Author: Naomi R. Wray

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,393
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  • Site-wide: 20,576
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  • Site-wide: 21,548

Genetic Consequences of Social Stratification in Great Britain

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  • Site-wide: 1,562
  • In genetics: 33
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  • Site-wide: 6,370
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  • Site-wide: 7,807

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,920
  • In genetics: 45
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  • Site-wide: 7,831
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  • Site-wide: 26,304

New mutations, old statistical challenges

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  • Site-wide: 2,052
  • In genetics: 50
• Year to date:
  • Site-wide: 132,623
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  • Site-wide: 74,903

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 3,272
  • In genomics: 280
• Year to date:
  • Site-wide: 13,869
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  • Site-wide: 32,839

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 3,617
  • In genetics: 100
• Year to date:
  • Site-wide: 114,409
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  • Site-wide: 206,684

Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • Site-wide: 3,858
  • In genetics: 106
• Year to date:
  • Site-wide: 62,819
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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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  • Site-wide: 4,930
  • In genomics: 452
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  • Site-wide: 143,218

A resource-efficient tool for mixed model association analysis of large-scale data

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  • Site-wide: 5,097
  • In genetics: 163
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  • Site-wide: 8,894
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  • Site-wide: 11,565

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 5,348
  • In psychiatry and clinical psychology: 20
• Year to date:
  • Site-wide: 9,333
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  • Site-wide: 18,379

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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  • Site-wide: 6,167
  • In genetics: 205
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  • Site-wide: 23,431
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  • Site-wide: 143,756

Haplotypes of common SNPs can explain missing heritability of complex diseases

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  • Site-wide: 6,435
  • In genetics: 217
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  • Site-wide: 71,063
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  • Site-wide: 151,283

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

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  • In genetics: 218
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  • Site-wide: 62,624
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A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

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  • Site-wide: 6,524
  • In genetic and genomic medicine: 36
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  • Site-wide: 9,311
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  • Site-wide: 12,178

Improved polygenic prediction by Bayesian multiple regression on summary statistics

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  • Site-wide: 7,066
  • In genetics: 256
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  • Site-wide: 49,788
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  • Site-wide: 43,443

A comparative study of techniques for differential expression analysis on RNA-Seq data

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  • Site-wide: 8,519
  • In bioinformatics: 865
• Year to date:
  • Site-wide: 94,279
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  • Site-wide: 93,301

Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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  • Site-wide: 8,575
  • In genomics: 802
• Year to date:
  • Site-wide: 115,179
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  • Site-wide: 198,789

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

• Downloaded 2,240 times
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  • Site-wide: 11,311
  • In neurology: 35
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  • Site-wide: None
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  • Site-wide: 22,062

GWAS on family history of Alzheimer's disease

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  • Site-wide: 12,158
  • In genetics: 447
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  • Site-wide: 167,488
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  • Site-wide: 175,121

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 13,665
  • In genetics: 525
• Year to date:
  • Site-wide: 41,150
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  • Site-wide: 198,181

Causal associations between risk factors and common diseases inferred from GWAS summary data

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  • Site-wide: 14,719
  • In genetics: 579
• Year to date:
  • Site-wide: 93,631
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  • Site-wide: 209,007

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • Site-wide: 15,452
  • In genetics: 619
• Year to date:
  • Site-wide: 138,147
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  • Site-wide: 92,386

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

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  • Site-wide: 16,764
  • In genetics: 679
• Year to date:
  • Site-wide: 49,733
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  • Site-wide: 153,155

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 18,558
  • In genomics: 1,676
• Year to date:
  • Site-wide: 112,578
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  • Site-wide: 51,987

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

• Downloaded 1,617 times
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  • Site-wide: 18,691
  • In genetics: 759
• Year to date:
  • Site-wide: 35,362
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  • Site-wide: 59,580

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

• Downloaded 1,563 times
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  • Site-wide: 19,716
  • In bioinformatics: 2,157
• Year to date:
  • Site-wide: 40,860
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  • Site-wide: 117,603

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 20,633
  • In genetics: 830
• Year to date:
  • Site-wide: 189,043
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  • Site-wide: 146,397

Bayesian reassessment of the epigenetic architecture of complex traits

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  • Site-wide: 22,842
  • In genomics: 2,001
• Year to date:
  • Site-wide: 113,500
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  • Site-wide: 59,548

Genetic Association Study of Childhood Aggression across raters, instruments and age

