Author: Matthias Schlesner

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Preprints

The evolutionary history of 2,658 cancers

• Downloaded 9,450 times
• Download rankings, all-time:
  • Site-wide: 802
  • In cancer biology: 8
• Year to date:
  • Site-wide: 22,976
• Since beginning of last month:
  • Site-wide: 14,704

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

• Downloaded 5,632 times
• Download rankings, all-time:
  • Site-wide: 1,596
  • In cancer biology: 21
• Year to date:
  • Site-wide: 3,611
• Since beginning of last month:
  • Site-wide: 3,020

Germline determinants of the somatic mutation landscape in 2,642 cancer genomes

• Downloaded 5,298 times
• Download rankings, all-time:
  • Site-wide: 1,720
  • In genomics: 174
• Year to date:
  • Site-wide: 13,962
• Since beginning of last month:
  • Site-wide: 9,450

Computational Pan-Genomics: Status, Promises and Challenges

• Downloaded 4,605 times
• Download rankings, all-time:
  • Site-wide: 2,086
  • In genomics: 226
• Year to date:
  • Site-wide: 17,622
• Since beginning of last month:
  • Site-wide: 25,120

A Comprehensive Assessment of Somatic Mutation Calling in Cancer Genomes

• Downloaded 2,400 times
• Download rankings, all-time:
  • Site-wide: 5,349
  • In genomics: 628
• Year to date:
  • Site-wide: 84,570
• Since beginning of last month:
  • Site-wide: 60,389

Large-Scale Uniform Analysis of Cancer Whole Genomes in Multiple Computing Environments

• Downloaded 2,307 times
• Download rankings, all-time:
  • Site-wide: 5,674
  • In genomics: 662
• Year to date:
  • Site-wide: 27,585
• Since beginning of last month:
  • Site-wide: 37,402

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

• Downloaded 2,146 times
• Download rankings, all-time:
  • Site-wide: 6,284
  • In genomics: 722
• Year to date:
  • Site-wide: 89,792
• Since beginning of last month:
  • Site-wide: 93,905

Cell segmentation-free inference of cell types from in situ transcriptomics data

• Downloaded 2,066 times
• Download rankings, all-time:
  • Site-wide: 6,640
  • In bioinformatics: 794
• Year to date:
  • Site-wide: 4,094
• Since beginning of last month:
  • Site-wide: 3,397

pheno-seq - linking morphological features to gene expression in 3D cell culture systems

• Downloaded 1,812 times
• Download rankings, all-time:
  • Site-wide: 8,066
  • In genomics: 906
• Year to date:
  • Site-wide: 41,946
• Since beginning of last month:
  • Site-wide: 32,259

Deciphering programs of transcriptional regulation by combined deconvolution of multiple omics layers

• Downloaded 1,639 times
• Download rankings, all-time:
  • Site-wide: 9,412
  • In genomics: 1,055
• Year to date:
  • Site-wide: 52,137
• Since beginning of last month:
  • Site-wide: 37,081

Questioning unexpected CRISPR off-target mutations in vivo

• Downloaded 1,476 times
• Download rankings, all-time:
  • Site-wide: 10,960
  • In genomics: 1,218
• Year to date:
  • Site-wide: 98,971
• Since beginning of last month:
  • Site-wide: 67,408

Genomic footprints of activated telomere maintenance mechanisms in cancer

• Downloaded 1,455 times
• Download rankings, all-time:
  • Site-wide: 11,182
  • In genomics: 1,248
• Year to date:
  • Site-wide: 82,546
• Since beginning of last month:
  • Site-wide: 60,289

ACEseq - allele specific copy number estimation from whole genome sequencing

• Downloaded 1,322 times
• Download rankings, all-time:
  • Site-wide: 12,932
  • In bioinformatics: 1,594
• Year to date:
  • Site-wide: 44,797
• Since beginning of last month:
  • Site-wide: 42,089

Framework For Quality Assessment Of Whole Genome, Cancer Sequences

• Downloaded 1,067 times
• Download rankings, all-time:
  • Site-wide: 17,847
  • In genomics: 1,847
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Dissecting intratumor heterogeneity of nodal B cell lymphomas on the transcriptional, genetic, and drug response level

• Downloaded 1,019 times
• Download rankings, all-time:
  • Site-wide: 19,166
  • In cancer biology: 455
• Year to date:
  • Site-wide: 12,157
• Since beginning of last month:
  • Site-wide: 9,012

Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations

• Downloaded 935 times
• Download rankings, all-time:
  • Site-wide: 21,632
  • In cancer biology: 525
• Year to date:
  • Site-wide: 119,706
• Since beginning of last month:
  • Site-wide: None

Identification and prioritisation of causal variants in human genetic disorders from exome or whole genome sequencing data

• Downloaded 716 times
• Download rankings, all-time:
  • Site-wide: 31,528
  • In bioinformatics: 3,585
• Year to date:
  • Site-wide: 99,600
• Since beginning of last month:
  • Site-wide: 101,511

Globally altered epigenetic landscape and lagging osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone

• Downloaded 433 times
• Download rankings, all-time:
  • Site-wide: 58,181
  • In oncology: 66
• Year to date:
  • Site-wide: 100,555
• Since beginning of last month:
  • Site-wide: 73,061

HTSlib-js: Developer toolkit for a client-side JavaScript interface for HTSlib

• Downloaded 374 times
• Download rankings, all-time:
  • Site-wide: 67,169
  • In bioinformatics: 6,494
• Year to date:
  • Site-wide: 82,931
• Since beginning of last month:
  • Site-wide: 50,903

Reprogramming of stromal fibroblasts by chemotherapy-induced secretion of IFNβ1 drives re-growth of breast cancer cells after treatment.

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 102,173
  • In cancer biology: 3,134
• Year to date:
  • Site-wide: 105,192
• Since beginning of last month:
  • Site-wide: None