,557

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

• Downloaded 1,447 times
• Download rankings, all-time:
  • Site-wide: 16,363
  • In genetics: 726
• Year to date:
  • Site-wide: 157,102
• Since beginning of last month:
  • Site-wide: 153,022

Leveraging polygenic functional enrichment to improve GWAS power

• Downloaded 1,394 times
• Download rankings, all-time:
  • Site-wide: 17,347
  • In genetics: 768
• Year to date:
  • Site-wide: 143,147
• Since beginning of last month:
  • Site-wide: 136,708

Combining case-control status and family history of disease increases association power

• Downloaded 1,349 times
• Download rankings, all-time:
  • Site-wide: 18,203
  • In genetics: 809
• Year to date:
  • Site-wide: 49,716
• Since beginning of last month:
  • Site-wide: 27,672

Evaluating the informativeness of deep learning annotations for human complex diseases

• Downloaded 1,334 times
• Download rankings, all-time:
  • Site-wide: 18,504
  • In genetics: 827
• Year to date:
  • Site-wide: 123,822
• Since beginning of last month:
  • Site-wide: 140,243

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,322 times
• Download rankings, all-time:
  • Site-wide: 18,760
  • In genomics: 1,759
• Year to date:
  • Site-wide: 111,643
• Since beginning of last month:
  • Site-wide: 115,020

High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability

• Downloaded 1,321 times
• Download rankings, all-time:
  • Site-wide: 18,780
  • In genetics: 837
• Year to date:
  • Site-wide: 131,612
• Since beginning of last month:
  • Site-wide: 115,431

Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS

• Downloaded 1,248 times
• Download rankings, all-time:
  • Site-wide: 20,457
  • In genetics: 904
• Year to date:
  • Site-wide: 15,020
• Since beginning of last month:
  • Site-wide: 64,996

Subtle stratification confounds estimates of heritability from rare variants

• Downloaded 1,241 times
• Download rankings, all-time:
  • Site-wide: 20,620
  • In genetics: 910
• Year to date:
  • Site-wide: 104,809
• Since beginning of last month:
  • Site-wide: 123,491

Improving the informativeness of Mendelian disease-derived pathogenicity scores for common disease

• Downloaded 1,190 times
• Download rankings, all-time:
  • Site-wide: 21,971
  • In genetics: 958
• Year to date:
  • Site-wide: 75,093
• Since beginning of last month:
  • Site-wide: 102,837

GBAT: a gene-based association method for robust trans-gene regulation detection

• Downloaded 1,142 times
• Download rankings, all-time:
  • Site-wide: 23,389
  • In genetics: 1,025
• Year to date:
  • Site-wide: 118,020
• Since beginning of last month:
  • Site-wide: 103,976

Low-frequency variant functional architectures reveal strength of negative selection across coding and non-coding annotations

• Downloaded 1,102 times
• Download rankings, all-time:
  • Site-wide: 24,726
  • In genetics: 1,080
• Year to date:
  • Site-wide: 105,923
• Since beginning of last month:
  • Site-wide: 127,273

Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selection

• Downloaded 1,076 times
• Download rankings, all-time:
  • Site-wide: 25,660
  • In genetics: 1,127
• Year to date:
  • Site-wide: 105,688
• Since beginning of last month:
  • Site-wide: 76,690

Correcting subtle stratification in summary association statistics

• Downloaded 1,066 times
• Download rankings, all-time:
  • Site-wide: 26,038
  • In genetics: 1,140
• Year to date:
  • Site-wide: 113,210
• Since beginning of last month:
  • Site-wide: 126,650

Two variance component model improves genetic prediction in family data sets

• Downloaded 1,053 times
• Download rankings, all-time:
  • Site-wide: 26,547
  • In genetics: 1,163
• Year to date:
  • Site-wide: 157,901
• Since beginning of last month:
  • Site-wide: 164,951

Genes with high network connectivity are enriched for disease heritability

• Downloaded 976 times
• Download rankings, all-time:
  • Site-wide: 29,664
  • In genetics: 1,305
• Year to date:
  • Site-wide: 148,695
• Since beginning of last month:
  • Site-wide: 154,407

Modeling memory T cell states at single-cell resolution identifies in vivo state-dependence of eQTLs influencing disease

• Downloaded 952 times
• Download rankings, all-time:
  • Site-wide: 30,723
  • In genetics: 1,352
• Year to date:
  • Site-wide: 5,862
• Since beginning of last month:
  • Site-wide: 2,546

