Author: 23andMe Research Team

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Preprints

A meta-analysis of the genome-wide association studies on two genetically correlated phenotypes (self-reported headache and self-reported migraine) identifies four new risk loci for headaches (N=397,385)

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,444 times
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  • Site-wide: 1,026
  • In genetics: 26
• Year to date:
  • Site-wide: 49,629
• Since beginning of last month:
  • Site-wide: 107,504

MTAG: Multi-Trait Analysis of GWAS

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  • Site-wide: 1,546
  • In genomics: 128
• Year to date:
  • Site-wide: 21,611
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  • Site-wide: 67,551

LDpred-funct: incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

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  • Site-wide: 2,445
  • In genetics: 76
• Year to date:
  • Site-wide: 5,618
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  • Site-wide: 63,278

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,611 times
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  • Site-wide: 2,671
  • In genetics: 87
• Year to date:
  • Site-wide: 41,931
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  • Site-wide: 110,434

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s Disease

• Downloaded 4,329 times
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  • Site-wide: 2,933
  • In genomics: 298
• Year to date:
  • Site-wide: 14,829
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  • Site-wide: 96,031

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

• Downloaded 2,796 times
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  • Site-wide: 5,412
  • In genetics: 222
• Year to date:
  • Site-wide: 8,422
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  • Site-wide: 89,021

Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

• Downloaded 2,618 times
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  • Site-wide: 5,944
  • In genetic and genomic medicine: 24
• Year to date:
  • Site-wide: 2,361
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  • Site-wide: 5,907

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

• Downloaded 1,935 times
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  • Site-wide: 9,287
  • In genetics: 396
• Year to date:
  • Site-wide: 74,700
• Since beginning of last month:
  • Site-wide: 17,574

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

• Downloaded 1,428 times
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  • Site-wide: 14,559
  • In genetics: 669
• Year to date:
  • Site-wide: 64,174
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  • Site-wide: None

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

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  • Site-wide: 15,946
  • In genetics: 735
• Year to date:
  • Site-wide: 29,422
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  • Site-wide: 8,657

Characterization of prevalence and health consequences of uniparental disomy in four million individuals from the general population

• Downloaded 1,244 times
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  • Site-wide: 17,923
  • In genomics: 1,740
• Year to date:
  • Site-wide: 84,055
• Since beginning of last month:
  • Site-wide: 18,673

Genome-wide association and multi-omic analyses reveal new mechanisms for Heart Failure

• Downloaded 1,105 times
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  • Site-wide: 21,367
  • In genetic and genomic medicine: 84
• Year to date:
  • Site-wide: 39,506
• Since beginning of last month:
  • Site-wide: 44,061

Large-Scale Genome-Wide Meta Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria.

• Downloaded 1,097 times
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  • Site-wide: 21,603
  • In genetics: 988
• Year to date:
  • Site-wide: 98,660
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  • Site-wide: None

Validity of the Cold Pressor Test and Pain Sensitivity Questionnaire via online self-administration

• Downloaded 1,036 times
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  • Site-wide: 23,478
  • In pain medicine: 5
• Year to date:
  • Site-wide: 22,631
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  • Site-wide: 36,764

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer's disease

• Downloaded 989 times
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  • Site-wide: 25,115
  • In genetics: 1,149
• Year to date:
  • Site-wide: 25,745
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  • Site-wide: 50,317

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

• Downloaded 827 times
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  • Site-wide: 32,354
  • In genetic and genomic medicine: 130
• Year to date:
  • Site-wide: 26,654
• Since beginning of last month:
  • Site-wide: 26,314

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

• Downloaded 736 times
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  • Site-wide: 38,125
  • In genetics: 1,717
• Year to date:
  • Site-wide: 133,421
• Since beginning of last month:
  • Site-wide: 90,215

A two-stage approach to identifying and validating modifiable factors for the prevention of depression

• Downloaded 734 times
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  • Site-wide: 38,248
  • In genetics: 1,719
• Year to date:
  • Site-wide: 109,889
• Since beginning of last month:
  • Site-wide: 92,057

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

• Downloaded 711 times
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  • Site-wide: 39,973
  • In genetics: 1,801
• Year to date:
  • Site-wide: 92,747
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  • Site-wide: None

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

• Downloaded 621 times
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  • Site-wide: 47,633
  • In genetics: 2,123
• Year to date:
  • Site-wide: 66,093
• Since beginning of last month:
  • Site-wide: 12,893

