Author: Tao Wang

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Preprints

Clinical characteristics of 2019 novel coronavirus infection in China

• Downloaded 202,858 times
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  • Site-wide: 15
  • In respiratory medicine: 1
• Year to date:
  • Site-wide: 369
• Since beginning of last month:
  • Site-wide: 332

Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis

• Downloaded 24,686 times
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  • Site-wide: 271
  • In respiratory medicine: 3
• Year to date:
  • Site-wide: 4,417
• Since beginning of last month:
  • Site-wide: 3,590

Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target

• Downloaded 10,116 times
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  • Site-wide: 798
  • In biochemistry: 8
• Year to date:
  • Site-wide: 5,009
• Since beginning of last month:
  • Site-wide: 5,488

Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types

• Downloaded 5,537 times
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  • Site-wide: 1,738
  • In neuroscience: 89
• Year to date:
  • Site-wide: 1,964
• Since beginning of last month:
  • Site-wide: 1,940

Early Detection Of COVID-19 Using A Smartwatch

• Downloaded 4,975 times
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  • Site-wide: 1,998
  • In infectious diseases: 460
• Year to date:
  • Site-wide: 3,023
• Since beginning of last month:
  • Site-wide: 4,816

Clinical and immunologic features in severe and moderate forms of Coronavirus Disease 2019

• Downloaded 4,415 times
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  • Site-wide: 2,396
  • In infectious diseases: 511
• Year to date:
  • Site-wide: 20,212
• Since beginning of last month:
  • Site-wide: 36,145

Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2

• Downloaded 3,479 times
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  • Site-wide: 3,370
  • In microbiology: 227
• Year to date:
  • Site-wide: 8,737
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  • Site-wide: 8,456

The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2

• Downloaded 3,406 times
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  • Site-wide: 3,481
  • In bioinformatics: 357
• Year to date:
  • Site-wide: 30,754
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  • Site-wide: 38,279

Estimating the case fatality ratio of the COVID-19 epidemic in China

• Downloaded 3,177 times
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  • Site-wide: 3,849
  • In infectious diseases: 682
• Year to date:
  • Site-wide: 26,061
• Since beginning of last month:
  • Site-wide: 23,972

Estimating the cure rate and case fatality rate of the ongoing epidemic COVID-19

• Downloaded 2,297 times
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  • Site-wide: 6,147
  • In epidemiology: 504
• Year to date:
  • Site-wide: 48,570
• Since beginning of last month:
  • Site-wide: 39,569

Caution: The clinical characteristics of COVID-19 patients at admission are changing

• Downloaded 1,671 times
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  • Site-wide: 9,841
  • In epidemiology: 718
• Year to date:
  • Site-wide: 56,347
• Since beginning of last month:
  • Site-wide: 49,207

The Evaluation of Sleep Disturbances for Chinese Frontline Medical Workers Under the Outbreak of COVID-19

• Downloaded 1,424 times
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  • Site-wide: 12,437
  • In neurology: 21
• Year to date:
  • Site-wide: 33,480
• Since beginning of last month:
  • Site-wide: 31,903

RISC: robust integration of single-cell RNA-seq datasets with different extents of cell cluster overlap

• Downloaded 1,088 times
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  • Site-wide: 18,653
  • In bioinformatics: 2,224
• Year to date:
  • Site-wide: 35,705
• Since beginning of last month:
  • Site-wide: 28,784

SCINA: Semi-Supervised Analysis of Single Cells in silico

• Downloaded 1,080 times
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  • Site-wide: 18,846
  • In bioinformatics: 2,253
• Year to date:
  • Site-wide: 52,985
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  • Site-wide: 72,224

Epigallocatechin Gallate from Green Tea Effectively Blocks Infection of SARS-CoV-2 and New Variants by Inhibiting Spike Binding to ACE2 Receptor

• Downloaded 1,049 times
• Download rankings, all-time:
  • Site-wide: 19,668
  • In microbiology: 1,108
• Year to date:
  • Site-wide: 1,104
• Since beginning of last month:
  • Site-wide: 372

Identification of a super-spreading chain of transmission associated with COVID-19

• Downloaded 920 times
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  • Site-wide: 23,778
  • In infectious diseases: 1,832
• Year to date:
  • Site-wide: 38,965
• Since beginning of last month:
  • Site-wide: 27,301

Computational staining of pathology images to study tumor microenvironment in lung cancer

• Downloaded 900 times
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  • Site-wide: 24,584
  • In bioinformatics: 2,887
• Year to date:
  • Site-wide: 40,212
• Since beginning of last month:
  • Site-wide: 47,243

A community-based collaboration to build prediction models for short-term discontinuation of docetaxel in metastatic castration-resistant prostate cancer

