Author: Naomi R. Wray

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 863
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  • Site-wide: 30,161
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  • Site-wide: 31,179

Genetic Consequences of Social Stratification in Great Britain

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  • Site-wide: 1,114
  • In genetics: 35
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  • Site-wide: 10,529
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  • Site-wide: 11,207

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,198
  • In genetics: 38
• Year to date:
  • Site-wide: 17,033
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  • Site-wide: 14,774

New mutations, old statistical challenges

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  • Site-wide: 1,234
  • In genetics: 40
• Year to date:
  • Site-wide: 67,543
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  • Site-wide: 64,168

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,126
  • In genomics: 222
• Year to date:
  • Site-wide: 14,885
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  • Site-wide: 17,029

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 2,276
  • In genetics: 85
• Year to date:
  • Site-wide: 36,011
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  • Site-wide: 45,623

Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • Site-wide: 2,316
  • In genetics: 87
• Year to date:
  • Site-wide: 85,749
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  • Site-wide: 79,666

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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  • Site-wide: 3,186
  • In genomics: 363
• Year to date:
  • Site-wide: 31,914
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  • Site-wide: 30,874

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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  • Site-wide: 3,797
  • In genetics: 161
• Year to date:
  • Site-wide: 55,057
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  • Site-wide: 52,656

Haplotypes of common SNPs can explain missing heritability of complex diseases

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  • Site-wide: 3,951
  • In genetics: 169
• Year to date:
  • Site-wide: 78,724
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  • Site-wide: 65,193

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

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  • Site-wide: 4,238
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  • Site-wide: 31,356
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  • Site-wide: 27,838

Improved polygenic prediction by Bayesian multiple regression on summary statistics

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  • Site-wide: 4,573
  • In genetics: 202
• Year to date:
  • Site-wide: 63,557
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  • Site-wide: 65,219

A resource-efficient tool for mixed model association analysis of large-scale data

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  • Site-wide: 4,660
  • In genetics: 205
• Year to date:
  • Site-wide: 13,588
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  • Site-wide: 10,885

A comparative study of techniques for differential expression analysis on RNA-Seq data

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  • Site-wide: 5,168
  • In bioinformatics: 567
• Year to date:
  • Site-wide: 73,493
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  • Site-wide: 66,023

Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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  • Site-wide: 5,288
  • In genomics: 602
• Year to date:
  • Site-wide: 73,301
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GWAS on family history of Alzheimer's disease

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  • Site-wide: 7,477
  • In genetics: 353
• Year to date:
  • Site-wide: 63,448
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  • Site-wide: 48,997

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 8,781
  • In genetics: 414
• Year to date:
  • Site-wide: 47,955
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  • Site-wide: 63,586

Causal associations between risk factors and common diseases inferred from GWAS summary data

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  • Site-wide: 8,880
  • In genetics: 423
• Year to date:
  • Site-wide: 94,030
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  • Site-wide: 104,792

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

• Downloaded 1,582 times
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  • Site-wide: 10,520
  • In psychiatry and clinical psychology: 35
• Year to date:
  • Site-wide: 5,280
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  • Site-wide: None

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

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  • Site-wide: 11,313
  • In genetics: 544
• Year to date:
  • Site-wide: 38,749
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  • Site-wide: 39,312

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

• Downloaded 1,486 times
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  • Site-wide: 11,480
  • In genetics: 560
• Year to date:
  • Site-wide: 17,997
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  • Site-wide: 22,239

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 11,850
  • In genomics: 1,293
• Year to date:
  • Site-wide: 73,338
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  • Site-wide: 76,747

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 12,475
  • In genetics: 616
• Year to date:
  • Site-wide: 52,254
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  • Site-wide: 52,494

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 1,326 times
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  • Site-wide: 13,695
  • In genomics: 1,455
• Year to date:
  • Site-wide: 114,530
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  • Site-wide: 98,208

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

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  • Site-wide: 13,892
  • In genetics: 682
• Year to date:
  • Site-wide: 24,058
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  • Site-wide: 19,708

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

• Downloaded 1,311 times
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  • Site-wide: 13,932
  • In bioinformatics: 1,700
• Year to date:
  • Site-wide: 53,634
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  • Site-wide: 48,646

Imprint of Assortative Mating on the Human Genome

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  • Site-wide: 14,487
  • In genetics: 721
• Year to date:
  • Site-wide: 119,437
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  • Site-wide: 123,315

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 15,655
  • In genetics: 777
• Year to date:
  • Site-wide: 60,924
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  • Site-wide: 48,579

Estimation of genetic correlation using linkage disequilibrium score regression and genomic restricted maximum likelihood

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  • Site-wide: 18,143
  • In genetics: 893
• Year to date:
  • Site-wide: 81,207
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  • Site-wide: 62,840

A comprehensive evaluation of polygenic score methods across cohorts in psychiatric disorders

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  • Site-wide: 18,489
  • In genetic and genomic medicine: 62
• Year to date:
  • Site-wide: 4,431
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  • Site-wide: 3,753

Using genotype data to distinguish pleiotropy from heterogeneity: deciphering coheritability in autoimmune and neuropsychiatric diseases

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  • Site-wide: 19,412
  • In genomics: 1,960
• Year to date:
  • Site-wide: 86,560
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  • Site-wide: 69,592

Identification of 55,000 Replicated DNA Methylation QTL

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  • Site-wide: 19,639
  • In genomics: 1,980
• Year to date:
  • Site-wide: 94,303
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  • Site-wide: 104,089

Epigenetic prediction of complex traits and death

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  • Site-wide: 20,894
  • In genomics: 2,083
• Year to date:
  • Site-wide: 72,465
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  • Site-wide: 64,069

