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Author: David A. Agard

Rankings

  • All-time downloads: 198,461 (rank: 90 out of 428,651)
  • Categories:
    • biochemistry: 3,950 (rank: 425 out of 20,842)
    • biophysics: 17,784 (rank: 31 out of 18,245)
    • cell biology: 2,163 (rank: 1,929 out of 33,061)
    • microbiology: 4,808 (rank: 1,970 out of 50,987)
    • molecular biology: 711 (rank: 6,556 (tie) out of 23,547)
    • neuroscience: 575 (rank: 31,722 (tie) out of 72,544)
    • systems biology: 168,470 (rank: 18 (tie) out of 12,514)

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Preprints

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

systems biology more details view paper
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    • In systems biology: 1 out of 2,575
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Anisotropic Correction of Beam-induced Motion for Improved Single-particle Electron Cryo-microscopy

biophysics more details view paper
  • Downloaded 6,863 times
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    • In biophysics: 11 out of 4,481
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A simple and robust procedure for preparing graphene-oxide cryo-EM grids

biophysics more details view paper
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    • In biophysics: 18 out of 4,481
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A nucleus-like compartment shields bacteriophage DNA from CRISPR-Cas and restriction nucleases

microbiology more details view paper
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Atomic structure of Hsp90:Cdc37:Cdk4 reveals Hsp90 regulates kinase via dramatic unfolding

biochemistry more details view paper
  • Downloaded 2,419 times
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    • In biochemistry: 74 out of 3,464
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General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM

biophysics more details view paper
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A molecular pore spans the double membrane of the coronavirus replication organelle

microbiology more details view paper
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    • In microbiology: 552 out of 9,019
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Microtubules form by progressively faster tubulin accretion, not by nucleation-elongation

cell biology more details view paper
  • Downloaded 1,222 times
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    • In cell biology: 359 out of 5,256
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    • Site-wide: 24,619 out of 101,463

Amino and PEG-Amino Graphene Oxide Grids Enrich and Protect Samples for High-resolution Single Particle Cryo-electron Microscopy

biophysics more details view paper
  • Downloaded 1,092 times
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    • Site-wide: 11,668 out of 101,463
    • In biophysics: 364 out of 4,481
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The Atomic Structure of the Microtubule-Nucleating γ-Tubulin Small Complex and its Implications for Regulation

biophysics more details view paper
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    • In biophysics: 425 out of 4,481
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Structural Basis of Mitochondrial Receptor Binding and GTP Driven Conformational Constriction by Dynamin-Related Protein 1

biophysics more details view paper
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    • In biophysics: 535 out of 4,481
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    • Site-wide: 61,439 out of 101,463

Mind the gap: micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae

microbiology more details view paper
  • Downloaded 724 times
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    • In microbiology: 1,499 out of 9,019
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    • Site-wide: 56,650 out of 101,463
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    • Site-wide: 50,162 out of 101,463

Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1

molecular biology more details view paper
  • Downloaded 576 times
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    • Site-wide: 30,494 out of 101,463
    • In molecular biology: 1,006 out of 3,519
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    • Site-wide: 61,035 out of 101,463

Electron Cryo-Tomography Provides Insight into Procentriole Architecture and Assembly Mechanism

cell biology more details view paper
  • Downloaded 563 times
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    • Site-wide: 31,415 out of 101,463
    • In cell biology: 1,497 out of 5,256
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    • Site-wide: 88,243 out of 101,463

Modulation of mitochondrial Hsp90 (TRAP1) ATPase activity by calcium and magnesium

biochemistry more details view paper
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    • In biochemistry: 986 out of 3,464
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Spc110 N-Terminal Domains Act Independently to Mediate Stable γ-Tubulin Small Complex Binding and γ-Tubulin Ring Complex Assembly

biochemistry more details view paper
  • Downloaded 521 times
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    • In biochemistry: 1,001 out of 3,464
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GR chaperone cycle mechanism revealed by cryo-EM: reactivation of GR by the GR:Hsp90:p23 client-maturation complex

biophysics more details view paper
  • Downloaded 431 times
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    • Site-wide: 43,461 out of 101,463
    • In biophysics: 1,748 out of 4,481
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    • Site-wide: 9,695 out of 101,463
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    • Site-wide: 714 out of 101,463

Mechanistic Origins of Dynamic Instability in Filaments from the Phage Tubulin, PhuZ

cell biology more details view paper
  • Downloaded 378 times
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    • In cell biology: 2,525 out of 5,256
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Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

neuroscience more details view paper
  • Downloaded 327 times
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    • In neuroscience: 10,124 out of 18,074
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    • Site-wide: 86,893 out of 101,463

Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1

biophysics more details view paper
  • Downloaded 291 times
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    • In biophysics: 2,696 out of 4,481
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    • Site-wide: 17,481 out of 101,463
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    • Site-wide: 5,248 out of 101,463

Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates

biophysics more details view paper
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    • Site-wide: 68,619 out of 101,463
    • In biophysics: 3,004 out of 4,481
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The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles

biochemistry more details view paper
  • Downloaded 254 times
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    • Site-wide: 69,139 out of 101,463
    • In biochemistry: 2,215 out of 3,464
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Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism

neuroscience more details view paper
  • Downloaded 248 times
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    • In neuroscience: 12,467 out of 18,074
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    • Site-wide: 18,363 out of 101,463

XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions

biochemistry more details view paper
  • Downloaded 229 times
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    • Site-wide: 73,719 out of 101,463
    • In biochemistry: 2,369 out of 3,464
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Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs

molecular biology more details view paper
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    • Site-wide: 89,399 out of 101,463
    • In molecular biology: 3,027 out of 3,519
  • Year to date:
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    • Site-wide: 4,680 out of 101,463

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