Author: 23andMe Research Team

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,389 times
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  • Site-wide: 863
  • In genetics: 25
• Year to date:
  • Site-wide: 30,309
• Since beginning of last month:
  • Site-wide: 31,599

MTAG: Multi-Trait Analysis of GWAS

• Downloaded 6,669 times
• Download rankings, all-time:
  • Site-wide: 1,319
  • In genomics: 122
• Year to date:
  • Site-wide: 21,401
• Since beginning of last month:
  • Site-wide: 28,218

LDpred-funct: incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

• Downloaded 4,547 times
• Download rankings, all-time:
  • Site-wide: 2,254
  • In genetics: 83
• Year to date:
  • Site-wide: 5,606
• Since beginning of last month:
  • Site-wide: 8,593

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,520 times
• Download rankings, all-time:
  • Site-wide: 2,279
  • In genetics: 85
• Year to date:
  • Site-wide: 36,414
• Since beginning of last month:
  • Site-wide: 46,158

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s Disease

• Downloaded 4,144 times
• Download rankings, all-time:
  • Site-wide: 2,574
  • In genomics: 290
• Year to date:
  • Site-wide: 12,578
• Since beginning of last month:
  • Site-wide: 17,300

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

• Downloaded 2,531 times
• Download rankings, all-time:
  • Site-wide: 5,230
  • In genetics: 240
• Year to date:
  • Site-wide: 7,017
• Since beginning of last month:
  • Site-wide: 7,146

Largest GWAS (N=1,126,563) of Alzheimer's Disease Implicates Microglia and Immune Cells

• Downloaded 1,905 times
• Download rankings, all-time:
  • Site-wide: 7,957
  • In genetic and genomic medicine: 29
• Year to date:
  • Site-wide: 2,365
• Since beginning of last month:
  • Site-wide: 2,583

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

• Downloaded 1,884 times
• Download rankings, all-time:
  • Site-wide: 8,111
  • In genetics: 373
• Year to date:
  • Site-wide: 62,781
• Since beginning of last month:
  • Site-wide: 53,550

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

• Downloaded 1,356 times
• Download rankings, all-time:
  • Site-wide: 13,252
  • In genetics: 650
• Year to date:
  • Site-wide: 68,296
• Since beginning of last month:
  • Site-wide: 93,224

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

• Downloaded 1,227 times
• Download rankings, all-time:
  • Site-wide: 15,430
  • In genetics: 763
• Year to date:
  • Site-wide: 25,435
• Since beginning of last month:
  • Site-wide: 23,923

Characterization of prevalence and health consequences of uniparental disomy in four million individuals from the general population

• Downloaded 1,203 times
• Download rankings, all-time:
  • Site-wide: 15,867
  • In genomics: 1,643
• Year to date:
  • Site-wide: 63,784
• Since beginning of last month:
  • Site-wide: 54,855

Large-Scale Genome-Wide Meta Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria.

• Downloaded 1,064 times
• Download rankings, all-time:
  • Site-wide: 19,053
  • In genetics: 926
• Year to date:
  • Site-wide: 78,360
• Since beginning of last month:
  • Site-wide: 65,952

Genome-wide association and multi-omic analyses reveal new mechanisms for Heart Failure

• Downloaded 1,009 times
• Download rankings, all-time:
  • Site-wide: 20,562
  • In genetic and genomic medicine: 71
• Year to date:
  • Site-wide: 34,250
• Since beginning of last month:
  • Site-wide: 32,651

Validity of the Cold Pressor Test and Pain Sensitivity Questionnaire via online self-administration

• Downloaded 945 times
• Download rankings, all-time:
  • Site-wide: 22,587
  • In pain medicine: 5
• Year to date:
  • Site-wide: 12,501
• Since beginning of last month:
  • Site-wide: 14,321

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer's disease

• Downloaded 879 times
• Download rankings, all-time:
  • Site-wide: 25,118
  • In genetics: 1,215
• Year to date:
  • Site-wide: 18,051
• Since beginning of last month:
  • Site-wide: 16,458

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

• Downloaded 717 times
• Download rankings, all-time:
  • Site-wide: 33,335
  • In genetics: 1,620
• Year to date:
  • Site-wide: 112,070
• Since beginning of last month:
  • Site-wide: 92,288

A two-stage approach to identifying and validating modifiable factors for the prevention of depression

• Downloaded 695 times
• Download rankings, all-time:
  • Site-wide: 34,836
  • In genetics: 1,672
• Year to date:
  • Site-wide: 118,031
• Since beginning of last month:
  • Site-wide: 87,992

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

• Downloaded 685 times
• Download rankings, all-time:
  • Site-wide: 35,430
  • In genetic and genomic medicine: 111
• Year to date:
  • Site-wide: 27,286
• Since beginning of last month:
  • Site-wide: 28,830

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

• Downloaded 678 times
• Download rankings, all-time:
  • Site-wide: 35,942
  • In genetics: 1,724
• Year to date:
  • Site-wide: 67,697
• Since beginning of last month:
  • Site-wide: 45,916

