Author: Andrew Ward

Downloads per author, site-wide

Preprints

Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens

No download data for this paper yet.

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

• Downloaded 5,973 times
• Download rankings, all-time:
  • Site-wide: 1,827
  • In microbiology: 154
• Year to date:
  • Site-wide: 32,681
• Since beginning of last month:
  • Site-wide: 68,462

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

• Downloaded 4,038 times
• Download rankings, all-time:
  • Site-wide: 3,148
  • In microbiology: 223
• Year to date:
  • Site-wide: 19,131
• Since beginning of last month:
  • Site-wide: 37,532

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

• Downloaded 3,005 times
• Download rankings, all-time:
  • Site-wide: 4,754
  • In microbiology: 310
• Year to date:
  • Site-wide: 9,630
• Since beginning of last month:
  • Site-wide: 38,015

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

• Downloaded 2,882 times
• Download rankings, all-time:
  • Site-wide: 5,053
  • In immunology: 177
• Year to date:
  • Site-wide: 6,108
• Since beginning of last month:
  • Site-wide: 4,617

Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

• Downloaded 2,533 times
• Download rankings, all-time:
  • Site-wide: 6,105
  • In immunology: 206
• Year to date:
  • Site-wide: 3,857
• Since beginning of last month:
  • Site-wide: 13,271

Cryo-EM structure of the mechanically activated ion channel OSCA1.2

• Downloaded 2,038 times
• Download rankings, all-time:
  • Site-wide: 8,369
  • In biophysics: 165
• Year to date:
  • Site-wide: 60,702
• Since beginning of last month:
  • Site-wide: 97,407

Structure of the SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors

• Downloaded 1,801 times
• Download rankings, all-time:
  • Site-wide: 10,096
  • In biophysics: 211
• Year to date:
  • Site-wide: 32,475
• Since beginning of last month:
  • Site-wide: 53,943

Tailored Design of Protein Nanoparticle Scaffolds for Multivalent Presentation of Viral Glycoprotein Antigens

• Downloaded 1,493 times
• Download rankings, all-time:
  • Site-wide: 13,268
  • In synthetic biology: 149
• Year to date:
  • Site-wide: 52,547
• Since beginning of last month:
  • Site-wide: 115,292

OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels

• Downloaded 1,491 times
• Download rankings, all-time:
  • Site-wide: 13,288
  • In biophysics: 308
• Year to date:
  • Site-wide: 96,291
• Since beginning of last month:
  • Site-wide: 70,189

Structures of the Otopetrin Proton Channels Otop1 and Otop3

• Downloaded 1,340 times
• Download rankings, all-time:
  • Site-wide: 15,639
  • In biochemistry: 319
• Year to date:
  • Site-wide: 109,685
• Since beginning of last month:
  • Site-wide: 122,687

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

• Downloaded 1,232 times
• Download rankings, all-time:
  • Site-wide: 17,730
  • In immunology: 570
• Year to date:
  • Site-wide: 126,033
• Since beginning of last month:
  • Site-wide: 83,811

Visualization of the HIV-1 Env Glycan Shield Across Scales

• Downloaded 1,122 times
• Download rankings, all-time:
  • Site-wide: 20,380
  • In biophysics: 527
• Year to date:
  • Site-wide: 84,254
• Since beginning of last month:
  • Site-wide: 77,274

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

• Downloaded 1,105 times
• Download rankings, all-time:
  • Site-wide: 20,852
  • In microbiology: 1,204
• Year to date:
  • Site-wide: 2,535
• Since beginning of last month:
  • Site-wide: 31,940

Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

• Downloaded 1,073 times
• Download rankings, all-time:
  • Site-wide: 21,731
  • In microbiology: 1,262
• Year to date:
  • Site-wide: 22,420
• Since beginning of last month:
  • Site-wide: 67,634

Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

• Downloaded 1,039 times
• Download rankings, all-time:
  • Site-wide: 22,842
  • In biochemistry: 492
• Year to date:
  • Site-wide: 82,241
• Since beginning of last month:
  • Site-wide: 91,227

An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain

• Downloaded 1,012 times
• Download rankings, all-time:
  • Site-wide: 23,687
  • In microbiology: 1,405
• Year to date:
  • Site-wide: 19,015
• Since beginning of last month:
  • Site-wide: 25,332

Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

• Downloaded 1,008 times
• Download rankings, all-time:
  • Site-wide: 23,811
  • In biophysics: 648
• Year to date:
  • Site-wide: 39,063
• Since beginning of last month:
  • Site-wide: 100,405

Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

• Downloaded 995 times
• Download rankings, all-time:
  • Site-wide: 24,272
  • In immunology: 794
• Year to date:
  • Site-wide: 85,398
• Since beginning of last month:
  • Site-wide: 109,837

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

• Downloaded 853 times
• Download rankings, all-time:
  • Site-wide: 30,229
  • In immunology: 946
• Year to date:
  • Site-wide: 3,686
• Since beginning of last month:
  • Site-wide: 3,726

Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

• Downloaded 823 times
• Download rankings, all-time:
  • Site-wide: 31,763
  • In immunology: 991
• Year to date:
  • Site-wide: 3,876
• Since beginning of last month:
  • Site-wide: 6,980

Structure of the Ebola virus nucleoprotein - RNA complex

• Downloaded 724 times
• Download rankings, all-time:
  • Site-wide: 38,030
  • In biophysics: 1,196
• Year to date:
  • Site-wide: 96,465
• Since beginning of last month:
  • Site-wide: 98,554

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

• Downloaded 720 times
• Download rankings, all-time:
  • Site-wide: 38,349
  • In immunology: 1,182
• Year to date:
  • Site-wide: 20,667
• Since beginning of last month:
  • Site-wide: 30,154

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

• Downloaded 719 times
• Download rankings, all-time:
  • Site-wide: 38,369
  • In immunology: 1,189
• Year to date:
  • Site-wide: 80,683
• Since beginning of last month:
  • Site-wide: 101,183

HIV-1 vaccine design through minimizing envelope metastability

• Downloaded 693 times
• Download rankings, all-time:
  • Site-wide: 40,263
  • In microbiology: 2,429
• Year to date:
  • Site-wide: 109,381
• Since beginning of last month:
  • Site-wide: 143,039

Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

• Downloaded 687 times
• Download rankings, all-time:
  • Site-wide: 40,767
  • In immunology: 1,254
• Year to date:
  • Site-wide: 104,183
• Since beginning of last month:
  • Site-wide: 88,171

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

• Downloaded 673 times
• Download rankings, all-time:
  • Site-wide: 41,851
  • In microbiology: 2,531
• Year to date:
  • Site-wide: 34,709
• Since beginning of last month:
  • Site-wide: 48,531

From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

• Downloaded 653 times
• Download rankings, all-time:
  • Site-wide: 43,603
  • In immunology: 1,328
• Year to date:
  • Site-wide: 5,456
• Since beginning of last month:
  • Site-wide: 12,612

HIV-1 Envelope and MPER antibody structures in lipid assemblies

• Downloaded 629 times
• Download rankings, all-time:
  • Site-wide: 45,625
  • In immunology: 1,376
• Year to date:
  • Site-wide: 92,179
• Since beginning of last month:
  • Site-wide: 102,642

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

• Downloaded 620 times
• Download rankings, all-time:
  • Site-wide: 46,493
  • In immunology: 1,394
• Year to date:
  • Site-wide: 71,824
• Since beginning of last month:
  • Site-wide: 129,635

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

• Downloaded 609 times
• Download rankings, all-time:
  • Site-wide: 47,574
  • In immunology: 1,429
• Year to date:
  • Site-wide: 95,048
• Since beginning of last month:
  • Site-wide: 103,577

