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Author: Alkes L. Price

Rankings

  • All-time downloads: 163,767 (rank: 476 )
  • Categories:
    • bioinformatics: 12,027 (rank: 548 )
    • genetic and genomic medicine: 908 (rank: 2,239 (tie) )
    • genetics: 98,033 (rank: 19 )
    • genomics: 52,799 (rank: 145 )

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Preprints

Quantitative analysis of population-scale family trees using millions of relatives

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    • Site-wide: 5,127
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An Atlas of Genetic Correlations across Human Diseases and Traits

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  • Downloaded 14,495 times
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    • Site-wide: 468
    • In genomics: 28
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Partitioning heritability by functional category using GWAS summary statistics

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  • Downloaded 7,883 times
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    • Site-wide: 1,081
    • In genetics: 32
  • Year to date:
    • Site-wide: 12,391
  • Since beginning of last month:
    • Site-wide: 8,981

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

bioinformatics more details view paper
  • Downloaded 7,275 times
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    • Site-wide: 1,208
    • In bioinformatics: 78
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LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

genomics more details view paper
  • Downloaded 7,173 times
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    • Site-wide: 1,224
    • In genomics: 114
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Distinguishing genetic correlation from causation across 52 diseases and complex traits

genetics more details view paper
  • Downloaded 4,618 times
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    • Site-wide: 2,212
    • In genetics: 79
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LDpred-funct: incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

genetics more details view paper
  • Downloaded 4,609 times
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    • Site-wide: 2,219
    • In genetics: 80
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    • Site-wide: 4,302
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    • Site-wide: 4,193

Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • Downloaded 4,460 times
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    • Site-wide: 2,320
    • In genetics: 87
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    • Site-wide: 87,909
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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

genetics more details view paper
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    • Site-wide: 2,422
    • In genetics: 91
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Mixed model association for biobank-scale data sets

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  • Downloaded 3,289 times
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    • Site-wide: 3,608
    • In genetics: 144
  • Year to date:
    • Site-wide: 64,139
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    • Site-wide: 46,271

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

genetics more details view paper
  • Downloaded 3,175 times
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    • Site-wide: 3,807
    • In genetics: 161
  • Year to date:
    • Site-wide: 56,383
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    • Site-wide: 53,773

Haplotypes of common SNPs can explain missing heritability of complex diseases

genetics more details view paper
  • Downloaded 3,080 times
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    • Site-wide: 3,957
    • In genetics: 169
  • Year to date:
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Fast principal components analysis reveals convergent evolution of ADH1B gene in Europe and East Asia

bioinformatics more details view paper
  • Downloaded 2,996 times
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    • Site-wide: 4,109
    • In bioinformatics: 428
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    • Site-wide: 51,082

Integrative approaches for large-scale transcriptome-wide association studies

genetics more details view paper
  • Downloaded 2,907 times
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    • Site-wide: 4,286
    • In genetics: 190
  • Year to date:
    • Site-wide: 36,198
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Dissecting the genetics of complex traits using summary association statistics

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  • Downloaded 2,865 times
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    • Site-wide: 4,373
    • In genetics: 192
  • Year to date:
    • Site-wide: 27,575
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Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

genetics more details view paper
  • Downloaded 2,807 times
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    • Site-wide: 4,505
    • In genetics: 198
  • Year to date:
    • Site-wide: 52,983
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Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

genetics more details view paper
  • Downloaded 2,579 times
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    • Site-wide: 5,089
    • In genetics: 229
  • Year to date:
    • Site-wide: 5,606
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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

genomics more details view paper
  • Downloaded 2,569 times
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    • Site-wide: 5,123
    • In genomics: 578
  • Year to date:
    • Site-wide: 116,605
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    • Site-wide: 109,063

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

genetics more details view paper
  • Downloaded 2,548 times
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    • Site-wide: 5,181
    • In genetics: 236
  • Year to date:
    • Site-wide: 69,397
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    • Site-wide: 63,557

Genome-wide maps of enhancer regulation connect risk variants to disease genes

genetics more details view paper
  • Downloaded 2,546 times
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    • Site-wide: 5,189
    • In genetics: 237
  • Year to date:
    • Site-wide: 2,726
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    • Site-wide: 2,884

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

genomics more details view paper
  • Downloaded 2,440 times
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    • Site-wide: 5,565
    • In genomics: 638
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    • Site-wide: 359
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Functionally-informed fine-mapping and polygenic localization of complex trait heritability

genetics more details view paper
  • Downloaded 2,419 times
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    • Site-wide: 5,625
    • In genetics: 263
  • Year to date:
    • Site-wide: 7,196
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    • Site-wide: 5,572

Fast and accurate long-range phasing in a UK Biobank cohort

genetics more details view paper
  • Downloaded 2,319 times
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    • Site-wide: 5,987
    • In genetics: 280
  • Year to date:
    • Site-wide: 93,157
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    • Site-wide: 110,890

