Author: Timothy M Frayling

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Preprints

Genetic Consequences of Social Stratification in Great Britain

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  • Site-wide: 1,196
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  • Site-wide: 10,616
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  • Site-wide: 9,561

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

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  • Site-wide: 1,469
  • In genetics: 46
• Year to date:
  • Site-wide: 19,081
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  • Site-wide: 16,119

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 4,018
  • In genomics: 434
• Year to date:
  • Site-wide: 71,051
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  • Site-wide: 80,014

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

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  • Site-wide: 6,447
  • In genetics: 292
• Year to date:
  • Site-wide: 42,095
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  • Site-wide: 32,903

Biological and clinical insights from genetics of insomnia symptoms

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  • Site-wide: 7,711
  • In genomics: 825
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  • Site-wide: 13,127
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  • Site-wide: 15,600

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

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  • Site-wide: 8,394
  • In epidemiology: 657
• Year to date:
  • Site-wide: 78,908
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  • Site-wide: 55,333

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 9,051
  • In genetics: 407
• Year to date:
  • Site-wide: 91,357
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  • Site-wide: 108,183

Assessing the pathogenicity, penetrance and expressivity of putative disease-causing variants in a population setting

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  • Site-wide: 9,151
  • In genetics: 410
• Year to date:
  • Site-wide: 64,934
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  • Site-wide: 45,032

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 10,382
  • In genetics: 475
• Year to date:
  • Site-wide: 55,564
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  • Site-wide: 40,185

Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases

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  • Site-wide: 10,391
  • In genetics: 476
• Year to date:
  • Site-wide: 42,036
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  • Site-wide: 30,001

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

• Downloaded 1,651 times
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  • Site-wide: 10,885
  • In genetics: 502
• Year to date:
  • Site-wide: 103,092
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  • Site-wide: 96,996

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

• Downloaded 1,638 times
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  • Site-wide: 11,007
  • In genetics: 509
• Year to date:
  • Site-wide: 62,769
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  • Site-wide: 64,253

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

• Downloaded 1,512 times
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  • Site-wide: 12,345
  • In genetics: 578
• Year to date:
  • Site-wide: 87,188
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  • Site-wide: 96,457

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 13,442
  • In genetics: 630
• Year to date:
  • Site-wide: 89,126
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  • Site-wide: 115,393

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

• Downloaded 1,310 times
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  • Site-wide: 15,356
  • In genetics: 727
• Year to date:
  • Site-wide: 78,410
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  • Site-wide: 69,081

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Site-wide: 15,763
  • In genetic and genomic medicine: 61
• Year to date:
  • Site-wide: 6,789
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  • Site-wide: 7,110

HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS

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  • Site-wide: 16,852
  • In genomics: 1,682
• Year to date:
  • Site-wide: 124,463
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  • Site-wide: 107,641

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

• Downloaded 1,217 times
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  • Site-wide: 17,183
  • In genetics: 818
• Year to date:
  • Site-wide: 91,170
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  • Site-wide: 89,127

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 21,923
  • In genetics: 1,026
• Year to date:
  • Site-wide: 8,296
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  • Site-wide: 4,538

A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

• Downloaded 965 times
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  • Site-wide: 24,169
  • In genetics: 1,131
• Year to date:
  • Site-wide: 79,935
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  • Site-wide: 75,445

Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers

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  • Site-wide: 24,331
  • In genomics: 2,307
• Year to date:
  • Site-wide: 107,688
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  • Site-wide: 82,347

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 956 times
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  • Site-wide: 24,532
  • In sexual and reproductive health: 14
• Year to date:
  • Site-wide: 2,369
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  • Site-wide: 1,973

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

• Downloaded 721 times
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  • Site-wide: 36,349
  • In genetics: 1,699
• Year to date:
  • Site-wide: 63,567
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  • Site-wide: 80,509

Quantifying the extent to which index event biases influence large genetic association studies

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  • Site-wide: 37,884
  • In genetics: 1,756
• Year to date:
  • Site-wide: 126,803
• Since beginning of last month:
  • Site-wide: 106,624

Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: an application to complex traits in the UK Biobank

• Downloaded 687 times
• Download rankings, all-time:
  • Site-wide: 38,769
  • In epidemiology: 1,907
• Year to date:
  • Site-wide: 93,440
• Since beginning of last month:
  • Site-wide: 109,021

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

• Downloaded 678 times
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  • Site-wide: 39,453
  • In genetics: 1,830
• Year to date:
  • Site-wide: 113,289
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  • Site-wide: 99,119

Genetic predictors of participation in optional components of UK Biobank

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  • Site-wide: 41,625
  • In genetics: 1,918
• Year to date:
  • Site-wide: 64,295
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  • Site-wide: 112,180

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

• Downloaded 640 times
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  • Site-wide: 42,550
  • In genomics: 3,469
• Year to date:
  • Site-wide: 110,095
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  • Site-wide: 95,554

Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

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  • Site-wide: 46,104
  • In genetics: 2,112
• Year to date:
  • Site-wide: 97,854
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  • Site-wide: 115,501

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 585 times
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  • Site-wide: 47,546
  • In epidemiology: 2,218
• Year to date:
  • Site-wide: 117,176
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  • Site-wide: 128,773

Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

• Downloaded 582 times
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  • Site-wide: 47,899
  • In genomics: 3,759
• Year to date:
  • Site-wide: 107,420
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  • Site-wide: 129,467

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

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  • Site-wide: 47,860
  • In genetics: 2,188
• Year to date:
  • Site-wide: 124,418
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  • Site-wide: 129,482

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

• Downloaded 519 times
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  • Site-wide: 54,933
  • In genetics: 2,482
• Year to date:
  • Site-wide: 113,315
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  • Site-wide: 99,039

Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank

• Downloaded 451 times
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  • Site-wide: 64,219
  • In epidemiology: 2,788
• Year to date:
  • Site-wide: 139,752
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  • Site-wide: 135,773

A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors

• Downloaded 429 times
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  • Site-wide: 67,703
  • In orthopedics: 26
• Year to date:
  • Site-wide: 10,495
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  • Site-wide: 11,310

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

• Downloaded 383 times
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  • Site-wide: 75,325
  • In epidemiology: 3,183
• Year to date:
  • Site-wide: 50,461
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  • Site-wide: 49,264

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

• Downloaded 205 times
• Download rankings, all-time:
  • Site-wide: 114,057
  • In genetic and genomic medicine: 565
• Year to date:
  • Site-wide: 101,439
• Since beginning of last month:
  • Site-wide: 78,554

Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study

• Downloaded 171 times
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  • Site-wide: 122,095
  • In epidemiology: 5,055
• Year to date:
  • Site-wide: 35,895
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  • Site-wide: 48,813

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

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  • Site-wide: 128,645
  • In genetics: 5,325
• Year to date:
  • Site-wide: 116,749
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  • Site-wide: 104,990

Associations of genetic scores for birth weight with newborn size and later Anthropometric traits and cardiometabolic risk markers in South Asians

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  • Site-wide: 138,721
  • In genetic and genomic medicine: 753
• Year to date:
  • Site-wide: 53,515
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  • Site-wide: 28,005

Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? A Mendelian randomization study.

• Downloaded 83 times
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  • Site-wide: 139,301
  • In epidemiology: 5,695
• Year to date:
  • Site-wide: 55,469
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  • Site-wide: 38,856