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Author: Naomi R. Wray

Rankings

  • All-time downloads: 110,737 (rank: 852 )
  • Categories:
    • bioinformatics: 3,860 (rank: 3,210 )
    • epidemiology: 427 (rank: 16,310 (tie) )
    • genetic and genomic medicine: 2,294 (rank: 610 (tie) )
    • genetics: 81,315 (rank: 36 )
    • genomics: 18,765 (rank: 574 )
    • neurology: 728 (rank: 1,171 (tie) )
    • neuroscience: 1,419 (rank: 15,985 (tie) )
    • psychiatry and clinical psychology: 1,929 (rank: 285 (tie) )

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

genetics more details view paper
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    • Site-wide: 863
    • In genetics: 25
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    • Site-wide: 30,161
  • Since beginning of last month:
    • Site-wide: 31,179

Genetic Consequences of Social Stratification in Great Britain

genetics more details view paper
  • Downloaded 7,720 times
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    • Site-wide: 1,114
    • In genetics: 35
  • Year to date:
    • Site-wide: 10,529
  • Since beginning of last month:
    • Site-wide: 11,207

Genomewide association study identifies 30 loci associated with bipolar disorder

genetics more details view paper
  • Downloaded 7,323 times
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    • Site-wide: 1,198
    • In genetics: 38
  • Year to date:
    • Site-wide: 17,033
  • Since beginning of last month:
    • Site-wide: 14,774

New mutations, old statistical challenges

genetics more details view paper
  • Downloaded 7,130 times
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    • Site-wide: 1,234
    • In genetics: 40
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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

genomics more details view paper
  • Downloaded 4,757 times
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    • Site-wide: 2,126
    • In genomics: 222
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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

genetics more details view paper
  • Downloaded 4,520 times
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    • Site-wide: 2,276
    • In genetics: 85
  • Year to date:
    • Site-wide: 36,011
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Regulatory variants explain much more heritability than coding variants across 11 common diseases

genetics more details view paper
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    • Site-wide: 2,316
    • In genetics: 87
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    • Site-wide: 85,749
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    • Site-wide: 79,666

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

genomics more details view paper
  • Downloaded 3,579 times
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    • Site-wide: 3,186
    • In genomics: 363
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Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

genetics more details view paper
  • Downloaded 3,175 times
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    • Site-wide: 3,797
    • In genetics: 161
  • Year to date:
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Haplotypes of common SNPs can explain missing heritability of complex diseases

genetics more details view paper
  • Downloaded 3,080 times
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    • Site-wide: 3,951
    • In genetics: 169
  • Year to date:
    • Site-wide: 78,724
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Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

genetics more details view paper
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    • Site-wide: 4,238
    • In genetics: 186
  • Year to date:
    • Site-wide: 31,356
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Improved polygenic prediction by Bayesian multiple regression on summary statistics

genetics more details view paper
  • Downloaded 2,772 times
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    • Site-wide: 4,573
    • In genetics: 202
  • Year to date:
    • Site-wide: 63,557
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    • Site-wide: 65,219

A resource-efficient tool for mixed model association analysis of large-scale data

genetics more details view paper
  • Downloaded 2,741 times
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    • Site-wide: 4,660
    • In genetics: 205
  • Year to date:
    • Site-wide: 13,588
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A comparative study of techniques for differential expression analysis on RNA-Seq data

bioinformatics more details view paper
  • Downloaded 2,549 times
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    • Site-wide: 5,168
    • In bioinformatics: 567
  • Year to date:
    • Site-wide: 73,493
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    • Site-wide: 66,023

Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

genomics more details view paper
  • Downloaded 2,511 times
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    • Site-wide: 5,288
    • In genomics: 602
  • Year to date:
    • Site-wide: 73,301
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    • Site-wide: 86,854

GWAS on family history of Alzheimer's disease

genetics more details view paper
  • Downloaded 1,987 times
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    • Site-wide: 7,477
    • In genetics: 353
  • Year to date:
    • Site-wide: 63,448
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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

genetics more details view paper
  • Downloaded 1,787 times
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    • Site-wide: 8,781
    • In genetics: 414
  • Year to date:
    • Site-wide: 47,955
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    • Site-wide: 63,586

Causal associations between risk factors and common diseases inferred from GWAS summary data

genetics more details view paper
  • Downloaded 1,773 times
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    • Site-wide: 8,880
    • In genetics: 423
  • Year to date:
    • Site-wide: 94,030
  • Since beginning of last month:
    • Site-wide: 104,792

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

psychiatry and clinical psychology more details view paper
  • Downloaded 1,582 times
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    • Site-wide: 10,520
    • In psychiatry and clinical psychology: 35
  • Year to date:
    • Site-wide: 5,280
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    • Site-wide: None

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

genetics more details view paper
  • Downloaded 1,501 times
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    • Site-wide: 11,313
    • In genetics: 544
  • Year to date:
    • Site-wide: 38,749
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    • Site-wide: 39,312

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

genetics more details view paper
  • Downloaded 1,486 times
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    • Site-wide: 11,480
    • In genetics: 560
  • Year to date:
    • Site-wide: 17,997
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    • Site-wide: 22,239

