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Author: James S. Fraser

Rankings

  • All-time downloads: 186,963 (rank: 91 out of 395,148)
  • Categories:
    • biochemistry: 3,649 (rank: 372 out of 18,428)
    • bioengineering: 666 (rank: 3,354 (tie) out of 11,560)
    • bioinformatics: 548 (rank: 18,384 (tie) out of 33,563)
    • biophysics: 16,577 (rank: 26 out of 16,363)
    • cancer biology: 1,065 (rank: 4,681 (tie) out of 27,369)
    • systems biology: 164,458 (rank: 9 out of 11,540)

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Preprints

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

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A multi-model approach to assessing local and global cryo-EM map quality

biophysics more details view paper
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Mapping the Conformational Landscape of a Dynamic Enzyme by XFEL and Multitemperature Crystallography

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Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta

biochemistry more details view paper
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Computational design of a modular protein sense/response system

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Co-occurring alterations in the RAS-MAPK pathway limit response to MET inhibitor treatment in MET exon 14 skipping mutation positive lung cancer

cancer biology more details view paper
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qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps

biophysics more details view paper
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Effects of α-tubulin acetylation on microtubule structure and stability

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Temperature-Jump Solution X-ray Scattering Reveals Distinct Motions in a Dynamic Enzyme

biophysics more details view paper
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Measuring and modeling diffuse scattering in protein X-ray crystallography

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Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis

biochemistry more details view paper
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Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals

biophysics more details view paper
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Side-chain-directed model and map validation for 3D Electron Cryomicroscopy

biophysics more details view paper
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Determination of Ubiquitin Fitness Landscapes Under Different Chemical Stresses in a Classroom Setting

systems biology more details view paper
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High-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit and validation of nucleotide modifications

biochemistry more details view paper
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Exposing hidden alternative backbone conformations in X-ray crystallography using qFit

biophysics more details view paper
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Predicting X-ray Diffuse Scattering from Translation Libration Screw Structural Ensembles

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New routes for PTP1B allosteric inhibition by multitemperature crystallography, fragment screening and covalent tethering

biophysics more details view paper
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Expanding the space of protein geometries by computational design of de novo fold families

bioengineering more details view paper
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Flexibility and design: conformational heterogeneity along the evolutionary trajectory of a redesigned ubiquitin

biophysics more details view paper
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Rescue of Conformational Dynamics in Enzyme Catalysis by Directed Evolution

biophysics more details view paper
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Bringing Diffuse X-ray Scattering Into Focus

biophysics more details view paper
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Extending Chemical Perturbations Of The Ubiquitin Fitness Landscape In A Classroom Setting

bioinformatics more details view paper
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Evolution of an enzyme conformational ensemble guides design of an efficient biocatalyst

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Model selection for biological crystallography

biophysics more details view paper
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Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles

biophysics more details view paper
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Differences in the chitinolytic activity of mammalian chitinases on soluble and crystalline substrates

biochemistry more details view paper
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Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution

biochemistry more details view paper
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From deep TLS validation to ensembles of atomic models built from elemental motions

biophysics more details view paper
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Liquid-like and rigid-body motions in molecular-dynamics simulations of a crystalline protein

biophysics more details view paper
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