Author: Norbert Perrimon

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Preprints

Directed evolution of TurboID for efficient proximity labeling in living cells and organisms

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  • Site-wide: 630
  • In bioengineering: 3
• Year to date:
  • Site-wide: 8,607
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  • Site-wide: 11,221

Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly

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  • Site-wide: 1,768
  • In genomics: 147
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  • Site-wide: 774
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  • Site-wide: 3,011

A cell atlas of the adult Drosophila midgut

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  • Site-wide: 5,725
  • In genetics: 195
• Year to date:
  • Site-wide: 85,309
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  • Site-wide: 90,912

Gene knock-ins in Drosophila using homology-independent insertion of universal donor plasmids

• Downloaded 2,735 times
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  • Site-wide: 7,444
  • In genetics: 282
• Year to date:
  • Site-wide: 45,584
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  • Site-wide: 40,470

In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer

• Downloaded 2,647 times
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  • Site-wide: 7,818
  • In developmental biology: 88
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  • Site-wide: 17,349
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  • Site-wide: 12,756

Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies

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  • Site-wide: 8,480
  • In genetics: 338
• Year to date:
  • Site-wide: 14,006
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  • Site-wide: 25,209

Proteomics of protein trafficking by in vivo tissue-specific labeling

• Downloaded 2,389 times
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  • Site-wide: 9,097
  • In physiology: 13
• Year to date:
  • Site-wide: 74,470
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  • Site-wide: 84,024

Horizontal Transfer of Histone H3 by Mammalian Cells

• Downloaded 2,014 times
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  • Site-wide: 11,746
  • In cell biology: 321
• Year to date:
  • Site-wide: 7,629
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  • Site-wide: 11,181

Lysosomal cystine efflux opposes mTORC1 reactivation through the TCA cycle

• Downloaded 1,814 times
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  • Site-wide: 13,669
  • In genetics: 656
• Year to date:
  • Site-wide: 9,042
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  • Site-wide: 8,078

A single-cell survey of Drosophila blood

• Downloaded 1,763 times
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  • Site-wide: 14,303
  • In immunology: 484
• Year to date:
  • Site-wide: 96,370
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  • Site-wide: 167,496

Precise genome engineering in Drosophila using prime editing

• Downloaded 1,504 times
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  • Site-wide: 18,176
  • In genetics: 744
• Year to date:
  • Site-wide: 79,539
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  • Site-wide: 53,924

Probe-Seq enables transcriptional profiling of specific cell types from heterogeneous tissue by RNA-based isolation

• Downloaded 1,430 times
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  • Site-wide: 19,650
  • In molecular biology: 482
• Year to date:
  • Site-wide: 125,580
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  • Site-wide: 164,616

Next generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM

• Downloaded 1,229 times
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  • Site-wide: 24,890
  • In genetics: 978
• Year to date:
  • Site-wide: 153,610
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  • Site-wide: 175,339

An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms

• Downloaded 1,215 times
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  • Site-wide: 25,325
  • In genomics: 2,135
• Year to date:
  • Site-wide: 103,867
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  • Site-wide: 119,660

Large-scale transgenic Drosophila resource collections for loss- and gain-of-function studies

• Downloaded 1,103 times
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  • Site-wide: 29,325
  • In genetics: 1,190
• Year to date:
  • Site-wide: 101,020
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  • Site-wide: 78,301

Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity

• Downloaded 1,086 times
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  • Site-wide: 30,055
  • In genetics: 1,227
• Year to date:
  • Site-wide: 95,596
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  • Site-wide: 156,944

Long-range Notch-mediated tissue patterning requires actomyosin contractility

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  • Site-wide: 31,901
  • In developmental biology: 550
• Year to date:
  • Site-wide: 154,898
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  • Site-wide: 140,615

Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila

• Downloaded 973 times
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  • Site-wide: 35,380
  • In developmental biology: 663
• Year to date:
  • Site-wide: 106,792
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  • Site-wide: 73,481

Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells

• Downloaded 962 times
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  • Site-wide: 35,960
  • In genetics: 1,446
• Year to date:
  • Site-wide: 102,142
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  • Site-wide: 93,415

iProteinDB: an integrative database of Drosophila post-translational modifications

