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Author: David A Agard

Rankings

  • All-time downloads: 232,552 (rank: 431 )
  • Categories:
    • biochemistry: 6,607 (rank: 617 )
    • biophysics: 30,581 (rank: 10 )
    • cell biology: 3,720 (rank: 1,760 )
    • microbiology: 5,624 (rank: 3,569 (tie) )
    • molecular biology: 1,241 (rank: 6,323 (tie) )
    • neuroscience: 837 (rank: 38,657 (tie) )
    • systems biology: 178,840 (rank: 20 (tie) )

Downloads per author, site-wide

Preprints

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

systems biology more details view paper
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Anisotropic Correction of Beam-induced Motion for Improved Single-particle Electron Cryo-microscopy

biophysics more details view paper
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    • Site-wide: 1,845
    • In biophysics: 17
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A simple and robust procedure for preparing graphene-oxide cryo-EM grids

biophysics more details view paper
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    • Site-wide: 2,557
    • In biophysics: 26
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Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM

biophysics more details view paper
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CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

biophysics more details view paper
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    • Site-wide: 5,333
    • In biophysics: 89
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A nucleus-like compartment shields bacteriophage DNA from CRISPR-Cas and restriction nucleases

microbiology more details view paper
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    • In microbiology: 391
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Atomic structure of Hsp90:Cdc37:Cdk4 reveals Hsp90 regulates kinase via dramatic unfolding

biochemistry more details view paper
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    • Site-wide: 8,246
    • In biochemistry: 135
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General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM

biophysics more details view paper
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    • In biophysics: 172
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A molecular pore spans the double membrane of the coronavirus replication organelle

microbiology more details view paper
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    • Site-wide: 13,728
    • In microbiology: 779
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Amino and PEG-Amino Graphene Oxide Grids Enrich and Protect Samples for High-resolution Single Particle Cryo-electron Microscopy

biophysics more details view paper
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    • Site-wide: 17,633
    • In biophysics: 394
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Structures of the active HER2/HER3 receptor complex reveal dynamics at the dimerization interface induced by binding of a single ligand

biophysics more details view paper
  • Downloaded 1,520 times
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    • Site-wide: 17,927
    • In biophysics: 472
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Microtubules form by progressively faster tubulin accretion, not by nucleation-elongation

cell biology more details view paper
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    • Site-wide: 18,191
    • In cell biology: 502
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GR chaperone cycle mechanism revealed by cryo-EM: inactivation of GR by GR:Hsp90:Hsp70:Hop client-loading complex

biochemistry more details view paper
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    • Site-wide: 24,014
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The Atomic Structure of the Microtubule-Nucleating γ-Tubulin Small Complex and its Implications for Regulation

biophysics more details view paper
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    • Site-wide: 26,700
    • In biophysics: 666
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    • Site-wide: 146,749
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    • Site-wide: 147,371

GR chaperone cycle mechanism revealed by cryo-EM: reactivation of GR by the GR:Hsp90:p23 client-maturation complex

biophysics more details view paper
  • Downloaded 1,142 times
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    • Site-wide: 27,908
    • In biophysics: 731
  • Year to date:
    • Site-wide: 75,297
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AreTomo: An integrated software package for automated marker-free, motion-corrected cryo-electron tomographic alignment and reconstruction

cell biology more details view paper
  • Downloaded 1,119 times
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    • Site-wide: 28,740
    • In cell biology: 2,679
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    • Site-wide: 1,414
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    • Site-wide: 5,040

Structural Basis of Mitochondrial Receptor Binding and GTP Driven Conformational Constriction by Dynamin-Related Protein 1

biophysics more details view paper
  • Downloaded 1,058 times
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    • Site-wide: 31,274
    • In biophysics: 825
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In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes

biophysics more details view paper
  • Downloaded 976 times
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    • Site-wide: 35,253
    • In biophysics: None
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Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1

biophysics more details view paper
  • Downloaded 930 times
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    • Site-wide: 37,916
    • In biophysics: 1,396
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Mind the gap: micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae

microbiology more details view paper
  • Downloaded 923 times
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    • Site-wide: 38,348
    • In microbiology: 2,111
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    • Site-wide: 138,714
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    • Site-wide: 133,129

Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1

molecular biology more details view paper
  • Downloaded 813 times
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    • Site-wide: 46,154
    • In molecular biology: 1,211
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    • Site-wide: 73,661

CM1-driven assembly and activation of Yeast γ-Tubulin Small Complex underlies microtubule nucleation

biochemistry more details view paper
  • Downloaded 748 times
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    • Site-wide: 52,205
    • In biochemistry: 1,339
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    • Site-wide: 59,598

Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates

biophysics more details view paper
  • Downloaded 707 times
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    • Site-wide: 56,376
    • In biophysics: 1,987
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    • Site-wide: 41,981
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Entropy Regularized Deconvolution of Cellular Cryo-Transmission Electron Tomograms

biophysics more details view paper
  • Downloaded 688 times
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    • Site-wide: 58,624
    • In biophysics: 1,927
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    • Site-wide: 60,696
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Electron Cryo-Tomography Provides Insight into Procentriole Architecture and Assembly Mechanism

cell biology more details view paper
  • Downloaded 683 times
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    • Site-wide: 59,288
    • In cell biology: 2,404
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    • Site-wide: 128,720
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    • Site-wide: 171,217

Cryo-EM analysis of human mitochondrial Hsp90 in multiple tetrameric states

biophysics more details view paper
  • Downloaded 671 times
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    • Site-wide: 60,763
    • In biophysics: 2,129
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    • Site-wide: 45,301
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Modulation of mitochondrial Hsp90 (TRAP1) ATPase activity by calcium and magnesium

biochemistry more details view paper
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    • Site-wide: 64,335
    • In biochemistry: 1,632
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    • Site-wide: 113,370
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Spc110 N-Terminal Domains Act Independently to Mediate Stable γ-Tubulin Small Complex Binding and γ-Tubulin Ring Complex Assembly

biochemistry more details view paper
  • Downloaded 642 times
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    • Site-wide: 64,360
    • In biochemistry: 1,587
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    • Site-wide: 182,842
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The {varphi}PA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice

biochemistry more details view paper
  • Downloaded 563 times
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    • Site-wide: 76,059
    • In biochemistry: None
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    • Site-wide: 4,179
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Mechanistic Origins of Dynamic Instability in Filaments from the Phage Tubulin, PhuZ

cell biology more details view paper
  • Downloaded 522 times
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    • Site-wide: 83,295
    • In cell biology: 3,508
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Electron Cryo-Tomography Structure of Axonemal Doublet Microtubule from Tetrahymena thermophila

cell biology more details view paper
  • Downloaded 480 times
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    • Site-wide: 91,906
    • In cell biology: 4,045
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    • Site-wide: 100,555
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Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs

molecular biology more details view paper
  • Downloaded 472 times
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    • Site-wide: 93,532
    • In molecular biology: 2,564
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    • Site-wide: 152,843
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Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism

neuroscience more details view paper
  • Downloaded 454 times
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    • Site-wide: 97,588
    • In neuroscience: 13,299
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Structural features of mTORC2 that control substrate-specific activities.

biochemistry more details view paper
  • Downloaded 446 times
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    • Site-wide: 99,312
    • In biochemistry: 3,927
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Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

neuroscience more details view paper
  • Downloaded 402 times
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    • Site-wide: 109,824
    • In neuroscience: 14,997
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XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions

biochemistry more details view paper
  • Downloaded 345 times
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    • Site-wide: 125,191
    • In biochemistry: 3,425
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The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles

biochemistry more details view paper
  • Downloaded 318 times
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    • Site-wide: 132,869
    • In biochemistry: 3,658
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