Author: Tao Wang

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Preprints

Clinical characteristics of 2019 novel coronavirus infection in China

• Downloaded 205,899 times
• Download rankings, all-time:
  • Site-wide: 15
  • In respiratory medicine: 1
• Year to date:
  • Site-wide: 387
• Since beginning of last month:
  • Site-wide: 979

Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis

• Downloaded 24,987 times
• Download rankings, all-time:
  • Site-wide: 313
  • In respiratory medicine: 4
• Year to date:
  • Site-wide: 5,624
• Since beginning of last month:
  • Site-wide: 22,130

Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target

• Downloaded 10,620 times
• Download rankings, all-time:
  • Site-wide: 896
  • In biochemistry: 8
• Year to date:
  • Site-wide: 4,126
• Since beginning of last month:
  • Site-wide: 2,285

Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types

• Downloaded 6,234 times
• Download rankings, all-time:
  • Site-wide: 1,774
  • In neuroscience: 86
• Year to date:
  • Site-wide: 2,092
• Since beginning of last month:
  • Site-wide: 57,388

Early Detection Of COVID-19 Using A Smartwatch

• Downloaded 5,319 times
• Download rankings, all-time:
  • Site-wide: 2,200
  • In infectious diseases: 546
• Year to date:
  • Site-wide: 4,198
• Since beginning of last month:
  • Site-wide: 77,284

Clinical and immunologic features in severe and moderate forms of Coronavirus Disease 2019

• Downloaded 4,508 times
• Download rankings, all-time:
  • Site-wide: 2,756
  • In infectious diseases: 621
• Year to date:
  • Site-wide: 28,355
• Since beginning of last month:
  • Site-wide: 73,836

Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2

• Downloaded 3,698 times
• Download rankings, all-time:
  • Site-wide: 3,665
  • In microbiology: 250
• Year to date:
  • Site-wide: 10,235
• Since beginning of last month:
  • Site-wide: 123,660

The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2

• Downloaded 3,482 times
• Download rankings, all-time:
  • Site-wide: 3,971
  • In bioinformatics: 377
• Year to date:
  • Site-wide: 40,746
• Since beginning of last month:
  • Site-wide: 102,115

Estimating the case fatality ratio of the COVID-19 epidemic in China

• Downloaded 3,303 times
• Download rankings, all-time:
  • Site-wide: 4,293
  • In infectious diseases: 824
• Year to date:
  • Site-wide: 27,369
• Since beginning of last month:
  • Site-wide: 90,026

Epigallocatechin Gallate from Green Tea Effectively Blocks Infection of SARS-CoV-2 and New Variants by Inhibiting Spike Binding to ACE2 Receptor

• Downloaded 2,574 times
• Download rankings, all-time:
  • Site-wide: 6,127
  • In microbiology: 377
• Year to date:
  • Site-wide: 956
• Since beginning of last month:
  • Site-wide: 32,661

Estimating the cure rate and case fatality rate of the ongoing epidemic COVID-19

• Downloaded 2,340 times
• Download rankings, all-time:
  • Site-wide: 7,056
  • In epidemiology: 589
• Year to date:
  • Site-wide: 69,631
• Since beginning of last month:
  • Site-wide: 81,082

Caution: The clinical characteristics of COVID-19 patients at admission are changing

• Downloaded 1,709 times
• Download rankings, all-time:
  • Site-wide: 11,199
  • In epidemiology: 824
• Year to date:
  • Site-wide: 78,946
• Since beginning of last month:
  • Site-wide: 124,180

The Evaluation of Sleep Disturbances for Chinese Frontline Medical Workers Under the Outbreak of COVID-19

• Downloaded 1,516 times
• Download rankings, all-time:
  • Site-wide: 13,274
  • In neurology: 30
• Year to date:
  • Site-wide: 38,314
• Since beginning of last month:
  • Site-wide: 39,516

RISC: robust integration of single-cell RNA-seq datasets with different extents of cell cluster overlap

• Downloaded 1,229 times
• Download rankings, all-time:
  • Site-wide: 18,323
  • In bioinformatics: 2,096
• Year to date:
  • Site-wide: 29,210
• Since beginning of last month:
  • Site-wide: 105,381

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,138 times
• Download rankings, all-time:
  • Site-wide: 20,538
  • In genetics: 943
• Year to date:
  • Site-wide: 8,951
• Since beginning of last month:
  • Site-wide: 5,336

SCINA: Semi-Supervised Analysis of Single Cells in silico

• Downloaded 1,109 times
• Download rankings, all-time:
  • Site-wide: 21,304
  • In bioinformatics: 2,433
• Year to date:
  • Site-wide: 83,406
• Since beginning of last month:
  • Site-wide: 103,601

Identification of a super-spreading chain of transmission associated with COVID-19

• Downloaded 983 times
• Download rankings, all-time:
  • Site-wide: 25,420
  • In infectious diseases: 2,161
• Year to date:
  • Site-wide: 51,584
• Since beginning of last month:
  • Site-wide: 89,938

Computational staining of pathology images to study tumor microenvironment in lung cancer