• Downloaded 952 times
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  • Site-wide: 36,540
  • In bioinformatics: 3,655
• Year to date:
  • Site-wide: 164,072
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  • Site-wide: 146,370

Conserved phosphorylation hotspots in eukaryotic protein domain families

• Downloaded 904 times
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  • Site-wide: 39,450
  • In cell biology: 1,400
• Year to date:
  • Site-wide: 182,037
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  • Site-wide: 187,144

ovoD co-selection: a method for enriching CRISPR/Cas9-edited alleles in Drosophila

• Downloaded 883 times
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  • Site-wide: 40,850
  • In genetics: 1,594
• Year to date:
  • Site-wide: 184,311
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  • Site-wide: 170,043

A genetic model for in vivo proximity labeling of the mammalian secretome

• Downloaded 822 times
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  • Site-wide: 45,419
  • In cell biology: None
• Year to date:
  • Site-wide: 2,298
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  • Site-wide: 2,481

A cell atlas of the fly kidney

• Downloaded 771 times
• Download rankings, all-time:
  • Site-wide: 49,828
  • In developmental biology: 1,285
• Year to date:
  • Site-wide: 16,486
• Since beginning of last month:
  • Site-wide: 36,469

Two neuronal peptides encoded from a single transcript regulate mitochondrial function in Drosophila

• Downloaded 727 times
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  • Site-wide: 54,245
  • In genomics: 4,043
• Year to date:
  • Site-wide: 58,785
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  • Site-wide: 61,285

Wnt ligands are not required for planar cell polarity in the Drosophila wing or notum

• Downloaded 684 times
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  • Site-wide: 59,035
  • In genetics: 2,316
• Year to date:
  • Site-wide: 124,239
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  • Site-wide: 88,869

TIMEOR: a web-based tool to uncover temporal regulatory mechanisms from multi-omics data

• Downloaded 680 times
• Download rankings, all-time:
  • Site-wide: 59,579
  • In bioinformatics: 5,465
• Year to date:
  • Site-wide: 141,373
• Since beginning of last month:
  • Site-wide: 159,436

An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR mediated homologous recombination

• Downloaded 650 times
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  • Site-wide: 63,316
  • In genetics: 3,828
• Year to date:
  • Site-wide: 6,135
• Since beginning of last month:
  • Site-wide: 11,032

CRISPR-Cas13 mediated Knock Down in Drosophila cultured cells.

• Downloaded 636 times
• Download rankings, all-time:
  • Site-wide: 65,073
  • In molecular biology: 1,947
• Year to date:
  • Site-wide: 53,529
• Since beginning of last month:
  • Site-wide: 21,164

The RhoGEF Cysts couples apical polarity proteins to Rho and myosin activity at adherens junctions

• Downloaded 622 times
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  • Site-wide: 67,019
  • In cell biology: 2,757
• Year to date:
  • Site-wide: 153,146
• Since beginning of last month:
  • Site-wide: 131,209

FlyPhoneDB: An integrated web-based resource for cell-cell communication prediction in Drosophila

• Downloaded 579 times
• Download rankings, all-time:
  • Site-wide: 73,306
  • In bioinformatics: 7,040
• Year to date:
  • Site-wide: 41,668
• Since beginning of last month:
  • Site-wide: 44,528

The Drosophila Gene Expression Tool (DGET) for expression analyses

• Downloaded 574 times
• Download rankings, all-time:
  • Site-wide: 74,227
  • In bioinformatics: 6,416
• Year to date:
  • Site-wide: 184,622
• Since beginning of last month:
  • Site-wide: 190,167

Gene2Function: An Integrated Online Resource For Gene Function Discovery

• Downloaded 505 times
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  • Site-wide: 86,541
  • In bioinformatics: 7,286
• Year to date:
  • Site-wide: 180,731
• Since beginning of last month:
  • Site-wide: 147,688

