Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,506 bioRxiv papers from 264,779 authors.

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • In genetics: 11 out of 3,295
• Year to date:
  • Site-wide: 1,929 out of 57,506
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  • Site-wide: 8,641 out of 57,506

New mutations, old statistical challenges

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  • Site-wide: 206 out of 57,506
  • In genetics: 22 out of 3,295
• Year to date:
  • Site-wide: 14,059 out of 57,506
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  • Site-wide: 24,766 out of 57,506

Regulatory variants explain much more heritability than coding variants across 11 common diseases

• Downloaded 4,218 times
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  • Site-wide: 512 out of 57,506
  • In genetics: 60 out of 3,295
• Year to date:
  • Site-wide: 26,004 out of 57,506
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  • Site-wide: 20,638 out of 57,506

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 3,495 times
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  • Site-wide: 748 out of 57,506
  • In genetics: 73 out of 3,295
• Year to date:
  • Site-wide: 366 out of 57,506
• Since beginning of last month:
  • Site-wide: 2,808 out of 57,506

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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  • Site-wide: 1,037 out of 57,506
  • In genetics: 101 out of 3,295
• Year to date:
  • Site-wide: 32,899 out of 57,506
• Since beginning of last month:
  • Site-wide: 20,392 out of 57,506

Haplotypes of common SNPs can explain missing heritability of complex diseases

• Downloaded 2,883 times
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  • Site-wide: 1,067 out of 57,506
  • In genetics: 102 out of 3,295
• Year to date:
  • Site-wide: 34,803 out of 57,506
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  • Site-wide: 23,336 out of 57,506

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

• Downloaded 2,628 times
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  • Site-wide: 1,268 out of 57,506
  • In genomics: 299 out of 4,027
• Year to date:
  • Site-wide: 166 out of 57,506
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  • Site-wide: 1,096 out of 57,506

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

• Downloaded 2,557 times
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  • Site-wide: 1,323 out of 57,506
  • In genomics: 312 out of 4,027
• Year to date:
  • Site-wide: 1,921 out of 57,506
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  • Site-wide: 2,975 out of 57,506

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

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  • In genetics: 138 out of 3,295
• Year to date:
  • Site-wide: 25,988 out of 57,506
• Since beginning of last month:
  • Site-wide: 26,439 out of 57,506

Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

• Downloaded 2,295 times
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  • Site-wide: 1,614 out of 57,506
  • In genomics: 366 out of 4,027
• Year to date:
  • Site-wide: 41,070 out of 57,506
• Since beginning of last month:
  • Site-wide: 51,836 out of 57,506

A comparative study of techniques for differential expression analysis on RNA-Seq data

• Downloaded 2,236 times
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  • Site-wide: 1,689 out of 57,506
  • In bioinformatics: 345 out of 5,863
• Year to date:
  • Site-wide: 22,775 out of 57,506
• Since beginning of last month:
  • Site-wide: 15,969 out of 57,506

Widespread signatures of negative selection in the genetic architecture of human complex traits

• Downloaded 2,033 times
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  • Site-wide: 1,972 out of 57,506
  • In genetics: 194 out of 3,295
• Year to date:
  • Site-wide: 31,793 out of 57,506
• Since beginning of last month:
  • Site-wide: 37,708 out of 57,506

Improved polygenic prediction by Bayesian multiple regression on summary statistics

• Downloaded 1,748 times
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  • Site-wide: 2,577 out of 57,506
  • In genetics: 234 out of 3,295
• Year to date:
  • Site-wide: 352 out of 57,506
• Since beginning of last month:
  • Site-wide: 1,015 out of 57,506

GWAS on family history of Alzheimer's disease

• Downloaded 1,719 times
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  • Site-wide: 2,656 out of 57,506
  • In genetics: 242 out of 3,295
• Year to date:
  • Site-wide: 15,501 out of 57,506
• Since beginning of last month:
  • Site-wide: 24,223 out of 57,506

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,588 times
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  • Site-wide: 3,033 out of 57,506
  • In genetics: 275 out of 3,295
• Year to date:
  • Site-wide: 41,957 out of 57,506
• Since beginning of last month:
  • Site-wide: 37,129 out of 57,506

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,260 times
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  • Site-wide: 4,431 out of 57,506
  • In genomics: 795 out of 4,027
• Year to date:
  • Site-wide: 16,217 out of 57,506
• Since beginning of last month:
  • Site-wide: 31,934 out of 57,506