• Downloaded 817 times
• Download rankings, all-time:
  • Site-wide: 28,123
  • In bioinformatics: 3,241
• Year to date:
  • Site-wide: 112,066
• Since beginning of last month:
  • Site-wide: 122,486

SCCNV: a software tool for identifying copy number variation from single-cell whole-genome sequencing

• Downloaded 801 times
• Download rankings, all-time:
  • Site-wide: 28,914
  • In bioinformatics: 3,311
• Year to date:
  • Site-wide: 102,363
• Since beginning of last month:
  • Site-wide: 103,672

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 794 times
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  • Site-wide: 29,245
  • In genetics: 1,418
• Year to date:
  • Site-wide: 14,968
• Since beginning of last month:
  • Site-wide: 12,380

The histone chaperone FACT modulates nucleosome structure by tethering its components

• Downloaded 677 times
• Download rankings, all-time:
  • Site-wide: 36,466
  • In biochemistry: 892
• Year to date:
  • Site-wide: 64,564
• Since beginning of last month:
  • Site-wide: 73,656

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

• Downloaded 667 times
• Download rankings, all-time:
  • Site-wide: 37,169
  • In genomics: 3,160
• Year to date:
  • Site-wide: 78,307
• Since beginning of last month:
  • Site-wide: 108,702

Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC

• Downloaded 650 times
• Download rankings, all-time:
  • Site-wide: 38,450
  • In infectious diseases: 2,374
• Year to date:
  • Site-wide: 9,458
• Since beginning of last month:
  • Site-wide: 19,504

Overcoming Genetic Drop-outs in Variants-based Lineage Tracing from Single-cell RNA Sequencing Data

• Downloaded 639 times
• Download rankings, all-time:
  • Site-wide: 39,357
  • In bioinformatics: 4,280
• Year to date:
  • Site-wide: 41,504
• Since beginning of last month:
  • Site-wide: 49,303

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

• Downloaded 592 times
• Download rankings, all-time:
  • Site-wide: 43,247
  • In genomics: 3,520
• Year to date:
  • Site-wide: 126,917
• Since beginning of last month:
  • Site-wide: 118,665

New Role of Red Blood Cells in Absorption of DNA Bearing Tumorigenic Mutations from Lung Cancer Tissue

• Downloaded 563 times
• Download rankings, all-time:
  • Site-wide: 46,037
  • In oncology: 55
• Year to date:
  • Site-wide: 2,632
• Since beginning of last month:
  • Site-wide: 7,278

Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

• Downloaded 535 times
• Download rankings, all-time:
  • Site-wide: 49,040
  • In genetics: 2,289
• Year to date:
  • Site-wide: 61,695
• Since beginning of last month:
  • Site-wide: 60,267

Large-scale Phenotypic Drug Screen Identifies Neuroprotectants in Zebrafish and Mouse Models of Retinitis Pigmentosa

• Downloaded 508 times
• Download rankings, all-time:
  • Site-wide: 52,131
  • In neuroscience: 7,683
• Year to date:
  • Site-wide: 24,766
• Since beginning of last month:
  • Site-wide: 42,117

Targeted deletion of Nmnat1 in mouse retina leads to early severe retinal dystrophy

• Downloaded 482 times
• Download rankings, all-time:
  • Site-wide: 55,377
  • In developmental biology: 1,353
• Year to date:
  • Site-wide: 99,184
• Since beginning of last month:
  • Site-wide: 87,097

Estimation of COVID-19 case fatality ratio based on a bi-directional correction method

• Downloaded 469 times
• Download rankings, all-time:
  • Site-wide: 57,052
  • In epidemiology: 2,470
• Year to date:
  • Site-wide: 94,369
• Since beginning of last month:
  • Site-wide: 83,537

LPM: a latent probit model to characterize the relationship among complex traits using summary statistics from multiple GWASs and functional annotations

• Downloaded 439 times
• Download rankings, all-time:
  • Site-wide: 61,057
  • In genetics: 2,831
• Year to date:
  • Site-wide: 94,812
• Since beginning of last month:
  • Site-wide: 96,291

Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer

• Downloaded 431 times
• Download rankings, all-time:
  • Site-wide: 62,170
  • In cancer biology: 1,771
• Year to date:
  • Site-wide: 26,708
• Since beginning of last month:
  • Site-wide: 23,970

α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation

• Downloaded 427 times
• Download rankings, all-time:
  • Site-wide: 62,900
  • In molecular biology: 1,797
• Year to date:
  • Site-wide: 93,600
• Since beginning of last month:
  • Site-wide: 78,745

Spontaneous retrotranspositions in normal tissues are rare and associated with cell-type-specific differentiation

