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Author: Timothy M Frayling

Rankings

  • All-time downloads: 55,470 (rank: 2,723 )
  • Categories:
    • epidemiology: 4,325 (rank: 2,916 )
    • genetic and genomic medicine: 1,580 (rank: 1,791 )
    • genetics: 39,412 (rank: 122 )
    • genomics: 8,768 (rank: 2,379 )
    • orthopedics: 429 (rank: 116 (tie) )
    • sexual and reproductive health: 956 (rank: 163 (tie) )

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Preprints

Genetic Consequences of Social Stratification in Great Britain

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    • Site-wide: 1,196
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    • Site-wide: 10,616
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Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

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    • Site-wide: 1,469
    • In genetics: 46
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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

genomics more details view paper
  • Downloaded 3,267 times
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    • Site-wide: 4,018
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    • Site-wide: 80,014

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

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  • Downloaded 2,359 times
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    • Site-wide: 6,447
    • In genetics: 292
  • Year to date:
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    • Site-wide: 32,903

Biological and clinical insights from genetics of insomnia symptoms

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  • Downloaded 2,085 times
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    • Site-wide: 7,711
    • In genomics: 825
  • Year to date:
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Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

epidemiology more details view paper
  • Downloaded 1,965 times
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    • Site-wide: 8,394
    • In epidemiology: 657
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    • Site-wide: 78,908
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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

genetics more details view paper
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    • Site-wide: 9,051
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Assessing the pathogenicity, penetrance and expressivity of putative disease-causing variants in a population setting

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    • Site-wide: 9,151
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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases

genetics more details view paper
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    • Site-wide: 10,391
    • In genetics: 476
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    • Site-wide: 42,036
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Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

genetics more details view paper
  • Downloaded 1,651 times
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    • Site-wide: 10,885
    • In genetics: 502
  • Year to date:
    • Site-wide: 103,092
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    • Site-wide: 96,996

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

genetics more details view paper
  • Downloaded 1,638 times
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    • Site-wide: 11,007
    • In genetics: 509
  • Year to date:
    • Site-wide: 62,769
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GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

genetics more details view paper
  • Downloaded 1,512 times
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    • Site-wide: 12,345
    • In genetics: 578
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    • Site-wide: 87,188
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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

genetics more details view paper
  • Downloaded 1,434 times
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    • Site-wide: 13,442
    • In genetics: 630
  • Year to date:
    • Site-wide: 89,126
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    • Site-wide: 115,393

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

genetics more details view paper
  • Downloaded 1,310 times
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    • Site-wide: 15,356
    • In genetics: 727
  • Year to date:
    • Site-wide: 78,410
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    • Site-wide: 69,081

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

genetic and genomic medicine more details view paper
  • Downloaded 1,288 times
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    • Site-wide: 15,763
    • In genetic and genomic medicine: 61
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    • Site-wide: 6,789
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    • Site-wide: 7,110

HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS

genomics more details view paper
  • Downloaded 1,233 times
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    • Site-wide: 16,852
    • In genomics: 1,682
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    • Site-wide: 124,463
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    • Site-wide: 107,641

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

genetics more details view paper
  • Downloaded 1,217 times
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    • Site-wide: 17,183
    • In genetics: 818
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    • Site-wide: 91,170
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    • Site-wide: 89,127

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Downloaded 1,031 times
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    • Site-wide: 21,923
    • In genetics: 1,026
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    • Site-wide: 8,296
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A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

genetics more details view paper
  • Downloaded 965 times
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    • Site-wide: 24,169
    • In genetics: 1,131
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    • Site-wide: 79,935
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    • Site-wide: 75,445

Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers

genomics more details view paper
  • Downloaded 961 times
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    • Site-wide: 24,331
    • In genomics: 2,307
  • Year to date:
    • Site-wide: 107,688
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    • Site-wide: 82,347

Genetic insights into the biological mechanisms governing human ovarian ageing

sexual and reproductive health more details view paper
  • Downloaded 956 times
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    • Site-wide: 24,532
    • In sexual and reproductive health: 14
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    • Site-wide: 2,369
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    • Site-wide: 1,973

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

genetics more details view paper
  • Downloaded 721 times
  • Download rankings, all-time:
    • Site-wide: 36,349
    • In genetics: 1,699
  • Year to date:
    • Site-wide: 63,567
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    • Site-wide: 80,509

Quantifying the extent to which index event biases influence large genetic association studies

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  • Downloaded 699 times
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    • Site-wide: 37,884
    • In genetics: 1,756
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    • Site-wide: 126,803
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    • Site-wide: 106,624

Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: an application to complex traits in the UK Biobank

epidemiology more details view paper
  • Downloaded 687 times
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    • Site-wide: 38,769
    • In epidemiology: 1,907
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    • Site-wide: 93,440
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    • Site-wide: 109,021

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

genetics more details view paper
  • Downloaded 678 times
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    • Site-wide: 39,453
    • In genetics: 1,830
  • Year to date:
    • Site-wide: 113,289
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    • Site-wide: 99,119

Genetic predictors of participation in optional components of UK Biobank

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  • Downloaded 651 times
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    • Site-wide: 41,625
    • In genetics: 1,918
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    • Site-wide: 64,295
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    • Site-wide: 112,180

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

genomics more details view paper
  • Downloaded 640 times
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    • Site-wide: 42,550
    • In genomics: 3,469
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    • Site-wide: 110,095
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Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

genetics more details view paper
  • Downloaded 600 times
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    • Site-wide: 46,104
    • In genetics: 2,112
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Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

epidemiology more details view paper
  • Downloaded 585 times
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    • Site-wide: 47,546
    • In epidemiology: 2,218
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    • Site-wide: 117,176
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Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

genomics more details view paper
  • Downloaded 582 times
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    • Site-wide: 47,899
    • In genomics: 3,759
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    • Site-wide: 107,420
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Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

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  • Downloaded 582 times
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    • Site-wide: 47,860
    • In genetics: 2,188
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    • Site-wide: 124,418
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Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

genetics more details view paper
  • Downloaded 519 times
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    • Site-wide: 54,933
    • In genetics: 2,482
  • Year to date:
    • Site-wide: 113,315
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Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank

epidemiology more details view paper
  • Downloaded 451 times
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    • Site-wide: 64,219
    • In epidemiology: 2,788
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    • Site-wide: 139,752
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A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors

orthopedics more details view paper
  • Downloaded 429 times
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    • Site-wide: 67,703
    • In orthopedics: 26
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    • Site-wide: 10,495
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Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

epidemiology more details view paper
  • Downloaded 383 times
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    • Site-wide: 75,325
    • In epidemiology: 3,183
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    • Site-wide: 50,461
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    • Site-wide: 49,264

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

genetic and genomic medicine more details view paper
  • Downloaded 205 times
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    • Site-wide: 114,057
    • In genetic and genomic medicine: 565
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    • Site-wide: 101,439
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Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study

epidemiology more details view paper
  • Downloaded 171 times
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    • Site-wide: 122,095
    • In epidemiology: 5,055
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Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

genetics more details view paper
  • Downloaded 141 times
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Associations of genetic scores for birth weight with newborn size and later Anthropometric traits and cardiometabolic risk markers in South Asians

genetic and genomic medicine more details view paper
  • Downloaded 87 times
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Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? A Mendelian randomization study.

epidemiology more details view paper
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    • Site-wide: 139,301
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