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

genomics more details view paper
  • Downloaded 1,456 times
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    • Site-wide: 11,850
    • In genomics: 1,293
  • Year to date:
    • Site-wide: 73,338
  • Since beginning of last month:
    • Site-wide: 76,747

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

genetics more details view paper
  • Downloaded 1,409 times
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    • Site-wide: 12,475
    • In genetics: 616
  • Year to date:
    • Site-wide: 52,254
  • Since beginning of last month:
    • Site-wide: 52,494

Bayesian reassessment of the epigenetic architecture of complex traits

genomics more details view paper
  • Downloaded 1,326 times
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    • Site-wide: 13,695
    • In genomics: 1,455
  • Year to date:
    • Site-wide: 114,530
  • Since beginning of last month:
    • Site-wide: 98,208

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

genetics more details view paper
  • Downloaded 1,313 times
  • Download rankings, all-time:
    • Site-wide: 13,892
    • In genetics: 682
  • Year to date:
    • Site-wide: 24,058
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    • Site-wide: 19,708

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

bioinformatics more details view paper
  • Downloaded 1,311 times
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    • Site-wide: 13,932
    • In bioinformatics: 1,700
  • Year to date:
    • Site-wide: 53,634
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    • Site-wide: 48,646

Imprint of Assortative Mating on the Human Genome

genetics more details view paper
  • Downloaded 1,278 times
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    • Site-wide: 14,487
    • In genetics: 721
  • Year to date:
    • Site-wide: 119,437
  • Since beginning of last month:
    • Site-wide: 123,315

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

genetics more details view paper
  • Downloaded 1,214 times
  • Download rankings, all-time:
    • Site-wide: 15,655
    • In genetics: 777
  • Year to date:
    • Site-wide: 60,924
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    • Site-wide: 48,579

Estimation of genetic correlation using linkage disequilibrium score regression and genomic restricted maximum likelihood

genetics more details view paper
  • Downloaded 1,098 times
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    • Site-wide: 18,143
    • In genetics: 893
  • Year to date:
    • Site-wide: 81,207
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    • Site-wide: 62,840

A comprehensive evaluation of polygenic score methods across cohorts in psychiatric disorders

genetic and genomic medicine more details view paper
  • Downloaded 1,085 times
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    • Site-wide: 18,489
    • In genetic and genomic medicine: 62
  • Year to date:
    • Site-wide: 4,431
  • Since beginning of last month:
    • Site-wide: 3,753

Using genotype data to distinguish pleiotropy from heterogeneity: deciphering coheritability in autoimmune and neuropsychiatric diseases

genomics more details view paper
  • Downloaded 1,051 times
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    • Site-wide: 19,412
    • In genomics: 1,960
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    • Site-wide: 86,560
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    • Site-wide: 69,592

Identification of 55,000 Replicated DNA Methylation QTL

genomics more details view paper
  • Downloaded 1,042 times
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    • Site-wide: 19,639
    • In genomics: 1,980
  • Year to date:
    • Site-wide: 94,303
  • Since beginning of last month:
    • Site-wide: 104,089

Epigenetic prediction of complex traits and death

genomics more details view paper
  • Downloaded 998 times
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    • Site-wide: 20,894
    • In genomics: 2,083
  • Year to date:
    • Site-wide: 72,465
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    • Site-wide: 64,069

Genetic Association Study of Childhood Aggression across raters, instruments and age

genomics more details view paper
  • Downloaded 898 times
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    • Site-wide: 24,354
    • In genomics: 2,330
  • Year to date:
    • Site-wide: 16,151
  • Since beginning of last month:
    • Site-wide: 9,151

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

genetics more details view paper
  • Downloaded 843 times
  • Download rankings, all-time:
    • Site-wide: 26,557
    • In genetics: 1,288
  • Year to date:
    • Site-wide: 73,727
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    • Site-wide: 64,532

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

genetics more details view paper
  • Downloaded 817 times
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    • Site-wide: 27,786
    • In genetics: 1,356
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    • Site-wide: 124,990
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    • Site-wide: 123,009

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

genetics more details view paper
  • Downloaded 797 times
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    • Site-wide: 28,766
    • In genetics: 1,394
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    • Site-wide: 91,703
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    • Site-wide: 69,624

Widespread associations between grey matter structure and the human phenome

neuroscience more details view paper
  • Downloaded 792 times
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    • Site-wide: 28,993
    • In neuroscience: 3,912
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    • Site-wide: 101,107
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    • Site-wide: 80,483

Cross-disorder GWAS meta-analysis for Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and Tourette Syndrome

genetics more details view paper
  • Downloaded 759 times
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    • Site-wide: 30,815
    • In genetics: 1,493
  • Year to date:
    • Site-wide: 27,720
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    • Site-wide: 25,548

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

genetics more details view paper
  • Downloaded 754 times
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    • Site-wide: 31,052
    • In genetics: 1,503
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    • Site-wide: 99,773
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Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

genetics more details view paper
  • Downloaded 717 times
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    • Site-wide: 33,323
    • In genetics: 1,619
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    • Site-wide: 112,108
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    • Site-wide: 86,981

