Author: Anders Børglum

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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  • Site-wide: 779
  • In genetics: 18
• Year to date:
  • Site-wide: 3,703
• Since beginning of last month:
  • Site-wide: 12,181

Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

• Downloaded 10,415 times
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  • Site-wide: 909
  • In genetics: 23
• Year to date:
  • Site-wide: 8,309
• Since beginning of last month:
  • Site-wide: 31,785

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,444 times
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  • Site-wide: 1,011
  • In genetics: 26
• Year to date:
  • Site-wide: 46,750
• Since beginning of last month:
  • Site-wide: 73,195

Common risk variants identified in autism spectrum disorder

• Downloaded 8,485 times
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  • Site-wide: 1,172
  • In genetics: 30
• Year to date:
  • Site-wide: 2,680
• Since beginning of last month:
  • Site-wide: 5,313

A Major Role for Common Genetic Variation in Anxiety Disorders

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  • Site-wide: 3,743
  • In genetics: 132
• Year to date:
  • Site-wide: 6,142
• Since beginning of last month:
  • Site-wide: 12,000

Genetic analyses identify widespread sex-differential participation bias

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  • Site-wide: 3,801
  • In genetics: 136
• Year to date:
  • Site-wide: 5,878
• Since beginning of last month:
  • Site-wide: 7,893

Psychiatric Genomics: An Update and an Agenda

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  • Site-wide: 4,005
  • In genetics: 147
• Year to date:
  • Site-wide: 66,454
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  • Site-wide: 33,375

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

• Downloaded 2,857 times
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  • Site-wide: 5,169
  • In psychiatry and clinical psychology: 20
• Year to date:
  • Site-wide: 1,658
• Since beginning of last month:
  • Site-wide: 38,183

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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  • Site-wide: 5,993
  • In genetics: 256
• Year to date:
  • Site-wide: 23,380
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  • Site-wide: None

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

• Downloaded 2,411 times
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  • Site-wide: 6,659
  • In genetics: 292
• Year to date:
  • Site-wide: 96,939
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  • Site-wide: 62,318

Genome-wide analyses of self-reported empathy: correlations with autism, schizophrenia, and anorexia nervosa

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  • Site-wide: 7,694
  • In genomics: 803
• Year to date:
  • Site-wide: 42,170
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  • Site-wide: 24,035

Genetic Architecture of 11 Major Psychiatric Disorders at Biobehavioral, Functional Genomic, and Molecular Genetic Levels of Analysis

• Downloaded 1,914 times
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  • Site-wide: 9,339
  • In genetic and genomic medicine: 39
• Year to date:
  • Site-wide: 3,958
• Since beginning of last month:
  • Site-wide: 10,867

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 9,817
  • In genetics: 429
• Year to date:
  • Site-wide: 21,258
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  • Site-wide: 23,324

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 9,959
  • In genetics: 444
• Year to date:
  • Site-wide: 67,320
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  • Site-wide: 31,534

ASD and ADHD have a similar burden of rare protein-truncating variants

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  • Site-wide: 10,076
  • In genetics: 448
• Year to date:
  • Site-wide: 42,164
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  • Site-wide: 61,097

Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

• Downloaded 1,681 times
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  • Site-wide: 11,298
  • In genetics: 506
• Year to date:
  • Site-wide: 140,989
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  • Site-wide: None

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

• Downloaded 1,432 times
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  • Site-wide: 14,309
  • In genetics: 658
• Year to date:
  • Site-wide: 87,143
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  • Site-wide: None

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

• Downloaded 1,339 times
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  • Site-wide: 15,843
  • In genetics: 729
• Year to date:
  • Site-wide: 5,304
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  • Site-wide: 6,617

Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort

• Downloaded 1,327 times
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  • Site-wide: 16,077
  • In genetics: 738
• Year to date:
  • Site-wide: 80,444
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  • Site-wide: 73,090

A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

• Downloaded 1,187 times
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  • Site-wide: 18,956
  • In genetics: 881
• Year to date:
  • Site-wide: 109,134
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  • Site-wide: None

Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

• Downloaded 1,164 times
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  • Site-wide: 19,512
  • In genomics: 1,901
• Year to date:
  • Site-wide: 38,736
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  • Site-wide: 66,895

Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.

