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Author: David A. Agard

Rankings

  • All-time downloads: 205,265 (rank: 247 )
  • Categories:
    • biochemistry: 4,826 (rank: 372 )
    • biophysics: 19,864 (rank: 26 )
    • cell biology: 2,263 (rank: 2,060 (tie) )
    • microbiology: 4,996 (rank: 2,263 )
    • molecular biology: 837 (rank: 6,098 )
    • neuroscience: 650 (rank: 31,527 (tie) )
    • systems biology: 171,829 (rank: 18 (tie) )

Downloads per author, site-wide

Preprints

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

systems biology more details view paper
  • Downloaded 171,829 times
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    • Site-wide: 19
    • In systems biology: 1
  • Year to date:
    • Site-wide: 183
  • Since beginning of last month:
    • Site-wide: 245

Anisotropic Correction of Beam-induced Motion for Improved Single-particle Electron Cryo-microscopy

biophysics more details view paper
  • Downloaded 6,970 times
  • Download rankings, all-time:
    • Site-wide: 1,115
    • In biophysics: 12
  • Year to date:
    • Site-wide: 28,744
  • Since beginning of last month:
    • Site-wide: 26,141

A simple and robust procedure for preparing graphene-oxide cryo-EM grids

biophysics more details view paper
  • Downloaded 5,150 times
  • Download rankings, all-time:
    • Site-wide: 1,659
    • In biophysics: 18
  • Year to date:
    • Site-wide: 7,968
  • Since beginning of last month:
    • Site-wide: 13,501

A nucleus-like compartment shields bacteriophage DNA from CRISPR-Cas and restriction nucleases

microbiology more details view paper
  • Downloaded 2,790 times
  • Download rankings, all-time:
    • Site-wide: 3,991
    • In microbiology: 253
  • Year to date:
    • Site-wide: 18,628
  • Since beginning of last month:
    • Site-wide: 42,639

Atomic structure of Hsp90:Cdc37:Cdk4 reveals Hsp90 regulates kinase via dramatic unfolding

biochemistry more details view paper
  • Downloaded 2,458 times
  • Download rankings, all-time:
    • Site-wide: 4,828
    • In biochemistry: 84
  • Year to date:
    • Site-wide: 100,221
  • Since beginning of last month:
    • Site-wide: 45,955

General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM

biophysics more details view paper
  • Downloaded 2,017 times
  • Download rankings, all-time:
    • Site-wide: 6,467
    • In biophysics: 126
  • Year to date:
    • Site-wide: 68,573
  • Since beginning of last month:
    • Site-wide: 20,097

A molecular pore spans the double membrane of the coronavirus replication organelle

microbiology more details view paper
  • Downloaded 1,450 times
  • Download rankings, all-time:
    • Site-wide: 10,590
    • In microbiology: 590
  • Year to date:
    • Site-wide: 24,206
  • Since beginning of last month:
    • Site-wide: 25,600

Microtubules form by progressively faster tubulin accretion, not by nucleation-elongation

cell biology more details view paper
  • Downloaded 1,284 times
  • Download rankings, all-time:
    • Site-wide: 12,714
    • In cell biology: 374
  • Year to date:
    • Site-wide: 31,065
  • Since beginning of last month:
    • Site-wide: 33,463

Amino and PEG-Amino Graphene Oxide Grids Enrich and Protect Samples for High-resolution Single Particle Cryo-electron Microscopy

biophysics more details view paper
  • Downloaded 1,176 times
  • Download rankings, all-time:
    • Site-wide: 14,513
    • In biophysics: 357
  • Year to date:
    • Site-wide: 18,128
  • Since beginning of last month:
    • Site-wide: 34,927

The Atomic Structure of the Microtubule-Nucleating γ-Tubulin Small Complex and its Implications for Regulation

biophysics more details view paper
  • Downloaded 1,052 times
  • Download rankings, all-time:
    • Site-wide: 17,180
    • In biophysics: 456
  • Year to date:
    • Site-wide: 82,141
  • Since beginning of last month:
    • Site-wide: 104,613

Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM

biophysics more details view paper
  • Downloaded 968 times
  • Download rankings, all-time:
    • Site-wide: 19,424
    • In biophysics: 527
  • Year to date:
    • Site-wide: 782
  • Since beginning of last month:
    • Site-wide: 2,665

Structural Basis of Mitochondrial Receptor Binding and GTP Driven Conformational Constriction by Dynamin-Related Protein 1

biophysics more details view paper
  • Downloaded 920 times
  • Download rankings, all-time:
    • Site-wide: 20,910
    • In biophysics: 576
  • Year to date:
    • Site-wide: 78,241
  • Since beginning of last month:
    • Site-wide: 88,155

Mind the gap: micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae

microbiology more details view paper
  • Downloaded 756 times
  • Download rankings, all-time:
    • Site-wide: 27,635
    • In microbiology: 1,624
  • Year to date:
    • Site-wide: 101,809
  • Since beginning of last month:
    • Site-wide: 50,758

Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1

molecular biology more details view paper
  • Downloaded 600 times
  • Download rankings, all-time:
    • Site-wide: 37,576
    • In molecular biology: 1,075
  • Year to date:
    • Site-wide: 54,954
  • Since beginning of last month:
    • Site-wide: 85,376