Accelerated Epigenetic Ageing in Major Depressive Disorder

• Downloaded 585 times
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  • Site-wide: 51,338
  • In genomics: 3,922
• Year to date:
  • Site-wide: 85,238
• Since beginning of last month:
  • Site-wide: 94,558

Genetic determinants of daytime napping and effects on cardiometabolic health

• Downloaded 578 times
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  • Site-wide: 52,129
  • In genetic and genomic medicine: 209
• Year to date:
  • Site-wide: 36,044
• Since beginning of last month:
  • Site-wide: 33,366

Insight into the genetic aetiology of retinal detachment by combining small clinical and large population-based datasets

• Downloaded 556 times
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  • Site-wide: 54,706
  • In genetics: 2,411
• Year to date:
  • Site-wide: 86,529
• Since beginning of last month:
  • Site-wide: 24,544

Genome-wide analyses in 1,987,836 participants identify 39 genetic loci associated with sleep apnoea

• Downloaded 553 times
• Download rankings, all-time:
  • Site-wide: 55,082
  • In genetic and genomic medicine: 225
• Year to date:
  • Site-wide: 19,793
• Since beginning of last month:
  • Site-wide: 48,119

Expanded genomic analyses for male voice-breaking highlights a shared phenotypic and genetic basis between puberty timing and hair colour

• Downloaded 541 times
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  • Site-wide: 56,466
  • In genomics: 4,215
• Year to date:
  • Site-wide: 101,607
• Since beginning of last month:
  • Site-wide: 108,790

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 523 times
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  • Site-wide: 58,855
  • In neuroscience: 8,525
• Year to date:
  • Site-wide: 138,942
• Since beginning of last month:
  • Site-wide: 109,176

Genome-wide association analysis and replication in 810,625 individuals identifies novel therapeutic targets for varicose veins

• Downloaded 520 times
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  • Site-wide: 59,345
  • In genetics: 2,606
• Year to date:
  • Site-wide: 45,938
• Since beginning of last month:
  • Site-wide: 69,605

Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

• Downloaded 492 times
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  • Site-wide: 63,031
  • In genetics: 2,783
• Year to date:
  • Site-wide: 61,208
• Since beginning of last month:
  • Site-wide: 14,996

Shared and distinct genetic influences between cognitive domains and psychiatric disorder risk based on genome-wide data

• Downloaded 491 times
• Download rankings, all-time:
  • Site-wide: 63,171
  • In genetics: 2,789
• Year to date:
  • Site-wide: 46,486
• Since beginning of last month:
  • Site-wide: 85,587

Overlapping Genetic Architecture between Parkinson Disease and Melanoma

• Downloaded 468 times
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  • Site-wide: 66,653
  • In genetics: 2,935
• Year to date:
  • Site-wide: 124,361
• Since beginning of last month:
  • Site-wide: None

Fox Insight Collects Online, Longitudinal Patient-Reported Outcomes and Genetic Data on Parkinson's Disease

• Downloaded 465 times
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  • Site-wide: 67,113
  • In epidemiology: 2,960
• Year to date:
  • Site-wide: 94,717
• Since beginning of last month:
  • Site-wide: 86,246

Demographic, spatial, and temporal dietary intake patterns among 526,774 23andMe research participants

• Downloaded 463 times
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  • Site-wide: 67,515
  • In nutrition: 47
• Year to date:
  • Site-wide: 43,965
• Since beginning of last month:
  • Site-wide: 29,029

Common variant burden contributes significantly to the familial aggregation of migraine in 1,589 families

• Downloaded 445 times
• Download rankings, all-time:
  • Site-wide: 70,242
  • In genetics: 3,094
• Year to date:
  • Site-wide: 148,473
• Since beginning of last month:
  • Site-wide: 107,669

Genome-wide meta-analysis of insomnia in over 2.3 million individuals indicates involvement of specific biological pathways through gene-prioritization

• Downloaded 435 times
• Download rankings, all-time:
  • Site-wide: 72,026
  • In psychiatry and clinical psychology: 255
• Year to date:
  • Site-wide: 25,458
• Since beginning of last month:
  • Site-wide: 37,211

Genome-wide association study of pain sensitivity assessed by questionnaire and the cold pressor test

• Downloaded 394 times
• Download rankings, all-time:
  • Site-wide: 79,247
  • In genetics: 3,450
• Year to date:
  • Site-wide: 59,855
• Since beginning of last month:
  • Site-wide: 93,426

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

• Downloaded 351 times
• Download rankings, all-time:
  • Site-wide: 87,709
  • In genetics: 3,801
• Year to date:
  • Site-wide: 148,913
• Since beginning of last month:
  • Site-wide: None