Efficient Bayesian mixed model analysis increases association power in large cohorts

genetics more details view paper
  • Downloaded 2,283 times
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    • Site-wide: 6,121
    • In genetics: 292
  • Year to date:
    • Site-wide: 57,000
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    • Site-wide: 44,124

Estimating the proportion of disease heritability mediated by gene expression levels

genetics more details view paper
  • Downloaded 2,208 times
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    • Site-wide: 6,428
    • In genetics: 309
  • Year to date:
    • Site-wide: 77,179
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    • Site-wide: 78,942

Polygenicity of complex traits is explained by negative selection

genetics more details view paper
  • Downloaded 1,933 times
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    • Site-wide: 7,823
    • In genetics: 363
  • Year to date:
    • Site-wide: 58,798
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    • Site-wide: 79,466

Abundant contribution of short tandem repeats to gene expression variation in humans

genomics more details view paper
  • Downloaded 1,893 times
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    • Site-wide: 8,061
    • In genomics: 878
  • Year to date:
    • Site-wide: 94,824
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    • Site-wide: 99,753

Reference-based phasing using the Haplotype Reference Consortium panel

genetics more details view paper
  • Downloaded 1,876 times
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    • Site-wide: 8,184
    • In genetics: 381
  • Year to date:
    • Site-wide: 59,744
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    • Site-wide: 88,484

Identifying disease-critical cell types and cellular processes across the human body by integration of single-cell profiles and human genetics

genomics more details view paper
  • Downloaded 1,803 times
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    • Site-wide: 8,680
    • In genomics: 947
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    • Site-wide: 519
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Population-specific causal disease effect sizes in functionally important regions impacted by selection

genetics more details view paper
  • Downloaded 1,757 times
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    • Site-wide: 9,028
    • In genetics: 432
  • Year to date:
    • Site-wide: 17,592
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    • Site-wide: 48,421

Reconciling S-LDSC and LDAK models and functional enrichment estimates

genetics more details view paper
  • Downloaded 1,757 times
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    • Site-wide: 9,033
    • In genetics: 431
  • Year to date:
    • Site-wide: 25,770
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    • Site-wide: 23,147

Multi-ethnic polygenic risk scores improve risk prediction in diverse populations.

bioinformatics more details view paper
  • Downloaded 1,756 times
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    • Site-wide: 9,036
    • In bioinformatics: 1,099
  • Year to date:
    • Site-wide: 51,911
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    • Site-wide: 30,589

Transethnic genetic correlation estimates from summary statistics

genetics more details view paper
  • Downloaded 1,741 times
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    • Site-wide: 9,171
    • In genetics: 439
  • Year to date:
    • Site-wide: 73,442
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    • Site-wide: 72,284

Quantifying genetic effects on disease mediated by assayed gene expression levels

genetics more details view paper
  • Downloaded 1,715 times
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    • Site-wide: 9,376
    • In genetics: 451
  • Year to date:
    • Site-wide: 29,104
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    • Site-wide: 26,331

Population structure of UK Biobank and ancient Eurasians reveals adaptation at genes influencing blood pressure

genetics more details view paper
  • Downloaded 1,715 times
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    • Site-wide: 9,378
    • In genetics: 450
  • Year to date:
    • Site-wide: 72,286
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    • Site-wide: 49,502

Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits

genetics more details view paper
  • Downloaded 1,685 times
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    • Site-wide: 9,629
    • In genetics: 458
  • Year to date:
    • Site-wide: 127,323
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    • Site-wide: 130,483

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

genetics more details view paper
  • Downloaded 1,418 times
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    • Site-wide: 12,398
    • In genetics: 607
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    • Site-wide: 104,766
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    • Site-wide: 88,612

In silico integration of thousands of epigenetic datasets into 707 cell type regulatory annotations improves the trans-ethnic portability of polygenic risk scores

genetics more details view paper
  • Downloaded 1,343 times
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    • Site-wide: 13,453
    • In genetics: 658
  • Year to date:
    • Site-wide: 31,181
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Leveraging polygenic functional enrichment to improve GWAS power

genetics more details view paper
  • Downloaded 1,340 times
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    • Site-wide: 13,488
    • In genetics: 661
  • Year to date:
    • Site-wide: 117,798
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    • Site-wide: 124,465

Evaluating the informativeness of deep learning annotations for human complex diseases

genetics more details view paper
  • Downloaded 1,281 times
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    • Site-wide: 14,478
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  • Year to date:
    • Site-wide: 62,963
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    • Site-wide: 60,980

