Author: Matthias Schlesner

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Preprints

The evolutionary history of 2,658 cancers

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Germline determinants of the somatic mutation landscape in 2,642 cancer genomes

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Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

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  • In cancer biology: 23 out of 2,965
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Computational Pan-Genomics: Status, Promises and Challenges

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A Comprehensive Assessment of Somatic Mutation Calling in Cancer Genomes

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  • In genomics: 512 out of 5,464
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Large-Scale Uniform Analysis of Cancer Whole Genomes in Multiple Computing Environments

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A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

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pheno-seq - linking morphological features to gene expression in 3D cell culture systems

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Deciphering programs of transcriptional regulation by combined deconvolution of multiple omics layers

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Questioning unexpected CRISPR off-target mutations in vivo

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Genomic footprints of activated telomere maintenance mechanisms in cancer

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  • Site-wide: 35,724 out of 84,647

Segmentation-free inference of cell-types from in situ transcriptomics data

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  • In bioinformatics: 1,194 out of 8,116
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ACEseq - allele specific copy number estimation from whole genome sequencing

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  • Site-wide: 11,593 out of 84,647

Framework For Quality Assessment Of Whole Genome, Cancer Sequences

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  • Site-wide: 31,107 out of 84,647

Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations

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  • In cancer biology: 375 out of 2,965
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Identification and prioritisation of causal variants in human genetic disorders from exome or whole genome sequencing data

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  • Site-wide: 9,610 out of 84,647

Dissecting intratumor heterogeneity of nodal B cell lymphomas on the transcriptional, genetic, and drug response level

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  • Site-wide: 4,866 out of 84,647

HTSlib-js: Developer toolkit for a client-side JavaScript interface for HTSlib

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