• Downloaded 414 times
• Download rankings, all-time:
  • Site-wide: 64,901
  • In genomics: 4,631
• Year to date:
  • Site-wide: 124,311
• Since beginning of last month:
  • Site-wide: 107,335

Tumor Neoantigenicity Assessment with CSiN Score Incorporates Clonality and Immunogenicity to Predict Immunotherapy Outcomes

• Downloaded 383 times
• Download rankings, all-time:
  • Site-wide: 69,851
  • In bioinformatics: 6,681
• Year to date:
  • Site-wide: 87,518
• Since beginning of last month:
  • Site-wide: 100,422

Shedding light on the control of CatSper Ca2+ channels by cAMP and chemicals used to probe cAMP signaling

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 73,448
  • In cell biology: 3,342
• Year to date:
  • Site-wide: 100,437
• Since beginning of last month:
  • Site-wide: 78,106

PTPN22 interacts with EB1 to regulate T cell receptor signaling

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 73,576
  • In cell biology: 3,351
• Year to date:
  • Site-wide: 77,948
• Since beginning of last month:
  • Site-wide: 54,646

Prediction of 7-year's Conversion from Subjective Cognitive Decline to Mild Cognitive Impairment

• Downloaded 330 times
• Download rankings, all-time:
  • Site-wide: 79,476
  • In geriatric medicine: 46
• Year to date:
  • Site-wide: 101,864
• Since beginning of last month:
  • Site-wide: 83,539

Discovery of A New Class of Integrin Antibodies for Fibrosis

• Downloaded 301 times
• Download rankings, all-time:
  • Site-wide: 85,478
  • In pharmacology and toxicology: 577
• Year to date:
  • Site-wide: 30,601
• Since beginning of last month:
  • Site-wide: 28,079

xQTLImp: efficient and accurate xQTL summary statistics imputation

• Downloaded 290 times
• Download rankings, all-time:
  • Site-wide: 87,816
  • In bioinformatics: 7,829
• Year to date:
  • Site-wide: 88,704
• Since beginning of last month:
  • Site-wide: 62,811

Prior hypoxia exposure enhances murine microglial inflammatory gene expression in vitro without concomitant H3K4me3 enrichment

• Downloaded 290 times
• Download rankings, all-time:
  • Site-wide: 87,736
  • In neuroscience: 13,511
• Year to date:
  • Site-wide: 89,417
• Since beginning of last month:
  • Site-wide: 99,196

Celastrol directly inhibits PFKM to induce weight loss and leptin sensitization

• Downloaded 226 times
• Download rankings, all-time:
  • Site-wide: 101,730
  • In physiology: 993
• Year to date:
  • Site-wide: 75,094
• Since beginning of last month:
  • Site-wide: 46,961

Association between temperature and back pain among lumbar disc herniation patients

• Downloaded 177 times
• Download rankings, all-time:
  • Site-wide: 112,568
  • In epidemiology: 4,622
• Year to date:
  • Site-wide: 89,508
• Since beginning of last month:
  • Site-wide: 90,636

PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity

• Downloaded 146 times
• Download rankings, all-time:
  • Site-wide: 119,207
  • In cancer biology: 3,670
• Year to date:
  • Site-wide: 46,282
• Since beginning of last month:
  • Site-wide: 52,868

Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients

• Downloaded 113 times
• Download rankings, all-time:
  • Site-wide: 125,703
  • In neuroscience: 19,289
• Year to date:
  • Site-wide: 23,871
• Since beginning of last month:
  • Site-wide: 37,545

De novo germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice

• Downloaded 101 times
• Download rankings, all-time:
  • Site-wide: 127,764
  • In immunology: 3,698
• Year to date:
  • Site-wide: 27,005
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  • Site-wide: 59,174

Establishment and characterization of fibroblast cultures derived from a female common hippopotamus (Hippopotamus amphibius) skin biopsy

• Downloaded 98 times
• Download rankings, all-time:
  • Site-wide: 128,312
  • In cell biology: 5,872
• Year to date:
  • Site-wide: 100,219
• Since beginning of last month:
  • Site-wide: 77,738

Time-restricted feeding near dawn entrains long-term behavioral changes through the suprachiasmatic nucleus

• Downloaded 81 times
• Download rankings, all-time:
  • Site-wide: 130,970
  • In physiology: 1,620
• Year to date:
  • Site-wide: 33,841
• Since beginning of last month:
  • Site-wide: 21,381

Human microglia extensively reconstitute in humanized BLT mice with human interleukin-34 transgene and support HIV-1 brain infection

• Downloaded 22 times
• Download rankings, all-time:
  • Site-wide: 135,074
  • In microbiology: 10,549
• Year to date:
  • Site-wide: 95,996
• Since beginning of last month:
  • Site-wide: 68,781