High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability

genetics more details view paper
  • Downloaded 1,251 times
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    • Site-wide: 14,980
    • In genetics: 743
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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

genomics more details view paper
  • Downloaded 1,243 times
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    • Site-wide: 15,137
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    • Site-wide: 86,408
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Combining case-control status and family history of disease increases association power

genetics more details view paper
  • Downloaded 1,204 times
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    • Site-wide: 15,881
    • In genetics: 789
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    • Site-wide: 29,712
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Subtle stratification confounds estimates of heritability from rare variants

genetics more details view paper
  • Downloaded 1,160 times
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    • Site-wide: 16,802
    • In genetics: 826
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    • Site-wide: 72,055
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Improving the informativeness of Mendelian disease-derived pathogenicity scores for common disease

genetics more details view paper
  • Downloaded 1,095 times
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    • Site-wide: 18,258
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GBAT: a gene-based association method for robust trans-gene regulation detection

genetics more details view paper
  • Downloaded 1,061 times
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    • Site-wide: 19,166
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Two variance component model improves genetic prediction in family data sets

genetics more details view paper
  • Downloaded 1,029 times
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    • Site-wide: 20,023
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    • Site-wide: 93,126
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Low-frequency variant functional architectures reveal strength of negative selection across coding and non-coding annotations

genetics more details view paper
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    • Site-wide: 20,183
    • In genetics: 974
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    • Site-wide: 68,690
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    • Site-wide: 90,294

Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selection

genetics more details view paper
  • Downloaded 984 times
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    • Site-wide: 21,317
    • In genetics: 1,024
  • Year to date:
    • Site-wide: 98,974
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    • Site-wide: 107,848

Correcting subtle stratification in summary association statistics

genetics more details view paper
  • Downloaded 983 times
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    • Site-wide: 21,374
    • In genetics: 1,026
  • Year to date:
    • Site-wide: 102,631
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    • Site-wide: 65,229

Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS

genetics more details view paper
  • Downloaded 960 times
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    • Site-wide: 22,112
    • In genetics: 1,066
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    • Site-wide: 8,350
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    • Site-wide: 6,119

Genes with high network connectivity are enriched for disease heritability

genetics more details view paper
  • Downloaded 937 times
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    • Site-wide: 22,919
    • In genetics: 1,108
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    • Site-wide: 93,150
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    • Site-wide: 73,366

Leveraging fine-mapping and non-European training data to improve trans-ethnic polygenic risk scores

genetic and genomic medicine more details view paper
  • Downloaded 908 times
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    • Site-wide: 23,990
    • In genetic and genomic medicine: 80
  • Year to date:
    • Site-wide: 1,195
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    • Site-wide: 2,326

Functional partitioning of local and distal gene expression regulation in multiple human tissues

genomics more details view paper
  • Downloaded 856 times
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    • Site-wide: 26,086
    • In genomics: 2,451
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    • Site-wide: 131,192
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Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits

genetics more details view paper
  • Downloaded 832 times
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    • Site-wide: 27,145
    • In genetics: 1,316
  • Year to date:
    • Site-wide: 108,456
  • Since beginning of last month:
    • Site-wide: 90,706

Leveraging distant relatedness to quantify human mutation and gene conversion rates

genetics more details view paper
  • Downloaded 764 times
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    • Site-wide: 30,603
    • In genetics: 1,482
  • Year to date:
    • Site-wide: 122,011
  • Since beginning of last month:
    • Site-wide: 113,738

Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

genetics more details view paper
  • Downloaded 624 times
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    • Site-wide: 40,080
    • In genetics: 1,905
  • Year to date:
    • Site-wide: 79,884
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    • Site-wide: 73,506

Local joint testing improves power and identifies missing heritability in association studies

genetics more details view paper
  • Downloaded 593 times
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    • Site-wide: 42,791
    • In genetics: 2,019
  • Year to date:
    • Site-wide: 114,103
  • Since beginning of last month:
    • Site-wide: 113,817

Negative short-range genomic autocorrelation of causal effects on human complex traits

genetics more details view paper
  • Downloaded 578 times
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    • Site-wide: 44,123
    • In genetics: 2,075
  • Year to date:
    • Site-wide: 23,167
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    • Site-wide: 18,045

Explicit modeling of ancestry improves polygenic risk scores and BLUP prediction

genetics more details view paper
  • Downloaded 561 times
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    • Site-wide: 45,871
    • In genetics: 2,161
  • Year to date:
    • Site-wide: 110,134
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Disease heritability enrichment of regulatory elements is concentrated in elements with ancient sequence age and conserved function across species

genetics more details view paper
  • Downloaded 561 times
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    • Site-wide: 45,850
    • In genetics: 2,162
  • Year to date:
    • Site-wide: 117,822
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Shared heritability and functional enrichment across six solid cancers

genomics more details view paper
  • Downloaded 530 times
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    • Site-wide: 49,069
    • In genomics: 3,873
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    • Site-wide: 116,128
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Mixed Model Association with Family-Biased Case-Control Ascertainment

genetics more details view paper
  • Downloaded 494 times
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    • Site-wide: 53,269
    • In genetics: 2,467
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    • Site-wide: 127,207
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    • Site-wide: 125,867

Functional disease architectures reveal unique biological role of transposable elements

genetics more details view paper
  • Downloaded 489 times
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    • Site-wide: 53,865
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    • Site-wide: 126,340
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Integrative approaches to improve the informativeness of deep learning models for human complex diseases

genetics more details view paper
  • Downloaded 363 times
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    • Site-wide: 72,709
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