Author: Tao Wang

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Preprints

Clinical characteristics of 2019 novel coronavirus infection in China

• Downloaded 200,526 times
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  • Site-wide: 15
  • In respiratory medicine: 1
• Year to date:
  • Site-wide: 430
• Since beginning of last month:
  • Site-wide: 266

Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis

• Downloaded 24,318 times
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  • Site-wide: 242
  • In respiratory medicine: 3
• Year to date:
  • Site-wide: 10,990
• Since beginning of last month:
  • Site-wide: 5,296

Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target

• Downloaded 9,793 times
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  • Site-wide: 717
  • In biochemistry: 7
• Year to date:
  • Site-wide: 6,143
• Since beginning of last month:
  • Site-wide: 2,904

Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types

• Downloaded 4,959 times
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  • Site-wide: 1,751
  • In neuroscience: 99
• Year to date:
  • Site-wide: 1,210
• Since beginning of last month:
  • Site-wide: 1,755

Early Detection Of COVID-19 Using A Smartwatch

• Downloaded 4,568 times
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  • Site-wide: 1,966
  • In infectious diseases: 422
• Year to date:
  • Site-wide: 1,559
• Since beginning of last month:
  • Site-wide: 1,233

Clinical and immunologic features in severe and moderate forms of Coronavirus Disease 2019

• Downloaded 4,315 times
• Download rankings, all-time:
  • Site-wide: 2,131
  • In infectious diseases: 441
• Year to date:
  • Site-wide: 8,487
• Since beginning of last month:
  • Site-wide: 18,322

The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2

• Downloaded 3,333 times
• Download rankings, all-time:
  • Site-wide: 3,115
  • In bioinformatics: 340
• Year to date:
  • Site-wide: 20,041
• Since beginning of last month:
  • Site-wide: 22,514

Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2

• Downloaded 3,267 times
• Download rankings, all-time:
  • Site-wide: 3,216
  • In microbiology: 210
• Year to date:
  • Site-wide: 7,253
• Since beginning of last month:
  • Site-wide: 10,987

Estimating the case fatality ratio of the COVID-19 epidemic in China

• Downloaded 3,087 times
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  • Site-wide: 3,500
  • In infectious diseases: 585
• Year to date:
  • Site-wide: 23,102
• Since beginning of last month:
  • Site-wide: 22,142

Estimating the cure rate and case fatality rate of the ongoing epidemic COVID-19

• Downloaded 2,248 times
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  • Site-wide: 5,536
  • In epidemiology: 451
• Year to date:
  • Site-wide: 57,834
• Since beginning of last month:
  • Site-wide: 40,549

Caution: The clinical characteristics of COVID-19 patients at admission are changing

• Downloaded 1,631 times
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  • Site-wide: 8,908
  • In epidemiology: 631
• Year to date:
  • Site-wide: 54,968
• Since beginning of last month:
  • Site-wide: 47,714

The Evaluation of Sleep Disturbances for Chinese Frontline Medical Workers Under the Outbreak of COVID-19

• Downloaded 1,347 times
• Download rankings, all-time:
  • Site-wide: 11,864
  • In neurology: 16
• Year to date:
  • Site-wide: 64,681
• Since beginning of last month:
  • Site-wide: 29,223

SCINA: Semi-Supervised Analysis of Single Cells in silico

• Downloaded 1,035 times
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  • Site-wide: 17,602
  • In bioinformatics: 2,173
• Year to date:
  • Site-wide: 68,929
• Since beginning of last month:
  • Site-wide: 48,304

RISC: robust integration of single-cell RNA-seq datasets with different extents of cell cluster overlap

• Downloaded 1,023 times
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  • Site-wide: 17,913
  • In bioinformatics: 2,215
• Year to date:
  • Site-wide: 27,563
• Since beginning of last month:
  • Site-wide: 58,492

Identification of a super-spreading chain of transmission associated with COVID-19

• Downloaded 852 times
• Download rankings, all-time:
  • Site-wide: 23,375
  • In infectious diseases: 1,612
• Year to date:
  • Site-wide: 106,738
• Since beginning of last month:
  • Site-wide: 73,643

Computational staining of pathology images to study tumor microenvironment in lung cancer

• Downloaded 839 times
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  • Site-wide: 23,926
  • In bioinformatics: 2,904
• Year to date:
  • Site-wide: 51,158
• Since beginning of last month:
  • Site-wide: 33,223