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

• Downloaded 588 times
• Download rankings, all-time:
  • Site-wide: 49,688
  • In immunology: 1,489
• Year to date:
  • Site-wide: 90,914
• Since beginning of last month:
  • Site-wide: 98,278

Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

• Downloaded 554 times
• Download rankings, all-time:
  • Site-wide: 53,495
  • In molecular biology: 1,505
• Year to date:
  • Site-wide: 40,311
• Since beginning of last month:
  • Site-wide: 77,799

Polyclonal epitope cartography reveals the temporal dynamics and diversity of human antibody responses to H5N1 vaccination

• Downloaded 548 times
• Download rankings, all-time:
  • Site-wide: 54,218
  • In immunology: 1,636
• Year to date:
  • Site-wide: 34,087
• Since beginning of last month:
  • Site-wide: 33,317

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

• Downloaded 541 times
• Download rankings, all-time:
  • Site-wide: 55,069
  • In immunology: 1,661
• Year to date:
  • Site-wide: 139,507
• Since beginning of last month:
  • Site-wide: 119,156

Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail

• Downloaded 518 times
• Download rankings, all-time:
  • Site-wide: 57,957
  • In biophysics: 1,987
• Year to date:
  • Site-wide: 102,822
• Since beginning of last month:
  • Site-wide: 103,832

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

• Downloaded 500 times
• Download rankings, all-time:
  • Site-wide: 60,475
  • In immunology: 1,812
• Year to date:
  • Site-wide: 8,095
• Since beginning of last month:
  • Site-wide: 14,557

A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection

• Downloaded 468 times
• Download rankings, all-time:
  • Site-wide: 64,872
  • In microbiology: 4,246
• Year to date:
  • Site-wide: 8,881
• Since beginning of last month:
  • Site-wide: 75,229

A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

• Downloaded 468 times
• Download rankings, all-time:
  • Site-wide: 64,862
  • In immunology: 1,945
• Year to date:
  • Site-wide: 8,883
• Since beginning of last month:
  • Site-wide: 24,992

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

• Downloaded 463 times
• Download rankings, all-time:
  • Site-wide: 65,692
  • In immunology: 1,965
• Year to date:
  • Site-wide: 135,436
• Since beginning of last month:
  • Site-wide: 109,355

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

• Downloaded 453 times
• Download rankings, all-time:
  • Site-wide: 67,140
  • In immunology: 1,997
• Year to date:
  • Site-wide: 148,169
• Since beginning of last month:
  • Site-wide: 145,093

EMHP: An accurate automated hole masking algorithm for single-particle cryo-EM image processing

• Downloaded 419 times
• Download rankings, all-time:
  • Site-wide: 72,786
  • In bioinformatics: 6,830
• Year to date:
  • Site-wide: 131,817
• Since beginning of last month:
  • Site-wide: 137,296

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 80,348
  • In immunology: 2,364
• Year to date:
  • Site-wide: 12,070
• Since beginning of last month:
  • Site-wide: 40,673

One dose of COVID-19 nanoparticle vaccine REVC-128 provides protection against SARS-CoV-2 challenge at two weeks post immunization

• Downloaded 366 times
• Download rankings, all-time:
  • Site-wide: 82,432
  • In microbiology: 5,657
• Year to date:
  • Site-wide: 12,571
• Since beginning of last month:
  • Site-wide: 27,395

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 87,516
  • In immunology: 2,574
• Year to date:
  • Site-wide: 134,080
• Since beginning of last month:
  • Site-wide: 147,108

Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface

• Downloaded 340 times
• Download rankings, all-time:
  • Site-wide: 87,648
  • In immunology: 2,577
• Year to date:
  • Site-wide: 14,035
• Since beginning of last month:
  • Site-wide: 75,331

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

• Downloaded 336 times
• Download rankings, all-time:
  • Site-wide: 88,577
  • In immunology: 2,596
• Year to date:
  • Site-wide: 14,245
• Since beginning of last month:
  • Site-wide: 674