Genetic Association Study of Childhood Aggression across raters, instruments and age

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  • Site-wide: 24,354
  • In genomics: 2,330
• Year to date:
  • Site-wide: 16,151
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  • Site-wide: 9,151

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 843 times
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  • Site-wide: 26,557
  • In genetics: 1,288
• Year to date:
  • Site-wide: 73,727
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  • Site-wide: 64,532

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

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  • Site-wide: 27,786
  • In genetics: 1,356
• Year to date:
  • Site-wide: 124,990
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  • Site-wide: 123,009

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

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  • Site-wide: 28,766
  • In genetics: 1,394
• Year to date:
  • Site-wide: 91,703
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  • Site-wide: 69,624

Widespread associations between grey matter structure and the human phenome

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  • Site-wide: 28,993
  • In neuroscience: 3,912
• Year to date:
  • Site-wide: 101,107
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  • Site-wide: 80,483

Cross-disorder GWAS meta-analysis for Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and Tourette Syndrome

• Downloaded 759 times
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  • Site-wide: 30,815
  • In genetics: 1,493
• Year to date:
  • Site-wide: 27,720
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  • Site-wide: 25,548

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

• Downloaded 754 times
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  • Site-wide: 31,052
  • In genetics: 1,503
• Year to date:
  • Site-wide: 99,773
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  • Site-wide: 83,652

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • Site-wide: 33,323
  • In genetics: 1,619
• Year to date:
  • Site-wide: 112,108
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  • Site-wide: 86,981

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 34,363
  • In genetics: 1,655
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  • Site-wide: 29,688
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  • Site-wide: 49,816

Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous system

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  • Site-wide: 35,277
  • In genomics: 3,056
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  • Site-wide: 17,102
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  • Site-wide: 11,985

Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

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  • Site-wide: 36,482
  • In genetics: 1,744
• Year to date:
  • Site-wide: 75,485
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  • Site-wide: 79,691

The Australian Genetics of Depression Study: Study Description and Sample Characteristics

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  • Site-wide: 37,374
  • In genetics: 1,786
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  • Site-wide: 62,460
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  • Site-wide: 41,609

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

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  • Site-wide: 41,167
  • In neurology: 74
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  • Site-wide: 2,082
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  • Site-wide: 519

Investigating the potential effect of antihypertensive medication on psychiatric disorders: a mendelian randomisation study

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  • Site-wide: 41,520
  • In genetic and genomic medicine: 130
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  • Site-wide: 21,760
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  • Site-wide: 16,647

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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  • Site-wide: 43,985
  • In genetics: 2,062
• Year to date:
  • Site-wide: 109,375
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  • Site-wide: 114,678

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

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  • Site-wide: 44,880
  • In genetics: 2,120
• Year to date:
  • Site-wide: 125,074
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  • Site-wide: 111,282

Exploring contributors to variability in estimates of SNP-heritability and genetic correlations from the iPSYCH case-cohort and published meta-studies of major psychiatric disorders.

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  • Site-wide: 47,499
  • In genetics: 2,238
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  • Site-wide: 81,399
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  • Site-wide: 70,913

Genetic analyses of medication-use and implications for precision medicine

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  • Site-wide: 47,677
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  • Site-wide: 56,937
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  • Site-wide: 53,470

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

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  • Site-wide: 48,133
  • In genetics: 2,264
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  • Site-wide: 16,155
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  • Site-wide: 17,271

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 52,137
  • In genetic and genomic medicine: 166
• Year to date:
  • Site-wide: 10,289
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  • Site-wide: 8,203

Age at first birth in women is genetically associated with increased risk of schizophrenia

• Downloaded 489 times
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  • Site-wide: 53,821
  • In genetics: 2,503
• Year to date:
  • Site-wide: 131,863
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  • Site-wide: 129,742

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

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  • Site-wide: 56,236
  • In genetics: 2,626
• Year to date:
  • Site-wide: 32,875
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  • Site-wide: 28,755

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

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  • Site-wide: 57,609
  • In genomics: 4,313
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  • Site-wide: 89,657
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  • Site-wide: 66,826

A better design for stratified medicine based on genomic prediction

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  • Site-wide: 60,257
  • In genetics: 2,809
• Year to date:
  • Site-wide: 132,826
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  • Site-wide: 111,802

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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  • Site-wide: 68,446
  • In neuroscience: 10,392
• Year to date:
  • Site-wide: 123,685
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  • Site-wide: 101,729

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

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  • Site-wide: 75,466
  • In psychiatry and clinical psychology: 243
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  • Site-wide: 9,307
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  • Site-wide: 27,585

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

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  • Site-wide: 75,588
  • In genetics: 3,459
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  • Site-wide: 77,531
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  • Site-wide: 66,884

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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  • Site-wide: 87,227
  • In epidemiology: 3,584
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  • Site-wide: 120,479
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  • Site-wide: 128,720

A parsimonious model for mass-univariate vertex-wise analysis

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  • Site-wide: 97,662
  • In neuroscience: 15,194
• Year to date:
  • Site-wide: 7,846
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  • Site-wide: 12,104

Comorbid chronic pain and depression: Shared risk factors and differential antidepressant effectiveness

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  • Site-wide: 119,400
  • In epidemiology: 4,874
• Year to date:
  • Site-wide: 116,457
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  • Site-wide: None

Genome-wide study of DNA methylation in Amyotrophic Lateral Sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol pathways

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  • Site-wide: 123,339
  • In neurology: 532
• Year to date:
  • Site-wide: 19,996
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  • Site-wide: 5,148

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

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  • Site-wide: 126,324
  • In genetic and genomic medicine: 615
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  • Site-wide: 6,422