A community-based collaboration to build prediction models for short-term discontinuation of docetaxel in metastatic castration-resistant prostate cancer

• Downloaded 804 times
• Download rankings, all-time:
  • Site-wide: 25,366
  • In bioinformatics: 3,051
• Year to date:
  • Site-wide: 81,541
• Since beginning of last month:
  • Site-wide: 84,032

SCCNV: a software tool for identifying copy number variation from single-cell whole-genome sequencing

• Downloaded 785 times
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  • Site-wide: 26,216
  • In bioinformatics: 3,129
• Year to date:
  • Site-wide: 83,969
• Since beginning of last month:
  • Site-wide: 107,656

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

• Downloaded 654 times
• Download rankings, all-time:
  • Site-wide: 33,685
  • In genomics: 2,986
• Year to date:
  • Site-wide: 17,187
• Since beginning of last month:
  • Site-wide: 50,872

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 645 times
• Download rankings, all-time:
  • Site-wide: 34,275
  • In genetics: 1,717
• Year to date:
  • Site-wide: 20,910
• Since beginning of last month:
  • Site-wide: 11,250

The histone chaperone FACT modulates nucleosome structure by tethering its components

• Downloaded 644 times
• Download rankings, all-time:
  • Site-wide: 34,337
  • In biochemistry: 844
• Year to date:
  • Site-wide: 58,175
• Since beginning of last month:
  • Site-wide: 81,911

Overcoming Genetic Drop-outs in Variants-based Lineage Tracing from Single-cell RNA Sequencing Data

• Downloaded 586 times
• Download rankings, all-time:
  • Site-wide: 38,782
  • In bioinformatics: 4,298
• Year to date:
  • Site-wide: 24,908
• Since beginning of last month:
  • Site-wide: 38,083

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

• Downloaded 585 times
• Download rankings, all-time:
  • Site-wide: 38,837
  • In genomics: 3,293
• Year to date:
  • Site-wide: 81,430
• Since beginning of last month:
  • Site-wide: 119,776

Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

• Downloaded 497 times
• Download rankings, all-time:
  • Site-wide: 47,314
  • In genetics: 2,303
• Year to date:
  • Site-wide: 79,833
• Since beginning of last month:
  • Site-wide: 50,083

Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC

• Downloaded 469 times
• Download rankings, all-time:
  • Site-wide: 50,586
  • In infectious diseases: 2,355
• Year to date:
  • Site-wide: 4,175
• Since beginning of last month:
  • Site-wide: 755

Targeted deletion of Nmnat1 in mouse retina leads to early severe retinal dystrophy

• Downloaded 463 times
• Download rankings, all-time:
  • Site-wide: 51,361
  • In developmental biology: 1,270
• Year to date:
  • Site-wide: 107,545
• Since beginning of last month:
  • Site-wide: 103,464

Estimation of COVID-19 case fatality ratio based on a bi-directional correction method

• Downloaded 450 times
• Download rankings, all-time:
  • Site-wide: 52,991
  • In epidemiology: 2,254
• Year to date:
  • Site-wide: 79,512
• Since beginning of last month:
  • Site-wide: 62,873

Large-scale Phenotypic Drug Screen Identifies Neuroprotectants in Zebrafish and Mouse Models of Retinitis Pigmentosa

• Downloaded 435 times
• Download rankings, all-time:
  • Site-wide: 54,933
  • In neuroscience: 8,378
• Year to date:
  • Site-wide: 6,807
• Since beginning of last month:
  • Site-wide: 25,987

LPM: a latent probit model to characterize the relationship among complex traits using summary statistics from multiple GWASs and functional annotations

• Downloaded 421 times
• Download rankings, all-time:
  • Site-wide: 56,760
  • In genetics: 2,740
• Year to date:
  • Site-wide: 70,602
• Since beginning of last month:
  • Site-wide: 80,999

α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation

• Downloaded 406 times
• Download rankings, all-time:
  • Site-wide: 58,812
  • In molecular biology: 1,699
• Year to date:
  • Site-wide: 105,167
• Since beginning of last month:
  • Site-wide: 59,991

Spontaneous retrotranspositions in normal tissues are rare and associated with cell-type-specific differentiation

