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Author: James S. Fraser

Rankings

  • All-time downloads: 188,781 (rank: 96 out of 424,267)
  • Categories:
    • biochemistry: 3,795 (rank: 432 out of 20,521)
    • bioengineering: 774 (rank: 3,187 (tie) out of 13,147)
    • bioinformatics: 549 (rank: 19,294 (tie) out of 35,926)
    • biophysics: 16,963 (rank: 28 out of 17,967)
    • cancer biology: 1,085 (rank: 4,829 (tie) out of 29,881)
    • systems biology: 165,615 (rank: 9 out of 12,231)

Downloads per author, site-wide

Preprints

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

systems biology more details view paper
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    • Site-wide: 5 out of 100,444
    • In systems biology: 1 out of 2,553
  • Year to date:
    • Site-wide: 4 out of 100,444
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A multi-model approach to assessing local and global cryo-EM map quality

biophysics more details view paper
  • Downloaded 1,942 times
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    • In biophysics: 113 out of 4,424
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  • Since beginning of last month:
    • Site-wide: 12,844 out of 100,444

Mapping the Conformational Landscape of a Dynamic Enzyme by XFEL and Multitemperature Crystallography

biophysics more details view paper
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    • In biophysics: 171 out of 4,424
  • Year to date:
    • Site-wide: 59,277 out of 100,444
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Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta

biochemistry more details view paper
  • Downloaded 1,163 times
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    • In biochemistry: 246 out of 3,429
  • Year to date:
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Computational design of a modular protein sense/response system

biophysics more details view paper
  • Downloaded 1,106 times
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    • In biophysics: 334 out of 4,424
  • Year to date:
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Co-occurring alterations in the RAS-MAPK pathway limit response to MET inhibitor treatment in MET exon 14 skipping mutation positive lung cancer

cancer biology more details view paper
  • Downloaded 1,085 times
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    • In cancer biology: 304 out of 3,590
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qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps

biophysics more details view paper
  • Downloaded 1,057 times
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    • In biophysics: 358 out of 4,424
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Effects of α-tubulin acetylation on microtubule structure and stability

biophysics more details view paper
  • Downloaded 1,054 times
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    • Site-wide: 11,592 out of 100,444
    • In biophysics: 362 out of 4,424
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    • Site-wide: 47,588 out of 100,444
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    • Site-wide: 13,436 out of 100,444

Temperature-Jump Solution X-ray Scattering Reveals Distinct Motions in a Dynamic Enzyme

biophysics more details view paper
  • Downloaded 1,034 times
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    • Site-wide: 11,967 out of 100,444
    • In biophysics: 376 out of 4,424
  • Year to date:
    • Site-wide: 30,361 out of 100,444
  • Since beginning of last month:
    • Site-wide: 14,261 out of 100,444

Measuring and modeling diffuse scattering in protein X-ray crystallography

biophysics more details view paper
  • Downloaded 955 times
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    • Site-wide: 13,515 out of 100,444
    • In biophysics: 436 out of 4,424
  • Year to date:
    • Site-wide: 54,116 out of 100,444
  • Since beginning of last month:
    • Site-wide: 22,712 out of 100,444

Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis

biochemistry more details view paper
  • Downloaded 955 times
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    • Site-wide: 13,506 out of 100,444
    • In biochemistry: 331 out of 3,429
  • Year to date:
    • Site-wide: 27,251 out of 100,444
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    • Site-wide: None out of 100,444

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals

biophysics more details view paper
  • Downloaded 902 times
  • Download rankings, all-time:
    • Site-wide: 14,821 out of 100,444
    • In biophysics: 486 out of 4,424
  • Year to date:
    • Site-wide: 27,247 out of 100,444
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Side-chain-directed model and map validation for 3D Electron Cryomicroscopy

biophysics more details view paper
  • Downloaded 890 times
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    • Site-wide: 15,177 out of 100,444
    • In biophysics: 500 out of 4,424
  • Year to date:
    • Site-wide: 85,388 out of 100,444
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Determination of Ubiquitin Fitness Landscapes Under Different Chemical Stresses in a Classroom Setting

systems biology more details view paper
  • Downloaded 849 times
  • Download rankings, all-time:
    • Site-wide: 16,298 out of 100,444
    • In systems biology: 431 out of 2,553
  • Year to date:
    • Site-wide: 96,743 out of 100,444
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    • Site-wide: None out of 100,444

High-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit and validation of nucleotide modifications

biochemistry more details view paper
  • Downloaded 841 times
  • Download rankings, all-time:
    • Site-wide: 16,558 out of 100,444
    • In biochemistry: 437 out of 3,429
  • Year to date:
    • Site-wide: 15,805 out of 100,444
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    • Site-wide: 9,793 out of 100,444

Expanding the space of protein geometries by computational design of de novo fold families

bioengineering more details view paper
  • Downloaded 774 times
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    • In bioengineering: 385 out of 2,328
  • Year to date:
    • Site-wide: 3,142 out of 100,444
  • Since beginning of last month:
    • Site-wide: 7,008 out of 100,444

Exposing hidden alternative backbone conformations in X-ray crystallography using qFit

biophysics more details view paper
  • Downloaded 731 times
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    • Site-wide: 20,456 out of 100,444
    • In biophysics: 707 out of 4,424
  • Year to date:
    • Site-wide: 95,687 out of 100,444
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    • Site-wide: None out of 100,444