GR chaperone cycle mechanism revealed by cryo-EM: reactivation of GR by the GR:Hsp90:p23 client-maturation complex

biophysics more details view paper
  • Downloaded 578 times
  • Download rankings, all-time:
    • Site-wide: 39,438
    • In biophysics: 1,318
  • Year to date:
    • Site-wide: 18,573
  • Since beginning of last month:
    • Site-wide: 22,882

Electron Cryo-Tomography Provides Insight into Procentriole Architecture and Assembly Mechanism

cell biology more details view paper
  • Downloaded 577 times
  • Download rankings, all-time:
    • Site-wide: 39,525
    • In cell biology: 1,639
  • Year to date:
    • Site-wide: 118,161
  • Since beginning of last month:
    • Site-wide: 114,545

Modulation of mitochondrial Hsp90 (TRAP1) ATPase activity by calcium and magnesium

biochemistry more details view paper
  • Downloaded 544 times
  • Download rankings, all-time:
    • Site-wide: 42,534
    • In biochemistry: 1,086
  • Year to date:
    • Site-wide: 109,389
  • Since beginning of last month:
    • Site-wide: 98,358

Spc110 N-Terminal Domains Act Independently to Mediate Stable γ-Tubulin Small Complex Binding and γ-Tubulin Ring Complex Assembly

biochemistry more details view paper
  • Downloaded 539 times
  • Download rankings, all-time:
    • Site-wide: 43,018
    • In biochemistry: 1,099
  • Year to date:
    • Site-wide: 91,918
  • Since beginning of last month:
    • Site-wide: 79,891

GR chaperone cycle mechanism revealed by cryo-EM: inactivation of GR by GR:Hsp90:Hsp70:Hop client-loading complex

biochemistry more details view paper
  • Downloaded 472 times
  • Download rankings, all-time:
    • Site-wide: 50,223
    • In biochemistry: 1,311
  • Year to date:
    • Site-wide: 5,636
  • Since beginning of last month:
    • Site-wide: 13,107

Mechanistic Origins of Dynamic Instability in Filaments from the Phage Tubulin, PhuZ

cell biology more details view paper
  • Downloaded 402 times
  • Download rankings, all-time:
    • Site-wide: 59,463
    • In cell biology: 2,649
  • Year to date:
    • Site-wide: 96,865
  • Since beginning of last month:
    • Site-wide: 68,353

Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1

biophysics more details view paper
  • Downloaded 383 times
  • Download rankings, all-time:
    • Site-wide: 62,416
    • In biophysics: 2,265
  • Year to date:
    • Site-wide: 17,890
  • Since beginning of last month:
    • Site-wide: 23,381

Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates

biophysics more details view paper
  • Downloaded 349 times
  • Download rankings, all-time:
    • Site-wide: 67,923
    • In biophysics: 2,529
  • Year to date:
    • Site-wide: 34,127
  • Since beginning of last month:
    • Site-wide: 38,034

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

neuroscience more details view paper
  • Downloaded 349 times
  • Download rankings, all-time:
    • Site-wide: 67,950
    • In neuroscience: 10,571
  • Year to date:
    • Site-wide: 56,537
  • Since beginning of last month:
    • Site-wide: 81,564

Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism

neuroscience more details view paper
  • Downloaded 301 times
  • Download rankings, all-time:
    • Site-wide: 76,443
    • In neuroscience: 11,967
  • Year to date:
    • Site-wide: 30,077
  • Since beginning of last month:
    • Site-wide: 33,442

Cryo-EM analysis of human mitochondrial Hsp90 in multiple tetrameric states

biophysics more details view paper
  • Downloaded 301 times
  • Download rankings, all-time:
    • Site-wide: 76,437
    • In biophysics: 2,920
  • Year to date:
    • Site-wide: 21,102
  • Since beginning of last month:
    • Site-wide: 19,165

CM1-driven assembly and activation of Yeast γ-Tubulin Small Complex underlies microtubule nucleation

biochemistry more details view paper
  • Downloaded 296 times
  • Download rankings, all-time:
    • Site-wide: 77,522
    • In biochemistry: 2,211
  • Year to date:
    • Site-wide: 20,946
  • Since beginning of last month:
    • Site-wide: 6,393

The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles

biochemistry more details view paper
  • Downloaded 273 times
  • Download rankings, all-time:
    • Site-wide: 81,962
    • In biochemistry: 2,364
  • Year to date:
    • Site-wide: 57,188
  • Since beginning of last month:
    • Site-wide: 94,834

XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions

biochemistry more details view paper
  • Downloaded 244 times
  • Download rankings, all-time:
    • Site-wide: 88,071
    • In biochemistry: 2,571
  • Year to date:
    • Site-wide: 107,121
  • Since beginning of last month:
    • Site-wide: 67,484

Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs

molecular biology more details view paper
  • Downloaded 237 times
  • Download rankings, all-time:
    • Site-wide: 89,597
    • In molecular biology: 2,680
  • Year to date:
    • Site-wide: 16,879
  • Since beginning of last month:
    • Site-wide: 19,472

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