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Author: John G Doench

Rankings

  • All-time downloads: 43,252 (rank: 906 out of 398,124)
  • Categories:
    • bioinformatics: 708 (rank: 15,331 (tie) out of 33,947)
    • cancer biology: 6,163 (rank: 266 out of 27,738)
    • genetics: 16,269 (rank: 678 out of 36,546)
    • genomics: 17,110 (rank: 546 out of 42,275)
    • microbiology: 2,135 (rank: 3,846 out of 45,823)
    • molecular biology: 867 (rank: 4,592 (tie) out of 21,184)

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Preprints

A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles

genomics more details view paper
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Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

genetics more details view paper
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Up, down, and out: optimized libraries for CRISPRa, CRISPRi, and CRISPR-knockout genetic screens

genomics more details view paper
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Non-oncology drugs are a source of previously unappreciated anti-cancer activity

cancer biology more details view paper
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Optimization of AsCas12a for combinatorial genetic screens in human cells

genetics more details view paper
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    • In genetics: 164 out of 4,770
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Massively parallel assessment of human variants with base editor screens

genetics more details view paper
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Genetic screens in isogenic mammalian cell lines without single cell cloning

genetics more details view paper
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Agreement between two large pan-cancer CRISPR-Cas9 gene dependency datasets

cancer biology more details view paper
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Mapping protein function with CRISPR/Cas9-mediated mutagenesis

genomics more details view paper
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Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens

molecular biology more details view paper
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    • In molecular biology: 499 out of 3,195
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Identification of anti-norovirus genes in mouse and human cells using genome-wide CRISPR activation screening

microbiology more details view paper
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Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map

bioinformatics more details view paper
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Illuminating host-mycobacterial interactions with functional genomic screening to inhibit mycobacterial pathogenesis

microbiology more details view paper
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Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

genomics more details view paper
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    • In genomics: 3,280 out of 5,873
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Natural variation in arsenic toxicity is explained by differences in branched chain amino acid catabolism

genetics more details view paper
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    • In genetics: 1,978 out of 4,770
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    • Site-wide: 66,797 out of 93,311

High-throughput CRISPR screens to dissect macrophage-Shigella interactions

microbiology more details view paper
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A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

cancer biology more details view paper
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Natural variation in a single amino acid underlies cellular responses to topoisomerase II poisons

genetics more details view paper
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    • In genetics: 2,709 out of 4,770
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CRISPR screen reveals that EHEC's T3SS and Shiga toxin rely on shared host factors for infection

microbiology more details view paper
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    • In microbiology: 3,445 out of 8,137
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    • Site-wide: 54,513 out of 93,311

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