SNP-CRISPR: a web tool for SNP-specific genome editing

• Downloaded 505 times
• Download rankings, all-time:
  • Site-wide: 86,476
  • In bioinformatics: 7,415
• Year to date:
  • Site-wide: 137,960
• Since beginning of last month:
  • Site-wide: 136,242

A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors

• Downloaded 422 times
• Download rankings, all-time:
  • Site-wide: 104,801
  • In cancer biology: 2,946
• Year to date:
  • Site-wide: 156,423
• Since beginning of last month:
  • Site-wide: 101,715

Zinc detoxification: a functional genomics and transcriptomics analysis in Drosophila melanogaster cultured cells

• Downloaded 422 times
• Download rankings, all-time:
  • Site-wide: 104,721
  • In genetics: 3,957
• Year to date:
  • Site-wide: 142,806
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  • Site-wide: 132,877

A genome-wide CRISPR screen identifies the glycosylation enzyme DPM1 as a modifier of DPAGT1 deficiency and ER stress

• Downloaded 419 times
• Download rankings, all-time:
  • Site-wide: 105,578
  • In genetics: 4,764
• Year to date:
  • Site-wide: 30,195
• Since beginning of last month:
  • Site-wide: 28,368

FIBCD1 is a Conserved Receptor for Chondroitin Sulphate Proteoglycans of the Brain Extracellular Matrix and a Candidate Gene for a Complex Neurodevelopmental Disorder

• Downloaded 418 times
• Download rankings, all-time:
  • Site-wide: 105,876
  • In neuroscience: 16,454
• Year to date:
  • Site-wide: 46,667
• Since beginning of last month:
  • Site-wide: 100,071

Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos

• Downloaded 404 times
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  • Site-wide: 109,260
  • In genetics: 4,289
• Year to date:
  • Site-wide: 78,494
• Since beginning of last month:
  • Site-wide: 60,072

CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila

• Downloaded 394 times
• Download rankings, all-time:
  • Site-wide: 111,615
  • In biochemistry: 3,041
• Year to date:
  • Site-wide: 177,853
• Since beginning of last month:
  • Site-wide: 165,570

REPTOR/CREBRF encode key regulators of muscle energy metabolism

• Downloaded 378 times
• Download rankings, all-time:
  • Site-wide: 115,959
  • In physiology: 1,184
• Year to date:
  • Site-wide: 18,287
• Since beginning of last month:
  • Site-wide: 60,264

Variable dose analysis: A novel RNAi-based method for detection of synthetic lethal interactions

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 118,481
  • In cancer biology: 3,333
• Year to date:
  • Site-wide: 175,207
• Since beginning of last month:
  • Site-wide: 163,349

Local assembly of long reads enables phylogenomics of transposable elements in a polyploid cell line

• Downloaded 318 times
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  • Site-wide: 132,778
  • In genomics: 7,695
• Year to date:
  • Site-wide: 9,806
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  • Site-wide: 29,285

Modeling exercise using optogenetically contractible Drosophila larvae

• Downloaded 297 times
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  • Site-wide: 139,121
  • In genomics: 7,689
• Year to date:
  • Site-wide: 10,839
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  • Site-wide: 43,319

Molecular and functional characterization of the Drosophila melanogaster conserved smORFome

• Downloaded 275 times
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  • Site-wide: 145,660
  • In genomics: None
• Year to date:
  • Site-wide: 12,189
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  • Site-wide: 10,132

Synthetic lethal screening identifies existing drugs with selective viability effects on Neurofibromatosis type-1 model systems

• Downloaded 262 times
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  • Site-wide: 149,316
  • In cancer biology: 4,759
• Year to date:
  • Site-wide: 24,309
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  • Site-wide: 67,577

Antagonistic regulation of Drosophila mitochondrial uncoupling protein UCP4b by cold and BMP signaling

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  • Site-wide: 150,232
  • In genetics: 5,780
• Year to date:
  • Site-wide: 13,307
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  • Site-wide: 54,573

BioLitMine: advanced mining of biomedical and biological literature about human genes and genes from major model organisms

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  • Site-wide: 172,293
  • In bioinformatics: 12,242
• Year to date:
  • Site-wide: 168,140
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  • Site-wide: 157,999