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  • Site-wide: 22,943
  • In genomics: 2,000
• Year to date:
  • Site-wide: 50,605
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  • Site-wide: 120,850

Imprint of Assortative Mating on the Human Genome

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  • Site-wide: 23,118
  • In genetics: 919
• Year to date:
  • Site-wide: 132,521
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  • Site-wide: 152,142

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 23,693
  • In genetics: 957
• Year to date:
  • Site-wide: 25,809
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  • Site-wide: 90,610

Cross-disorder GWAS meta-analysis for Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and Tourette Syndrome

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  • Site-wide: 29,350
  • In genetics: 1,175
• Year to date:
  • Site-wide: 35,494
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  • Site-wide: 100,452

Estimation of genetic correlation using linkage disequilibrium score regression and genomic restricted maximum likelihood

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  • Site-wide: 29,701
  • In genetics: 1,174
• Year to date:
  • Site-wide: 167,950
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  • Site-wide: 198,545

Using genotype data to distinguish pleiotropy from heterogeneity: deciphering coheritability in autoimmune and neuropsychiatric diseases

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  • Site-wide: 30,732
  • In genomics: 2,558
• Year to date:
  • Site-wide: 112,225
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  • Site-wide: 174,965

Identification of 55,000 Replicated DNA Methylation QTL

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  • Site-wide: 31,241
  • In genomics: 2,617
• Year to date:
  • Site-wide: 40,160
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  • Site-wide: 144,423

Epigenetic prediction of complex traits and death

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  • Site-wide: 32,791
  • In genomics: 2,691
• Year to date:
  • Site-wide: 96,422
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  • Site-wide: 199,144

Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference

• Downloaded 1,028 times
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  • Site-wide: 38,178
  • In genetics: 1,673
• Year to date:
  • Site-wide: 2,726
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  • Site-wide: 4,462

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 979 times
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  • Site-wide: 41,248
  • In genetics: 1,628
• Year to date:
  • Site-wide: 135,961
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  • Site-wide: 201,487

Investigating the potential effect of antihypertensive medication on psychiatric disorders: a mendelian randomisation study

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  • Site-wide: 42,385
  • In genetic and genomic medicine: 268
• Year to date:
  • Site-wide: 36,907
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  • Site-wide: 64,545

Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous system

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  • Site-wide: 43,018
  • In genomics: 3,281
• Year to date:
  • Site-wide: 71,240
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  • Site-wide: 192,216

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 44,052
  • In genetic and genomic medicine: 273
• Year to date:
  • Site-wide: 83,879
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  • Site-wide: 112,490

Widespread associations between grey matter structure and the human phenome

• Downloaded 937 times
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  • Site-wide: 44,092
  • In neuroscience: 5,800
• Year to date:
  • Site-wide: 60,936
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  • Site-wide: 151,856

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

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  • Site-wide: 46,162
  • In genetics: 1,802
• Year to date:
  • Site-wide: 161,632
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  • Site-wide: 163,887

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

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  • Site-wide: 46,240
  • In genetics: 1,811
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  • Site-wide: 166,830
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  • Site-wide: 175,207

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

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  • Site-wide: 47,735
  • In genetics: 1,863
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  • Site-wide: 167,753
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  • Site-wide: 198,519

The Australian Genetics of Depression Study: Study Description and Sample Characteristics

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  • Site-wide: 20,524
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  • Site-wide: 43,577

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

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  • Site-wide: 49,690
  • In genetics: 1,932
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  • Site-wide: 113,252
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  • Site-wide: 190,621

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • Site-wide: 51,378
  • In genetics: 1,993
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  • Site-wide: 171,114
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  • Site-wide: 120,170

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 52,353
  • In genetics: 2,055
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  • Site-wide: 45,221
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  • Site-wide: 211,128

Genome-wide study of DNA methylation in Amyotrophic Lateral Sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol pathways

• Downloaded 821 times
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  • Site-wide: 54,016
  • In neurology: 180
• Year to date:
  • Site-wide: 145,972
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  • Site-wide: 64,003

Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

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  • Site-wide: 56,829
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  • Site-wide: 193,373
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  • Site-wide: 90,622

Exploring contributors to variability in estimates of SNP-heritability and genetic correlations from the iPSYCH case-cohort and published meta-studies of major psychiatric disorders.

