Author: Tao Wang

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Preprints

An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission

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Clinical characteristics of 2019 novel coronavirus infection in China

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  • Site-wide: 26
  • In respiratory medicine: 1
• Year to date:
  • Site-wide: 673
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  • Site-wide: 333

Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis

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  • Site-wide: 410
  • In respiratory medicine: 4
• Year to date:
  • Site-wide: 4,124
• Since beginning of last month:
  • Site-wide: 4,393

Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target

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  • Site-wide: 1,189
  • In biochemistry: 12
• Year to date:
  • Site-wide: 20,915
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  • Site-wide: 31,498

Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types

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  • Site-wide: 1,999
  • In neuroscience: 89
• Year to date:
  • Site-wide: 9,210
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  • Site-wide: 45,965

Early Detection Of COVID-19 Using A Smartwatch

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  • Site-wide: 2,513
  • In infectious diseases: 667
• Year to date:
  • Site-wide: 9,484
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Clinical and immunologic features in severe and moderate forms of Coronavirus Disease 2019

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  • Site-wide: 3,622
  • In infectious diseases: 830
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  • Site-wide: 59,411

Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2

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  • Site-wide: 4,687
  • In microbiology: 313
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  • Site-wide: 19,158

The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2

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  • Site-wide: 5,201
  • In bioinformatics: 437
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  • Site-wide: 77,909
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  • Site-wide: 159,592

Epigallocatechin Gallate from Green Tea Effectively Blocks Infection of SARS-CoV-2 and New Variants by Inhibiting Spike Binding to ACE2 Receptor

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  • Site-wide: 5,340
  • In microbiology: 351
• Year to date:
  • Site-wide: 21,862
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  • Site-wide: 51,588

Estimating the case fatality ratio of the COVID-19 epidemic in China

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  • Site-wide: 5,430
  • In infectious diseases: 1,080
• Year to date:
  • Site-wide: 74,454
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  • Site-wide: 80,622

Estimating the cure rate and case fatality rate of the ongoing epidemic COVID-19

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  • Site-wide: 9,432
  • In epidemiology: 753
• Year to date:
  • Site-wide: 118,799
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  • Site-wide: 109,952

Caution: The clinical characteristics of COVID-19 patients at admission are changing

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  • Site-wide: 14,351
  • In epidemiology: 1,020
• Year to date:
  • Site-wide: 127,204
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  • Site-wide: 157,720

The Evaluation of Sleep Disturbances for Chinese Frontline Medical Workers Under the Outbreak of COVID-19

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  • Site-wide: 16,003
  • In neurology: 48
• Year to date:
  • Site-wide: 82,839
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  • Site-wide: None

RISC: robust integration of single-cell RNA-seq datasets with different extents of cell cluster overlap

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  • Site-wide: 21,651
  • In bioinformatics: 2,369
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  • Site-wide: 79,583
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  • Site-wide: 56,621

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 26,020
  • In genetics: 1,018
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  • Site-wide: 104,950
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SCINA: Semi-Supervised Analysis of Single Cells in silico

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  • Site-wide: 28,230
  • In bioinformatics: 2,955
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  • Site-wide: 118,345
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  • Site-wide: 172,978

Identification of a super-spreading chain of transmission associated with COVID-19

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  • Site-wide: 29,766
  • In infectious diseases: 2,795
• Year to date:
  • Site-wide: 102,033
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  • Site-wide: 102,727

Structural insights into p300 regulation and acetylation-dependent genome organisation

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  • Site-wide: 29,778
  • In biochemistry: 943
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  • Site-wide: 2,645
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  • Site-wide: 3,716

New Role of Red Blood Cells in Absorption of DNA Bearing Tumorigenic Mutations from Lung Cancer Tissue

• Downloaded 1,142 times
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  • Site-wide: 31,342
  • In oncology: 53
• Year to date:
  • Site-wide: 29,183
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  • Site-wide: 61,413

Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC

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  • Site-wide: 33,134
  • In infectious diseases: 2,963
• Year to date:
  • Site-wide: 79,526
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  • Site-wide: 106,871

Computational staining of pathology images to study tumor microenvironment in lung cancer

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  • Site-wide: 33,331
  • In bioinformatics: 3,446
• Year to date:
  • Site-wide: 110,826
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  • Site-wide: None