• Downloaded 1,150 times
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  • Site-wide: 19,889
  • In genetics: 920
• Year to date:
  • Site-wide: 107,772
• Since beginning of last month:
  • Site-wide: 61,509

Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

• Downloaded 1,140 times
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  • Site-wide: 20,152
  • In genomics: 1,937
• Year to date:
  • Site-wide: 59,504
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  • Site-wide: None

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

• Downloaded 1,135 times
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  • Site-wide: 20,275
  • In genetics: 936
• Year to date:
  • Site-wide: 51,407
• Since beginning of last month:
  • Site-wide: 88,853

Transcriptomic Imputation of Bipolar Disorder and Bipolar subtypes reveals 29 novel associated genes

• Downloaded 999 times
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  • Site-wide: 24,442
  • In genetics: 1,121
• Year to date:
  • Site-wide: 64,725
• Since beginning of last month:
  • Site-wide: 61,514

Complex spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes

• Downloaded 953 times
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  • Site-wide: 26,202
  • In genomics: 2,412
• Year to date:
  • Site-wide: 70,243
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  • Site-wide: None

Shared risk alleles with discordant polygenic effects: Disentangling the genetic overlap between ASD and ADHD

• Downloaded 870 times
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  • Site-wide: 29,746
  • In genetics: 1,367
• Year to date:
  • Site-wide: 77,112
• Since beginning of last month:
  • Site-wide: 84,458

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 866 times
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  • Site-wide: 29,978
  • In genetics: 1,378
• Year to date:
  • Site-wide: 103,482
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  • Site-wide: None

Genetic markers of ADHD-related variations in intracranial volume

• Downloaded 864 times
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  • Site-wide: 30,049
  • In genetics: 1,390
• Year to date:
  • Site-wide: 73,304
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  • Site-wide: None

Social and non-social autism symptom and trait domains are genetically dissociable

• Downloaded 829 times
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  • Site-wide: 31,850
  • In genetics: 1,470
• Year to date:
  • Site-wide: 57,373
• Since beginning of last month:
  • Site-wide: 73,137

The female protective effect against autism spectrum disorder

• Downloaded 796 times
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  • Site-wide: 33,709
  • In genetic and genomic medicine: 132
• Year to date:
  • Site-wide: 4,304
• Since beginning of last month:
  • Site-wide: 10,729

The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders

• Downloaded 789 times
• Download rankings, all-time:
  • Site-wide: 34,155
  • In genetics: 1,555
• Year to date:
  • Site-wide: 111,505
• Since beginning of last month:
  • Site-wide: None

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

• Downloaded 745 times
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  • Site-wide: 37,013
  • In genetics: 1,679
• Year to date:
  • Site-wide: 50,237
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  • Site-wide: None

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

• Downloaded 743 times
• Download rankings, all-time:
  • Site-wide: 37,130
  • In genetics: 1,683
• Year to date:
  • Site-wide: 125,918
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  • Site-wide: None

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

• Downloaded 735 times
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  • Site-wide: 37,694
  • In genetics: 1,702
• Year to date:
  • Site-wide: 93,362
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  • Site-wide: None

The neurobiology of BRD1 implicates sex-biased dysregulation of nuclear receptor signaling in mental disorders

• Downloaded 720 times
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  • Site-wide: 38,776
  • In neuroscience: 5,329
• Year to date:
  • Site-wide: 67,297
• Since beginning of last month:
  • Site-wide: 74,530

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

• Downloaded 716 times
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  • Site-wide: 39,099
  • In genetics: 1,754
• Year to date:
  • Site-wide: 105,365
• Since beginning of last month:
  • Site-wide: 83,248

Investigating the Association Between Body Fat and Depression via Mendelian Randomization

• Downloaded 712 times
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  • Site-wide: 39,358
  • In genetics: 1,769
• Year to date:
  • Site-wide: 103,714
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  • Site-wide: None

Elevated polygenic burden for autism is associated with differential DNA methylation at birth.

