Author: Xin He

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Preprints

Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

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  • Site-wide: 1,022
  • In genetics: 23
• Year to date:
  • Site-wide: 10,218
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  • Site-wide: 31,385

Glycopeptide antibiotic teicoplanin inhibits cell entry of SARS-CoV-2 by suppressing the proteolytic activity of cathepsin L

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  • Site-wide: 1,445
  • In microbiology: 136
• Year to date:
  • Site-wide: 7,554
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  • Site-wide: 8,338

Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics

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  • Site-wide: 4,511
  • In genetics: 160
• Year to date:
  • Site-wide: 8,373
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  • Site-wide: 16,756

Limited contribution of rare, noncoding variation to autism spectrum disorder from sequencing of 2,076 genomes in quartet families

• Downloaded 2,624 times
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  • Site-wide: 6,662
  • In genomics: 675
• Year to date:
  • Site-wide: 99,559
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  • Site-wide: 81,951

A statistical framework for mapping risk genes from de novo mutations in whole-genome sequencing studies

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  • Site-wide: 10,516
  • In genetics: 439
• Year to date:
  • Site-wide: 76,697
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Post-transcriptionally impaired de novo mutations contribute to the genetic etiology of four neuropsychiatric disorders

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  • Site-wide: 14,500
  • In genomics: 1,427
• Year to date:
  • Site-wide: 44,745
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  • Site-wide: 46,911

Ultra-high throughput multiplexing and sequencing of >500 bp amplicon regions on the Illumina HiSeq 2500 platform

• Downloaded 1,539 times
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  • Site-wide: 14,787
  • In microbiology: 851
• Year to date:
  • Site-wide: 73,100
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  • Site-wide: 74,276

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

• Downloaded 1,535 times
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  • Site-wide: 14,834
  • In genomics: 1,452
• Year to date:
  • Site-wide: 115,103
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  • Site-wide: 129,639

Benchmarking Deep Learning Models and Automated Model Design for COVID-19 Detection with Chest CT Scans

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  • Site-wide: 15,150
  • In epidemiology: 1,054
• Year to date:
  • Site-wide: 8,798
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  • Site-wide: 5,000

Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits

• Downloaded 1,406 times
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  • Site-wide: 17,064
  • In genomics: 1,637
• Year to date:
  • Site-wide: 116,531
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  • Site-wide: 149,194

Model-based analysis of positive selection significantly expands the list of cancer driver genes, including RNA methyltransferases

• Downloaded 1,081 times
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  • Site-wide: 25,414
  • In genomics: 2,300
• Year to date:
  • Site-wide: 117,743
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  • Site-wide: 135,251

Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes

• Downloaded 858 times
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  • Site-wide: 35,659
  • In genomics: 2,955
• Year to date:
  • Site-wide: 91,474
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  • Site-wide: 66,273

The impact of goggle-associated harms to health and working status of nurses during management of COVID-19

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  • Site-wide: 55,984
  • In health systems and quality improvement: 81
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  • Site-wide: 58,320
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  • Site-wide: 45,702

Allele-specific open chromatin in human iPSC neurons elucidates functional non-coding disease variants

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  • Site-wide: 56,263
  • In genetics: 2,389
• Year to date:
  • Site-wide: 95,077
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  • Site-wide: 69,600

A Bayesian method for rare variant analysis using functional annotations and its application to Autism

• Downloaded 588 times
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  • Site-wide: 60,227
  • In genetics: 2,555
• Year to date:
  • Site-wide: 39,338
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  • Site-wide: 36,723

CCmed: cross-condition mediation analysis for identifying robust trans-eQTLs and assessing their effects on human traits

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  • Site-wide: 61,567
  • In genetics: 2,631
• Year to date:
  • Site-wide: 74,665
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  • Site-wide: 56,654

Predicting Epigenomic Functions of Genetic Variants in the Context of Neurodevelopment via Deep Transfer Learning

• Downloaded 434 times
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  • Site-wide: 85,085
  • In bioinformatics: 7,649
• Year to date:
  • Site-wide: 19,813
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  • Site-wide: 7,160

Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth

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  • Site-wide: 94,154
  • In genomics: 5,849
• Year to date:
  • Site-wide: 119,636
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  • Site-wide: 141,303

mTADA: a framework for analyzing de novo mutations in multiple traits

• Downloaded 369 times
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  • Site-wide: 99,191
  • In genomics: 6,033
• Year to date:
  • Site-wide: 149,844
• Since beginning of last month:
  • Site-wide: 127,049

Imbalance of flight-freeze responses and their cellular correlates in the Nlgn3-/y rat model of autism

• Downloaded 366 times
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  • Site-wide: 99,984
  • In neuroscience: 14,907
• Year to date:
  • Site-wide: 54,368
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  • Site-wide: 40,153

Smart Film Impacts Stomatal Sensitivity of Greenhouse Capsicum Through Altered Light

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  • Site-wide: 102,858
  • In plant biology: 2,745
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  • Site-wide: 44,758
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  • Site-wide: 68,552

A configurable model of the synaptic proteome reveals the molecular mechanisms of disease co-morbidity.

• Downloaded 296 times
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  • Site-wide: 117,548
  • In systems biology: 2,550
• Year to date:
  • Site-wide: 77,126
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  • Site-wide: 80,606

Integrated analyses of the single-cell ATAC-seq and RNA-seq reveal the epigenetic landscape of human ovarian aging

• Downloaded 215 times
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  • Site-wide: 138,568
  • In genetics: 5,505
• Year to date:
  • Site-wide: 53,136
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  • Site-wide: 4,719

Effects of Antipsychotic Drugs and Potassium Channel Modulators on Cognition-related Local Field Potential Spectral Properties in Mouse Hippocampus and Frontal Cortex

• Downloaded 189 times
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  • Site-wide: 144,806
  • In neuroscience: 21,596
• Year to date:
  • Site-wide: 134,016
• Since beginning of last month:
  • Site-wide: 130,695

Eye-specific voluntary attention can induce a shift of perceptual ocular dominance

• Downloaded 149 times
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  • Site-wide: 153,139
  • In neuroscience: 22,781
• Year to date:
  • Site-wide: 144,441
• Since beginning of last month:
  • Site-wide: 123,193

A Computer-aided Method for Identifying the Presence of Softwood Growth Ring Boundaries

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  • Site-wide: 158,929
  • In plant biology: 4,456
• Year to date:
  • Site-wide: 153,843
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  • Site-wide: 151,095

Ribosomal protein L23 drives the metastasis of hepatocellular carcinoma via upregulating MMP9

• Downloaded 59 times
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  • Site-wide: 163,562
  • In cancer biology: 5,042
• Year to date:
  • Site-wide: 149,032
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  • Site-wide: 132,436