Author: Timothy M. Frayling

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Preprints

Genetic Consequences of Social Stratification in Great Britain

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  • Site-wide: 9,598
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  • Site-wide: 11,218

Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry

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  • Site-wide: 1,983
  • In genetics: 46
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  • Site-wide: 25,819
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  • Site-wide: 38,958

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

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  • In genetics: 128
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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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  • Site-wide: 5,562
  • In genomics: 494
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  • Site-wide: 116,783

Biological and clinical insights from genetics of insomnia symptoms

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  • Site-wide: 7,436
  • In genomics: 758
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Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

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  • Site-wide: 7,774
  • In genetics: 296
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Genetic insights into the biological mechanisms governing human ovarian ageing

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  • In sexual and reproductive health: 13
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  • Site-wide: 40,291

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Site-wide: 9,616
  • In genetic and genomic medicine: 50
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  • Site-wide: 5,829

Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study

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  • Site-wide: 11,126
  • In epidemiology: 832
• Year to date:
  • Site-wide: 96,650
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  • Site-wide: 113,919

Assessing the pathogenicity, penetrance and expressivity of putative disease-causing variants in a population setting

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  • Site-wide: 11,988
  • In genetics: 456
• Year to date:
  • Site-wide: 68,994
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  • Site-wide: 76,125

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 12,458
  • In genetics: 468
• Year to date:
  • Site-wide: 148,816
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  • Site-wide: 143,414

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 45,225

Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases

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  • Site-wide: 13,451
  • In genetics: 516
• Year to date:
  • Site-wide: 93,912
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  • Site-wide: 104,572

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

• Downloaded 1,776 times
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  • Site-wide: 14,124
  • In genetics: 551
• Year to date:
  • Site-wide: 61,453
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  • Site-wide: 91,943

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

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  • Site-wide: 14,787
  • In genetics: 583
• Year to date:
  • Site-wide: 124,945
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  • Site-wide: 115,214

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

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  • Site-wide: 16,294
  • In genetics: 646
• Year to date:
  • Site-wide: 102,009
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  • Site-wide: 143,372

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

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  • Site-wide: 18,454
  • In genetics: 739
• Year to date:
  • Site-wide: 155,290
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  • Site-wide: 113,844

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

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  • Site-wide: 19,362
  • In genetics: 785
• Year to date:
  • Site-wide: 93,965
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  • Site-wide: 117,684

HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS

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  • Site-wide: 22,476
  • In genomics: 1,897
• Year to date:
  • Site-wide: 149,004
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  • Site-wide: 140,457

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

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  • Site-wide: 23,094
  • In genetics: 916
• Year to date:
  • Site-wide: 139,562
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  • Site-wide: 146,596

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 24,415
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A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

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  • Site-wide: 30,150
  • In genetics: 1,212
• Year to date:
  • Site-wide: 118,257
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  • Site-wide: 115,434

Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers

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  • Site-wide: 32,264
  • In genomics: 2,598
• Year to date:
  • Site-wide: 125,537
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  • Site-wide: 112,193

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

• Downloaded 854 times
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  • Site-wide: 42,903
  • In genetics: 1,780
• Year to date:
  • Site-wide: 74,883
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  • Site-wide: 65,165

Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: an application to complex traits in the UK Biobank

• Downloaded 783 times
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  • Site-wide: 48,744
  • In epidemiology: 2,328
• Year to date:
  • Site-wide: 139,958
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  • Site-wide: 173,700

A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors

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  • Site-wide: 49,372
  • In orthopedics: 15
• Year to date:
  • Site-wide: 58,385
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  • Site-wide: 64,508

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

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  • Site-wide: 49,427
  • In genetics: 1,963
• Year to date:
  • Site-wide: 118,193
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  • Site-wide: 104,380

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

• Downloaded 743 times
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  • Site-wide: 52,630
  • In genomics: 3,733
• Year to date:
  • Site-wide: 99,370
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  • Site-wide: 169,897

Quantifying the extent to which index event biases influence large genetic association studies

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  • Site-wide: 53,996
  • In genetics: 2,061
• Year to date:
  • Site-wide: 185,925
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  • Site-wide: 187,630

Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study

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  • Site-wide: 56,773
  • In genetics: 2,206
• Year to date:
  • Site-wide: 153,614
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  • Site-wide: 116,711

Genetic predictors of participation in optional components of UK Biobank

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  • Site-wide: 57,113
  • In genetics: 2,198
• Year to date:
  • Site-wide: 168,243
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  • Site-wide: 135,121

Across-cohort QC analyses of genome-wide association study summary statistics from complex traits

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  • Site-wide: 63,560
  • In genetics: 2,444
• Year to date:
  • Site-wide: 159,559
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  • Site-wide: 170,176

Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

• Downloaded 637 times
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  • Site-wide: 64,987
  • In genomics: 4,313
• Year to date:
  • Site-wide: 160,171
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  • Site-wide: 140,298

Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

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  • Site-wide: 66,780
  • In epidemiology: 2,897
• Year to date:
  • Site-wide: 188,026
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  • Site-wide: 189,641

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

• Downloaded 562 times
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  • Site-wide: 76,112
  • In genetics: 2,915
• Year to date:
  • Site-wide: 173,746
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  • Site-wide: 182,963

Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank

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  • Site-wide: 80,523
  • In epidemiology: 3,394
• Year to date:
  • Site-wide: 163,729
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  • Site-wide: 162,722

Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives

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  • Site-wide: 85,832
  • In epidemiology: 3,534
• Year to date:
  • Site-wide: 150,541
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  • Site-wide: 168,820

Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study

• Downloaded 384 times
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  • Site-wide: 114,192
  • In epidemiology: 4,906
• Year to date:
  • Site-wide: 70,803
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  • Site-wide: 100,341

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

• Downloaded 339 times
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  • Site-wide: 126,656
  • In genetic and genomic medicine: 756
• Year to date:
  • Site-wide: 101,340
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  • Site-wide: 136,758

Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? A Mendelian randomization study.

• Downloaded 284 times
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  • Site-wide: 142,876
  • In epidemiology: 6,015
• Year to date:
  • Site-wide: 60,314
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  • Site-wide: 39,823

Associations of genetic scores for birth weight with newborn size and later Anthropometric traits and cardiometabolic risk markers in South Asians

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  • Site-wide: 147,408
  • In genetic and genomic medicine: 967
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  • Site-wide: 30,032

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

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  • Site-wide: 160,235
  • In genetics: 5,798
• Year to date:
  • Site-wide: 157,541
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  • Site-wide: 178,897

Age-specific effects of body size on fracture risk in later life: A lifecourse Mendelian randomization study

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  • Site-wide: 177,864
  • In epidemiology: 7,018
• Year to date:
  • Site-wide: 65,127
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  • Site-wide: 60,328

Genomic insights into the mechanism of NK3R antagonists for treatment of menopausal vasomotor symptoms

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  • Site-wide: 188,641
  • In genetic and genomic medicine: None
• Year to date:
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  • Site-wide: 14,308