• Downloaded 979 times
• Download rankings, all-time:
  • Site-wide: 25,568
  • In bioinformatics: 2,889
• Year to date:
  • Site-wide: 46,360
• Since beginning of last month:
  • Site-wide: 29,471

Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC

• Downloaded 860 times
• Download rankings, all-time:
  • Site-wide: 30,825
  • In infectious diseases: 2,414
• Year to date:
  • Site-wide: 10,980
• Since beginning of last month:
  • Site-wide: 4,267

A community-based collaboration to build prediction models for short-term discontinuation of docetaxel in metastatic castration-resistant prostate cancer

• Downloaded 856 times
• Download rankings, all-time:
  • Site-wide: 31,001
  • In bioinformatics: 3,440
• Year to date:
  • Site-wide: 106,039
• Since beginning of last month:
  • Site-wide: 35,539

SCCNV: a software tool for identifying copy number variation from single-cell whole-genome sequencing

• Downloaded 812 times
• Download rankings, all-time:
  • Site-wide: 33,319
  • In bioinformatics: 3,661
• Year to date:
  • Site-wide: 139,224
• Since beginning of last month:
  • Site-wide: 104,167

The histone chaperone FACT modulates nucleosome structure by tethering its components

• Downloaded 722 times
• Download rankings, all-time:
  • Site-wide: 39,310
  • In biochemistry: 978
• Year to date:
  • Site-wide: 78,601
• Since beginning of last month:
  • Site-wide: 29,929

Overcoming Genetic Drop-outs in Variants-based Lineage Tracing from Single-cell RNA Sequencing Data

• Downloaded 696 times
• Download rankings, all-time:
  • Site-wide: 41,244
  • In bioinformatics: 4,402
• Year to date:
  • Site-wide: 55,844
• Since beginning of last month:
  • Site-wide: 114,148

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

• Downloaded 692 times
• Download rankings, all-time:
  • Site-wide: 41,529
  • In genomics: 3,356
• Year to date:
  • Site-wide: 106,156
• Since beginning of last month:
  • Site-wide: 53,221

New Role of Red Blood Cells in Absorption of DNA Bearing Tumorigenic Mutations from Lung Cancer Tissue

• Downloaded 667 times
• Download rankings, all-time:
  • Site-wide: 43,570
  • In oncology: 60
• Year to date:
  • Site-wide: 5,977
• Since beginning of last month:
  • Site-wide: 82,138

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

• Downloaded 616 times
• Download rankings, all-time:
  • Site-wide: 48,338
  • In genomics: 3,759
• Year to date:
  • Site-wide: 132,964
• Since beginning of last month:
  • Site-wide: 37,275

Large-scale Phenotypic Drug Screen Identifies Neuroprotectants in Zebrafish and Mouse Models of Retinitis Pigmentosa

• Downloaded 599 times
• Download rankings, all-time:
  • Site-wide: 49,965
  • In neuroscience: 7,084
• Year to date:
  • Site-wide: 32,515
• Since beginning of last month:
  • Site-wide: 94,920

Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer

• Downloaded 598 times
• Download rankings, all-time:
  • Site-wide: 50,082
  • In cancer biology: 1,423
• Year to date:
  • Site-wide: 22,167
• Since beginning of last month:
  • Site-wide: 4,980

Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

• Downloaded 579 times
• Download rankings, all-time:
  • Site-wide: 52,262
  • In genetics: 2,307
• Year to date:
  • Site-wide: 77,708
• Since beginning of last month:
  • Site-wide: 106,243

Targeted deletion of Nmnat1 in mouse retina leads to early severe retinal dystrophy

• Downloaded 527 times
• Download rankings, all-time:
  • Site-wide: 58,577
  • In developmental biology: 1,397
• Year to date:
  • Site-wide: 94,931
• Since beginning of last month:
  • Site-wide: 27,236

Estimation of COVID-19 case fatality ratio based on a bi-directional correction method

• Downloaded 500 times
• Download rankings, all-time:
  • Site-wide: 62,103
  • In epidemiology: 2,781
• Year to date:
  • Site-wide: 108,553
• Since beginning of last month:
  • Site-wide: 123,298

α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation

• Downloaded 494 times
• Download rankings, all-time:
  • Site-wide: 62,929
  • In molecular biology: 1,801
• Year to date:
  • Site-wide: 74,516
• Since beginning of last month:
  • Site-wide: 17,959

LPM: a latent probit model to characterize the relationship among complex traits using summary statistics from multiple GWASs and functional annotations

• Downloaded 494 times
• Download rankings, all-time:
  • Site-wide: 62,990
  • In genetics: 2,784
• Year to date:
  • Site-wide: 83,441
• Since beginning of last month:
  • Site-wide: 22,499

Spontaneous retrotranspositions in normal tissues are rare and associated with cell-type-specific differentiation

• Downloaded 430 times
• Download rankings, all-time:
  • Site-wide: 73,085
  • In genomics: 4,979
• Year to date:
  • Site-wide: 142,622
• Since beginning of last month:
  • Site-wide: None

