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Author: Timothy M. Frayling

Rankings

  • All-time downloads: 69,171 (rank: 3,277 )
  • Categories:
    • epidemiology: 5,149 (rank: 3,643 )
    • genetic and genomic medicine: 2,561 (rank: 1,892 )
    • genetics: 45,945 (rank: 110 )
    • genomics: 9,509 (rank: 2,491 )
    • orthopedics: 722 (rank: 87 (tie) )
    • sexual and reproductive health: 2,366 (rank: 158 (tie) )

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Preprints

Genetic Consequences of Social Stratification in Great Britain

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    • Site-wide: 9,598
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Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

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  • Downloaded 7,071 times
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    • Site-wide: 1,983
    • In genetics: 46
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A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

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  • Downloaded 4,927 times
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    • Site-wide: 3,222
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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

genomics more details view paper
  • Downloaded 3,347 times
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    • Site-wide: 5,562
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Biological and clinical insights from genetics of insomnia symptoms

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  • Downloaded 2,736 times
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    • Site-wide: 7,436
    • In genomics: 758
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Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

genetics more details view paper
  • Downloaded 2,656 times
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    • Site-wide: 7,774
    • In genetics: 296
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Genetic insights into the biological mechanisms governing human ovarian ageing

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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Downloaded 2,300 times
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Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

epidemiology more details view paper
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    • Site-wide: 11,126
    • In epidemiology: 832
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Assessing the pathogenicity, penetrance and expressivity of putative disease-causing variants in a population setting

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    • Site-wide: 11,988
    • In genetics: 456
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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

genetics more details view paper
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    • Site-wide: 12,458
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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

genetics more details view paper
  • Downloaded 1,840 times
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    • Site-wide: 13,391
    • In genetics: 524
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Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases

genetics more details view paper
  • Downloaded 1,834 times
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    • Site-wide: 13,451
    • In genetics: 516
  • Year to date:
    • Site-wide: 93,912
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Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

genetics more details view paper
  • Downloaded 1,776 times
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    • Site-wide: 14,124
    • In genetics: 551
  • Year to date:
    • Site-wide: 61,453
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    • Site-wide: 91,943

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

genetics more details view paper
  • Downloaded 1,722 times
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    • Site-wide: 14,787
    • In genetics: 583
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    • Site-wide: 124,945
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GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

genetics more details view paper
  • Downloaded 1,613 times
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    • Site-wide: 16,294
    • In genetics: 646
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    • Site-wide: 102,009
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    • Site-wide: 143,372

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

genetics more details view paper
  • Downloaded 1,488 times
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    • Site-wide: 18,454
    • In genetics: 739
  • Year to date:
    • Site-wide: 155,290
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    • Site-wide: 113,844

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

genetics more details view paper
  • Downloaded 1,444 times
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    • Site-wide: 19,362
    • In genetics: 785
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HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS

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    • In genomics: 1,897
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    • Site-wide: 149,004
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Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

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  • Downloaded 1,289 times
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    • Site-wide: 23,094
    • In genetics: 916
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    • Site-wide: 139,562
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    • Site-wide: 146,596

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Downloaded 1,244 times
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    • Site-wide: 24,415
    • In genetics: 979
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    • Site-wide: 90,753
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A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

genetics more details view paper
  • Downloaded 1,084 times
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    • Site-wide: 30,150
    • In genetics: 1,212
  • Year to date:
    • Site-wide: 118,257
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    • Site-wide: 115,434

Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers

genomics more details view paper
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    • Site-wide: 32,264
    • In genomics: 2,598
  • Year to date:
    • Site-wide: 125,537
  • Since beginning of last month:
    • Site-wide: 112,193

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

genetics more details view paper
  • Downloaded 854 times
  • Download rankings, all-time:
    • Site-wide: 42,903
    • In genetics: 1,780
  • Year to date:
    • Site-wide: 74,883
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    • Site-wide: 65,165

Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: an application to complex traits in the UK Biobank

epidemiology more details view paper
  • Downloaded 783 times
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    • Site-wide: 48,744
    • In epidemiology: 2,328
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    • Site-wide: 139,958
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    • Site-wide: 173,700

A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors

orthopedics more details view paper
  • Downloaded 776 times
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    • Site-wide: 49,372
    • In orthopedics: 15
  • Year to date:
    • Site-wide: 58,385
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    • Site-wide: 64,508

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

genetics more details view paper
  • Downloaded 776 times
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    • Site-wide: 49,427
    • In genetics: 1,963
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    • Site-wide: 104,380

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

genomics more details view paper
  • Downloaded 743 times
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    • Site-wide: 52,630
    • In genomics: 3,733
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    • Site-wide: 99,370
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Quantifying the extent to which index event biases influence large genetic association studies

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    • Site-wide: 53,996
    • In genetics: 2,061
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Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

genetics more details view paper
  • Downloaded 703 times
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    • Site-wide: 56,773
    • In genetics: 2,206
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    • Site-wide: 116,711

Genetic predictors of participation in optional components of UK Biobank

genetics more details view paper
  • Downloaded 700 times
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    • Site-wide: 57,113
    • In genetics: 2,198
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    • Site-wide: 168,243
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    • Site-wide: 135,121

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

genetics more details view paper
  • Downloaded 648 times
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    • Site-wide: 63,560
    • In genetics: 2,444
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Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

genomics more details view paper
  • Downloaded 637 times
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    • Site-wide: 64,987
    • In genomics: 4,313
  • Year to date:
    • Site-wide: 160,171
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Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

epidemiology more details view paper
  • Downloaded 624 times
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    • Site-wide: 66,780
    • In epidemiology: 2,897
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    • Site-wide: 188,026
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Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

genetics more details view paper
  • Downloaded 562 times
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    • Site-wide: 76,112
    • In genetics: 2,915
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    • Site-wide: 173,746
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Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank

epidemiology more details view paper
  • Downloaded 537 times
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    • Site-wide: 80,523
    • In epidemiology: 3,394
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    • Site-wide: 163,729
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    • Site-wide: 162,722

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

epidemiology more details view paper
  • Downloaded 509 times
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    • Site-wide: 85,832
    • In epidemiology: 3,534
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    • Site-wide: 150,541
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    • Site-wide: 168,820

Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study

epidemiology more details view paper
  • Downloaded 384 times
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    • Site-wide: 114,192
    • In epidemiology: 4,906
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    • Site-wide: 70,803
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Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

genetic and genomic medicine more details view paper
  • Downloaded 339 times
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    • Site-wide: 126,656
    • In genetic and genomic medicine: 756
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Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? A Mendelian randomization study.

epidemiology more details view paper
  • Downloaded 284 times
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    • Site-wide: 142,876
    • In epidemiology: 6,015
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    • Site-wide: 60,314
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Associations of genetic scores for birth weight with newborn size and later Anthropometric traits and cardiometabolic risk markers in South Asians

genetic and genomic medicine more details view paper
  • Downloaded 269 times
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Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

genetics more details view paper
  • Downloaded 224 times
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    • Site-wide: 160,235
    • In genetics: 5,798
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    • Site-wide: 157,541
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Age-specific effects of body size on fracture risk in later life: A lifecourse Mendelian randomization study

epidemiology more details view paper
  • Downloaded 151 times
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    • Site-wide: 177,864
    • In epidemiology: 7,018
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Genomic insights into the mechanism of NK3R antagonists for treatment of menopausal vasomotor symptoms

genetic and genomic medicine more details view paper
  • Downloaded 70 times
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    • Site-wide: 188,641
    • In genetic and genomic medicine: None
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