Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 60,222 bioRxiv papers from 267,720 authors.

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Preprints

Quantitative analysis of population-scale family trees using millions of relatives

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  • Site-wide: 31 out of 60,222
  • In genomics: 8 out of 4,168
• Year to date:
  • Site-wide: 2,057 out of 60,222
• Since beginning of last month:
  • Site-wide: 5,675 out of 60,222

An Atlas of Genetic Correlations across Human Diseases and Traits

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  • Site-wide: 63 out of 60,222
  • In genomics: 18 out of 4,168
• Year to date:
  • Site-wide: 2,779 out of 60,222
• Since beginning of last month:
  • Site-wide: 5,582 out of 60,222

LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

• Downloaded 6,910 times
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  • Site-wide: 207 out of 60,222
  • In genomics: 60 out of 4,168
• Year to date:
  • Site-wide: 32,905 out of 60,222
• Since beginning of last month:
  • Site-wide: 22,654 out of 60,222

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

• Downloaded 6,883 times
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  • Site-wide: 211 out of 60,222
  • In bioinformatics: 36 out of 6,078
• Year to date:
  • Site-wide: 13,165 out of 60,222
• Since beginning of last month:
  • Site-wide: 14,777 out of 60,222

Partitioning heritability by functional category using GWAS summary statistics

• Downloaded 6,681 times
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  • Site-wide: 225 out of 60,222
  • In genetics: 25 out of 3,432
• Year to date:
  • Site-wide: 2,223 out of 60,222
• Since beginning of last month:
  • Site-wide: 3,351 out of 60,222

Regulatory variants explain much more heritability than coding variants across 11 common diseases

• Downloaded 4,237 times
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  • Site-wide: 538 out of 60,222
  • In genetics: 60 out of 3,432
• Year to date:
  • Site-wide: 26,167 out of 60,222
• Since beginning of last month:
  • Site-wide: 21,441 out of 60,222

Distinguishing genetic correlation from causation across 52 diseases and complex traits

• Downloaded 4,050 times
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  • Site-wide: 588 out of 60,222
  • In genetics: 62 out of 3,432
• Year to date:
  • Site-wide: 3,895 out of 60,222
• Since beginning of last month:
  • Site-wide: 7,216 out of 60,222

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

• Downloaded 3,772 times
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  • Site-wide: 677 out of 60,222
  • In genetics: 68 out of 3,432
• Year to date:
  • Site-wide: 10,066 out of 60,222
• Since beginning of last month:
  • Site-wide: 15,221 out of 60,222

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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  • Site-wide: 1,088 out of 60,222
  • In genetics: 102 out of 3,432
• Year to date:
  • Site-wide: 35,153 out of 60,222
• Since beginning of last month:
  • Site-wide: 40,660 out of 60,222

Haplotypes of common SNPs can explain missing heritability of complex diseases

• Downloaded 2,894 times
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  • Site-wide: 1,119 out of 60,222
  • In genetics: 104 out of 3,432
• Year to date:
  • Site-wide: 36,050 out of 60,222
• Since beginning of last month:
  • Site-wide: 40,015 out of 60,222

Mixed model association for biobank-scale data sets

• Downloaded 2,888 times
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  • Site-wide: 1,125 out of 60,222
  • In genetics: 106 out of 3,432
• Year to date:
  • Site-wide: 9,168 out of 60,222
• Since beginning of last month:
  • Site-wide: 21,823 out of 60,222

Fast principal components analysis reveals convergent evolution of ADH1B gene in Europe and East Asia

• Downloaded 2,647 times
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  • Site-wide: 1,301 out of 60,222
  • In bioinformatics: 263 out of 6,078
• Year to date:
  • Site-wide: 27,124 out of 60,222
• Since beginning of last month:
  • Site-wide: 33,776 out of 60,222

Integrative approaches for large-scale transcriptome-wide association studies

• Downloaded 2,598 times
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  • Site-wide: 1,338 out of 60,222
  • In genetics: 130 out of 3,432
• Year to date:
  • Site-wide: 20,362 out of 60,222
• Since beginning of last month:
  • Site-wide: 37,051 out of 60,222

Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

• Downloaded 2,519 times
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  • Site-wide: 1,410 out of 60,222
  • In genetics: 139 out of 3,432
• Year to date:
  • Site-wide: 22,339 out of 60,222
• Since beginning of last month:
  • Site-wide: 21,582 out of 60,222

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

• Downloaded 2,380 times
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  • Site-wide: 1,581 out of 60,222
  • In genomics: 359 out of 4,168
• Year to date:
  • Site-wide: 19,887 out of 60,222
• Since beginning of last month:
  • Site-wide: 13,681 out of 60,222

Dissecting the genetics of complex traits using summary association statistics

• Downloaded 2,358 times
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  • Site-wide: 1,605 out of 60,222
  • In genetics: 157 out of 3,432
• Year to date:
  • Site-wide: 18,463 out of 60,222
• Since beginning of last month:
  • Site-wide: 17,623 out of 60,222

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

• Downloaded 2,265 times
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  • Site-wide: 1,723 out of 60,222
  • In genetics: 164 out of 3,432
• Year to date:
  • Site-wide: 16,096 out of 60,222
• Since beginning of last month:
  • Site-wide: 15,066 out of 60,222

Fast and accurate long-range phasing in a UK Biobank cohort

• Downloaded 2,139 times
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  • Site-wide: 1,898 out of 60,222
  • In genetics: 182 out of 3,432
• Year to date:
  • Site-wide: 27,012 out of 60,222
• Since beginning of last month:
  • Site-wide: 37,957 out of 60,222

Efficient Bayesian mixed model analysis increases association power in large cohorts

• Downloaded 2,102 times
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  • Site-wide: 1,953 out of 60,222
  • In genetics: 191 out of 3,432
• Year to date:
  • Site-wide: 35,190 out of 60,222
• Since beginning of last month:
  • Site-wide: 32,458 out of 60,222

Modeling functional enrichment improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

• Downloaded 2,013 times
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  • Site-wide: 2,123 out of 60,222
  • In genetics: 206 out of 3,432
• Year to date:
  • Site-wide: 1,029 out of 60,222
• Since beginning of last month:
  • Site-wide: 490 out of 60,222

Estimating the proportion of disease heritability mediated by gene expression levels

• Downloaded 1,993 times
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  • Site-wide: 2,168 out of 60,222
  • In genetics: 211 out of 3,432
• Year to date:
  • Site-wide: 14,218 out of 60,222
• Since beginning of last month:
  • Site-wide: 8,518 out of 60,222

Abundant contribution of short tandem repeats to gene expression variation in humans

• Downloaded 1,786 times
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  • Site-wide: 2,609 out of 60,222
  • In genomics: 533 out of 4,168
• Year to date:
  • Site-wide: 57,342 out of 60,222
• Since beginning of last month:
  • Site-wide: 52,549 out of 60,222

Reference-based phasing using the Haplotype Reference Consortium panel

• Downloaded 1,635 times
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  • Site-wide: 3,031 out of 60,222
  • In genetics: 269 out of 3,432
• Year to date:
  • Site-wide: 35,816 out of 60,222
• Since beginning of last month:
  • Site-wide: 27,887 out of 60,222

Polygenicity of complex traits is explained by negative selection

• Downloaded 1,561 times
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  • Site-wide: 3,252 out of 60,222
  • In genetics: 291 out of 3,432
• Year to date:
  • Site-wide: 2,262 out of 60,222
• Since beginning of last month:
  • Site-wide: 4,599 out of 60,222

Transethnic genetic correlation estimates from summary statistics

• Downloaded 1,536 times
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  • Site-wide: 3,355 out of 60,222
  • In genetics: 297 out of 3,432
• Year to date:
  • Site-wide: 42,342 out of 60,222
• Since beginning of last month:
  • Site-wide: 42,492 out of 60,222

Population structure of UK Biobank and ancient Eurasians reveals adaptation at genes influencing blood pressure

• Downloaded 1,516 times
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  • Site-wide: 3,425 out of 60,222
  • In genetics: 302 out of 3,432
• Year to date:
  • Site-wide: 46,157 out of 60,222
• Since beginning of last month:
  • Site-wide: 35,932 out of 60,222

Multi-ethnic polygenic risk scores improve risk prediction in diverse populations.