• Downloaded 405 times
• Download rankings, all-time:
  • Site-wide: 58,987
  • In genomics: 4,406
• Year to date:
  • Site-wide: 96,154
• Since beginning of last month:
  • Site-wide: 110,236

Tumor Neoantigenicity Assessment with CSiN Score Incorporates Clonality and Immunogenicity to Predict Immunotherapy Outcomes

• Downloaded 363 times
• Download rankings, all-time:
  • Site-wide: 65,617
  • In bioinformatics: 6,411
• Year to date:
  • Site-wide: 55,592
• Since beginning of last month:
  • Site-wide: 63,397

Shedding light on the control of CatSper Ca2+ channels by cAMP and chemicals used to probe cAMP signaling

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 69,377
  • In cell biology: 3,162
• Year to date:
  • Site-wide: 120,473
• Since beginning of last month:
  • Site-wide: 42,892

Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer

• Downloaded 339 times
• Download rankings, all-time:
  • Site-wide: 69,692
  • In cancer biology: 2,020
• Year to date:
  • Site-wide: 33,796
• Since beginning of last month:
  • Site-wide: 12,306

PTPN22 interacts with EB1 to regulate T cell receptor signaling

• Downloaded 332 times
• Download rankings, all-time:
  • Site-wide: 70,784
  • In cell biology: 3,250
• Year to date:
  • Site-wide: 112,122
• Since beginning of last month:
  • Site-wide: 113,511

Prediction of 7-year's Conversion from Subjective Cognitive Decline to Mild Cognitive Impairment

• Downloaded 313 times
• Download rankings, all-time:
  • Site-wide: 74,206
  • In geriatric medicine: 32
• Year to date:
  • Site-wide: 87,103
• Since beginning of last month:
  • Site-wide: 63,519

Prior hypoxia exposure enhances murine microglial inflammatory gene expression in vitro without concomitant H3K4me3 enrichment

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 81,792
  • In neuroscience: 12,865
• Year to date:
  • Site-wide: 37,390
• Since beginning of last month:
  • Site-wide: 40,352

xQTLImp: efficient and accurate xQTL summary statistics imputation

• Downloaded 267 times
• Download rankings, all-time:
  • Site-wide: 83,183
  • In bioinformatics: 7,562
• Year to date:
  • Site-wide: 88,371
• Since beginning of last month:
  • Site-wide: 106,488

Discovery of A New Class of Integrin Antibodies for Fibrosis

• Downloaded 230 times
• Download rankings, all-time:
  • Site-wide: 91,084
  • In pharmacology and toxicology: 651
• Year to date:
  • Site-wide: 15,850
• Since beginning of last month:
  • Site-wide: 23,005

Celastrol directly inhibits PFKM to induce weight loss and leptin sensitization

• Downloaded 194 times
• Download rankings, all-time:
  • Site-wide: 98,702
  • In physiology: 1,018
• Year to date:
  • Site-wide: 119,889
• Since beginning of last month:
  • Site-wide: 17,462

Association between temperature and back pain among lumbar disc herniation patients

• Downloaded 158 times
• Download rankings, all-time:
  • Site-wide: 105,809
  • In epidemiology: 4,276
• Year to date:
  • Site-wide: 54,785
• Since beginning of last month:
  • Site-wide: 105,467

PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity

• Downloaded 96 times
• Download rankings, all-time:
  • Site-wide: 116,767
  • In cancer biology: 3,675
• Year to date:
  • Site-wide: 43,441
• Since beginning of last month:
  • Site-wide: 41,779

Establishment and characterization of fibroblast cultures derived from a female common hippopotamus (Hippopotamus amphibius) skin biopsy

• Downloaded 83 times
• Download rankings, all-time:
  • Site-wide: 118,858
  • In cell biology: 5,488
• Year to date:
  • Site-wide: 55,838
• Since beginning of last month:
  • Site-wide: 52,027

De novo germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice

• Downloaded 51 times
• Download rankings, all-time:
  • Site-wide: 122,483
  • In immunology: 3,468
• Year to date:
  • Site-wide: 4,194
• Since beginning of last month:
  • Site-wide: None

Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients

• Downloaded 36 times
• Download rankings, all-time:
  • Site-wide: 123,134
  • In neuroscience: 19,221
• Year to date:
  • Site-wide: 6,704
• Since beginning of last month:
  • Site-wide: None