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Author: Andrew Ward

Rankings

  • All-time downloads: 73,413 (rank: 3,064 )
  • Categories:
    • biochemistry: 3,305 (rank: 1,425 )
    • bioengineering: 523 (rank: 10,667 (tie) )
    • bioinformatics: 442 (rank: 34,271 (tie) )
    • biophysics: 9,421 (rank: 212 )
    • immunology: 30,710 (rank: 525 )
    • microbiology: 21,965 (rank: 995 (tie) )
    • molecular biology: 752 (rank: 11,573 (tie) )
    • synthetic biology: 1,532 (rank: 1,590 (tie) )

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Preprints

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

microbiology more details view paper
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Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

microbiology more details view paper
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    • Site-wide: 3,981
    • In microbiology: 266
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Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

immunology more details view paper
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    • Site-wide: 4,417
    • In immunology: 167
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SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

microbiology more details view paper
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Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

immunology more details view paper
  • Downloaded 2,795 times
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    • Site-wide: 7,201
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Cryo-EM structure of the mechanically activated ion channel OSCA1.2

biophysics more details view paper
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    • Site-wide: 10,445
    • In biophysics: 194
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Structure of the SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors

biophysics more details view paper
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    • Site-wide: 12,715
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    • Site-wide: 94,168

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

immunology more details view paper
  • Downloaded 1,788 times
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    • Site-wide: 13,984
    • In immunology: 515
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Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

immunology more details view paper
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    • Site-wide: 14,250
    • In immunology: 645
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Structure of the hepatitis C virus E1E2 glycoprotein complex

immunology more details view paper
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    • Site-wide: 16,150
    • In immunology: 835
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OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels

biophysics more details view paper
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    • Site-wide: 16,238
    • In biophysics: 361
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Tailored Design of Protein Nanoparticle Scaffolds for Multivalent Presentation of Viral Glycoprotein Antigens

synthetic biology more details view paper
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    • Site-wide: 17,197
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Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

microbiology more details view paper
  • Downloaded 1,543 times
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    • Site-wide: 17,501
    • In microbiology: 1,044
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Structures of the Otopetrin Proton Channels Otop1 and Otop3

biochemistry more details view paper
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    • Site-wide: 19,655
    • In biochemistry: 401
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Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

microbiology more details view paper
  • Downloaded 1,326 times
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    • Site-wide: 22,112
    • In microbiology: 1,272
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    • Site-wide: 47,670
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Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

immunology more details view paper
  • Downloaded 1,289 times
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    • Site-wide: 23,116
    • In immunology: 871
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Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

immunology more details view paper
  • Downloaded 1,280 times
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    • Site-wide: 23,366
    • In immunology: 778
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Visualization of the HIV-1 Env Glycan Shield Across Scales

biophysics more details view paper
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    • In biophysics: 646
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An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain

microbiology more details view paper
  • Downloaded 1,198 times
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    • Site-wide: 25,904
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Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

biochemistry more details view paper
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    • Site-wide: 29,330
    • In biochemistry: 614
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Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses

immunology more details view paper
  • Downloaded 1,084 times
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    • Site-wide: 30,138
    • In immunology: 1,249
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    • Site-wide: 4,840
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    • Site-wide: 13,301

Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

biophysics more details view paper
  • Downloaded 1,084 times
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    • Site-wide: 30,167
    • In biophysics: 790
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    • Site-wide: 119,677
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    • Site-wide: 110,195

Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

immunology more details view paper
  • Downloaded 1,060 times
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    • Site-wide: 31,150
    • In immunology: 1,016
  • Year to date:
    • Site-wide: 149,133
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    • Site-wide: 130,758

HIV-1 vaccine design through minimizing envelope metastability

microbiology more details view paper
  • Downloaded 1,027 times
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    • Site-wide: 32,667
    • In microbiology: 1,761
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    • Site-wide: 167,065
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    • Site-wide: 161,276

From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

immunology more details view paper
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    • Site-wide: 33,480
    • In immunology: 1,119
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    • Site-wide: 33,653
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    • Site-wide: 52,672

A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

immunology more details view paper
  • Downloaded 851 times
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    • Site-wide: 43,139
    • In immunology: 1,453
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    • Site-wide: 52,434
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A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection

microbiology more details view paper
  • Downloaded 849 times
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    • Site-wide: 43,352
    • In microbiology: 2,554
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    • Site-wide: 40,228

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

immunology more details view paper
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    • Site-wide: 43,511
    • In immunology: 1,555
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    • Site-wide: 31,048
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Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

immunology more details view paper
  • Downloaded 841 times
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    • Site-wide: 43,969
    • In immunology: 1,496
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Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

immunology more details view paper
  • Downloaded 821 times
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    • Site-wide: 45,513
    • In immunology: 1,437
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    • Site-wide: 97,482
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A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

microbiology more details view paper
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    • Site-wide: 45,717
    • In microbiology: 2,567
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    • Site-wide: 116,034
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    • Site-wide: 169,162

