Author: Naomi R. Wray

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,148
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  • Site-wide: 45,117
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  • Site-wide: 37,882

Genetic Consequences of Social Stratification in Great Britain

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  • Site-wide: 1,373
  • In genetics: 34
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  • Site-wide: 8,357
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  • Site-wide: 10,566

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,550
  • In genetics: 41
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  • Site-wide: 29,936
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  • Site-wide: 88,324

New mutations, old statistical challenges

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  • Site-wide: 1,616
  • In genetics: 44
• Year to date:
  • Site-wide: 80,944
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  • Site-wide: 79,847

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,692
  • In genomics: 250
• Year to date:
  • Site-wide: 23,552
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  • Site-wide: 58,203

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 2,917
  • In genetics: 91
• Year to date:
  • Site-wide: 47,311
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  • Site-wide: 118,997

Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • Site-wide: 3,050
  • In genetics: 93
• Year to date:
  • Site-wide: 110,476
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  • Site-wide: 98,491

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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  • Site-wide: 4,007
  • In genomics: 397
• Year to date:
  • Site-wide: 48,111
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  • Site-wide: 50,625

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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  • Site-wide: 4,810
  • In genetics: 179
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  • Site-wide: 75,385
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  • Site-wide: 64,431

Haplotypes of common SNPs can explain missing heritability of complex diseases

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  • Site-wide: 4,995
  • In genetics: 191
• Year to date:
  • Site-wide: 79,290
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  • Site-wide: 78,869

A resource-efficient tool for mixed model association analysis of large-scale data

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  • Site-wide: 4,998
  • In genetics: 192
• Year to date:
  • Site-wide: 11,417
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  • Site-wide: 10,565

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 5,183
  • In psychiatry and clinical psychology: 20
• Year to date:
  • Site-wide: 2,176
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  • Site-wide: 8,623

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

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  • Site-wide: 5,256
  • In genetics: 202
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  • Site-wide: 46,544
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  • Site-wide: 130,536

Improved polygenic prediction by Bayesian multiple regression on summary statistics

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  • Site-wide: 5,865
  • In genetics: 231
• Year to date:
  • Site-wide: 90,676
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  • Site-wide: 145,896

A comparative study of techniques for differential expression analysis on RNA-Seq data

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  • Site-wide: 6,683
  • In bioinformatics: 689
• Year to date:
  • Site-wide: 114,273
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  • Site-wide: 141,041

Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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  • Site-wide: 6,753
  • In genomics: 685
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  • Site-wide: 98,712
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  • Site-wide: 97,468

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

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  • Site-wide: 7,195
  • In genetic and genomic medicine: 34
• Year to date:
  • Site-wide: 2,335
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  • Site-wide: 6,577

GWAS on family history of Alzheimer's disease

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  • Site-wide: 9,564
  • In genetics: 393
• Year to date:
  • Site-wide: 111,569
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  • Site-wide: 113,434

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 10,777
  • In genetics: 458
• Year to date:
  • Site-wide: 73,128
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  • Site-wide: 58,857

Causal associations between risk factors and common diseases inferred from GWAS summary data

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  • Site-wide: 11,348
  • In genetics: 476
• Year to date:
  • Site-wide: 129,122
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  • Site-wide: 150,397

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

• Downloaded 1,726 times
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  • Site-wide: 12,431
  • In neurology: 29
• Year to date:
  • Site-wide: 2,414
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  • Site-wide: 3,707

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • Site-wide: 12,516
  • In genetics: 538
• Year to date:
  • Site-wide: 26,335
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  • Site-wide: 64,492

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

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  • Site-wide: 13,716
  • In genetics: 597
• Year to date:
  • Site-wide: 67,680
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  • Site-wide: 143,903

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 15,286
  • In genomics: 1,493
• Year to date:
  • Site-wide: 129,258
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  • Site-wide: 140,967

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

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  • Site-wide: 15,563
  • In genetics: 688
• Year to date:
  • Site-wide: 37,854
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  • Site-wide: 56,110

