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Author: Timothy M. Frayling

Rankings

  • All-time downloads: 49,728 (rank: 2,406 out of 512,356)
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    • epidemiology: 3,774 (rank: 2,365 (tie) out of 23,892)
    • genetic and genomic medicine: 855 (rank: 1,148 (tie) out of 6,821)
    • genetics: 36,879 (rank: 130 out of 38,759)
    • genomics: 8,185 (rank: 2,199 out of 45,764)
    • orthopedics: 35 (rank: 130 (tie) out of 138)

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Preprints

Genetic Consequences of Social Stratification in Great Britain

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Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

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Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

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Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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Assessing the pathogenicity, penetrance and expressivity of putative disease-causing variants in a population setting

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Biological and clinical insights from genetics of insomnia symptoms

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Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases

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Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

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GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

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HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS

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Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

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Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers

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A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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Quantifying the extent to which index event biases influence large genetic association studies

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Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

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Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: an application to complex traits in the UK Biobank

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Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

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Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

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Genetic predictors of participation in optional components of UK Biobank

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Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

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The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

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Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

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Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

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Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

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Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank

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Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

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Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

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Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

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A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors

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