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Author: Stefan Knapp

Rankings

  • All-time downloads: 14,571 (rank: 13,025 (tie) )
  • Categories:
    • biochemistry: 6,370 (rank: 301 (tie) )
    • biophysics: 3,552 (rank: 724 )
    • cancer biology: 533 (rank: 16,568 (tie) )
    • cell biology: 3,128 (rank: 1,530 (tie) )
    • pharmacology and toxicology: 988 (rank: 1,188 (tie) )

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Preprints

Parkinson's Disease-linked LRRK2 structure and model for microtubule interaction

biophysics more details view paper
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    • Site-wide: 5,000
    • In biophysics: 83
  • Year to date:
    • Site-wide: 15,772
  • Since beginning of last month:
    • Site-wide: 21,358

The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification

cell biology more details view paper
  • Downloaded 1,437 times
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    • Site-wide: 12,670
    • In cell biology: 352
  • Year to date:
    • Site-wide: 12,646
  • Since beginning of last month:
    • Site-wide: 8,438

A Chemical Toolbox for the Study of Bromodomains and Epigenetic Signaling

cell biology more details view paper
  • Downloaded 1,119 times
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    • Site-wide: 18,471
    • In cell biology: 601
  • Year to date:
    • Site-wide: 77,611
  • Since beginning of last month:
    • Site-wide: 71,839

Progress Towards a Public Chemogenomic Set for Protein Kinases and a Call for Contributions

pharmacology and toxicology more details view paper
  • Downloaded 988 times
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    • Site-wide: 22,089
    • In pharmacology and toxicology: 120
  • Year to date:
    • Site-wide: 90,157
  • Since beginning of last month:
    • Site-wide: 115,092

Crystallizing the Parkinson's Disease Protein LRRK2 Under Microgravity Conditions

biochemistry more details view paper
  • Downloaded 937 times
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    • Site-wide: 23,947
    • In biochemistry: 538
  • Year to date:
    • Site-wide: 84,823
  • Since beginning of last month:
    • Site-wide: 89,527

Halogen-aromatic π-interactions modulate inhibitor residence time

biophysics more details view paper
  • Downloaded 858 times
  • Download rankings, all-time:
    • Site-wide: 27,096
    • In biophysics: 800
  • Year to date:
    • Site-wide: 30,029
  • Since beginning of last month:
    • Site-wide: 17,069

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

biochemistry more details view paper
  • Downloaded 790 times
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    • Site-wide: 30,429
    • In biochemistry: 708
  • Year to date:
    • Site-wide: 29,533
  • Since beginning of last month:
    • Site-wide: 20,633

Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces

biochemistry more details view paper
  • Downloaded 704 times
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    • Site-wide: 35,693
    • In biochemistry: 868
  • Year to date:
    • Site-wide: 84,924
  • Since beginning of last month:
    • Site-wide: 90,394

SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)

cell biology more details view paper
  • Downloaded 572 times
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    • Site-wide: 46,543
    • In cell biology: 1,985
  • Year to date:
    • Site-wide: 84,905
  • Since beginning of last month:
    • Site-wide: 89,743

A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5

biochemistry more details view paper
  • Downloaded 533 times
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    • Site-wide: 50,678
    • In biochemistry: 1,309
  • Year to date:
    • Site-wide: 29,366
  • Since beginning of last month:
    • Site-wide: 25,280

Design, Synthesis and Evaluation of WD-repeat containing protein 5 (WDR5) degraders

cancer biology more details view paper
  • Downloaded 533 times
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    • Site-wide: 50,711
    • In cancer biology: 1,434
  • Year to date:
    • Site-wide: 3,780
  • Since beginning of last month:
    • Site-wide: 643

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

biochemistry more details view paper
  • Downloaded 439 times
  • Download rankings, all-time:
    • Site-wide: 62,774
    • In biochemistry: 1,700
  • Year to date:
    • Site-wide: 25,399
  • Since beginning of last month:
    • Site-wide: 29,403

