Author: Naomi R. Wray

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 936
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  • Site-wide: 37,520
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  • Site-wide: 43,817

Genetic Consequences of Social Stratification in Great Britain

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  • Site-wide: 1,181
  • In genetics: 34
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  • Site-wide: 9,749
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  • Site-wide: 6,256

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,280
  • In genetics: 39
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  • Site-wide: 21,254
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  • Site-wide: 25,966

New mutations, old statistical challenges

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  • Site-wide: 1,323
  • In genetics: 43
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  • Site-wide: 68,320
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  • Site-wide: 39,832

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,280
  • In genomics: 234
• Year to date:
  • Site-wide: 19,210
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  • Site-wide: 24,512

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 2,433
  • In genetics: 87
• Year to date:
  • Site-wide: 33,421
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  • Site-wide: 28,784

Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • Site-wide: 2,522
  • In genetics: 90
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  • Site-wide: 89,394
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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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  • Site-wide: 3,422
  • In genomics: 373
• Year to date:
  • Site-wide: 36,144
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  • Site-wide: 32,418

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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  • Site-wide: 4,084
  • In genetics: 165
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  • Site-wide: 66,214
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  • Site-wide: 63,394

Haplotypes of common SNPs can explain missing heritability of complex diseases

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  • Site-wide: 4,251
  • In genetics: 173
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  • Site-wide: 75,959
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  • Site-wide: 63,340

Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

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  • Site-wide: 26,976
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  • Site-wide: 25,965

A resource-efficient tool for mixed model association analysis of large-scale data

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  • Site-wide: 4,748
  • In genetics: 204
• Year to date:
  • Site-wide: 12,376
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  • Site-wide: 12,924

Improved polygenic prediction by Bayesian multiple regression on summary statistics

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  • Site-wide: 4,930
  • In genetics: 211
• Year to date:
  • Site-wide: 68,820
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  • Site-wide: 63,159

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 5,229
  • In psychiatry and clinical psychology: 20
• Year to date:
  • Site-wide: 1,259
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  • Site-wide: 889

A comparative study of techniques for differential expression analysis on RNA-Seq data

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  • Site-wide: 5,602
  • In bioinformatics: 603
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  • Site-wide: 87,266
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  • Site-wide: 95,737

Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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  • Site-wide: 5,708
  • In genomics: 625
• Year to date:
  • Site-wide: 75,924
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  • Site-wide: 52,236

GWAS on family history of Alzheimer's disease

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  • Site-wide: 8,037
  • In genetics: 362
• Year to date:
  • Site-wide: 75,003
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  • Site-wide: 87,670

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 9,318
  • In genetics: 425
• Year to date:
  • Site-wide: 53,272
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  • Site-wide: 50,721

Causal associations between risk factors and common diseases inferred from GWAS summary data

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  • Site-wide: 9,485
  • In genetics: 436
• Year to date:
  • Site-wide: 87,548
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  • Site-wide: 88,457

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

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  • Site-wide: 9,555
  • In genetic and genomic medicine: 36
• Year to date:
  • Site-wide: 1,860
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  • Site-wide: 486

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • Site-wide: 11,680
  • In genetics: 547
• Year to date:
  • Site-wide: 19,598
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  • Site-wide: 24,508

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

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  • Site-wide: 11,943
  • In genetics: 562
• Year to date:
  • Site-wide: 46,651
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  • Site-wide: 77,460

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 12,729
  • In genomics: 1,347
• Year to date:
  • Site-wide: 87,442
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  • Site-wide: 127,931

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 13,323
  • In genetics: 634
• Year to date:
  • Site-wide: 64,536
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  • Site-wide: 62,862

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

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  • Site-wide: 14,363
  • In genetics: 680
• Year to date:
  • Site-wide: 29,257
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  • Site-wide: 28,634

Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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  • Site-wide: 14,645
  • In bioinformatics: 1,743
• Year to date:
  • Site-wide: 56,954
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  • Site-wide: 88,841

Bayesian reassessment of the epigenetic architecture of complex traits

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  • Site-wide: 14,761
  • In genomics: 1,513
• Year to date:
  • Site-wide: 124,454
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  • Site-wide: 127,118

Imprint of Assortative Mating on the Human Genome

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  • Site-wide: 15,676
  • In genetics: 750
• Year to date:
  • Site-wide: 133,667
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  • Site-wide: 127,180

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 16,624
  • In genetics: 793
• Year to date:
  • Site-wide: 71,929
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  • Site-wide: 64,533

Estimation of genetic correlation using linkage disequilibrium score regression and genomic restricted maximum likelihood

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  • Site-wide: 19,426
  • In genetics: 930
• Year to date:
  • Site-wide: 98,377
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  • Site-wide: 123,645

Using genotype data to distinguish pleiotropy from heterogeneity: deciphering coheritability in autoimmune and neuropsychiatric diseases

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  • Site-wide: 20,711
  • In genomics: 2,037
• Year to date:
  • Site-wide: 99,167
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  • Site-wide: 78,694

Identification of 55,000 Replicated DNA Methylation QTL

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  • Site-wide: 20,923
  • In genomics: 2,060
• Year to date:
  • Site-wide: 103,128
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  • Site-wide: 125,826

Epigenetic prediction of complex traits and death

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  • Site-wide: 21,984
  • In genomics: 2,138
• Year to date:
  • Site-wide: 75,901
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  • Site-wide: 56,233

Genetic Association Study of Childhood Aggression across raters, instruments and age