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

• Downloaded 567 times
• Download rankings, all-time:
  • Site-wide: 45,182
  • In genetics: 2,130
• Year to date:
  • Site-wide: 50,264
• Since beginning of last month:
  • Site-wide: 48,633

Accelerated Epigenetic Ageing in Major Depressive Disorder

• Downloaded 549 times
• Download rankings, all-time:
  • Site-wide: 46,941
  • In genomics: 3,737
• Year to date:
  • Site-wide: 59,726
• Since beginning of last month:
  • Site-wide: 33,490

Genetic determinants of daytime napping and effects on cardiometabolic health

• Downloaded 511 times
• Download rankings, all-time:
  • Site-wide: 51,094
  • In genetic and genomic medicine: 162
• Year to date:
  • Site-wide: 20,920
• Since beginning of last month:
  • Site-wide: 31,054

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 51,571
  • In neuroscience: 7,624
• Year to date:
  • Site-wide: 117,084
• Since beginning of last month:
  • Site-wide: 133,056

Expanded genomic analyses for male voice-breaking highlights a shared phenotypic and genetic basis between puberty timing and hair colour

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 51,580
  • In genomics: 4,011
• Year to date:
  • Site-wide: 85,436
• Since beginning of last month:
  • Site-wide: 80,930

Insight into the genetic aetiology of retinal detachment by combining small clinical and large population-based datasets

• Downloaded 506 times
• Download rankings, all-time:
  • Site-wide: 51,746
  • In genetics: 2,422
• Year to date:
  • Site-wide: 86,124
• Since beginning of last month:
  • Site-wide: 92,807

Genome-wide association analysis and replication in 810,625 individuals identifies novel therapeutic targets for varicose veins

• Downloaded 461 times
• Download rankings, all-time:
  • Site-wide: 57,346
  • In genetics: 2,678
• Year to date:
  • Site-wide: 27,855
• Since beginning of last month:
  • Site-wide: 29,398

Overlapping Genetic Architecture between Parkinson Disease and Melanoma

• Downloaded 448 times
• Download rankings, all-time:
  • Site-wide: 59,180
  • In genetics: 2,749
• Year to date:
  • Site-wide: 93,745
• Since beginning of last month:
  • Site-wide: 117,846

Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

• Downloaded 438 times
• Download rankings, all-time:
  • Site-wide: 60,609
  • In genetics: 2,829
• Year to date:
  • Site-wide: 42,865
• Since beginning of last month:
  • Site-wide: 33,146

Common variant burden contributes significantly to the familial aggregation of migraine in 1,589 families

• Downloaded 430 times
• Download rankings, all-time:
  • Site-wide: 61,716
  • In genetics: 2,872
• Year to date:
  • Site-wide: 132,156
• Since beginning of last month:
  • Site-wide: 132,770

Fox Insight Collects Online, Longitudinal Patient-Reported Outcomes and Genetic Data on Parkinson's Disease

• Downloaded 421 times
• Download rankings, all-time:
  • Site-wide: 63,032
  • In epidemiology: 2,703
• Year to date:
  • Site-wide: 95,164
• Since beginning of last month:
  • Site-wide: 70,307

Shared and distinct genetic influences between cognitive domains and psychiatric disorder risk based on genome-wide data

• Downloaded 401 times
• Download rankings, all-time:
  • Site-wide: 66,128
  • In genetics: 3,053
• Year to date:
  • Site-wide: 44,113
• Since beginning of last month:
  • Site-wide: 34,339

Demographic, spatial, and temporal dietary intake patterns among 526,774 23andMe research participants

• Downloaded 380 times
• Download rankings, all-time:
  • Site-wide: 69,533
  • In nutrition: 41
• Year to date:
  • Site-wide: 35,155
• Since beginning of last month:
  • Site-wide: 27,863

Genome-wide analyses in 1,987,836 participants identify 39 genetic loci associated with sleep apnoea

• Downloaded 374 times
• Download rankings, all-time:
  • Site-wide: 70,709
  • In genetic and genomic medicine: 236
• Year to date:
  • Site-wide: 21,464
• Since beginning of last month:
  • Site-wide: 21,817

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

• Downloaded 340 times
• Download rankings, all-time:
  • Site-wide: 76,819
  • In genetics: 3,517
• Year to date:
  • Site-wide: 128,203
• Since beginning of last month:
  • Site-wide: 125,565

Genome-wide association study of pain sensitivity assessed by questionnaire and the cold pressor test

• Downloaded 330 times
• Download rankings, all-time:
  • Site-wide: 78,659
  • In genetics: 3,599
• Year to date:
  • Site-wide: 49,273
• Since beginning of last month:
  • Site-wide: 41,283

Genome-wide meta-analysis of insomnia in over 2.3 million individuals indicates involvement of specific biological pathways through gene-prioritization

• Downloaded 323 times
• Download rankings, all-time:
  • Site-wide: 80,111
  • In psychiatry and clinical psychology: 263
• Year to date:
  • Site-wide: 18,132
• Since beginning of last month:
  • Site-wide: 11,744