A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL) YEATS domain

biochemistry more details view paper
  • Downloaded 412 times
  • Download rankings, all-time:
    • Site-wide: 67,144
    • In biochemistry: 1,847
  • Year to date:
    • Site-wide: 95,949
  • Since beginning of last month:
    • Site-wide: 113,846

p63 sets the threshold for induction of apoptosis using a kinetically encoded 'doorbell-like' mechanism

biochemistry more details view paper
  • Downloaded 335 times
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    • Site-wide: 80,816
    • In biochemistry: 2,296
  • Year to date:
    • Site-wide: 118,491
  • Since beginning of last month:
    • Site-wide: 132,724

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

biochemistry more details view paper
  • Downloaded 320 times
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    • Site-wide: 83,818
    • In biochemistry: 2,411
  • Year to date:
    • Site-wide: 50,597
  • Since beginning of last month:
    • Site-wide: 64,541

Structural insights into interaction mechanisms of alternative piperazine-urea YEATS domain binders in MLLT1

biochemistry more details view paper
  • Downloaded 319 times
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    • Site-wide: 83,965
    • In biochemistry: 2,415
  • Year to date:
    • Site-wide: 47,069
  • Since beginning of last month:
    • Site-wide: 30,427

Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor

biochemistry more details view paper
  • Downloaded 290 times
  • Download rankings, all-time:
    • Site-wide: 90,301
    • In biochemistry: 2,611
  • Year to date:
    • Site-wide: 29,003
  • Since beginning of last month:
    • Site-wide: 36,789

DFG-1 residue controls inhibitor binding mode and affinity providing a basis for rational design of kinase inhibitor selectivity

biochemistry more details view paper
  • Downloaded 239 times
  • Download rankings, all-time:
    • Site-wide: 101,622
    • In biochemistry: 2,978
  • Year to date:
    • Site-wide: 64,766
  • Since beginning of last month:
    • Site-wide: 106,039

Nucleotide binding, evolutionary insights and interaction partners of the pseudokinase Unc-51-like kinase 4

biochemistry more details view paper
  • Downloaded 237 times
  • Download rankings, all-time:
    • Site-wide: 102,017
    • In biochemistry: 2,992
  • Year to date:
    • Site-wide: 47,688
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    • Site-wide: 48,734

STK32A is a dual-specificity AGC kinase with a preference for acidic substrates

biochemistry more details view paper
  • Downloaded 208 times
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    • Site-wide: 108,636
    • In biochemistry: 3,197
  • Year to date:
    • Site-wide: 79,398
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    • Site-wide: 54,143

Catalytic domain plasticity of MKK7 reveals structural mechanisms of allosteric activation and new targeting opportunities

biochemistry more details view paper
  • Downloaded 185 times
  • Download rankings, all-time:
    • Site-wide: 113,755
    • In biochemistry: 3,393
  • Year to date:
    • Site-wide: 84,179
  • Since beginning of last month:
    • Site-wide: 122,142

Structure-based design of selective salt-inducible kinase (SIK) inhibitors

biochemistry more details view paper
  • Downloaded 167 times
  • Download rankings, all-time:
    • Site-wide: 117,723
    • In biochemistry: 3,536
  • Year to date:
    • Site-wide: 19,248
  • Since beginning of last month:
    • Site-wide: 3,305

Structure and inhibitor binding characterization of oncogenic MLLT1 mutants

biochemistry more details view paper
  • Downloaded 139 times
  • Download rankings, all-time:
    • Site-wide: 123,686
    • In biochemistry: 3,720
  • Year to date:
    • Site-wide: 24,062
  • Since beginning of last month:
    • Site-wide: 38,253

Structural insights into plasticity and discovery of remdesivir metabolite GS-441524 binding in SARS-CoV-2 macrodomain

biochemistry more details view paper
  • Downloaded 116 times
  • Download rankings, all-time:
    • Site-wide: 128,246
    • In biochemistry: 3,882
  • Year to date:
    • Site-wide: 29,646
  • Since beginning of last month:
    • Site-wide: 35,832

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