Predicting X-ray Diffuse Scattering from Translation Libration Screw Structural Ensembles

biophysics more details view paper
  • Downloaded 726 times
  • Download rankings, all-time:
    • Site-wide: 20,665 out of 100,444
    • In biophysics: 718 out of 4,424
  • Year to date:
    • Site-wide: 95,689 out of 100,444
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    • Site-wide: None out of 100,444

New routes for PTP1B allosteric inhibition by multitemperature crystallography, fragment screening and covalent tethering

biophysics more details view paper
  • Downloaded 726 times
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    • Site-wide: 20,660 out of 100,444
    • In biophysics: 720 out of 4,424
  • Year to date:
    • Site-wide: 60,499 out of 100,444
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    • Site-wide: None out of 100,444

Flexibility and design: conformational heterogeneity along the evolutionary trajectory of a redesigned ubiquitin

biophysics more details view paper
  • Downloaded 667 times
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    • Site-wide: 23,446 out of 100,444
    • In biophysics: 859 out of 4,424
  • Year to date:
    • Site-wide: 66,436 out of 100,444
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    • Site-wide: None out of 100,444

Rescue of Conformational Dynamics in Enzyme Catalysis by Directed Evolution

biophysics more details view paper
  • Downloaded 630 times
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    • Site-wide: 25,456 out of 100,444
    • In biophysics: 939 out of 4,424
  • Year to date:
    • Site-wide: 54,111 out of 100,444
  • Since beginning of last month:
    • Site-wide: 17,298 out of 100,444

Bringing Diffuse X-ray Scattering Into Focus

biophysics more details view paper
  • Downloaded 593 times
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    • Site-wide: 27,668 out of 100,444
    • In biophysics: 1,056 out of 4,424
  • Year to date:
    • Site-wide: 50,114 out of 100,444
  • Since beginning of last month:
    • Site-wide: 16,217 out of 100,444

Evolution of an enzyme conformational ensemble guides design of an efficient biocatalyst

biophysics more details view paper
  • Downloaded 558 times
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    • Site-wide: 29,876 out of 100,444
    • In biophysics: 1,163 out of 4,424
  • Year to date:
    • Site-wide: 5,215 out of 100,444
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    • Site-wide: None out of 100,444

Extending Chemical Perturbations Of The Ubiquitin Fitness Landscape In A Classroom Setting

bioinformatics more details view paper
  • Downloaded 549 times
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    • Site-wide: 30,527 out of 100,444
    • In bioinformatics: 4,039 out of 9,219
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    • Site-wide: 83,751 out of 100,444
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    • Site-wide: None out of 100,444

Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles

biophysics more details view paper
  • Downloaded 529 times
  • Download rankings, all-time:
    • Site-wide: 32,020 out of 100,444
    • In biophysics: 1,253 out of 4,424
  • Year to date:
    • Site-wide: 15,492 out of 100,444
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    • Site-wide: None out of 100,444

Model selection for biological crystallography

biophysics more details view paper
  • Downloaded 519 times
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    • Site-wide: 32,745 out of 100,444
    • In biophysics: 1,286 out of 4,424
  • Year to date:
    • Site-wide: 51,666 out of 100,444
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    • Site-wide: None out of 100,444

Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution

biochemistry more details view paper
  • Downloaded 436 times
  • Download rankings, all-time:
    • Site-wide: 40,390 out of 100,444
    • In biochemistry: 1,224 out of 3,429
  • Year to date:
    • Site-wide: 7,609 out of 100,444
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    • Site-wide: None out of 100,444

Differences in the chitinolytic activity of mammalian chitinases on soluble and crystalline substrates

biochemistry more details view paper
  • Downloaded 400 times
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    • Site-wide: 44,314 out of 100,444
    • In biochemistry: 1,343 out of 3,429
  • Year to date:
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    • Site-wide: None out of 100,444

From deep TLS validation to ensembles of atomic models built from elemental motions

biophysics more details view paper
  • Downloaded 396 times
  • Download rankings, all-time:
    • Site-wide: 44,870 out of 100,444
    • In biophysics: 1,818 out of 4,424
  • Year to date:
    • Site-wide: 88,578 out of 100,444
  • Since beginning of last month:
    • Site-wide: 21,684 out of 100,444

Liquid-like and rigid-body motions in molecular-dynamics simulations of a crystalline protein

biophysics more details view paper
  • Downloaded 290 times
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    • Site-wide: 59,560 out of 100,444
    • In biophysics: 2,539 out of 4,424
  • Year to date:
    • Site-wide: 75,719 out of 100,444
  • Since beginning of last month:
    • Site-wide: None out of 100,444

qFit 3: Protein and ligand multiconformer modeling for X-ray crystallographic and single-particle cryo-EM density maps

biophysics more details view paper
  • Downloaded 109 times
  • Download rankings, all-time:
    • Site-wide: 89,275 out of 100,444
    • In biophysics: 3,925 out of 4,424
  • Year to date:
    • Site-wide: 49,259 out of 100,444
  • Since beginning of last month:
    • Site-wide: 2,658 out of 100,444

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