De-noising Spatial Transcriptomics Data Based on Position and Image Information

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  • Site-wide: 33,808
  • In bioinformatics: 5,178
• Year to date:
  • Site-wide: 4,543
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  • Site-wide: 7,225

A community-based collaboration to build prediction models for short-term discontinuation of docetaxel in metastatic castration-resistant prostate cancer

• Downloaded 981 times
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  • Site-wide: 39,556
  • In bioinformatics: 4,003
• Year to date:
  • Site-wide: 155,801
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  • Site-wide: 73,126

A Deep Learning-based Genome-wide Polygenic Risk Score for Common Diseases Identifies Individuals with Risk

• Downloaded 960 times
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  • Site-wide: 40,895
  • In genetic and genomic medicine: 342
• Year to date:
  • Site-wide: 4,755
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  • Site-wide: 11,445

JAK-STAT Signaling Enables Lineage Plasticity-driven AR Targeted Therapy Resistance

• Downloaded 918 times
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  • Site-wide: 43,757
  • In cancer biology: 1,487
• Year to date:
  • Site-wide: 12,352
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  • Site-wide: 23,619

SCCNV: a software tool for identifying copy number variation from single-cell whole-genome sequencing

• Downloaded 878 times
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  • Site-wide: 46,898
  • In bioinformatics: 4,595
• Year to date:
  • Site-wide: 188,622
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  • Site-wide: 119,153

Sleep Need, the Key Regulator of Sleep Homeostasis, Is Indicated and Controlled by Phosphorylation of Threonine 221 in Salt Inducible Kinase 3

• Downloaded 819 times
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  • Site-wide: 52,086
  • In neuroscience: 7,631
• Year to date:
  • Site-wide: 23,728
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  • Site-wide: 65,319

Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer

• Downloaded 798 times
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  • Site-wide: 54,138
  • In cancer biology: 1,510
• Year to date:
  • Site-wide: 100,303
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  • Site-wide: None

The histone chaperone FACT modulates nucleosome structure by tethering its components

• Downloaded 784 times
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  • Site-wide: 55,610
  • In biochemistry: 1,379
• Year to date:
  • Site-wide: 192,236
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  • Site-wide: None

Overcoming Genetic Drop-outs in Variants-based Lineage Tracing from Single-cell RNA Sequencing Data

• Downloaded 783 times
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  • Site-wide: 55,650
  • In bioinformatics: 5,226
• Year to date:
  • Site-wide: 202,148
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  • Site-wide: 176,517

α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation

• Downloaded 780 times
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  • Site-wide: 55,960
  • In molecular biology: 1,703
• Year to date:
  • Site-wide: 33,644
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  • Site-wide: 10,930

Mitochondrial structure and function adaptation in residual triple negative breast cancer cells surviving chemotherapy treatment

• Downloaded 761 times
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  • Site-wide: 58,026
  • In cancer biology: 2,076
• Year to date:
  • Site-wide: 5,364
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  • Site-wide: 13,908

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

• Downloaded 755 times
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  • Site-wide: 58,717
  • In genomics: 4,067
• Year to date:
  • Site-wide: 178,624
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  • Site-wide: 67,493

Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

• Downloaded 749 times
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  • Site-wide: 59,396
  • In genetics: 2,301
• Year to date:
  • Site-wide: 117,873
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  • Site-wide: 100,118

Large-scale Phenotypic Drug Screen Identifies Neuroprotectants in Zebrafish and Mouse Models of Retinitis Pigmentosa

• Downloaded 737 times
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  • Site-wide: 60,859
  • In neuroscience: 8,157
• Year to date:
  • Site-wide: 135,803
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  • Site-wide: 130,961

PTPN22 interacts with EB1 to regulate T cell receptor signaling

• Downloaded 702 times
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  • Site-wide: 65,182
  • In cell biology: 2,977
• Year to date:
  • Site-wide: 55,201
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  • Site-wide: 35,469

Epidemiological characteristics and transmission dynamics of the outbreak caused by the SARS-CoV-2 Omicron variant in Shanghai, China: a descriptive study