• Downloaded 1,488 times
• Download rankings, all-time:
  • Site-wide: 3,546 out of 60,222
  • In bioinformatics: 718 out of 6,078
• Year to date:
  • Site-wide: 19,797 out of 60,222
• Since beginning of last month:
  • Site-wide: 22,620 out of 60,222

Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits

• Downloaded 1,488 times
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  • Site-wide: 3,544 out of 60,222
  • In genetics: 316 out of 3,432
• Year to date:
  • Site-wide: 23,595 out of 60,222
• Since beginning of last month:
  • Site-wide: 34,359 out of 60,222

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

• Downloaded 1,318 times
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  • Site-wide: 4,327 out of 60,222
  • In genetics: 361 out of 3,432
• Year to date:
  • Site-wide: 52,618 out of 60,222
• Since beginning of last month:
  • Site-wide: 52,777 out of 60,222

Reconciling S-LDSC and LDAK models and functional enrichment estimates

• Downloaded 1,258 times
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  • Site-wide: 4,655 out of 60,222
  • In genetics: 387 out of 3,432
• Year to date:
  • Site-wide: 7,620 out of 60,222
• Since beginning of last month:
  • Site-wide: 14,690 out of 60,222

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,091 times
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  • Site-wide: 5,919 out of 60,222
  • In genomics: 991 out of 4,168
• Year to date:
  • Site-wide: 38,565 out of 60,222
• Since beginning of last month:
  • Site-wide: 23,591 out of 60,222

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

• Downloaded 1,073 times
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  • Site-wide: 6,097 out of 60,222
  • In genetics: 498 out of 3,432
• Year to date:
  • Site-wide: 2,011 out of 60,222
• Since beginning of last month:
  • Site-wide: 7,284 out of 60,222

High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability

• Downloaded 1,061 times
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  • Site-wide: 6,207 out of 60,222
  • In genetics: 508 out of 3,432
• Year to date:
  • Site-wide: 19,759 out of 60,222
• Since beginning of last month:
  • Site-wide: 26,872 out of 60,222

Leveraging polygenic functional enrichment to improve GWAS power

• Downloaded 963 times
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  • Site-wide: 7,229 out of 60,222
  • In genetics: 567 out of 3,432
• Year to date:
  • Site-wide: 19,241 out of 60,222
• Since beginning of last month:
  • Site-wide: 32,644 out of 60,222

Subtle stratification confounds estimates of heritability from rare variants

• Downloaded 939 times
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  • Site-wide: 7,513 out of 60,222
  • In genetics: 587 out of 3,432
• Year to date:
  • Site-wide: 36,682 out of 60,222
• Since beginning of last month:
  • Site-wide: 34,241 out of 60,222

Two variance component model improves genetic prediction in family data sets

• Downloaded 870 times
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  • Site-wide: 8,493 out of 60,222
  • In genetics: 645 out of 3,432
• Year to date:
  • Site-wide: 50,468 out of 60,222
• Since beginning of last month:
  • Site-wide: 52,940 out of 60,222

Low-frequency variant functional architectures reveal strength of negative selection across coding and non-coding annotations

• Downloaded 834 times
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  • Site-wide: 9,087 out of 60,222
  • In genetics: 676 out of 3,432
• Year to date:
  • Site-wide: 27,501 out of 60,222
• Since beginning of last month:
  • Site-wide: 56,209 out of 60,222

GBAT: a gene-based association method for robust trans-gene regulation detection

• Downloaded 795 times
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  • Site-wide: 9,756 out of 60,222
  • In genetics: 721 out of 3,432
• Year to date:
  • Site-wide: 9,563 out of 60,222
• Since beginning of last month:
  • Site-wide: 8,899 out of 60,222

Functional partitioning of local and distal gene expression regulation in multiple human tissues

• Downloaded 766 times
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  • Site-wide: 10,294 out of 60,222
  • In genomics: 1,486 out of 4,168
• Year to date:
  • Site-wide: 54,177 out of 60,222
• Since beginning of last month:
  • Site-wide: 58,226 out of 60,222

Correcting subtle stratification in summary association statistics

• Downloaded 757 times
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  • Site-wide: 10,490 out of 60,222
  • In genetics: 762 out of 3,432
• Year to date:
  • Site-wide: 30,646 out of 60,222
• Since beginning of last month:
  • Site-wide: 40,102 out of 60,222

Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selection

• Downloaded 734 times
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  • Site-wide: 10,937 out of 60,222
  • In genetics: 789 out of 3,432
• Year to date:
  • Site-wide: 20,775 out of 60,222
• Since beginning of last month:
  • Site-wide: 23,248 out of 60,222

Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits

• Downloaded 700 times
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  • Site-wide: 11,706 out of 60,222
  • In genetics: 833 out of 3,432
• Year to date:
  • Site-wide: 44,163 out of 60,222
• Since beginning of last month:
  • Site-wide: 58,398 out of 60,222

Genes with high network connectivity are enriched for disease heritability

• Downloaded 682 times
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  • Site-wide: 12,168 out of 60,222
  • In genetics: 863 out of 3,432
• Year to date:
  • Site-wide: 6,172 out of 60,222
• Since beginning of last month:
  • Site-wide: 7,924 out of 60,222

Leveraging distant relatedness to quantify human mutation and gene conversion rates

• Downloaded 659 times
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  • Site-wide: 12,788 out of 60,222
  • In genetics: 910 out of 3,432
• Year to date:
  • Site-wide: 53,136 out of 60,222
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  • Site-wide: 52,967 out of 60,222

Local joint testing improves power and identifies missing heritability in association studies

• Downloaded 503 times
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  • Site-wide: 18,250 out of 60,222
  • In genetics: 1,236 out of 3,432
• Year to date:
  • Site-wide: 57,040 out of 60,222
• Since beginning of last month:
  • Site-wide: 52,576 out of 60,222

Explicit modeling of ancestry improves polygenic risk scores and BLUP prediction

• Downloaded 458 times
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  • Site-wide: 20,430 out of 60,222
  • In genetics: 1,375 out of 3,432
• Year to date:
  • Site-wide: 57,434 out of 60,222
• Since beginning of last month:
  • Site-wide: 57,153 out of 60,222

Quantifying genetic effects on disease mediated by assayed gene expression levels

• Downloaded 446 times
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  • Site-wide: 21,092 out of 60,222
  • In genetics: 1,408 out of 3,432
• Year to date:
  • Site-wide: 5,180 out of 60,222
• Since beginning of last month:
  • Site-wide: 259 out of 60,222

Disease heritability enrichment of regulatory elements is concentrated in elements with ancient sequence age and conserved function across species

• Downloaded 443 times
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  • Site-wide: 21,271 out of 60,222
  • In genetics: 1,423 out of 3,432
• Year to date:
  • Site-wide: 28,604 out of 60,222
• Since beginning of last month:
  • Site-wide: 32,202 out of 60,222

Mixed Model Association with Family-Biased Case-Control Ascertainment

• Downloaded 409 times
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  • Site-wide: 23,222 out of 60,222
  • In genetics: 1,546 out of 3,432
• Year to date:
  • Site-wide: 50,784 out of 60,222
• Since beginning of last month:
  • Site-wide: 51,491 out of 60,222

Shared heritability and functional enrichment across six solid cancers

• Downloaded 394 times
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  • Site-wide: 24,206 out of 60,222
  • In genomics: 2,594 out of 4,168
• Year to date:
  • Site-wide: 24,769 out of 60,222
• Since beginning of last month:
  • Site-wide: 46,348 out of 60,222

Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

• Downloaded 390 times
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  • Site-wide: 24,453 out of 60,222
  • In genetics: 1,613 out of 3,432
• Year to date:
  • Site-wide: 21,233 out of 60,222
• Since beginning of last month:
  • Site-wide: 39,060 out of 60,222

Functional disease architectures reveal unique biological role of transposable elements

• Downloaded 373 times
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  • Site-wide: 25,572 out of 60,222
  • In genetics: 1,684 out of 3,432
• Year to date:
  • Site-wide: 23,473 out of 60,222
• Since beginning of last month:
  • Site-wide: 36,622 out of 60,222

Combining case-control status and family history of disease increases association power

• Downloaded 320 times
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  • Site-wide: 29,759 out of 60,222
  • In genetics: 1,913 out of 3,432
• Year to date:
  • Site-wide: 8,951 out of 60,222
• Since beginning of last month:
  • Site-wide: 519 out of 60,222