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 16,141
  • In genetics: 716
• Year to date:
  • Site-wide: 120,392
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  • Site-wide: 154,590

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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  • Site-wide: 16,531
  • In bioinformatics: 1,864
• Year to date:
  • Site-wide: 70,338
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  • Site-wide: 72,117

Bayesian reassessment of the epigenetic architecture of complex traits

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  • Site-wide: 17,957
  • In genomics: 1,712
• Year to date:
  • Site-wide: 156,579
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  • Site-wide: 162,867

Imprint of Assortative Mating on the Human Genome

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  • Site-wide: 18,263
  • In genetics: 815
• Year to date:
  • Site-wide: 133,967
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  • Site-wide: 107,670

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 19,095
  • In genetics: 853
• Year to date:
  • Site-wide: 93,542
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  • Site-wide: 65,192

Genetic Association Study of Childhood Aggression across raters, instruments and age

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  • Site-wide: 21,819
  • In genomics: 2,032
• Year to date:
  • Site-wide: 19,721
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  • Site-wide: 76,313

Estimation of genetic correlation using linkage disequilibrium score regression and genomic restricted maximum likelihood

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  • Site-wide: 23,252
  • In genetics: 1,019
• Year to date:
  • Site-wide: 138,206
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  • Site-wide: 151,922

Using genotype data to distinguish pleiotropy from heterogeneity: deciphering coheritability in autoimmune and neuropsychiatric diseases

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  • Site-wide: 24,317
  • In genomics: 2,214
• Year to date:
  • Site-wide: 126,649
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  • Site-wide: 119,290

Identification of 55,000 Replicated DNA Methylation QTL

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  • Site-wide: 24,997
  • In genomics: 2,279
• Year to date:
  • Site-wide: 140,043
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  • Site-wide: 147,428

Epigenetic prediction of complex traits and death

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  • Site-wide: 26,291
  • In genomics: 2,361
• Year to date:
  • Site-wide: 122,851
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  • Site-wide: 140,989

Cross-disorder GWAS meta-analysis for Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and Tourette Syndrome

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  • Site-wide: 29,333
  • In genetics: 1,295
• Year to date:
  • Site-wide: 32,630
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  • Site-wide: 27,765

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 923 times
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  • Site-wide: 32,119
  • In genetics: 1,411
• Year to date:
  • Site-wide: 106,461
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  • Site-wide: 98,201

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

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  • Site-wide: 34,691
  • In genetics: 1,517
• Year to date:
  • Site-wide: 141,662
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  • Site-wide: 107,860

Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous system

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  • Site-wide: 36,176
  • In genomics: 2,989
• Year to date:
  • Site-wide: 35,133
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  • Site-wide: 62,272

Widespread associations between grey matter structure and the human phenome

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  • Site-wide: 36,287
  • In neuroscience: 4,799
• Year to date:
  • Site-wide: 136,496
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  • Site-wide: 157,600

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

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  • Site-wide: 36,793
  • In genetics: 1,607
• Year to date:
  • Site-wide: 144,942
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  • Site-wide: 150,641

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

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  • Site-wide: 37,361
  • In genetics: 1,627
• Year to date:
  • Site-wide: 19,838
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  • Site-wide: 29,679

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 38,173
  • In genetic and genomic medicine: 179
• Year to date:
  • Site-wide: 15,182
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  • Site-wide: 23,538

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

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  • Site-wide: 38,967
  • In genetics: 1,690
• Year to date:
  • Site-wide: 138,713
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  • Site-wide: 145,469

Investigating the potential effect of antihypertensive medication on psychiatric disorders: a mendelian randomisation study

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  • Site-wide: 39,187
  • In genetic and genomic medicine: 183
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  • Site-wide: 33,060
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  • Site-wide: 46,201

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • Site-wide: 40,623
  • In genetics: 1,755
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  • Site-wide: 129,905
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  • Site-wide: 108,454

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 40,988
  • In genetics: 1,775
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  • Site-wide: 74,440
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  • Site-wide: 155,626

The Australian Genetics of Depression Study: Study Description and Sample Characteristics

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  • Site-wide: 43,714
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  • Site-wide: 95,602
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  • Site-wide: 83,362

Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

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  • Site-wide: 45,695
  • In genetics: 1,979
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  • Site-wide: 130,999
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  • Site-wide: 137,765

Exploring contributors to variability in estimates of SNP-heritability and genetic correlations from the iPSYCH case-cohort and published meta-studies of major psychiatric disorders.

