Author: Anders D Børglum

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

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  • Site-wide: 858
  • In genetics: 23
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 948
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Common risk variants identified in autism spectrum disorder

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  • Site-wide: 1,121
  • In genetics: 31
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A Major Role for Common Genetic Variation in Anxiety Disorders

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Genetic analyses identify widespread sex-differential participation bias

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  • Site-wide: 3,744
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Psychiatric Genomics: An Update and an Agenda

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  • Site-wide: 3,793
  • In genetics: 144
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Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 5,155
  • In psychiatry and clinical psychology: 20
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Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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  • Site-wide: 5,768
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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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  • Site-wide: 6,309
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• Year to date:
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Genome-wide analyses of self-reported empathy: correlations with autism, schizophrenia, and anorexia nervosa

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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 9,465
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  • Site-wide: 57,503
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Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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ASD and ADHD have a similar burden of rare protein-truncating variants

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Genetic Architecture of 11 Major Psychiatric Disorders at Biobehavioral, Functional Genomic, and Molecular Genetic Levels of Analysis

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  • In genetic and genomic medicine: 38
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Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

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  • Site-wide: 10,597
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  • Site-wide: 122,900
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A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 13,515
  • In genetics: 638
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  • Site-wide: 69,511
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  • Site-wide: 83,468

Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort

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  • Site-wide: 15,306
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Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 17,487
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• Year to date:
  • Site-wide: 5,155
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A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

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  • Site-wide: 17,868
  • In genetics: 852
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  • Site-wide: 91,007
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Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.

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  • Site-wide: 18,871
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• Year to date:
  • Site-wide: 95,261
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Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

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  • Site-wide: 19,203
  • In genomics: 1,901
• Year to date:
  • Site-wide: 36,983
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Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

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  • Site-wide: 19,415
  • In genetics: 924
• Year to date:
  • Site-wide: 43,223
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Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

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  • Site-wide: 19,546
  • In genomics: 1,931
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  • Site-wide: 45,672

Transcriptomic Imputation of Bipolar Disorder and Bipolar subtypes reveals 29 novel associated genes

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  • Site-wide: 23,556
  • In genetics: 1,109
• Year to date:
  • Site-wide: 58,393
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Complex spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes

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  • Site-wide: 25,948
  • In genomics: 2,416
• Year to date:
  • Site-wide: 78,648
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  • Site-wide: 82,658

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 28,583
  • In genetics: 1,350
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  • Site-wide: 91,422
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  • Site-wide: 107,682

Genetic markers of ADHD-related variations in intracranial volume

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  • Site-wide: 29,005
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  • Site-wide: 65,028
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  • Site-wide: 81,157

Shared risk alleles with discordant polygenic effects: Disentangling the genetic overlap between ASD and ADHD

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  • Site-wide: 29,175
  • In genetics: 1,376
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  • Site-wide: 128,705

Social and non-social autism symptom and trait domains are genetically dissociable

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  • Site-wide: 30,734
  • In genetics: 1,452
• Year to date:
  • Site-wide: 49,188
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The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders

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  • Site-wide: 32,251
  • In genetics: 1,518
• Year to date:
  • Site-wide: 92,928
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  • Site-wide: 108,316

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

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  • Site-wide: 35,142
  • In genetics: 1,646
• Year to date:
  • Site-wide: 110,259
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  • Site-wide: 133,338

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

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  • Site-wide: 35,820
  • In genetics: 1,673
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  • Site-wide: 78,587
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  • Site-wide: 81,393

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 36,281
  • In genetics: 1,694
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  • Site-wide: 45,259
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  • Site-wide: 67,616

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

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  • Site-wide: 37,118
  • In genetics: 1,728
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  • Site-wide: 89,948
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  • Site-wide: 118,646

The female protective effect against autism spectrum disorder

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  • Site-wide: 37,086
  • In genetic and genomic medicine: 134
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Investigating the Association Between Body Fat and Depression via Mendelian Randomization

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  • Site-wide: 37,423
  • In genetics: 1,739
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  • Site-wide: 68,617

The neurobiology of BRD1 implicates sex-biased dysregulation of nuclear receptor signaling in mental disorders

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  • Site-wide: 38,357
  • In neuroscience: 5,301
• Year to date:
  • Site-wide: 67,250
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Elevated polygenic burden for autism is associated with differential DNA methylation at birth.

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  • Site-wide: 41,794
  • In genetics: 1,929
• Year to date:
  • Site-wide: 124,349
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  • Site-wide: 133,858

Identification of risk variants and characterization of the polygenic architecture of disruptive behavior disorders in the context of ADHD

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  • Site-wide: 44,859
  • In genomics: 3,600
• Year to date:
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Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

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  • Site-wide: 47,338
  • In genetics: 2,159
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  • Site-wide: 13,916

Estimating the functional impact of INDELs in transcription factor binding sites: a genome-wide landscape

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  • Site-wide: 49,330
  • In bioinformatics: 5,097
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Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

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Gestational-age-dependent development of the neonatal metabolome

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  • Site-wide: 56,876
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Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder and case subgroups.

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  • Site-wide: 60,891
  • In psychiatry and clinical psychology: 207
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  • Site-wide: 6,500
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  • Site-wide: 938

Meta-analysis of Scandinavian Schizophrenia Exomes

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Does Neuroticism Cause Depression? A Mendelian Randomization Study

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  • Site-wide: 68,420
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  • Site-wide: 141,969
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Genetic factors underlying the bidirectional relationship between autoimmune and mental disorders – findings from a Danish population-based study

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  • Site-wide: 83,700
  • In bioinformatics: 7,547
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  • Site-wide: 55,601

Polygenic prediction of school performance in children with and without psychiatric disorders

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  • Site-wide: 84,388
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Intellectual Disability-related genes increase ADHD risk and locomotor activity in Drosophila

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The iPSYCH2015 Case-Cohort sample: updated directions for unravelling genetic and environmental architectures of severe mental disorders

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  • Site-wide: 99,640
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Genome-wide association study of febrile seizures identifies seven new loci implicating fever response and neuronal excitability genes

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  • Site-wide: 123,266
  • In genetic and genomic medicine: 627
• Year to date:
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  • Site-wide: 42,036

Accounting for age-of-onset and family history improves power in genome-wide association studies

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  • Site-wide: 124,709
  • In bioinformatics: 10,003
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  • Site-wide: 28,564
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  • Site-wide: 20,891

Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci

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  • Site-wide: 138,262
  • In genetic and genomic medicine: 750
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