• Downloaded 688 times
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  • Site-wide: 67,092
  • In epidemiology: 3,910
• Year to date:
  • Site-wide: 6,351
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  • Site-wide: 4,104

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

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  • Site-wide: 70,162
  • In genomics: 4,602
• Year to date:
  • Site-wide: 201,221
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  • Site-wide: 96,671

LPM: a latent probit model to characterize the relationship among complex traits using summary statistics from multiple GWASs and functional annotations

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  • Site-wide: 74,115
  • In genetics: 2,897
• Year to date:
  • Site-wide: 118,313
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  • Site-wide: 43,940

Targeted deletion of Nmnat1 in mouse retina leads to early severe retinal dystrophy

• Downloaded 630 times
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  • Site-wide: 75,634
  • In developmental biology: 1,824
• Year to date:
  • Site-wide: 144,301
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  • Site-wide: 30,337

Estimation of COVID-19 case fatality ratio based on a bi-directional correction method

• Downloaded 619 times
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  • Site-wide: 77,323
  • In epidemiology: 3,446
• Year to date:
  • Site-wide: 137,335
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  • Site-wide: 158,476

Discovery of A New Class of Integrin Antibodies for Fibrosis

• Downloaded 608 times
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  • Site-wide: 79,100
  • In pharmacology and toxicology: 499
• Year to date:
  • Site-wide: 63,914
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  • Site-wide: 61,417

De novo germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice

• Downloaded 556 times
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  • Site-wide: 88,474
  • In immunology: 2,815
• Year to date:
  • Site-wide: 22,005
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  • Site-wide: 133,588

Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients

• Downloaded 536 times
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  • Site-wide: 92,352
  • In neuroscience: 12,859
• Year to date:
  • Site-wide: 27,855
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  • Site-wide: 176,400

Tumor Neoantigenicity Assessment with CSiN Score Incorporates Clonality and Immunogenicity to Predict Immunotherapy Outcomes

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  • Site-wide: 93,208
  • In bioinformatics: 7,985
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  • Site-wide: 190,339
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  • Site-wide: 132,829

Establishment and characterization of fibroblast cultures derived from a female common hippopotamus (Hippopotamus amphibius) skin biopsy

• Downloaded 530 times
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  • Site-wide: 93,784
  • In cell biology: 5,792
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  • Site-wide: 26,397
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  • Site-wide: 5,220

Spontaneous retrotranspositions in normal tissues are rare and associated with cell-type-specific differentiation

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  • Site-wide: 95,898
  • In genomics: 5,737
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  • Site-wide: 126,689

Shedding light on the control of CatSper Ca2+ channels by cAMP and chemicals used to probe cAMP signaling

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  • Site-wide: 96,413
  • In cell biology: 4,265
• Year to date:
  • Site-wide: 146,251
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  • Site-wide: 100,112

A novel framework for single-cell Hi-C clustering based on graph-convolution-based imputation and two-phase-based feature extraction

• Downloaded 445 times
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  • Site-wide: 113,193
  • In bioinformatics: 9,588
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  • Site-wide: 61,345
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  • Site-wide: 141,863

xQTLImp: efficient and accurate xQTL summary statistics imputation

• Downloaded 435 times
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  • Site-wide: 115,694
  • In bioinformatics: 9,498
• Year to date:
  • Site-wide: 133,181
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  • Site-wide: 117,288

Celastrol directly inhibits PFKM to induce weight loss and leptin sensitization

• Downloaded 432 times
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  • Site-wide: 116,561
  • In physiology: 1,014
• Year to date:
  • Site-wide: 101,122
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  • Site-wide: 129,691

A vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of COVID-19 and related diseases

• Downloaded 432 times
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  • Site-wide: 116,482
  • In pharmacology and toxicology: 811
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  • Site-wide: 91,752
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  • Site-wide: 88,534

Prediction of 7-year's Conversion from Subjective Cognitive Decline to Mild Cognitive Impairment

• Downloaded 426 times
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  • Site-wide: 118,144
  • In geriatric medicine: 86
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  • Site-wide: 176,872
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  • Site-wide: 108,963

Deficiency in endocannabinoid synthase DAGLB contributes to Parkinson's disease and dopaminergic neuron dysfunction

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  • Site-wide: 122,881
  • In neuroscience: 18,119
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  • Site-wide: 26,490
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  • Site-wide: 51,519

