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Author: Andrew Ward

Rankings

  • All-time downloads: 53,830 (rank: 3,013 )
  • Categories:
    • biochemistry: 2,828 (rank: 1,261 )
    • bioinformatics: 419 (rank: 29,937 (tie) )
    • biophysics: 8,939 (rank: 183 )
    • immunology: 20,238 (rank: 496 )
    • microbiology: 19,359 (rank: 825 )
    • molecular biology: 554 (rank: 12,426 (tie) )
    • synthetic biology: 1,493 (rank: 1,229 (tie) )

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Preprints

Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens

molecular biology more details view paper

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Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

microbiology more details view paper
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    • Site-wide: 1,827
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Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

microbiology more details view paper
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    • Site-wide: 3,148
    • In microbiology: 223
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SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

microbiology more details view paper
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Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

immunology more details view paper
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    • Site-wide: 5,053
    • In immunology: 177
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Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

immunology more details view paper
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    • Site-wide: 6,105
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Cryo-EM structure of the mechanically activated ion channel OSCA1.2

biophysics more details view paper
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    • In biophysics: 165
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Structure of the SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors

biophysics more details view paper
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    • Site-wide: 10,096
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Tailored Design of Protein Nanoparticle Scaffolds for Multivalent Presentation of Viral Glycoprotein Antigens

synthetic biology more details view paper
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OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels

biophysics more details view paper
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Structures of the Otopetrin Proton Channels Otop1 and Otop3

biochemistry more details view paper
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    • Site-wide: 15,639
    • In biochemistry: 319
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Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

immunology more details view paper
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    • Site-wide: 17,730
    • In immunology: 570
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Visualization of the HIV-1 Env Glycan Shield Across Scales

biophysics more details view paper
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    • Site-wide: 20,380
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Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

microbiology more details view paper
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    • Site-wide: 20,852
    • In microbiology: 1,204
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Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

microbiology more details view paper
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    • Site-wide: 21,731
    • In microbiology: 1,262
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Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

biochemistry more details view paper
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    • Site-wide: 22,842
    • In biochemistry: 492
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An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain

microbiology more details view paper
  • Downloaded 1,012 times
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    • Site-wide: 23,687
    • In microbiology: 1,405
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Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

biophysics more details view paper
  • Downloaded 1,008 times
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    • Site-wide: 23,811
    • In biophysics: 648
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Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

immunology more details view paper
  • Downloaded 995 times
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    • Site-wide: 24,272
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Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

immunology more details view paper
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    • Site-wide: 30,229
    • In immunology: 946
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Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

immunology more details view paper
  • Downloaded 823 times
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    • Site-wide: 31,763
    • In immunology: 991
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Structure of the Ebola virus nucleoprotein - RNA complex

biophysics more details view paper
  • Downloaded 724 times
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    • Site-wide: 38,030
    • In biophysics: 1,196
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    • Site-wide: 96,465
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    • Site-wide: 98,554

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

immunology more details view paper
  • Downloaded 720 times
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    • Site-wide: 38,349
    • In immunology: 1,182
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    • Site-wide: 20,667
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Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

immunology more details view paper
  • Downloaded 719 times
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    • Site-wide: 38,369
    • In immunology: 1,189
  • Year to date:
    • Site-wide: 80,683
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    • Site-wide: 101,183

HIV-1 vaccine design through minimizing envelope metastability

microbiology more details view paper
  • Downloaded 693 times
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    • Site-wide: 40,263
    • In microbiology: 2,429
  • Year to date:
    • Site-wide: 109,381
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Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

immunology more details view paper
  • Downloaded 687 times
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    • Site-wide: 40,767
    • In immunology: 1,254
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    • Site-wide: 104,183
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A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

microbiology more details view paper
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    • Site-wide: 41,851
    • In microbiology: 2,531
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    • Site-wide: 34,709
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    • Site-wide: 48,531

From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

immunology more details view paper
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    • Site-wide: 43,603
    • In immunology: 1,328
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    • Site-wide: 5,456
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    • Site-wide: 12,612

HIV-1 Envelope and MPER antibody structures in lipid assemblies

immunology more details view paper
  • Downloaded 629 times
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    • Site-wide: 45,625
    • In immunology: 1,376
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    • Site-wide: 92,179
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    • Site-wide: 102,642

