Author: Timothy M Frayling

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Preprints

Genetic Consequences of Social Stratification in Great Britain

• Downloaded 7,979 times
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  • Site-wide: 1,260
  • In genetics: 34
• Year to date:
  • Site-wide: 9,848
• Since beginning of last month:
  • Site-wide: 34,205

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

• Downloaded 6,761 times
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  • Site-wide: 1,549
  • In genetics: 46
• Year to date:
  • Site-wide: 19,841
• Since beginning of last month:
  • Site-wide: 60,982

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,277 times
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  • Site-wide: 4,265
  • In genomics: 440
• Year to date:
  • Site-wide: 83,079
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  • Site-wide: 58,257

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

• Downloaded 2,402 times
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  • Site-wide: 6,691
  • In genetics: 293
• Year to date:
  • Site-wide: 40,773
• Since beginning of last month:
  • Site-wide: 34,406

Biological and clinical insights from genetics of insomnia symptoms

• Downloaded 2,179 times
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  • Site-wide: 7,718
  • In genomics: 805
• Year to date:
  • Site-wide: 12,510
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  • Site-wide: 21,666

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

• Downloaded 1,979 times
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  • Site-wide: 8,895
  • In epidemiology: 699
• Year to date:
  • Site-wide: 87,238
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  • Site-wide: 23,363

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,881 times
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  • Site-wide: 9,587
  • In genetics: 417
• Year to date:
  • Site-wide: 100,017
• Since beginning of last month:
  • Site-wide: 61,450

Assessing the pathogenicity, penetrance and expressivity of putative disease-causing variants in a population setting

• Downloaded 1,876 times
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  • Site-wide: 9,622
  • In genetics: 419
• Year to date:
  • Site-wide: 72,379
• Since beginning of last month:
  • Site-wide: 80,461

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,726 times
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  • Site-wide: 10,867
  • In genetics: 481
• Year to date:
  • Site-wide: 61,148
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  • Site-wide: None

Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases

• Downloaded 1,722 times
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  • Site-wide: 10,922
  • In genetics: 483
• Year to date:
  • Site-wide: 49,003
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  • Site-wide: 73,025

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

• Downloaded 1,662 times
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  • Site-wide: 11,492
  • In genetics: 515
• Year to date:
  • Site-wide: 65,460
• Since beginning of last month:
  • Site-wide: 60,434

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

• Downloaded 1,659 times
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  • Site-wide: 11,527
  • In genetics: 519
• Year to date:
  • Site-wide: 114,661
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  • Site-wide: None

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

• Downloaded 1,522 times
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  • Site-wide: 13,008
  • In genetics: 589
• Year to date:
  • Site-wide: 97,851
• Since beginning of last month:
  • Site-wide: 73,005

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

• Downloaded 1,440 times
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  • Site-wide: 14,202
  • In genetics: 652
• Year to date:
  • Site-wide: 103,642
• Since beginning of last month:
  • Site-wide: 60,337

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 1,440 times
• Download rankings, all-time:
  • Site-wide: 14,197
  • In genetic and genomic medicine: 60
• Year to date:
  • Site-wide: 6,285
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  • Site-wide: 13,572

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

• Downloaded 1,325 times
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  • Site-wide: 16,113
  • In genetics: 739
• Year to date:
  • Site-wide: 84,503
• Since beginning of last month:
  • Site-wide: 73,004

HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS

• Downloaded 1,244 times
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  • Site-wide: 17,683
  • In genomics: 1,722
• Year to date:
  • Site-wide: 127,517
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  • Site-wide: 72,764

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

• Downloaded 1,224 times
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  • Site-wide: 18,127
  • In genetics: 843
• Year to date:
  • Site-wide: 105,165
• Since beginning of last month:
  • Site-wide: None

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 1,138 times
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  • Site-wide: 20,197
  • In sexual and reproductive health: 15
• Year to date:
  • Site-wide: 2,596
• Since beginning of last month:
  • Site-wide: 2,007

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,074 times
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  • Site-wide: 22,003
  • In genetics: 1,004
• Year to date:
  • Site-wide: 10,170
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  • Site-wide: 43,841

A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

• Downloaded 982 times
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  • Site-wide: 25,041
  • In genetics: 1,144
• Year to date:
  • Site-wide: 84,412
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  • Site-wide: None

Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers

• Downloaded 972 times
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  • Site-wide: 25,467
  • In genomics: 2,364
• Year to date:
  • Site-wide: 114,825
• Since beginning of last month:
  • Site-wide: 24,485