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

immunology more details view paper
  • Downloaded 803 times
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    • Site-wide: 47,017
    • In immunology: 1,436
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Structure of the Ebola virus nucleoprotein - RNA complex

biophysics more details view paper
  • Downloaded 792 times
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    • Site-wide: 47,984
    • In biophysics: 1,423
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A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spike

immunology more details view paper
  • Downloaded 780 times
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    • Site-wide: 49,133
    • In immunology: 2,307
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    • Site-wide: 6,826
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Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

immunology more details view paper
  • Downloaded 722 times
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    • Site-wide: 54,776
    • In immunology: 1,636
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Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

immunology more details view paper
  • Downloaded 707 times
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    • Site-wide: 56,309
    • In immunology: 1,934
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    • Site-wide: 27,960
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Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

immunology more details view paper
  • Downloaded 701 times
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    • Site-wide: 57,063
    • In immunology: 1,718
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    • Site-wide: 126,976
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Polyclonal epitope cartography reveals the temporal dynamics and diversity of human antibody responses to H5N1 vaccination

immunology more details view paper
  • Downloaded 697 times
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    • Site-wide: 57,546
    • In immunology: 1,767
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    • Site-wide: 75,937
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Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

bioengineering more details view paper
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Murine monoclonal antibodies against RBD of SARS-CoV-2 neutralize authentic wild type SARS-CoV-2 as well as B.1.1.7 and B.1.351 viruses and protect in vivo in a mouse model in a neutralization dependent manner

microbiology more details view paper
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HIV-1 Envelope and MPER antibody structures in lipid assemblies

immunology more details view paper
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    • Site-wide: 59,381
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Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

immunology more details view paper
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    • Site-wide: 59,430
    • In immunology: 1,779
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Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

molecular biology more details view paper
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    • Site-wide: 65,102
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Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

immunology more details view paper
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    • Site-wide: 66,148
    • In immunology: 1,908
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Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail

biophysics more details view paper
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    • Site-wide: 72,891
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    • Site-wide: 75,490

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

immunology more details view paper
  • Downloaded 575 times
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    • Site-wide: 74,145
    • In immunology: 2,146
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    • Site-wide: 168,921
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    • Site-wide: 118,081

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

immunology more details view paper
  • Downloaded 571 times
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    • Site-wide: 74,727
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    • Site-wide: 55,220
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    • Site-wide: 20,281

Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface

immunology more details view paper
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    • Site-wide: 77,665
    • In immunology: 2,542
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One dose of COVID-19 nanoparticle vaccine REVC-128 provides protection against SARS-CoV-2 challenge at two weeks post immunization

microbiology more details view paper
  • Downloaded 552 times
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    • Site-wide: 77,853
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Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

immunology more details view paper
  • Downloaded 531 times
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    • Site-wide: 81,639
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    • Site-wide: 137,713
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    • Site-wide: 143,579

Structural Insights into the Venus flytrap Mechanosensitive Ion Channel Flycatcher1

biochemistry more details view paper
  • Downloaded 520 times
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    • Site-wide: 83,679
    • In biochemistry: 2,233
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Structural mapping of antibody landscapes to human betacoronavirus spike proteins

immunology more details view paper
  • Downloaded 483 times
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    • Site-wide: 91,015
    • In immunology: 3,111
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    • Site-wide: 22,645
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Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

immunology more details view paper
  • Downloaded 482 times
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    • Site-wide: 91,303
    • In immunology: 2,608
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    • Site-wide: 180,032
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    • Site-wide: 176,166

EMHP: An accurate automated hole masking algorithm for single-particle cryo-EM image processing

bioinformatics more details view paper
  • Downloaded 457 times
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    • Site-wide: 96,690
    • In bioinformatics: 7,970
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Protective pan-ebolavirus combination therapy by two multifunctional human antibodies

immunology more details view paper
  • Downloaded 409 times
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    • Site-wide: 108,032
    • In immunology: 3,282
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    • Site-wide: 78,203
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Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

immunology more details view paper
  • Downloaded 398 times
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    • Site-wide: 110,643
    • In immunology: 3,606
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    • Site-wide: 17,405
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    • Site-wide: 45,465

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

immunology more details view paper
  • Downloaded 381 times
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    • Site-wide: 115,086
    • In immunology: 3,320
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Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

microbiology more details view paper
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    • Site-wide: 115,693
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HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

immunology more details view paper
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    • Site-wide: 124,481
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    • Site-wide: 176,180
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    • Site-wide: 158,833

High-resolution structural analysis of enterovirus-reactive polyclonal antibodies in complex with whole virions

immunology more details view paper
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    • Site-wide: 125,218
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Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

biochemistry more details view paper
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Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

immunology more details view paper
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    • Site-wide: 126,673
    • In immunology: 3,702
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High-resolution mapping of the neutralizing and binding specificities of polyclonal rabbit serum elicited by HIV Env trimer immunization

microbiology more details view paper
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    • Site-wide: 129,139
    • In microbiology: 8,581
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Lassa virus glycoprotein nanoparticles elicit a neutralizing antibody that defines a new site of vulnerability

immunology more details view paper
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    • Site-wide: 10,858
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Convergence of a common solution to broad ebolavirus neutralization by glycan cap directed human antibodies

immunology more details view paper
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A strain-specific inhibitor of receptor-bound HIV-1 targets a pocket near the fusion peptide and offers a template for drug design

biophysics more details view paper
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Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

immunology more details view paper
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    • Site-wide: 147,838
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    • Site-wide: 137,697

Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

immunology more details view paper
  • Downloaded 224 times
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    • Site-wide: 160,419
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Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens

molecular biology more details view paper
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Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

microbiology more details view paper
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Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels

biophysics more details view paper
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The pre-existing human antibody repertoire to computationally optimized influenza H1 hemagglutinin vaccines

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