Murine monoclonal antibodies against RBD of SARS-CoV-2 neutralize authentic wild type SARS-CoV-2 as well as B.1.1.7 and B.1.351 viruses and protect in vivo in a mouse model in a neutralization dependent manner

• Downloaded 323 times
• Download rankings, all-time:
  • Site-wide: 91,458
  • In microbiology: 6,407
• Year to date:
  • Site-wide: 15,074
• Since beginning of last month:
  • Site-wide: 32,742

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

• Downloaded 312 times
• Download rankings, all-time:
  • Site-wide: 93,868
  • In immunology: 2,765
• Year to date:
  • Site-wide: 134,069
• Since beginning of last month:
  • Site-wide: 129,724

Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

• Downloaded 294 times
• Download rankings, all-time:
  • Site-wide: 98,031
  • In immunology: 2,885
• Year to date:
  • Site-wide: 119,480
• Since beginning of last month:
  • Site-wide: 134,004

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

• Downloaded 281 times
• Download rankings, all-time:
  • Site-wide: 100,857
  • In biochemistry: 2,936
• Year to date:
  • Site-wide: 62,211
• Since beginning of last month:
  • Site-wide: 88,615

Convergence of a common solution to broad ebolavirus neutralization by glycan cap directed human antibodies

• Downloaded 260 times
• Download rankings, all-time:
  • Site-wide: 105,766
  • In immunology: 3,123
• Year to date:
  • Site-wide: 100,682
• Since beginning of last month:
  • Site-wide: 134,168

Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

• Downloaded 251 times
• Download rankings, all-time:
  • Site-wide: 108,164
  • In microbiology: 7,797
• Year to date:
  • Site-wide: 43,423
• Since beginning of last month:
  • Site-wide: 35,794

High-resolution mapping of the neutralizing and binding specificities of polyclonal rabbit serum elicited by HIV Env trimer immunization

• Downloaded 239 times
• Download rankings, all-time:
  • Site-wide: 110,841
  • In microbiology: 8,086
• Year to date:
  • Site-wide: 93,653
• Since beginning of last month:
  • Site-wide: 115,427

A strain-specific inhibitor of receptor-bound HIV-1 targets a pocket near the fusion peptide and offers a template for drug design

• Downloaded 237 times
• Download rankings, all-time:
  • Site-wide: 111,429
  • In biophysics: 4,281
• Year to date:
  • Site-wide: 120,950
• Since beginning of last month:
  • Site-wide: 129,783

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

• Downloaded 194 times
• Download rankings, all-time:
  • Site-wide: 122,064
  • In immunology: 3,580
• Year to date:
  • Site-wide: 84,247
• Since beginning of last month:
  • Site-wide: 59,674

Protective pan-ebolavirus combination therapy by two multifunctional human antibodies

• Downloaded 182 times
• Download rankings, all-time:
  • Site-wide: 125,068
  • In immunology: 3,661
• Year to date:
  • Site-wide: 31,940
• Since beginning of last month:
  • Site-wide: 22,935

Structural Insights into the Venus flytrap Mechanosensitive Ion Channel Flycatcher1

• Downloaded 168 times
• Download rankings, all-time:
  • Site-wide: 128,238
  • In biochemistry: 3,851
• Year to date:
  • Site-wide: 35,043
• Since beginning of last month:
  • Site-wide: 1,607

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

• Downloaded 140 times
• Download rankings, all-time:
  • Site-wide: 134,299
  • In microbiology: 10,179
• Year to date:
  • Site-wide: 107,860
• Since beginning of last month:
  • Site-wide: 141,901

Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

• Downloaded 86 times
• Download rankings, all-time:
  • Site-wide: 144,547
  • In immunology: 4,321
• Year to date:
  • Site-wide: 68,345
• Since beginning of last month:
  • Site-wide: 50,891