Imprint of Assortative Mating on the Human Genome

• Downloaded 1,072 times
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  • Site-wide: 5,791 out of 57,506
  • In genetics: 476 out of 3,295
• Year to date:
  • Site-wide: 10,037 out of 57,506
• Since beginning of last month:
  • Site-wide: 11,059 out of 57,506

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

• Downloaded 923 times
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  • Site-wide: 7,366 out of 57,506
  • In genetics: 585 out of 3,295
• Year to date:
  • Site-wide: 1,234 out of 57,506
• Since beginning of last month:
  • Site-wide: 8,215 out of 57,506

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 909 times
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  • Site-wide: 7,540 out of 57,506
  • In bioinformatics: 1,352 out of 5,863
• Year to date:
  • Site-wide: 3,089 out of 57,506
• Since beginning of last month:
  • Site-wide: 22,882 out of 57,506

Using genotype data to distinguish pleiotropy from heterogeneity: deciphering coheritability in autoimmune and neuropsychiatric diseases

• Downloaded 902 times
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  • Site-wide: 7,631 out of 57,506
  • In genomics: 1,200 out of 4,027
• Year to date:
  • Site-wide: 42,782 out of 57,506
• Since beginning of last month:
  • Site-wide: 39,441 out of 57,506

Estimation of genetic correlation using linkage disequilibrium score regression and genomic restricted maximum likelihood

• Downloaded 891 times
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  • Site-wide: 7,769 out of 57,506
  • In genetics: 607 out of 3,295
• Year to date:
  • Site-wide: 31,047 out of 57,506
• Since beginning of last month:
  • Site-wide: 25,603 out of 57,506

A resource-efficient tool for mixed model association analysis of large-scale data

• Downloaded 890 times
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  • Site-wide: 7,792 out of 57,506
  • In genetics: 609 out of 3,295
• Year to date:
  • Site-wide: 1,299 out of 57,506
• Since beginning of last month:
  • Site-wide: 3,013 out of 57,506

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 846 times
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  • Site-wide: 8,420 out of 57,506
  • In genomics: 1,291 out of 4,027
• Year to date:
  • Site-wide: 29,681 out of 57,506
• Since beginning of last month:
  • Site-wide: 19,735 out of 57,506

Epigenetic prediction of complex traits and death

• Downloaded 841 times
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  • Site-wide: 8,518 out of 57,506
  • In genomics: 1,307 out of 4,027
• Year to date:
  • Site-wide: 34,548 out of 57,506
• Since beginning of last month:
  • Site-wide: 39,957 out of 57,506

The Project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public

• Downloaded 745 times
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  • Site-wide: 10,200 out of 57,506
  • In genomics: 1,480 out of 4,027
• Year to date:
  • Site-wide: 6,181 out of 57,506
• Since beginning of last month:
  • Site-wide: 11,539 out of 57,506

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

• Downloaded 676 times
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  • Site-wide: 11,715 out of 57,506
  • In genetics: 844 out of 3,295
• Year to date:
  • Site-wide: 34,579 out of 57,506
• Since beginning of last month:
  • Site-wide: 49,932 out of 57,506

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 652 times
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  • Site-wide: 12,363 out of 57,506
  • In genetics: 886 out of 3,295
• Year to date:
  • Site-wide: 25,556 out of 57,506
• Since beginning of last month:
  • Site-wide: 49,309 out of 57,506

Bayesian reassessment of the epigenetic architecture of complex traits

• Downloaded 573 times
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  • Site-wide: 14,699 out of 57,506
  • In genomics: 1,895 out of 4,027
• Year to date:
  • Site-wide: 10,824 out of 57,506
• Since beginning of last month:
  • Site-wide: 18,280 out of 57,506

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

• Downloaded 545 times
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  • Site-wide: 15,716 out of 57,506
  • In genetics: 1,087 out of 3,295
• Year to date:
  • Site-wide: 15,341 out of 57,506
• Since beginning of last month:
  • Site-wide: 21,215 out of 57,506

DEAR-O: Differential Expression Analysis based on RNA-seq data - Online

• Downloaded 506 times
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  • Site-wide: 17,250 out of 57,506
  • In bioinformatics: 2,631 out of 5,863
• Year to date:
  • Site-wide: 46,390 out of 57,506
• Since beginning of last month:
  • Site-wide: 51,533 out of 57,506