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

immunology more details view paper
  • Downloaded 620 times
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    • Site-wide: 46,493
    • In immunology: 1,394
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    • Site-wide: 71,824
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Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

immunology more details view paper
  • Downloaded 609 times
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    • Site-wide: 47,574
    • In immunology: 1,429
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Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

immunology more details view paper
  • Downloaded 588 times
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    • Site-wide: 49,688
    • In immunology: 1,489
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    • Site-wide: 90,914
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Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

molecular biology more details view paper
  • Downloaded 554 times
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    • Site-wide: 53,495
    • In molecular biology: 1,505
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Polyclonal epitope cartography reveals the temporal dynamics and diversity of human antibody responses to H5N1 vaccination

immunology more details view paper
  • Downloaded 548 times
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    • Site-wide: 54,218
    • In immunology: 1,636
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    • Site-wide: 34,087
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Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

immunology more details view paper
  • Downloaded 541 times
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    • Site-wide: 55,069
    • In immunology: 1,661
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Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail

biophysics more details view paper
  • Downloaded 518 times
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Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

immunology more details view paper
  • Downloaded 500 times
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    • Site-wide: 60,475
    • In immunology: 1,812
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    • Site-wide: 8,095
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A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection

microbiology more details view paper
  • Downloaded 468 times
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    • Site-wide: 64,872
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    • Site-wide: 8,881
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A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

immunology more details view paper
  • Downloaded 468 times
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    • Site-wide: 64,862
    • In immunology: 1,945
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Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

immunology more details view paper
  • Downloaded 463 times
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    • Site-wide: 65,692
    • In immunology: 1,965
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Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

immunology more details view paper
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    • Site-wide: 67,140
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EMHP: An accurate automated hole masking algorithm for single-particle cryo-EM image processing

bioinformatics more details view paper
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    • Site-wide: 72,786
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Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

immunology more details view paper
  • Downloaded 377 times
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    • Site-wide: 80,348
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One dose of COVID-19 nanoparticle vaccine REVC-128 provides protection against SARS-CoV-2 challenge at two weeks post immunization

microbiology more details view paper
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    • Site-wide: 82,432
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Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

immunology more details view paper
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Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface

immunology more details view paper
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    • Site-wide: 87,648
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    • Site-wide: 75,331

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

immunology more details view paper
  • Downloaded 336 times
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    • Site-wide: 88,577
    • In immunology: 2,596
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    • Site-wide: 14,245
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    • Site-wide: 674

Murine monoclonal antibodies against RBD of SARS-CoV-2 neutralize authentic wild type SARS-CoV-2 as well as B.1.1.7 and B.1.351 viruses and protect in vivo in a mouse model in a neutralization dependent manner

microbiology more details view paper
  • Downloaded 323 times
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    • Site-wide: 91,458
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    • Site-wide: 15,074
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    • Site-wide: 32,742

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

immunology more details view paper
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    • Site-wide: 93,868
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Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

immunology more details view paper
  • Downloaded 294 times
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    • Site-wide: 98,031
    • In immunology: 2,885
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Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

biochemistry more details view paper
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    • Site-wide: 88,615

Convergence of a common solution to broad ebolavirus neutralization by glycan cap directed human antibodies

immunology more details view paper
  • Downloaded 260 times
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    • Site-wide: 105,766
    • In immunology: 3,123
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Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

microbiology more details view paper
  • Downloaded 251 times
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    • Site-wide: 108,164
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High-resolution mapping of the neutralizing and binding specificities of polyclonal rabbit serum elicited by HIV Env trimer immunization

microbiology more details view paper
  • Downloaded 239 times
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    • Site-wide: 110,841
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A strain-specific inhibitor of receptor-bound HIV-1 targets a pocket near the fusion peptide and offers a template for drug design

biophysics more details view paper
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Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

immunology more details view paper
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    • Site-wide: 122,064
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    • Site-wide: 59,674

Protective pan-ebolavirus combination therapy by two multifunctional human antibodies

immunology more details view paper
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    • Site-wide: 125,068
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    • Site-wide: 31,940
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    • Site-wide: 22,935

Structural Insights into the Venus flytrap Mechanosensitive Ion Channel Flycatcher1

biochemistry more details view paper
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Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

microbiology more details view paper
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Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

immunology more details view paper
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