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  • Site-wide: 22,809
  • In genomics: 2,198
• Year to date:
  • Site-wide: 15,934
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  • Site-wide: 13,548

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

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  • Site-wide: 24,121
  • In neurology: 48
• Year to date:
  • Site-wide: 2,159
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  • Site-wide: 2,806

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 857 times
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  • Site-wide: 28,172
  • In genetics: 1,342
• Year to date:
  • Site-wide: 85,918
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  • Site-wide: 85,814

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

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  • Site-wide: 29,650
  • In genetics: 1,409
• Year to date:
  • Site-wide: 128,320
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  • Site-wide: 104,403

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

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  • Site-wide: 30,319
  • In genetics: 1,442
• Year to date:
  • Site-wide: 94,717
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  • Site-wide: 104,170

Cross-disorder GWAS meta-analysis for Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and Tourette Syndrome

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  • Site-wide: 30,625
  • In genetics: 1,451
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  • Site-wide: 31,109
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  • Site-wide: 35,199

Widespread associations between grey matter structure and the human phenome

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  • Site-wide: 30,810
  • In neuroscience: 4,096
• Year to date:
  • Site-wide: 105,957
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  • Site-wide: 130,051

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

• Downloaded 774 times
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  • Site-wide: 32,469
  • In genetics: 1,532
• Year to date:
  • Site-wide: 92,613
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  • Site-wide: 59,030

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • Site-wide: 35,328
  • In genetics: 1,661
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  • Site-wide: 116,410
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  • Site-wide: 89,045

Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous system

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  • Site-wide: 35,660
  • In genomics: 3,047
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  • Site-wide: 24,498
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  • Site-wide: 33,065

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 35,672
  • In genetics: 1,679
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  • Site-wide: 41,734
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  • Site-wide: 48,755

Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

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  • Site-wide: 38,693
  • In genetics: 1,800
• Year to date:
  • Site-wide: 93,485
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  • Site-wide: 121,858

The Australian Genetics of Depression Study: Study Description and Sample Characteristics

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  • Site-wide: 39,825
  • In genetics: 1,857
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  • Site-wide: 85,210
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  • Site-wide: 112,881

Investigating the potential effect of antihypertensive medication on psychiatric disorders: a mendelian randomisation study

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  • Site-wide: 40,598
  • In genetic and genomic medicine: 138
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  • Site-wide: 26,097
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  • Site-wide: 35,087

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

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  • Site-wide: 42,838
  • In genetics: 1,981
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  • Site-wide: 16,203
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  • Site-wide: 20,513

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

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  • Site-wide: 46,717
  • In genetics: 2,141
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  • Site-wide: 20,796
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  • Site-wide: 9,063

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

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  • Site-wide: 46,728
  • In genetics: 2,143
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  • Site-wide: 120,749
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  • Site-wide: 123,739

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

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  • Site-wide: 47,237
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• Year to date:
  • Site-wide: 120,615
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  • Site-wide: 112,014

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 49,324
  • In genetic and genomic medicine: 176
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  • Site-wide: 14,130
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  • Site-wide: 24,015

Genetic analyses of medication-use and implications for precision medicine

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  • Site-wide: 49,915
  • In genetics: 2,283
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  • Site-wide: 73,005
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  • Site-wide: 123,504

Exploring contributors to variability in estimates of SNP-heritability and genetic correlations from the iPSYCH case-cohort and published meta-studies of major psychiatric disorders.

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  • Site-wide: 50,571
  • In genetics: 2,312
• Year to date:
  • Site-wide: 104,573
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  • Site-wide: 138,004

Age at first birth in women is genetically associated with increased risk of schizophrenia

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  • Site-wide: 56,306
  • In genetics: 2,560
• Year to date:
  • Site-wide: 128,457
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  • Site-wide: 121,478

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

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  • Site-wide: 60,730
  • In genomics: 4,431
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  • Site-wide: 102,855
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  • Site-wide: 94,017

A better design for stratified medicine based on genomic prediction

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  • Site-wide: 64,609
  • In genetics: 2,933
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  • Site-wide: 141,995
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  • Site-wide: 126,588

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

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  • Site-wide: 70,027
  • In psychiatry and clinical psychology: 233
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  • Site-wide: 12,824
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  • Site-wide: 24,002

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

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  • Site-wide: 72,848
  • In neuroscience: 10,983
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  • Site-wide: 135,625
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  • Site-wide: 125,040

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

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  • Site-wide: 78,720
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  • Site-wide: 88,264
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  • Site-wide: 92,088

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

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  • Site-wide: 92,547
  • In epidemiology: 3,827
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  • Site-wide: 135,804
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  • Site-wide: 140,417

A parsimonious model for mass-univariate vertex-wise analysis

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  • Site-wide: 98,508
  • In neuroscience: 15,133
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  • Site-wide: 13,494
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  • Site-wide: 54,378

Comorbid chronic pain and depression: Shared risk factors and differential antidepressant effectiveness

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  • Site-wide: 107,764
  • In epidemiology: 4,469
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  • Site-wide: 42,779
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  • Site-wide: 34,966

Genome-wide study of DNA methylation in Amyotrophic Lateral Sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol pathways

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  • Site-wide: 110,034
  • In neurology: 369
• Year to date:
  • Site-wide: 17,626
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  • Site-wide: 18,101

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

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  • Site-wide: 129,504
  • In genetic and genomic medicine: 665
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  • Site-wide: 50,349