Comparison of Genotypic and Phenotypic Correlations: Cheverud’s Conjecture in Humans

• Downloaded 483 times
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  • Site-wide: 18,253 out of 57,506
  • In genetics: 1,247 out of 3,295
• Year to date:
  • Site-wide: 38,469 out of 57,506
• Since beginning of last month:
  • Site-wide: 36,877 out of 57,506

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

• Downloaded 466 times
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  • Site-wide: 19,039 out of 57,506
  • In genetics: 1,306 out of 3,295
• Year to date:
  • Site-wide: 54,666 out of 57,506
• Since beginning of last month:
  • Site-wide: 54,087 out of 57,506

Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

• Downloaded 443 times
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  • Site-wide: 20,161 out of 57,506
  • In genetics: 1,362 out of 3,295
• Year to date:
  • Site-wide: 20,561 out of 57,506
• Since beginning of last month:
  • Site-wide: 35,825 out of 57,506

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

• Downloaded 378 times
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  • Site-wide: 23,967 out of 57,506
  • In genetics: 1,587 out of 3,295
• Year to date:
  • Site-wide: 5,641 out of 57,506
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  • Site-wide: 9,342 out of 57,506

A better design for stratified medicine based on genomic prediction

• Downloaded 362 times
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  • Site-wide: 25,046 out of 57,506
  • In genetics: 1,651 out of 3,295
• Year to date:
  • Site-wide: 53,710 out of 57,506
• Since beginning of last month:
  • Site-wide: 53,386 out of 57,506

Widespread associations between grey matter structure and the human phenome

• Downloaded 360 times
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  • Site-wide: 25,152 out of 57,506
  • In neuroscience: 4,250 out of 10,103
• Year to date:
  • Site-wide: 6,127 out of 57,506
• Since beginning of last month:
  • Site-wide: 429 out of 57,506

Age at first birth in women is genetically associated with increased risk of schizophrenia

• Downloaded 340 times
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  • Site-wide: 26,622 out of 57,506
  • In genetics: 1,731 out of 3,295
• Year to date:
  • Site-wide: 34,980 out of 57,506
• Since beginning of last month:
  • Site-wide: 7,123 out of 57,506

Genetic analyses of medication-use and implications for precision medicine

• Downloaded 330 times
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  • Site-wide: 27,352 out of 57,506
  • In genetics: 1,780 out of 3,295
• Year to date:
  • Site-wide: 13,777 out of 57,506
• Since beginning of last month:
  • Site-wide: 39,758 out of 57,506

The Australian Genetics of Depression Study: Study Description and Sample Characteristics

• Downloaded 315 times
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  • Site-wide: 28,567 out of 57,506
  • In genetics: 1,851 out of 3,295
• Year to date:
  • Site-wide: 7,636 out of 57,506
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  • Site-wide: 12,288 out of 57,506

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

• Downloaded 311 times
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  • Site-wide: 28,968 out of 57,506
  • In genetics: 1,867 out of 3,295
• Year to date:
  • Site-wide: 7,804 out of 57,506
• Since beginning of last month:
  • Site-wide: 30,047 out of 57,506

Exploring contributors to variability in estimates of SNP-heritability and genetic correlations from the iPSYCH case-cohort and published meta-studies of major psychiatric disorders.

• Downloaded 265 times
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  • Site-wide: 33,137 out of 57,506
  • In genetics: 2,103 out of 3,295
• Year to date:
  • Site-wide: 17,731 out of 57,506
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  • Site-wide: 16,424 out of 57,506

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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  • Site-wide: 35,281 out of 57,506
  • In neuroscience: 6,065 out of 10,103
• Year to date:
  • Site-wide: 11,431 out of 57,506
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  • Site-wide: 16,422 out of 57,506

Genetic comorbidity between major depression and cardio-metabolic disease, stratified by age at onset of major depression.

• Downloaded 188 times
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  • Site-wide: 41,540 out of 57,506
  • In genetics: 2,550 out of 3,295
• Year to date:
  • Site-wide: 16,290 out of 57,506
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  • Site-wide: 20,704 out of 57,506

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

• Downloaded 187 times
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  • Site-wide: 41,559 out of 57,506
  • In epidemiology: 787 out of 1,556
• Year to date:
  • Site-wide: 35,822 out of 57,506
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  • Site-wide: 48,534 out of 57,506