Author: 23andMe Research Team

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,423 times
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  • Site-wide: 936
  • In genetics: 26
• Year to date:
  • Site-wide: 37,520
• Since beginning of last month:
  • Site-wide: 43,817

MTAG: Multi-Trait Analysis of GWAS

• Downloaded 6,728 times
• Download rankings, all-time:
  • Site-wide: 1,428
  • In genomics: 126
• Year to date:
  • Site-wide: 24,177
• Since beginning of last month:
  • Site-wide: 37,141

LDpred-funct: incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

• Downloaded 4,785 times
• Download rankings, all-time:
  • Site-wide: 2,298
  • In genetics: 76
• Year to date:
  • Site-wide: 4,844
• Since beginning of last month:
  • Site-wide: 4,601

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,581 times
• Download rankings, all-time:
  • Site-wide: 2,433
  • In genetics: 87
• Year to date:
  • Site-wide: 33,421
• Since beginning of last month:
  • Site-wide: 28,784

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s Disease

• Downloaded 4,270 times
• Download rankings, all-time:
  • Site-wide: 2,689
  • In genomics: 290
• Year to date:
  • Site-wide: 11,528
• Since beginning of last month:
  • Site-wide: 11,195

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

• Downloaded 2,689 times
• Download rankings, all-time:
  • Site-wide: 5,221
  • In genetics: 231
• Year to date:
  • Site-wide: 7,054
• Since beginning of last month:
  • Site-wide: 11,189

Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

• Downloaded 2,228 times
• Download rankings, all-time:
  • Site-wide: 6,882
  • In genetic and genomic medicine: 27
• Year to date:
  • Site-wide: 2,426
• Since beginning of last month:
  • Site-wide: 2,173

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

• Downloaded 1,900 times
• Download rankings, all-time:
  • Site-wide: 8,700
  • In genetics: 389
• Year to date:
  • Site-wide: 74,687
• Since beginning of last month:
  • Site-wide: 52,710

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

• Downloaded 1,414 times
• Download rankings, all-time:
  • Site-wide: 13,524
  • In genetics: 642
• Year to date:
  • Site-wide: 47,459
• Since beginning of last month:
  • Site-wide: 50,813

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

• Downloaded 1,268 times
• Download rankings, all-time:
  • Site-wide: 15,927
  • In genetics: 764
• Year to date:
  • Site-wide: 31,186
• Since beginning of last month:
  • Site-wide: 28,057

Characterization of prevalence and health consequences of uniparental disomy in four million individuals from the general population

• Downloaded 1,213 times
• Download rankings, all-time:
  • Site-wide: 17,019
  • In genomics: 1,712
• Year to date:
  • Site-wide: 83,468
• Since beginning of last month:
  • Site-wide: 111,851

Large-Scale Genome-Wide Meta Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria.

• Downloaded 1,079 times
• Download rankings, all-time:
  • Site-wide: 20,220
  • In genetics: 958
• Year to date:
  • Site-wide: 86,890
• Since beginning of last month:
  • Site-wide: 112,294

Genome-wide association and multi-omic analyses reveal new mechanisms for Heart Failure

• Downloaded 1,042 times
• Download rankings, all-time:
  • Site-wide: 21,279
  • In genetic and genomic medicine: 77
• Year to date:
  • Site-wide: 41,190
• Since beginning of last month:
  • Site-wide: 57,015

Validity of the Cold Pressor Test and Pain Sensitivity Questionnaire via online self-administration

• Downloaded 995 times
• Download rankings, all-time:
  • Site-wide: 22,710
  • In pain medicine: 5
• Year to date:
  • Site-wide: 17,200
• Since beginning of last month:
  • Site-wide: 41,310

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer's disease

• Downloaded 931 times
• Download rankings, all-time:
  • Site-wide: 25,063
  • In genetics: 1,184
• Year to date:
  • Site-wide: 22,570
• Since beginning of last month:
  • Site-wide: 44,529

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

• Downloaded 766 times
• Download rankings, all-time:
  • Site-wide: 32,966
  • In genetic and genomic medicine: 113
• Year to date:
  • Site-wide: 24,028
• Since beginning of last month:
  • Site-wide: 31,272

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

• Downloaded 728 times
• Download rankings, all-time:
  • Site-wide: 35,328
  • In genetics: 1,661
• Year to date:
  • Site-wide: 116,410
• Since beginning of last month:
  • Site-wide: 89,045

A two-stage approach to identifying and validating modifiable factors for the prevention of depression

• Downloaded 714 times
• Download rankings, all-time:
  • Site-wide: 36,303
  • In genetics: 1,706
• Year to date:
  • Site-wide: 105,634
• Since beginning of last month:
  • Site-wide: 65,656

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

• Downloaded 688 times
• Download rankings, all-time:
  • Site-wide: 38,196
  • In genetics: 1,770
• Year to date:
  • Site-wide: 85,938
• Since beginning of last month:
  • Site-wide: 98,799