Time-restricted feeding near dawn entrains long-term behavioral changes through the suprachiasmatic nucleus

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  • Site-wide: 123,660
  • In physiology: 1,089
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  • Site-wide: 43,490
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  • Site-wide: 137,840

Prior hypoxia exposure enhances murine microglial inflammatory gene expression in vitro without concomitant H3K4me3 enrichment

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  • Site-wide: 132,847
  • In neuroscience: 18,776
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  • Site-wide: 205,330
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  • Site-wide: 179,903

IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration

• Downloaded 347 times
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  • Site-wide: 140,253
  • In developmental biology: None
• Year to date:
  • Site-wide: 19,701
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  • Site-wide: 6,987

Association between temperature and back pain among lumbar disc herniation patients

• Downloaded 343 times
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  • Site-wide: 141,478
  • In epidemiology: 5,781
• Year to date:
  • Site-wide: 150,623
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  • Site-wide: 186,636

Comparative Analysis of Dimension Reduction Methods for Cytometry by Time-of-Flight Data

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  • Site-wide: 142,107
  • In bioinformatics: 11,752
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  • Site-wide: 20,274
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  • Site-wide: 91,434

PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity

• Downloaded 307 times
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  • Site-wide: 152,369
  • In cancer biology: 4,588
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  • Site-wide: 156,661
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  • Site-wide: 129,306

Intracellular Energy Controls Dynamics of Stress-induced Ribonucleoprotein Granules

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  • Site-wide: 161,770
  • In neuroscience: 23,858
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  • Site-wide: 28,376
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  • Site-wide: 84,048

Drosulfakinin signaling modulates female sexual receptivity in Drosophila

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  • Site-wide: 162,481
  • In neuroscience: 23,679
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  • Site-wide: 58,788
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  • Site-wide: 113,979

Efficient Dlx2-mediated astrocyte-to-neuron conversion and inhibition of neuroinflammation by NeuroD1

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  • Site-wide: 167,016
  • In neuroscience: 26,568
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  • Site-wide: 31,445
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  • Site-wide: 15,481

Specific Pupylation as IDEntity Reporter (SPIDER) for the identification of Protein-Biomolecule interactions

• Downloaded 251 times
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  • Site-wide: 168,784
  • In systems biology: 3,609
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  • Site-wide: 32,569
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  • Site-wide: 4,481

Human microglia extensively reconstitute in humanized BLT mice with human interleukin-34 transgene and support HIV-1 brain infection

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  • Site-wide: 179,563
  • In microbiology: 13,341
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  • Site-wide: 156,855

Cytomulate: Accurate and Efficient Simulation of CyTOF data

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  • Site-wide: 180,502
  • In bioinformatics: 14,182
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  • Site-wide: 43,281
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  • Site-wide: 39,226

Donor whole blood DNA methylation is not a strong predictor of acute graft versus host disease in unrelated donor allogeneic haematopoietic cell transplantation

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  • Site-wide: 187,604
  • In genetic and genomic medicine: 1,354
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  • Site-wide: 54,145
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  • Site-wide: None

Tadr Is an Axonal Histidine Transporter Required for Visual Neurotransmission in Drosophila

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  • Site-wide: 196,104
  • In neuroscience: 27,719
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  • Site-wide: 117,226
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  • Site-wide: 180,361

Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

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  • Site-wide: 200,207
  • In neuroscience: None
• Year to date:
  • Site-wide: 90,126
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  • Site-wide: 5,853

Immune response of primary and booster immunity of SARS-CoV-2 vaccination among patients with chronic liver disease: a real-world study

• Downloaded 82 times
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  • Site-wide: 203,945
  • In gastroenterology: None
• Year to date:
  • Site-wide: 113,219
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  • Site-wide: 1,702

Image-based quantification of histological features as a function of spatial location using the Tissue Positioning System

• Downloaded 80 times
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  • Site-wide: 204,119
  • In bioinformatics: None
• Year to date:
  • Site-wide: 114,846
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  • Site-wide: 35,062

Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS and sporadic congenital heart disease

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  • Site-wide: 205,357
  • In genetics: None
• Year to date:
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  • Site-wide: 12,566