Tumor Neoantigenicity Assessment with CSiN Score Incorporates Clonality and Immunogenicity to Predict Immunotherapy Outcomes

• Downloaded 418 times
• Download rankings, all-time:
  • Site-wide: 75,067
  • In bioinformatics: 7,003
• Year to date:
  • Site-wide: 99,932
• Since beginning of last month:
  • Site-wide: 28,811

PTPN22 interacts with EB1 to regulate T cell receptor signaling

• Downloaded 406 times
• Download rankings, all-time:
  • Site-wide: 77,312
  • In cell biology: 3,525
• Year to date:
  • Site-wide: 86,347
• Since beginning of last month:
  • Site-wide: 75,344

Shedding light on the control of CatSper Ca2+ channels by cAMP and chemicals used to probe cAMP signaling

• Downloaded 400 times
• Download rankings, all-time:
  • Site-wide: 78,289
  • In cell biology: 3,582
• Year to date:
  • Site-wide: 103,095
• Since beginning of last month:
  • Site-wide: None

Discovery of A New Class of Integrin Antibodies for Fibrosis

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 85,635
  • In pharmacology and toxicology: 563
• Year to date:
  • Site-wide: 45,021
• Since beginning of last month:
  • Site-wide: 80,188

Prediction of 7-year's Conversion from Subjective Cognitive Decline to Mild Cognitive Impairment

• Downloaded 360 times
• Download rankings, all-time:
  • Site-wide: 86,142
  • In geriatric medicine: 55
• Year to date:
  • Site-wide: 113,808
• Since beginning of last month:
  • Site-wide: 50,790

xQTLImp: efficient and accurate xQTL summary statistics imputation

• Downloaded 315 times
• Download rankings, all-time:
  • Site-wide: 95,849
  • In bioinformatics: 8,333
• Year to date:
  • Site-wide: 111,753
• Since beginning of last month:
  • Site-wide: 85,015

Prior hypoxia exposure enhances murine microglial inflammatory gene expression in vitro without concomitant H3K4me3 enrichment

• Downloaded 313 times
• Download rankings, all-time:
  • Site-wide: 96,309
  • In neuroscience: 14,500
• Year to date:
  • Site-wide: 116,494
• Since beginning of last month:
  • Site-wide: None

Celastrol directly inhibits PFKM to induce weight loss and leptin sensitization

• Downloaded 277 times
• Download rankings, all-time:
  • Site-wide: 104,736
  • In physiology: 980
• Year to date:
  • Site-wide: 79,965
• Since beginning of last month:
  • Site-wide: 51,543

A vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of COVID-19 and related diseases

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 116,100
  • In pharmacology and toxicology: 877
• Year to date:
  • Site-wide: 27,198
• Since beginning of last month:
  • Site-wide: 888

Association between temperature and back pain among lumbar disc herniation patients

• Downloaded 208 times
• Download rankings, all-time:
  • Site-wide: 121,986
  • In epidemiology: 5,124
• Year to date:
  • Site-wide: 106,354
• Since beginning of last month:
  • Site-wide: None

PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity

• Downloaded 200 times
• Download rankings, all-time:
  • Site-wide: 123,863
  • In cancer biology: 3,770
• Year to date:
  • Site-wide: 61,014
• Since beginning of last month:
  • Site-wide: None

Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients

• Downloaded 175 times
• Download rankings, all-time:
  • Site-wide: 129,793
  • In neuroscience: 19,562
• Year to date:
  • Site-wide: 38,157
• Since beginning of last month:
  • Site-wide: 127,606

De novo germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice

• Downloaded 151 times
• Download rankings, all-time:
  • Site-wide: 135,350
  • In immunology: 4,009
• Year to date:
  • Site-wide: 45,106
• Since beginning of last month:
  • Site-wide: 48,751

A novel framework for single-cell Hi-C clustering based on graph-convolution-based imputation and two-phase-based feature extraction

• Downloaded 143 times
• Download rankings, all-time:
  • Site-wide: 136,989
  • In bioinformatics: 10,697
• Year to date:
  • Site-wide: 47,778
• Since beginning of last month:
  • Site-wide: 89,021

Establishment and characterization of fibroblast cultures derived from a female common hippopotamus (Hippopotamus amphibius) skin biopsy

• Downloaded 135 times
• Download rankings, all-time:
  • Site-wide: 138,959
  • In cell biology: 6,346
• Year to date:
  • Site-wide: 103,591
• Since beginning of last month:
  • Site-wide: None

Time-restricted feeding near dawn entrains long-term behavioral changes through the suprachiasmatic nucleus

• Downloaded 133 times
• Download rankings, all-time:
  • Site-wide: 139,365
  • In physiology: 1,615
• Year to date:
  • Site-wide: 51,723
• Since beginning of last month:
  • Site-wide: None

Human microglia extensively reconstitute in humanized BLT mice with human interleukin-34 transgene and support HIV-1 brain infection

• Downloaded 62 times
• Download rankings, all-time:
  • Site-wide: 150,845
  • In microbiology: 11,679
• Year to date:
  • Site-wide: 98,706
• Since beginning of last month:
  • Site-wide: 122,819