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  • Site-wide: 61,020
  • In genetics: 2,366
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  • Site-wide: 70,139
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  • Site-wide: 154,762

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

• Downloaded 726 times
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  • Site-wide: 64,750
  • In genetics: 2,508
• Year to date:
  • Site-wide: 79,969
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  • Site-wide: 173,466

Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries

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  • Site-wide: 65,074
  • In genetics: 2,790
• Year to date:
  • Site-wide: 6,138
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  • Site-wide: 7,254

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

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  • Site-wide: 66,291
  • In psychiatry and clinical psychology: 306
• Year to date:
  • Site-wide: 126,424
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  • Site-wide: 43,930

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

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  • Site-wide: 70,752
  • In genetics: 2,709
• Year to date:
  • Site-wide: 188,029
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  • Site-wide: 198,159

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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  • Site-wide: 71,124
  • In genetics: 2,742
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  • Site-wide: 114,571
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  • Site-wide: 202,364

Genetic analyses of medication-use and implications for precision medicine

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  • Site-wide: 71,371
  • In genetics: 2,753
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  • Site-wide: 70,292
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  • Site-wide: 180,498

Comprehensive genetic analysis of the human lipidome identifies novel loci controlling lipid homeostasis with links to coronary artery disease

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  • Site-wide: 77,428
  • In genetic and genomic medicine: 509
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  • Site-wide: 53,632
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  • Site-wide: 72,677

mBAT-combo: a more powerful test to detect gene-trait associations from GWAS data

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  • Site-wide: 77,596
  • In genetics: 3,316
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  • Site-wide: 2,499
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  • Site-wide: 12,364

A parsimonious model for mass-univariate vertex-wise analysis

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  • Site-wide: 81,269
  • In neuroscience: 11,563
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  • Site-wide: 82,877
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  • Site-wide: 156,492

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

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  • Site-wide: 83,548
  • In genomics: 5,367
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  • Site-wide: 162,736
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  • Site-wide: 215,141

Comorbid chronic pain and depression: Shared risk factors and differential antidepressant effectiveness

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  • Site-wide: 84,860
  • In epidemiology: 3,766
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  • Site-wide: 124,942
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  • Site-wide: 65,001

Age at first birth in women is genetically associated with increased risk of schizophrenia

• Downloaded 548 times
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  • Site-wide: 93,661
  • In genetics: 3,551
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  • Site-wide: 190,188
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  • Site-wide: 198,409

The genetic and phenotypic correlates of neonatal Complement Component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders

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  • Site-wide: 98,475
  • In genetic and genomic medicine: 699
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  • Site-wide: 6,252

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

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  • Site-wide: 99,656
  • In genetics: 3,820
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Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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  • Site-wide: 100,734
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A better design for stratified medicine based on genomic prediction

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  • Site-wide: 107,368
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  • Site-wide: 188,232
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  • Site-wide: 198,214

Gene expression and RNA splicing explain large proportions of the heritability for complex traits in cattle

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  • Site-wide: 118,581
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  • Site-wide: 16,160

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

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  • Site-wide: 121,928
  • In genetic and genomic medicine: 844
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  • Site-wide: 55,519

Significance tests for R2 of out-of-sample prediction using polygenic scores

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  • Site-wide: 124,148
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  • Site-wide: 25,880

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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  • Site-wide: 130,066
  • In epidemiology: 5,385
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Understanding genetic risk factors for common side effects of antidepressant medications

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  • Site-wide: 159,046
  • In psychiatry and clinical psychology: 990
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  • Site-wide: 100,947
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  • Site-wide: 82,665

Genetic correlates of vitamin D-binding protein and 25 hydroxyvitamin D in neonatal dried blood spots

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  • Site-wide: 178,436
  • In genetic and genomic medicine: 1,366
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Phenotypic and genetic factors associated with differential consent to record linkage for prescription history in the Australian Genetics of Depression Study

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  • Site-wide: 186,547
  • In genetic and genomic medicine: 1,402
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  • Site-wide: 75,689
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  • Site-wide: 99,555

Polygenic Prediction of Molecular Traits using Large-Scale Meta-analysis Summary Statistics

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  • Site-wide: 186,495
  • In genomics: 9,099
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  • Site-wide: 5,186

A higher genetic risk for depression is a greater risk factor for cardiovascular disease in women

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  • Site-wide: 205,841
  • In genetic and genomic medicine: 1,645
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  • Site-wide: 23,176