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

• Downloaded 581 times
• Download rankings, all-time:
  • Site-wide: 47,288
  • In genetics: 2,173
• Year to date:
  • Site-wide: 66,316
• Since beginning of last month:
  • Site-wide: 105,662

Accelerated Epigenetic Ageing in Major Depressive Disorder

• Downloaded 568 times
• Download rankings, all-time:
  • Site-wide: 48,631
  • In genomics: 3,817
• Year to date:
  • Site-wide: 69,746
• Since beginning of last month:
  • Site-wide: 78,624

Genetic determinants of daytime napping and effects on cardiometabolic health

• Downloaded 533 times
• Download rankings, all-time:
  • Site-wide: 52,430
  • In genetic and genomic medicine: 185
• Year to date:
  • Site-wide: 31,497
• Since beginning of last month:
  • Site-wide: 59,469

Insight into the genetic aetiology of retinal detachment by combining small clinical and large population-based datasets

• Downloaded 526 times
• Download rankings, all-time:
  • Site-wide: 53,286
  • In genetics: 2,434
• Year to date:
  • Site-wide: 85,914
• Since beginning of last month:
  • Site-wide: 63,042

Expanded genomic analyses for male voice-breaking highlights a shared phenotypic and genetic basis between puberty timing and hair colour

• Downloaded 519 times
• Download rankings, all-time:
  • Site-wide: 54,210
  • In genomics: 4,131
• Year to date:
  • Site-wide: 95,741
• Since beginning of last month:
  • Site-wide: 111,095

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 515 times
• Download rankings, all-time:
  • Site-wide: 54,732
  • In neuroscience: 8,008
• Year to date:
  • Site-wide: 123,766
• Since beginning of last month:
  • Site-wide: 136,176

Genome-wide association analysis and replication in 810,625 individuals identifies novel therapeutic targets for varicose veins

• Downloaded 491 times
• Download rankings, all-time:
  • Site-wide: 57,774
  • In genetics: 2,635
• Year to date:
  • Site-wide: 36,608
• Since beginning of last month:
  • Site-wide: 57,491

Overlapping Genetic Architecture between Parkinson Disease and Melanoma

• Downloaded 463 times
• Download rankings, all-time:
  • Site-wide: 61,503
  • In genetics: 2,787
• Year to date:
  • Site-wide: 98,406
• Since beginning of last month:
  • Site-wide: 121,707

Genome-wide analyses in 1,987,836 participants identify 39 genetic loci associated with sleep apnoea

• Downloaded 457 times
• Download rankings, all-time:
  • Site-wide: 62,458
  • In genetic and genomic medicine: 227
• Year to date:
  • Site-wide: 20,516
• Since beginning of last month:
  • Site-wide: 24,316

Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

• Downloaded 457 times
• Download rankings, all-time:
  • Site-wide: 62,452
  • In genetics: 2,828
• Year to date:
  • Site-wide: 56,062
• Since beginning of last month:
  • Site-wide: 116,018

Shared and distinct genetic influences between cognitive domains and psychiatric disorder risk based on genome-wide data

• Downloaded 453 times
• Download rankings, all-time:
  • Site-wide: 63,044
  • In genetics: 2,857
• Year to date:
  • Site-wide: 40,409
• Since beginning of last month:
  • Site-wide: 22,686

Common variant burden contributes significantly to the familial aggregation of migraine in 1,589 families

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 64,773
  • In genetics: 2,942
• Year to date:
  • Site-wide: 132,834
• Since beginning of last month:
  • Site-wide: 76,266

Fox Insight Collects Online, Longitudinal Patient-Reported Outcomes and Genetic Data on Parkinson's Disease

• Downloaded 440 times
• Download rankings, all-time:
  • Site-wide: 64,946
  • In epidemiology: 2,808
• Year to date:
  • Site-wide: 92,354
• Since beginning of last month:
  • Site-wide: 64,823

Demographic, spatial, and temporal dietary intake patterns among 526,774 23andMe research participants

• Downloaded 399 times
• Download rankings, all-time:
  • Site-wide: 71,730
  • In nutrition: 46
• Year to date:
  • Site-wide: 48,579
• Since beginning of last month:
  • Site-wide: 118,221

Genome-wide meta-analysis of insomnia in over 2.3 million individuals indicates involvement of specific biological pathways through gene-prioritization

• Downloaded 392 times
• Download rankings, all-time:
  • Site-wide: 72,781
  • In psychiatry and clinical psychology: 242
• Year to date:
  • Site-wide: 20,101
• Since beginning of last month:
  • Site-wide: 29,909

Genome-wide association study of pain sensitivity assessed by questionnaire and the cold pressor test

• Downloaded 371 times
• Download rankings, all-time:
  • Site-wide: 76,523
  • In genetics: 3,443
• Year to date:
  • Site-wide: 47,774
• Since beginning of last month:
  • Site-wide: 31,668

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

• Downloaded 345 times
• Download rankings, all-time:
  • Site-wide: 81,474
  • In genetics: 3,654
• Year to date:
  • Site-wide: 137,609
• Since beginning of last month:
  • Site-wide: 112,287