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Author: David A. Agard

Rankings

  • All-time downloads: 210,124 (rank: 246 )
  • Categories:
    • biochemistry: 5,275 (rank: 373 )
    • biophysics: 21,292 (rank: 26 )
    • cell biology: 2,336 (rank: 2,332 )
    • microbiology: 5,165 (rank: 2,558 )
    • molecular biology: 907 (rank: 6,172 (tie) )
    • neuroscience: 702 (rank: 32,416 (tie) )
    • systems biology: 174,447 (rank: 18 (tie) )

Downloads per author, site-wide

Preprints

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

systems biology more details view paper
  • Downloaded 174,447 times
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    • Site-wide: 20
    • In systems biology: 1
  • Year to date:
    • Site-wide: 288
  • Since beginning of last month:
    • Site-wide: 305

Anisotropic Correction of Beam-induced Motion for Improved Single-particle Electron Cryo-microscopy

biophysics more details view paper
  • Downloaded 7,085 times
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    • Site-wide: 1,254
    • In biophysics: 13
  • Year to date:
    • Site-wide: 20,840
  • Since beginning of last month:
    • Site-wide: 24,910

A simple and robust procedure for preparing graphene-oxide cryo-EM grids

biophysics more details view paper
  • Downloaded 5,365 times
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    • Site-wide: 1,815
    • In biophysics: 20
  • Year to date:
    • Site-wide: 8,699
  • Since beginning of last month:
    • Site-wide: 8,471

A nucleus-like compartment shields bacteriophage DNA from CRISPR-Cas and restriction nucleases

microbiology more details view paper
  • Downloaded 2,843 times
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    • Site-wide: 4,476
    • In microbiology: 286
  • Year to date:
    • Site-wide: 39,184
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    • Site-wide: 42,758

Atomic structure of Hsp90:Cdc37:Cdk4 reveals Hsp90 regulates kinase via dramatic unfolding

biochemistry more details view paper
  • Downloaded 2,478 times
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    • Site-wide: 5,497
    • In biochemistry: 94
  • Year to date:
    • Site-wide: 97,134
  • Since beginning of last month:
    • Site-wide: 100,556

General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM

biophysics more details view paper
  • Downloaded 2,090 times
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    • Site-wide: 7,041
    • In biophysics: 137
  • Year to date:
    • Site-wide: 35,106
  • Since beginning of last month:
    • Site-wide: 29,796

A molecular pore spans the double membrane of the coronavirus replication organelle

microbiology more details view paper
  • Downloaded 1,529 times
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    • Site-wide: 11,188
    • In microbiology: 629
  • Year to date:
    • Site-wide: 29,527
  • Since beginning of last month:
    • Site-wide: 39,661

Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM

biophysics more details view paper
  • Downloaded 1,499 times
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    • Site-wide: 11,481
    • In biophysics: 266
  • Year to date:
    • Site-wide: 1,981
  • Since beginning of last month:
    • Site-wide: 2,162

Microtubules form by progressively faster tubulin accretion, not by nucleation-elongation

cell biology more details view paper
  • Downloaded 1,335 times
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    • Site-wide: 13,729
    • In cell biology: 399
  • Year to date:
    • Site-wide: 43,816
  • Since beginning of last month:
    • Site-wide: 38,609

Amino and PEG-Amino Graphene Oxide Grids Enrich and Protect Samples for High-resolution Single Particle Cryo-electron Microscopy

biophysics more details view paper
  • Downloaded 1,273 times
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    • Site-wide: 14,778
    • In biophysics: 361
  • Year to date:
    • Site-wide: 23,615
  • Since beginning of last month:
    • Site-wide: 25,546

The Atomic Structure of the Microtubule-Nucleating γ-Tubulin Small Complex and its Implications for Regulation

biophysics more details view paper
  • Downloaded 1,070 times
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    • Site-wide: 19,111
    • In biophysics: 505
  • Year to date:
    • Site-wide: 98,359
  • Since beginning of last month:
    • Site-wide: 105,882

Structural Basis of Mitochondrial Receptor Binding and GTP Driven Conformational Constriction by Dynamin-Related Protein 1

biophysics more details view paper
  • Downloaded 943 times
  • Download rankings, all-time:
    • Site-wide: 22,945
    • In biophysics: 634
  • Year to date:
    • Site-wide: 84,665
  • Since beginning of last month:
    • Site-wide: 115,708

Mind the gap: micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae

microbiology more details view paper
  • Downloaded 793 times
  • Download rankings, all-time:
    • Site-wide: 29,290
    • In microbiology: 1,727
  • Year to date:
    • Site-wide: 64,495
  • Since beginning of last month:
    • Site-wide: 38,792

GR chaperone cycle mechanism revealed by cryo-EM: reactivation of GR by the GR:Hsp90:p23 client-maturation complex

biophysics more details view paper
  • Downloaded 740 times
  • Download rankings, all-time:
    • Site-wide: 32,338
    • In biophysics: 1,001
  • Year to date:
    • Site-wide: 13,379
  • Since beginning of last month:
    • Site-wide: 11,545