• Downloaded 654 times
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  • Site-wide: 44,027
  • In genetics: 1,968
• Year to date:
  • Site-wide: 136,697
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  • Site-wide: None

Identification of risk variants and characterization of the polygenic architecture of disruptive behavior disorders in the context of ADHD

• Downloaded 620 times
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  • Site-wide: 47,032
  • In genomics: 3,696
• Year to date:
  • Site-wide: 68,693
• Since beginning of last month:
  • Site-wide: 90,540

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

• Downloaded 604 times
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  • Site-wide: 48,592
  • In genetics: 2,160
• Year to date:
  • Site-wide: 28,565
• Since beginning of last month:
  • Site-wide: 99,135

Estimating the functional impact of INDELs in transcription factor binding sites: a genome-wide landscape

• Downloaded 575 times
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  • Site-wide: 51,781
  • In bioinformatics: 5,292
• Year to date:
  • Site-wide: 117,197
• Since beginning of last month:
  • Site-wide: 64,768

Gestational-age-dependent development of the neonatal metabolome

• Downloaded 541 times
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  • Site-wide: 55,752
  • In pediatrics: 77
• Year to date:
  • Site-wide: 47,902
• Since beginning of last month:
  • Site-wide: 17,900

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

• Downloaded 521 times
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  • Site-wide: 58,311
  • In genetics: 2,566
• Year to date:
  • Site-wide: 143,090
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  • Site-wide: 81,045

Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder and case subgroups.

• Downloaded 518 times
• Download rankings, all-time:
  • Site-wide: 58,620
  • In psychiatry and clinical psychology: 204
• Year to date:
  • Site-wide: 8,111
• Since beginning of last month:
  • Site-wide: 53,868

Meta-analysis of Scandinavian Schizophrenia Exomes

• Downloaded 492 times
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  • Site-wide: 62,155
  • In genetics: 2,755
• Year to date:
  • Site-wide: 71,896
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  • Site-wide: 91,965

Genetic correlates of phenotypic heterogeneity in autism

• Downloaded 467 times
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  • Site-wide: 65,858
  • In genetic and genomic medicine: 264
• Year to date:
  • Site-wide: 31,802
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  • Site-wide: 28,033

Does Neuroticism Cause Depression? A Mendelian Randomization Study

• Downloaded 428 times
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  • Site-wide: 72,131
  • In genetics: 3,171
• Year to date:
  • Site-wide: 150,461
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  • Site-wide: None

Polygenic prediction of school performance in children with and without psychiatric disorders

• Downloaded 361 times
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  • Site-wide: 84,464
  • In genetics: 3,691
• Year to date:
  • Site-wide: 85,977
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  • Site-wide: None

Genetic factors underlying the bidirectional relationship between autoimmune and mental disorders – findings from a Danish population-based study

• Downloaded 360 times
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  • Site-wide: 84,626
  • In bioinformatics: 7,649
• Year to date:
  • Site-wide: 68,525
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  • Site-wide: 87,637

The iPSYCH2015 Case-Cohort sample: updated directions for unravelling genetic and environmental architectures of severe mental disorders

• Downloaded 317 times
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  • Site-wide: 93,649
  • In epidemiology: 3,938
• Year to date:
  • Site-wide: 22,206
• Since beginning of last month:
  • Site-wide: 28,376

Intellectual Disability-related genes increase ADHD risk and locomotor activity in Drosophila

• Downloaded 303 times
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  • Site-wide: 96,940
  • In genetics: 4,165
• Year to date:
  • Site-wide: 99,569
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  • Site-wide: 88,423

Accounting for age-of-onset and family history improves power in genome-wide association studies

• Downloaded 300 times
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  • Site-wide: 97,703
  • In bioinformatics: 8,480
• Year to date:
  • Site-wide: 17,733
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  • Site-wide: 1,214

Genome-wide association study of febrile seizures identifies seven new loci implicating fever response and neuronal excitability genes

• Downloaded 250 times
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  • Site-wide: 109,528
  • In genetic and genomic medicine: 538
• Year to date:
  • Site-wide: 38,357
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  • Site-wide: 40,046

Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci

• Downloaded 123 times
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  • Site-wide: 139,442
  • In genetic and genomic medicine: 770
• Year to date:
  • Site-wide: 51,800
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  • Site-wide: 104,154

Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention deficit hyperactivity disorder

• Downloaded 10 times
• Download rankings, all-time:
  • Site-wide: 152,409
  • In psychiatry and clinical psychology: 957
• Year to date:
  • Site-wide: 152,362
• Since beginning of last month:
  • Site-wide: 7,232