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  • Site-wide: 50,203
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  • Site-wide: 76,192
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  • Site-wide: 109,806

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

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  • Site-wide: 52,751
  • In genetics: 2,255
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  • Site-wide: 42,837
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  • Site-wide: 101,921

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

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  • Site-wide: 55,610
  • In genetics: 2,361
• Year to date:
  • Site-wide: 142,869
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  • Site-wide: 132,460

Genetic analyses of medication-use and implications for precision medicine

• Downloaded 624 times
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  • Site-wide: 55,840
  • In genetics: 2,370
• Year to date:
  • Site-wide: 96,709
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  • Site-wide: 93,514

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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  • Site-wide: 56,162
  • In genetics: 2,384
• Year to date:
  • Site-wide: 149,693
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  • Site-wide: 156,684

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

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  • Site-wide: 64,906
  • In psychiatry and clinical psychology: 247
• Year to date:
  • Site-wide: 20,959
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  • Site-wide: 91,512

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

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  • Site-wide: 67,678
  • In genomics: 4,711
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  • Site-wide: 116,097
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  • Site-wide: 114,555

Age at first birth in women is genetically associated with increased risk of schizophrenia

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  • Site-wide: 70,265
  • In genetics: 2,980
• Year to date:
  • Site-wide: 162,365
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  • Site-wide: 160,345

Genome-wide study of DNA methylation in Amyotrophic Lateral Sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol pathways

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  • Site-wide: 71,535
  • In neurology: 211
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  • Site-wide: 15,467
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  • Site-wide: 10,639

A better design for stratified medicine based on genomic prediction

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  • Site-wide: 79,494
  • In genetics: 3,367
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  • Site-wide: 164,107
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  • Site-wide: 157,227

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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  • Site-wide: 80,842
  • In neuroscience: 11,936
• Year to date:
  • Site-wide: 132,182
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  • Site-wide: 99,173

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

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  • Site-wide: 84,301
  • In genetics: 3,536
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  • Site-wide: 98,175
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  • Site-wide: 110,952

Comorbid chronic pain and depression: Shared risk factors and differential antidepressant effectiveness

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  • Site-wide: 101,990
  • In epidemiology: 4,349
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  • Site-wide: 48,049
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  • Site-wide: 36,704

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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  • Site-wide: 105,368
  • In epidemiology: 4,464
• Year to date:
  • Site-wide: 142,882
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  • Site-wide: 114,286

A parsimonious model for mass-univariate vertex-wise analysis

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  • Site-wide: 105,940
  • In neuroscience: 15,862
• Year to date:
  • Site-wide: 28,524
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  • Site-wide: 87,293

Comprehensive genetic analysis of the human lipidome identifies novel loci controlling lipid homeostasis with links to coronary artery disease

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  • Site-wide: 122,516
  • In genetic and genomic medicine: 704
• Year to date:
  • Site-wide: 38,254
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  • Site-wide: 28,953

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

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  • Site-wide: 136,367
  • In genetic and genomic medicine: 794
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  • Site-wide: 67,484

Understanding genetic risk factors for common side effects of antidepressant medications

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  • Site-wide: 153,771
  • In psychiatry and clinical psychology: 945
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  • Site-wide: 82,826
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  • Site-wide: 107,555

Phenotypic and genetic factors associated with differential consent to record linkage for prescription history in the Australian Genetics of Depression Study

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  • Site-wide: 161,150
  • In genetic and genomic medicine: 1,039
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  • Site-wide: 123,350
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  • Site-wide: 19,989