Author: Andrew B. Ward

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Preprints

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

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One dose of COVID-19 nanoparticle vaccine REVC-128 provides protection against SARS-CoV-2 challenge at two weeks post immunization

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From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

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Murine monoclonal antibodies against RBD of SARS-CoV-2 neutralize authentic wild type SARS-CoV-2 as well as B.1.1.7 and B.1.351 viruses and protect in vivo in a mouse model in a neutralization dependent manner

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Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

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Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

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SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

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Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

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Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

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Cryo-EM structure of the mechanically activated ion channel OSCA1.2

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Structure of the SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors

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OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels

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Tailored Design of Protein Nanoparticle Scaffolds for Multivalent Presentation of Viral Glycoprotein Antigens

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Structures of the Otopetrin Proton Channels Otop1 and Otop3

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Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

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Visualization of the HIV-1 Env Glycan Shield Across Scales

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Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

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Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

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Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

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Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

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An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain

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Structure of the Ebola virus nucleoprotein - RNA complex

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Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

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HIV-1 vaccine design through minimizing envelope metastability

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Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

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Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

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Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

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A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

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HIV-1 Envelope and MPER antibody structures in lipid assemblies

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Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

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Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

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Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

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Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

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Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

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Polyclonal epitope cartography reveals the temporal dynamics and diversity of human antibody responses to H5N1 vaccination

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Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail

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Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

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Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

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EMHP: An accurate automated hole masking algorithm for single-particle cryo-EM image processing

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Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

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A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

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Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

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Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

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HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

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Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

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Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

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A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection

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Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface

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Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

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Convergence of a common solution to broad ebolavirus neutralization by glycan cap directed human antibodies

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A strain-specific inhibitor of receptor-bound HIV-1 targets a pocket near the fusion peptide and offers a template for drug design

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High-resolution mapping of the neutralizing and binding specificities of polyclonal rabbit serum elicited by HIV Env trimer immunization

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Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

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Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

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Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

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