Author: Anders D Børglum

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

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  • Site-wide: 738
  • In genetics: 22
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 810
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Common risk variants identified in autism spectrum disorder

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  • Site-wide: 1,047
  • In genetics: 34
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  • Site-wide: 1,998
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  • Site-wide: 1,998

Psychiatric Genomics: An Update and an Agenda

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  • Site-wide: 52,890
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A Major Role for Common Genetic Variation in Anxiety Disorders

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  • Site-wide: 3,697
  • In genetics: 162
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Genetic analyses identify widespread sex-differential participation bias

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  • Site-wide: 3,766
  • In genetics: 170
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Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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  • Site-wide: 5,259
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  • Site-wide: 13,119
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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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  • Site-wide: 5,416
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• Year to date:
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Genome-wide analyses of self-reported empathy: correlations with autism, schizophrenia, and anorexia nervosa

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  • Site-wide: 6,540
  • In genomics: 748
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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 8,283
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ASD and ADHD have a similar burden of rare protein-truncating variants

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  • Site-wide: 8,685
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• Year to date:
  • Site-wide: 21,910
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Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

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  • Site-wide: 9,110
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• Year to date:
  • Site-wide: 78,133
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  • Site-wide: 78,133

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 9,228
  • In genetics: 456
• Year to date:
  • Site-wide: 16,509
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Genetic Architecture of 11 Major Psychiatric Disorders at Biobehavioral, Functional Genomic, and Molecular Genetic Levels of Analysis

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  • Site-wide: 11,743
  • In genetic and genomic medicine: 39
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A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 11,858
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  • Site-wide: 38,911
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Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort

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  • Site-wide: 13,651
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• Year to date:
  • Site-wide: 65,060
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A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

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  • Site-wide: 15,750
  • In genetics: 804
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  • Site-wide: 70,593
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Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.

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  • Site-wide: 16,651
  • In genetics: 845
• Year to date:
  • Site-wide: 82,275
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  • Site-wide: 82,275

Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

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  • Site-wide: 17,698
  • In genomics: 1,837
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  • Site-wide: 16,441
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  • Site-wide: 16,441

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

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  • Site-wide: 17,890
  • In genetics: 901
• Year to date:
  • Site-wide: 22,588
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  • Site-wide: 22,588

Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

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  • Site-wide: 17,951
  • In genomics: 1,861
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  • Site-wide: 46,511
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  • Site-wide: 46,511

Transcriptomic Imputation of Bipolar Disorder and Bipolar subtypes reveals 29 novel associated genes

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  • Site-wide: 21,811
  • In genetics: 1,076
• Year to date:
  • Site-wide: 48,975
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  • Site-wide: 48,975

Complex spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes

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  • Site-wide: 23,506
  • In genomics: 2,293
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  • Site-wide: 69,891

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 24,467
  • In genetics: 1,216
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Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 25,406
  • In genetics: 1,264
• Year to date:
  • Site-wide: 60,618
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  • Site-wide: 60,618

Shared risk alleles with discordant polygenic effects: Disentangling the genetic overlap between ASD and ADHD

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  • Site-wide: 26,457
  • In genetics: 1,322
• Year to date:
  • Site-wide: 65,842
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  • Site-wide: 65,842

Genetic markers of ADHD-related variations in intracranial volume

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  • Site-wide: 26,632
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• Year to date:
  • Site-wide: 49,051
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  • Site-wide: 49,051

The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders

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  • Site-wide: 28,331
  • In genetics: 1,413
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  • Site-wide: 43,649
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Social and non-social autism symptom and trait domains are genetically dissociable

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  • Site-wide: 29,351
  • In genetics: 1,462
• Year to date:
  • Site-wide: 35,561
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  • Site-wide: 35,561

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

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  • Site-wide: 30,831
  • In genetics: 1,532
• Year to date:
  • Site-wide: 65,215
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  • Site-wide: 65,215

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

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  • Site-wide: 32,829
  • In genetics: 1,626
• Year to date:
  • Site-wide: 63,725
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  • Site-wide: 63,725

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 33,496
  • In genetics: 1,652
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  • Site-wide: 17,350
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  • Site-wide: 17,350

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

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  • Site-wide: 33,546
  • In genetics: 1,654
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  • Site-wide: 70,206
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  • Site-wide: 70,206

Investigating the Association Between Body Fat and Depression via Mendelian Randomization

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  • Site-wide: 34,243
  • In genetics: 1,680
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  • Site-wide: 96,244
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  • Site-wide: 96,244

The neurobiology of BRD1 implicates sex-biased dysregulation of nuclear receptor signaling in mental disorders

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  • Site-wide: 35,688
  • In neuroscience: 5,042
• Year to date:
  • Site-wide: 50,014
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  • Site-wide: 50,014

Elevated polygenic burden for autism is associated with differential DNA methylation at birth.

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  • Site-wide: 36,556
  • In genetics: 1,793
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  • Site-wide: 82,273

Identification of risk variants and characterization of the polygenic architecture of disruptive behavior disorders in the context of ADHD

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  • Site-wide: 42,791
  • In genomics: 3,518
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Estimating the functional impact of INDELs in transcription factor binding sites: a genome-wide landscape

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  • Site-wide: 44,998
  • In bioinformatics: 4,771
• Year to date:
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  • Site-wide: 107,607

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

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  • Site-wide: 48,532
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Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

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  • Site-wide: 57,119
  • In genetics: 2,702
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  • Site-wide: 25,938
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  • Site-wide: 25,938

Gestational-age-dependent development of the neonatal metabolome

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  • Site-wide: 57,635
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Meta-analysis of Scandinavian Schizophrenia Exomes

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  • Site-wide: 57,711
  • In genetics: 2,739
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  • Site-wide: 41,349
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  • Site-wide: 41,349

Does Neuroticism Cause Depression? A Mendelian Randomization Study

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  • Site-wide: 60,026
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Polygenic prediction of school performance in children with and without psychiatric disorders

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  • Site-wide: 77,687
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  • Site-wide: 53,683
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Genetic factors underlying the bidirectional relationship between autoimmune and mental disorders – findings from a Danish population-based study

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  • Site-wide: 86,297
  • In bioinformatics: 7,705
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Intellectual Disability-related genes increase ADHD risk and locomotor activity in Drosophila

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The iPSYCH2015 Case-Cohort sample: updated directions for unravelling genetic and environmental architectures of severe mental disorders

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  • Site-wide: 116,948
  • In epidemiology: 4,730
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  • Site-wide: 18,989
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Genome-wide association study of febrile seizures identifies seven new loci implicating fever response and neuronal excitability genes

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  • Site-wide: 119,044
  • In genetic and genomic medicine: 542
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