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

genetics more details view paper
  • Downloaded 701 times
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    • Site-wide: 34,363
    • In genetics: 1,655
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    • Site-wide: 29,688
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    • Site-wide: 49,816

Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous system

genomics more details view paper
  • Downloaded 688 times
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    • Site-wide: 35,277
    • In genomics: 3,056
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    • Site-wide: 17,102
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Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

genetics more details view paper
  • Downloaded 671 times
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    • Site-wide: 36,482
    • In genetics: 1,744
  • Year to date:
    • Site-wide: 75,485
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The Australian Genetics of Depression Study: Study Description and Sample Characteristics

genetics more details view paper
  • Downloaded 658 times
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    • Site-wide: 37,374
    • In genetics: 1,786
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Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

neurology more details view paper
  • Downloaded 610 times
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    • Site-wide: 41,167
    • In neurology: 74
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    • Site-wide: 2,082
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Investigating the potential effect of antihypertensive medication on psychiatric disorders: a mendelian randomisation study

genetic and genomic medicine more details view paper
  • Downloaded 606 times
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    • Site-wide: 41,520
    • In genetic and genomic medicine: 130
  • Year to date:
    • Site-wide: 21,760
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Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

genetics more details view paper
  • Downloaded 579 times
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    • Site-wide: 43,985
    • In genetics: 2,062
  • Year to date:
    • Site-wide: 109,375
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    • Site-wide: 114,678

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

genetics more details view paper
  • Downloaded 569 times
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    • Site-wide: 44,880
    • In genetics: 2,120
  • Year to date:
    • Site-wide: 125,074
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    • Site-wide: 111,282

Exploring contributors to variability in estimates of SNP-heritability and genetic correlations from the iPSYCH case-cohort and published meta-studies of major psychiatric disorders.

genetics more details view paper
  • Downloaded 544 times
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    • Site-wide: 47,499
    • In genetics: 2,238
  • Year to date:
    • Site-wide: 81,399
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    • Site-wide: 70,913

Genetic analyses of medication-use and implications for precision medicine

genetics more details view paper
  • Downloaded 542 times
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    • Site-wide: 47,677
    • In genetics: 2,246
  • Year to date:
    • Site-wide: 56,937
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    • Site-wide: 53,470

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

genetics more details view paper
  • Downloaded 538 times
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    • Site-wide: 48,133
    • In genetics: 2,264
  • Year to date:
    • Site-wide: 16,155
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    • Site-wide: 17,271

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

genetic and genomic medicine more details view paper
  • Downloaded 502 times
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    • Site-wide: 52,137
    • In genetic and genomic medicine: 166
  • Year to date:
    • Site-wide: 10,289
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    • Site-wide: 8,203

Age at first birth in women is genetically associated with increased risk of schizophrenia

genetics more details view paper
  • Downloaded 489 times
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    • Site-wide: 53,821
    • In genetics: 2,503
  • Year to date:
    • Site-wide: 131,863
  • Since beginning of last month:
    • Site-wide: 129,742

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

genetics more details view paper
  • Downloaded 470 times
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    • Site-wide: 56,236
    • In genetics: 2,626
  • Year to date:
    • Site-wide: 32,875
  • Since beginning of last month:
    • Site-wide: 28,755

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

genomics more details view paper
  • Downloaded 459 times
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    • Site-wide: 57,609
    • In genomics: 4,313
  • Year to date:
    • Site-wide: 89,657
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    • Site-wide: 66,826

A better design for stratified medicine based on genomic prediction

genetics more details view paper
  • Downloaded 440 times
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    • Site-wide: 60,257
    • In genetics: 2,809
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    • Site-wide: 111,802

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

neuroscience more details view paper
  • Downloaded 387 times
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    • Site-wide: 68,446
    • In neuroscience: 10,392
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    • Site-wide: 123,685
  • Since beginning of last month:
    • Site-wide: 101,729

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

psychiatry and clinical psychology more details view paper
  • Downloaded 347 times
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    • Site-wide: 75,466
    • In psychiatry and clinical psychology: 243
  • Year to date:
    • Site-wide: 9,307
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    • Site-wide: 27,585

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

genetics more details view paper
  • Downloaded 346 times
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    • Site-wide: 75,588
    • In genetics: 3,459
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Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

epidemiology more details view paper
  • Downloaded 288 times
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    • Site-wide: 87,227
    • In epidemiology: 3,584
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A parsimonious model for mass-univariate vertex-wise analysis

neuroscience more details view paper
  • Downloaded 240 times
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Comorbid chronic pain and depression: Shared risk factors and differential antidepressant effectiveness

epidemiology more details view paper
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    • Site-wide: 119,400
    • In epidemiology: 4,874
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    • Site-wide: 116,457
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Genome-wide study of DNA methylation in Amyotrophic Lateral Sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol pathways

neurology more details view paper
  • Downloaded 118 times
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    • Site-wide: 123,339
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Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

genetic and genomic medicine more details view paper
  • Downloaded 101 times
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