Author: Laurence Florens

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Preprints

A chemoproteomic portrait of the oncometabolite fumarate

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  • Site-wide: 18,646
  • In cancer biology: 377
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  • Site-wide: 105,691
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  • Site-wide: 76,991

The Human Cytoplasmic Dynein Interactome Reveals Novel Activators Of Motility

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  • Site-wide: 23,770
  • In cell biology: 727
• Year to date:
  • Site-wide: 130,457
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  • Site-wide: 164,049

A systems chemoproteomic analysis of acyl-CoA/protein interaction networks

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  • Site-wide: 27,251
  • In biochemistry: 600
• Year to date:
  • Site-wide: 75,127
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  • Site-wide: 51,943

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169

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  • Site-wide: 39,547
  • In molecular biology: 1,007
• Year to date:
  • Site-wide: 131,341
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  • Site-wide: 137,759

Ataxin-7 and Non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization

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  • Site-wide: 56,469
  • In cell biology: 2,219
• Year to date:
  • Site-wide: 135,172
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  • Site-wide: 185,903

BRK Phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG and metastatic potential.

• Downloaded 701 times
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  • Site-wide: 57,246
  • In cancer biology: 1,550
• Year to date:
  • Site-wide: 121,733
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  • Site-wide: 91,742

Host Vesicle Fusion Proteins VAPB, Rab11b and Rab18 Contribute to HSV-1 Infectivity by Facilitating Egress through the Nuclear Membrane

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  • Site-wide: 57,941
  • In cell biology: 2,324
• Year to date:
  • Site-wide: 158,338
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  • Site-wide: 124,305

Decellularization enables functional analysis of ECM remodeling in planarian regeneration

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  • Site-wide: 58,702
  • In developmental biology: 1,290
• Year to date:
  • Site-wide: 133,818
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  • Site-wide: 99,594

A new coactivator complex required for retinoic acid-dependent regulation of embryonic symmetry

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  • Site-wide: 64,301
  • In developmental biology: 1,372
• Year to date:
  • Site-wide: 190,298
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  • Site-wide: 190,505

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation

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  • Site-wide: 68,250
  • In cancer biology: 1,819
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  • Site-wide: 175,378
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  • Site-wide: 141,674

Proteome plasticity in response to persistent environmental change

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  • Site-wide: 77,877
  • In molecular biology: 2,490
• Year to date:
  • Site-wide: 46,082
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  • Site-wide: 17,684

Topological Scoring of Protein Interaction Networks

• Downloaded 554 times
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  • Site-wide: 77,762
  • In systems biology: 1,554
• Year to date:
  • Site-wide: 175,003
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  • Site-wide: 185,704

Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome

• Downloaded 493 times
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  • Site-wide: 89,321
  • In systems biology: 1,868
• Year to date:
  • Site-wide: 126,118
• Since beginning of last month:
  • Site-wide: 141,675

Integrative Modeling of a Sin3/HDAC Complex Sub-structure

• Downloaded 478 times
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  • Site-wide: 92,531
  • In biochemistry: 2,497
• Year to date:
  • Site-wide: 132,650
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  • Site-wide: 131,436

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation

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  • Site-wide: 94,521
  • In cancer biology: 2,804
• Year to date:
  • Site-wide: 77,952
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  • Site-wide: 51,347

The ULK1-FBXW5-SEC23B nexus controls autophagy

• Downloaded 438 times
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  • Site-wide: 101,460
  • In cell biology: 4,315
• Year to date:
  • Site-wide: 181,728
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  • Site-wide: 180,604

Differential complex formation via paralogs in the human Sin3 protein interaction network.

• Downloaded 415 times
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  • Site-wide: 107,031
  • In systems biology: 2,225
• Year to date:
  • Site-wide: 116,563
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  • Site-wide: 106,858

The histone methyltransferase SETD2 couples transcription and splicing by engaging pre-mRNA processing factors through its SHI domain

• Downloaded 399 times
• Download rankings, all-time:
  • Site-wide: 110,773
  • In biochemistry: 3,011
• Year to date:
  • Site-wide: 167,162
• Since beginning of last month:
  • Site-wide: 115,951

Harnessing Ionic Selectivity In Acetyltransferase Chemoproteomic Probes

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  • Site-wide: 112,683
  • In biochemistry: 3,402
• Year to date:
  • Site-wide: 79,053
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  • Site-wide: 46,349

Driving Integrative Structural Modeling with Serial Capture Affinity Purification

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  • Site-wide: 117,935
  • In systems biology: 2,379
• Year to date:
  • Site-wide: 146,725
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  • Site-wide: 95,408

Stem cell-free therapy for glaucoma to preserve vision

• Downloaded 336 times
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  • Site-wide: 128,114
  • In cell biology: 6,051
• Year to date:
  • Site-wide: 56,857
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  • Site-wide: 49,734

Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing

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  • Site-wide: 134,564
  • In biochemistry: 3,820
• Year to date:
  • Site-wide: 93,952
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  • Site-wide: 86,642

Genome-wide binding analyses of HOXB1 revealed a novel DNA binding motif associated with gene repression

• Downloaded 308 times
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  • Site-wide: 136,425
  • In developmental biology: 3,494
• Year to date:
  • Site-wide: 112,656
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  • Site-wide: 118,087

The plasticity of the pyruvate dehydrogenase complex confers a labile structure that is associated with its catalytic activity

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  • Site-wide: 149,285
  • In biochemistry: 4,305
• Year to date:
  • Site-wide: 128,749
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  • Site-wide: 121,445

The C. elegans ASPP homolog APE-1 is a junctional protein phosphatase 1 modulator

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  • Site-wide: 158,997
  • In cell biology: 7,623
• Year to date:
  • Site-wide: 16,351
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  • Site-wide: 48,519

A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis.

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  • Site-wide: 161,639
  • In molecular biology: 4,563
• Year to date:
  • Site-wide: 40,699
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  • Site-wide: 130,527

Metabolic reprogramming underlies cavefish muscular endurance despite loss of muscle mass and contractility

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  • Site-wide: 166,877
  • In evolutionary biology: None
• Year to date:
  • Site-wide: 20,060
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  • Site-wide: 38,956

Hypoxic response is driven by the BAF form of SWI/SNF

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  • Site-wide: 167,712
  • In biochemistry: 5,305
• Year to date:
  • Site-wide: 20,547
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  • Site-wide: 61,282

Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress conditions by the cooperation of AMPK and CK2 signaling

• Downloaded 189 times
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  • Site-wide: 169,723
  • In cell biology: 7,412
• Year to date:
  • Site-wide: 146,839
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  • Site-wide: 94,912

An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii

• Downloaded 168 times
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  • Site-wide: 174,633
  • In cell biology: None
• Year to date:
  • Site-wide: 25,610
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  • Site-wide: 3,903