Author: Timothy M. Frayling

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Preprints

Genetic Consequences of Social Stratification in Great Britain

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  • Site-wide: 1,056
  • In genetics: 35
• Year to date:
  • Site-wide: 8,817
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  • Site-wide: 8,817

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

• Downloaded 6,541 times
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  • Site-wide: 1,269
  • In genetics: 45
• Year to date:
  • Site-wide: 19,263
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  • Site-wide: 19,263

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,218 times
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  • Site-wide: 3,477
  • In genomics: 397
• Year to date:
  • Site-wide: 78,839
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  • Site-wide: 78,839

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

• Downloaded 2,289 times
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  • Site-wide: 5,691
  • In genetics: 273
• Year to date:
  • Site-wide: 26,598
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  • Site-wide: 26,598

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

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  • Site-wide: 7,331
  • In epidemiology: 567
• Year to date:
  • Site-wide: 108,276
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  • Site-wide: 108,276

Biological and clinical insights from genetics of insomnia symptoms

• Downloaded 1,885 times
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  • Site-wide: 7,511
  • In genomics: 837
• Year to date:
  • Site-wide: 11,216
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  • Site-wide: 11,216

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,826 times
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  • Site-wide: 7,888
  • In genetics: 385
• Year to date:
  • Site-wide: None
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Assessing the pathogenicity, penetrance and expressivity of putative disease-causing variants in a population setting

• Downloaded 1,815 times
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  • Site-wide: 7,954
  • In genetics: 390
• Year to date:
  • Site-wide: 43,902
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  • Site-wide: 43,902

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,634 times
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  • Site-wide: 9,385
  • In genetics: 465
• Year to date:
  • Site-wide: 81,710
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  • Site-wide: 81,710

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

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  • Site-wide: 9,412
  • In genetics: 469
• Year to date:
  • Site-wide: 65,818
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  • Site-wide: 65,818

Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases

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  • Site-wide: 9,480
  • In genetics: 471
• Year to date:
  • Site-wide: 37,084
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  • Site-wide: 37,084

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

• Downloaded 1,589 times
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  • Site-wide: 9,761
  • In genetics: 492
• Year to date:
  • Site-wide: 46,611
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  • Site-wide: 46,611

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

• Downloaded 1,482 times
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  • Site-wide: 10,783
  • In genetics: 537
• Year to date:
  • Site-wide: 60,898
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  • Site-wide: 60,898

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,401 times
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  • Site-wide: 11,757
  • In genetics: 593
• Year to date:
  • Site-wide: 77,431
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  • Site-wide: 77,431

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

• Downloaded 1,271 times
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  • Site-wide: 13,580
  • In genetics: 699
• Year to date:
  • Site-wide: 65,756
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  • Site-wide: 65,756

HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS

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  • Site-wide: 14,544
  • In genomics: 1,546
• Year to date:
  • Site-wide: 112,274
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  • Site-wide: 112,274

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

• Downloaded 1,188 times
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  • Site-wide: 15,044
  • In genetics: 775
• Year to date:
  • Site-wide: 70,380
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  • Site-wide: 70,380

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 980 times
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  • Site-wide: 20,038
  • In genetic and genomic medicine: 60
• Year to date:
  • Site-wide: 5,687
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  • Site-wide: 5,687

Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers

• Downloaded 941 times
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  • Site-wide: 21,244
  • In genomics: 2,118
• Year to date:
  • Site-wide: 76,677
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  • Site-wide: 76,677

A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

• Downloaded 933 times
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  • Site-wide: 21,509
  • In genetics: 1,064
• Year to date:
  • Site-wide: 51,882
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  • Site-wide: 51,882

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 689 times
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  • Site-wide: 32,898
  • In genetics: 1,628
• Year to date:
  • Site-wide: 18,454
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  • Site-wide: 18,454

Quantifying the extent to which index event biases influence large genetic association studies

• Downloaded 684 times
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  • Site-wide: 33,233
  • In genetics: 1,643
• Year to date:
  • Site-wide: 100,069
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  • Site-wide: 100,069

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

• Downloaded 669 times
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  • Site-wide: 34,236
  • In genetics: 1,683
• Year to date:
  • Site-wide: 57,278
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  • Site-wide: 57,278

Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: an application to complex traits in the UK Biobank

• Downloaded 661 times
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  • Site-wide: 34,784
  • In epidemiology: 1,681
• Year to date:
  • Site-wide: 61,029
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  • Site-wide: 61,029

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

• Downloaded 658 times
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  • Site-wide: 35,022
  • In genetics: 1,713
• Year to date:
  • Site-wide: 92,356
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  • Site-wide: 92,356

Genetic predictors of participation in optional components of UK Biobank

• Downloaded 630 times
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  • Site-wide: 37,078
  • In genetics: 1,813
• Year to date:
  • Site-wide: 22,450
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  • Site-wide: 22,450

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

• Downloaded 622 times
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  • Site-wide: 37,705
  • In genomics: 3,224
• Year to date:
  • Site-wide: 71,872
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  • Site-wide: 71,872

Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

• Downloaded 569 times
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  • Site-wide: 42,096
  • In genetics: 2,033
• Year to date:
  • Site-wide: 98,132
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  • Site-wide: 98,132

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 568 times
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  • Site-wide: 42,204
  • In epidemiology: 1,970
• Year to date:
  • Site-wide: 85,682
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  • Site-wide: 85,682

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

• Downloaded 565 times
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  • Site-wide: 42,454
  • In genetics: 2,049
• Year to date:
  • Site-wide: 107,515
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  • Site-wide: 107,515

Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

• Downloaded 559 times
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  • Site-wide: 43,071
  • In genomics: 3,538
• Year to date:
  • Site-wide: 84,666
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  • Site-wide: 84,666

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

• Downloaded 504 times
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  • Site-wide: 48,747
  • In genetics: 2,345
• Year to date:
  • Site-wide: 70,161
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  • Site-wide: 70,161

Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank

• Downloaded 443 times
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  • Site-wide: 56,268
  • In epidemiology: 2,402
• Year to date:
  • Site-wide: 107,823
• Since beginning of last month:
  • Site-wide: 107,823

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 385 times
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  • Site-wide: 64,806
  • In sexual and reproductive health: 30
• Year to date:
  • Site-wide: 1,536
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  • Site-wide: 1,536

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

• Downloaded 321 times
• Download rankings, all-time:
  • Site-wide: 75,865
  • In epidemiology: 3,119
• Year to date:
  • Site-wide: 35,371
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  • Site-wide: 35,371

A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors

• Downloaded 208 times
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  • Site-wide: 99,487
  • In orthopedics: 26
• Year to date:
  • Site-wide: 7,986
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  • Site-wide: 7,986

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

• Downloaded 177 times
• Download rankings, all-time:
  • Site-wide: 105,897
  • In genetic and genomic medicine: 429
• Year to date:
  • Site-wide: 94,089
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  • Site-wide: 94,089

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

• Downloaded 125 times
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  • Site-wide: 116,098
  • In genetics: 5,050
• Year to date:
  • Site-wide: 79,750
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  • Site-wide: 79,750

Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study

• Downloaded 103 times
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  • Site-wide: 120,002
  • In epidemiology: 4,812
• Year to date:
  • Site-wide: 17,283
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  • Site-wide: 17,283