GR chaperone cycle mechanism revealed by cryo-EM: inactivation of GR by GR:Hsp90:Hsp70:Hop client-loading complex

biochemistry more details view paper
  • Downloaded 665 times
  • Download rankings, all-time:
    • Site-wide: 37,314
    • In biochemistry: 913
  • Year to date:
    • Site-wide: 9,366
  • Since beginning of last month:
    • Site-wide: 11,828

Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1

molecular biology more details view paper
  • Downloaded 618 times
  • Download rankings, all-time:
    • Site-wide: 41,011
    • In molecular biology: 1,176
  • Year to date:
    • Site-wide: 91,968
  • Since beginning of last month:
    • Site-wide: 73,888

Electron Cryo-Tomography Provides Insight into Procentriole Architecture and Assembly Mechanism

cell biology more details view paper
  • Downloaded 583 times
  • Download rankings, all-time:
    • Site-wide: 44,079
    • In cell biology: 1,860
  • Year to date:
    • Site-wide: 133,574
  • Since beginning of last month:
    • Site-wide: 129,122

Spc110 N-Terminal Domains Act Independently to Mediate Stable γ-Tubulin Small Complex Binding and γ-Tubulin Ring Complex Assembly

biochemistry more details view paper
  • Downloaded 563 times
  • Download rankings, all-time:
    • Site-wide: 46,148
    • In biochemistry: 1,182
  • Year to date:
    • Site-wide: 84,526
  • Since beginning of last month:
    • Site-wide: 71,214

Modulation of mitochondrial Hsp90 (TRAP1) ATPase activity by calcium and magnesium

biochemistry more details view paper
  • Downloaded 562 times
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    • Site-wide: 46,159
    • In biochemistry: 1,189
  • Year to date:
    • Site-wide: 102,268
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    • Site-wide: 96,479

CM1-driven assembly and activation of Yeast γ-Tubulin Small Complex underlies microtubule nucleation

biochemistry more details view paper
  • Downloaded 469 times
  • Download rankings, all-time:
    • Site-wide: 57,047
    • In biochemistry: 1,497
  • Year to date:
    • Site-wide: 12,554
  • Since beginning of last month:
    • Site-wide: 6,043

Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1

biophysics more details view paper
  • Downloaded 462 times
  • Download rankings, all-time:
    • Site-wide: 57,886
    • In biophysics: 2,016
  • Year to date:
    • Site-wide: 28,606
  • Since beginning of last month:
    • Site-wide: 25,526

Mechanistic Origins of Dynamic Instability in Filaments from the Phage Tubulin, PhuZ

cell biology more details view paper
  • Downloaded 418 times
  • Download rankings, all-time:
    • Site-wide: 64,230
    • In cell biology: 2,873
  • Year to date:
    • Site-wide: 105,279
  • Since beginning of last month:
    • Site-wide: 85,412

Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates

biophysics more details view paper
  • Downloaded 410 times
  • Download rankings, all-time:
    • Site-wide: 65,494
    • In biophysics: 2,357
  • Year to date:
    • Site-wide: 38,289
  • Since beginning of last month:
    • Site-wide: 37,802

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

neuroscience more details view paper
  • Downloaded 357 times
  • Download rankings, all-time:
    • Site-wide: 74,526
    • In neuroscience: 11,354
  • Year to date:
    • Site-wide: 120,039
  • Since beginning of last month:
    • Site-wide: 122,130

Cryo-EM analysis of human mitochondrial Hsp90 in multiple tetrameric states

biophysics more details view paper
  • Downloaded 355 times
  • Download rankings, all-time:
    • Site-wide: 74,880
    • In biophysics: 2,776
  • Year to date:
    • Site-wide: 39,702
  • Since beginning of last month:
    • Site-wide: 41,716

Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism

neuroscience more details view paper
  • Downloaded 345 times
  • Download rankings, all-time:
    • Site-wide: 76,615
    • In neuroscience: 11,718
  • Year to date:
    • Site-wide: 48,623
  • Since beginning of last month:
    • Site-wide: 56,605

Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs

molecular biology more details view paper
  • Downloaded 289 times
  • Download rankings, all-time:
    • Site-wide: 88,082
    • In molecular biology: 2,598
  • Year to date:
    • Site-wide: 38,997
  • Since beginning of last month:
    • Site-wide: 39,715

The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles

biochemistry more details view paper
  • Downloaded 282 times
  • Download rankings, all-time:
    • Site-wide: 89,506
    • In biochemistry: 2,584
  • Year to date:
    • Site-wide: 115,618
  • Since beginning of last month:
    • Site-wide: 129,073

XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions

biochemistry more details view paper
  • Downloaded 256 times
  • Download rankings, all-time:
    • Site-wide: 95,136
    • In biochemistry: 2,757
  • Year to date:
    • Site-wide: 118,405
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    • Site-wide: 131,895

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