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

• Downloaded 724 times
• Download rankings, all-time:
  • Site-wide: 38,442
  • In genetics: 1,735
• Year to date:
  • Site-wide: 81,701
• Since beginning of last month:
  • Site-wide: 73,400

Quantifying the extent to which index event biases influence large genetic association studies

• Downloaded 702 times
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  • Site-wide: 40,064
  • In genetics: 1,802
• Year to date:
  • Site-wide: 141,065
• Since beginning of last month:
  • Site-wide: None

Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: an application to complex traits in the UK Biobank

• Downloaded 698 times
• Download rankings, all-time:
  • Site-wide: 40,422
  • In epidemiology: 1,996
• Year to date:
  • Site-wide: 101,716
• Since beginning of last month:
  • Site-wide: 67,201

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

• Downloaded 683 times
• Download rankings, all-time:
  • Site-wide: 41,616
  • In genetics: 1,871
• Year to date:
  • Site-wide: 127,662
• Since beginning of last month:
  • Site-wide: None

Genetic predictors of participation in optional components of UK Biobank

• Downloaded 657 times
• Download rankings, all-time:
  • Site-wide: 43,733
  • In genetics: 1,957
• Year to date:
  • Site-wide: 79,959
• Since beginning of last month:
  • Site-wide: 14,967

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

• Downloaded 648 times
• Download rankings, all-time:
  • Site-wide: 44,500
  • In genomics: 3,550
• Year to date:
  • Site-wide: 120,005
• Since beginning of last month:
  • Site-wide: 58,965

Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

• Downloaded 610 times
• Download rankings, all-time:
  • Site-wide: 47,974
  • In genetics: 2,142
• Year to date:
  • Site-wide: 107,118
• Since beginning of last month:
  • Site-wide: None

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

• Downloaded 592 times
• Download rankings, all-time:
  • Site-wide: 49,834
  • In genetics: 2,217
• Year to date:
  • Site-wide: 128,130
• Since beginning of last month:
  • Site-wide: 73,383

Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

• Downloaded 589 times
• Download rankings, all-time:
  • Site-wide: 50,170
  • In genomics: 3,857
• Year to date:
  • Site-wide: 118,888
• Since beginning of last month:
  • Site-wide: None

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

• Downloaded 588 times
• Download rankings, all-time:
  • Site-wide: 50,296
  • In epidemiology: 2,345
• Year to date:
  • Site-wide: 132,797
• Since beginning of last month:
  • Site-wide: 66,452

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

• Downloaded 526 times
• Download rankings, all-time:
  • Site-wide: 57,597
  • In genetics: 2,545
• Year to date:
  • Site-wide: 124,110
• Since beginning of last month:
  • Site-wide: None

A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors

• Downloaded 516 times
• Download rankings, all-time:
  • Site-wide: 59,009
  • In orthopedics: 24
• Year to date:
  • Site-wide: 10,806
• Since beginning of last month:
  • Site-wide: 35,992

Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank

• Downloaded 466 times
• Download rankings, all-time:
  • Site-wide: 65,963
  • In epidemiology: 2,893
• Year to date:
  • Site-wide: 134,606
• Since beginning of last month:
  • Site-wide: 83,243

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

• Downloaded 408 times
• Download rankings, all-time:
  • Site-wide: 75,601
  • In epidemiology: 3,243
• Year to date:
  • Site-wide: 54,359
• Since beginning of last month:
  • Site-wide: 107,286

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

• Downloaded 226 times
• Download rankings, all-time:
  • Site-wide: 115,516
  • In genetic and genomic medicine: 595
• Year to date:
  • Site-wide: 97,287
• Since beginning of last month:
  • Site-wide: None

Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study

• Downloaded 203 times
• Download rankings, all-time:
  • Site-wide: 121,171
  • In epidemiology: 5,073
• Year to date:
  • Site-wide: 38,613
• Since beginning of last month:
  • Site-wide: 42,854

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

• Downloaded 150 times
• Download rankings, all-time:
  • Site-wide: 133,518
  • In genetics: 5,422
• Year to date:
  • Site-wide: 124,843
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  • Site-wide: None

Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? A Mendelian randomization study.

• Downloaded 122 times
• Download rankings, all-time:
  • Site-wide: 139,617
  • In epidemiology: 5,752
• Year to date:
  • Site-wide: 52,444
• Since beginning of last month:
  • Site-wide: 19,074

Associations of genetic scores for birth weight with newborn size and later Anthropometric traits and cardiometabolic risk markers in South Asians

• Downloaded 105 times
• Download rankings, all-time:
  • Site-wide: 142,881
  • In genetic and genomic medicine: 806
• Year to date:
  • Site-wide: 60,226
• Since beginning of last month:
  • Site-wide: 43,674