Functional partitioning of local and distal gene expression regulation in multiple human tissues

• Downloaded 937 times
• Download rankings, all-time:
  • Site-wide: 31,476
  • In genomics: 2,679
• Year to date:
  • Site-wide: 124,430
• Since beginning of last month:
  • Site-wide: 115,442

Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits

• Downloaded 893 times
• Download rankings, all-time:
  • Site-wide: 33,789
  • In genetics: 1,476
• Year to date:
  • Site-wide: 134,440
• Since beginning of last month:
  • Site-wide: 137,081

Leveraging single-cell ATAC-seq to identify disease-critical fetal and adult brain cell types

• Downloaded 846 times
• Download rankings, all-time:
  • Site-wide: 36,476
  • In genetics: 1,589
• Year to date:
  • Site-wide: 7,040
• Since beginning of last month:
  • Site-wide: 5,240

Incorporating family history of disease improves polygenic risk scores in diverse populations

• Downloaded 825 times
• Download rankings, all-time:
  • Site-wide: 37,920
  • In genetics: 1,651
• Year to date:
  • Site-wide: 7,343
• Since beginning of last month:
  • Site-wide: 26,281

Leveraging distant relatedness to quantify human mutation and gene conversion rates

• Downloaded 806 times
• Download rankings, all-time:
  • Site-wide: 39,171
  • In genetics: 1,696
• Year to date:
  • Site-wide: 153,034
• Since beginning of last month:
  • Site-wide: 144,541

Negative short-range genomic autocorrelation of causal effects on human complex traits

• Downloaded 749 times
• Download rankings, all-time:
  • Site-wide: 43,590
  • In genetics: 1,883
• Year to date:
  • Site-wide: 38,610
• Since beginning of last month:
  • Site-wide: 27,616

Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

• Downloaded 705 times
• Download rankings, all-time:
  • Site-wide: 47,428
  • In genetics: 2,035
• Year to date:
  • Site-wide: 107,929
• Since beginning of last month:
  • Site-wide: 106,059

Integrative approaches to improve the informativeness of deep learning models for human complex diseases

• Downloaded 665 times
• Download rankings, all-time:
  • Site-wide: 51,376
  • In genetics: 2,185
• Year to date:
  • Site-wide: 20,516
• Since beginning of last month:
  • Site-wide: 18,252

Local joint testing improves power and identifies missing heritability in association studies

• Downloaded 641 times
• Download rankings, all-time:
  • Site-wide: 53,952
  • In genetics: 2,299
• Year to date:
  • Site-wide: 147,031
• Since beginning of last month:
  • Site-wide: 129,291

Explicit modeling of ancestry improves polygenic risk scores and BLUP prediction

• Downloaded 609 times
• Download rankings, all-time:
  • Site-wide: 57,802
  • In genetics: 2,443
• Year to date:
  • Site-wide: 146,669
• Since beginning of last month:
  • Site-wide: 123,467

Disease heritability enrichment of regulatory elements is concentrated in elements with ancient sequence age and conserved function across species

• Downloaded 603 times
• Download rankings, all-time:
  • Site-wide: 58,522
  • In genetics: 2,467
• Year to date:
  • Site-wide: 151,881
• Since beginning of last month:
  • Site-wide: 146,117

Shared heritability and functional enrichment across six solid cancers

• Downloaded 577 times
• Download rankings, all-time:
  • Site-wide: 61,758
  • In genomics: 4,426
• Year to date:
  • Site-wide: 148,816
• Since beginning of last month:
  • Site-wide: 154,409

Functional disease architectures reveal unique biological role of transposable elements

• Downloaded 530 times
• Download rankings, all-time:
  • Site-wide: 68,451
  • In genetics: 2,915
• Year to date:
  • Site-wide: 154,470
• Since beginning of last month:
  • Site-wide: 142,393

Mixed Model Association with Family-Biased Case-Control Ascertainment

• Downloaded 525 times
• Download rankings, all-time:
  • Site-wide: 69,324
  • In genetics: 2,934
• Year to date:
  • Site-wide: 160,728
• Since beginning of last month:
  • Site-wide: 147,926

Leveraging gene co-regulation to identify gene sets enriched for disease heritability

• Downloaded 453 times
• Download rankings, all-time:
  • Site-wide: 81,712
  • In genetics: 3,443
• Year to date:
  • Site-wide: 18,750
• Since beginning of last month:
  • Site-wide: 36,779