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Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 60,222 bioRxiv papers from 267,720 authors.

Author: Alkes L. Price

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    • bioinformatics: 11,018 (rank: 222 out of 23,839)
    • genetics: 69,163 (rank: 35 out of 27,054)
    • genomics: 44,517 (rank: 112 out of 31,222)

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Preprints

Quantitative analysis of population-scale family trees using millions of relatives

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An Atlas of Genetic Correlations across Human Diseases and Traits

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LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

genomics more details view paper
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LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

bioinformatics more details view paper
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Partitioning heritability by functional category using GWAS summary statistics

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Regulatory variants explain much more heritability than coding variants across 11 common diseases

genetics more details view paper
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Distinguishing genetic correlation from causation across 52 diseases and complex traits

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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

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Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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Haplotypes of common SNPs can explain missing heritability of complex diseases

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Mixed model association for biobank-scale data sets

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Fast principal components analysis reveals convergent evolution of ADH1B gene in Europe and East Asia

bioinformatics more details view paper
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Integrative approaches for large-scale transcriptome-wide association studies

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Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

genomics more details view paper
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Dissecting the genetics of complex traits using summary association statistics

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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

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Fast and accurate long-range phasing in a UK Biobank cohort

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Efficient Bayesian mixed model analysis increases association power in large cohorts

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    • In genetics: 191 out of 3,432
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Modeling functional enrichment improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

genetics more details view paper
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Estimating the proportion of disease heritability mediated by gene expression levels

genetics more details view paper
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Abundant contribution of short tandem repeats to gene expression variation in humans

genomics more details view paper
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Reference-based phasing using the Haplotype Reference Consortium panel

genetics more details view paper
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Polygenicity of complex traits is explained by negative selection

genetics more details view paper
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Transethnic genetic correlation estimates from summary statistics

genetics more details view paper
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Population structure of UK Biobank and ancient Eurasians reveals adaptation at genes influencing blood pressure

genetics more details view paper
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Multi-ethnic polygenic risk scores improve risk prediction in diverse populations.

bioinformatics more details view paper
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    • In bioinformatics: 718 out of 6,078
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Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits

genetics more details view paper
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Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

genetics more details view paper
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Reconciling S-LDSC and LDAK models and functional enrichment estimates

genetics more details view paper
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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

genomics more details view paper
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Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

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High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability

genetics more details view paper
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Leveraging polygenic functional enrichment to improve GWAS power

genetics more details view paper
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Subtle stratification confounds estimates of heritability from rare variants

genetics more details view paper
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Two variance component model improves genetic prediction in family data sets

genetics more details view paper
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Low-frequency variant functional architectures reveal strength of negative selection across coding and non-coding annotations

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GBAT: a gene-based association method for robust trans-gene regulation detection

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Functional partitioning of local and distal gene expression regulation in multiple human tissues

genomics more details view paper
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Correcting subtle stratification in summary association statistics

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Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selection

genetics more details view paper
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Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits

genetics more details view paper
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Genes with high network connectivity are enriched for disease heritability

genetics more details view paper
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Leveraging distant relatedness to quantify human mutation and gene conversion rates

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Local joint testing improves power and identifies missing heritability in association studies

genetics more details view paper
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Explicit modeling of ancestry improves polygenic risk scores and BLUP prediction

genetics more details view paper
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Quantifying genetic effects on disease mediated by assayed gene expression levels

genetics more details view paper
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Disease heritability enrichment of regulatory elements is concentrated in elements with ancient sequence age and conserved function across species

genetics more details view paper
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Mixed Model Association with Family-Biased Case-Control Ascertainment

genetics more details view paper
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Shared heritability and functional enrichment across six solid cancers

genomics more details view paper
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Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

genetics more details view paper
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Functional disease architectures reveal unique biological role of transposable elements

genetics more details view paper
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Combining case-control status and family history of disease increases association power

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