Author: Andrew B Ward

Downloads per author, site-wide

Preprints

High-resolution mapping of the neutralizing and binding specificities of polyclonal rabbit serum elicited by HIV Env trimer immunization

No bioRxiv download data for this paper yet.

Convergence of a common solution to broad ebolavirus neutralization by glycan cap directed human antibodies

No bioRxiv download data for this paper yet.

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

• Downloaded 5,708 times
• Download rankings, all-time:
  • Site-wide: 668 out of 100,621
  • In microbiology: 97 out of 8,911
• Year to date:
  • Site-wide: 216 out of 100,621
• Since beginning of last month:
  • Site-wide: 4,326 out of 100,621

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

• Downloaded 3,350 times
• Download rankings, all-time:
  • Site-wide: 1,711 out of 100,621
  • In microbiology: 169 out of 8,911
• Year to date:
  • Site-wide: 423 out of 100,621
• Since beginning of last month:
  • Site-wide: None out of 100,621

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

• Downloaded 2,269 times
• Download rankings, all-time:
  • Site-wide: 3,324 out of 100,621
  • In microbiology: 250 out of 8,911
• Year to date:
  • Site-wide: 679 out of 100,621
• Since beginning of last month:
  • Site-wide: 143 out of 100,621

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

• Downloaded 1,956 times
• Download rankings, all-time:
  • Site-wide: 4,233 out of 100,621
  • In immunology: 124 out of 3,123
• Year to date:
  • Site-wide: 832 out of 100,621
• Since beginning of last month:
  • Site-wide: 365 out of 100,621

Cryo-EM structure of the mechanically activated ion channel OSCA1.2

• Downloaded 1,885 times
• Download rankings, all-time:
  • Site-wide: 4,511 out of 100,621
  • In biophysics: 122 out of 4,433
• Year to date:
  • Site-wide: 19,540 out of 100,621
• Since beginning of last month:
  • Site-wide: 24,916 out of 100,621

Structure of the SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors

• Downloaded 1,561 times
• Download rankings, all-time:
  • Site-wide: 6,197 out of 100,621
  • In biophysics: 178 out of 4,433
• Year to date:
  • Site-wide: 1,749 out of 100,621
• Since beginning of last month:
  • Site-wide: 11,421 out of 100,621

OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels

• Downloaded 1,397 times
• Download rankings, all-time:
  • Site-wide: 7,432 out of 100,621
  • In biophysics: 229 out of 4,433
• Year to date:
  • Site-wide: 49,852 out of 100,621
• Since beginning of last month:
  • Site-wide: 24,915 out of 100,621

Tailored Design of Protein Nanoparticle Scaffolds for Multivalent Presentation of Viral Glycoprotein Antigens

• Downloaded 1,293 times
• Download rankings, all-time:
  • Site-wide: 8,505 out of 100,621
  • In synthetic biology: 134 out of 917
• Year to date:
  • Site-wide: 1,584 out of 100,621
• Since beginning of last month:
  • Site-wide: 12,771 out of 100,621

Structures of the Otopetrin Proton Channels Otop1 and Otop3

• Downloaded 1,249 times
• Download rankings, all-time:
  • Site-wide: 8,994 out of 100,621
  • In biochemistry: 223 out of 3,441
• Year to date:
  • Site-wide: 40,802 out of 100,621
• Since beginning of last month:
  • Site-wide: 27,654 out of 100,621

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

• Downloaded 1,182 times
• Download rankings, all-time:
  • Site-wide: 9,875 out of 100,621
  • In immunology: 294 out of 3,123
• Year to date:
  • Site-wide: 30,926 out of 100,621
• Since beginning of last month:
  • Site-wide: 26,032 out of 100,621

Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

• Downloaded 1,114 times
• Download rankings, all-time:
  • Site-wide: 10,894 out of 100,621
  • In immunology: 319 out of 3,123
• Year to date:
  • Site-wide: 2,007 out of 100,621
• Since beginning of last month:
  • Site-wide: 76 out of 100,621

Visualization of the HIV-1 Env Glycan Shield Across Scales

• Downloaded 1,026 times
• Download rankings, all-time:
  • Site-wide: 12,445 out of 100,621
  • In biophysics: 397 out of 4,433
• Year to date:
  • Site-wide: 5,025 out of 100,621
• Since beginning of last month:
  • Site-wide: 14,177 out of 100,621

Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

• Downloaded 927 times
• Download rankings, all-time:
  • Site-wide: 14,641 out of 100,621
  • In biochemistry: 377 out of 3,441
• Year to date:
  • Site-wide: 5,724 out of 100,621
• Since beginning of last month:
  • Site-wide: 21,633 out of 100,621

Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

• Downloaded 913 times
• Download rankings, all-time:
  • Site-wide: 14,998 out of 100,621
  • In immunology: 428 out of 3,123
• Year to date:
  • Site-wide: 52,233 out of 100,621
• Since beginning of last month:
  • Site-wide: 40,169 out of 100,621

Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

• Downloaded 807 times
• Download rankings, all-time:
  • Site-wide: 18,172 out of 100,621
  • In biophysics: 639 out of 4,433
• Year to date:
  • Site-wide: 3,243 out of 100,621
• Since beginning of last month:
  • Site-wide: 12,163 out of 100,621

Structure of the Ebola virus nucleoprotein - RNA complex

• Downloaded 640 times
• Download rankings, all-time:
  • Site-wide: 25,611 out of 100,621
  • In biophysics: 972 out of 4,433
• Year to date:
  • Site-wide: 44,450 out of 100,621
• Since beginning of last month:
  • Site-wide: 42,796 out of 100,621

HIV-1 vaccine design through minimizing envelope metastability

• Downloaded 627 times
• Download rankings, all-time:
  • Site-wide: 26,360 out of 100,621
  • In microbiology: 1,725 out of 8,911
• Year to date:
  • Site-wide: 54,283 out of 100,621
• Since beginning of last month:
  • Site-wide: 39,470 out of 100,621

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

• Downloaded 613 times
• Download rankings, all-time:
  • Site-wide: 27,167 out of 100,621
  • In immunology: 760 out of 3,123
• Year to date:
  • Site-wide: 4,913 out of 100,621
• Since beginning of last month:
  • Site-wide: 11,883 out of 100,621

Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

• Downloaded 607 times
• Download rankings, all-time:
  • Site-wide: 27,571 out of 100,621
  • In immunology: 774 out of 3,123
• Year to date:
  • Site-wide: 4,993 out of 100,621
• Since beginning of last month:
  • Site-wide: 14,641 out of 100,621

HIV-1 Envelope and MPER antibody structures in lipid assemblies

• Downloaded 522 times
• Download rankings, all-time:
  • Site-wide: 33,433 out of 100,621
  • In immunology: 913 out of 3,123
• Year to date:
  • Site-wide: 17,758 out of 100,621
• Since beginning of last month:
  • Site-wide: None out of 100,621

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

• Downloaded 513 times
• Download rankings, all-time:
  • Site-wide: 34,100 out of 100,621
  • In immunology: 929 out of 3,123
• Year to date:
  • Site-wide: 6,491 out of 100,621
• Since beginning of last month:
  • Site-wide: 19,403 out of 100,621

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

• Downloaded 513 times
• Download rankings, all-time:
  • Site-wide: 34,113 out of 100,621
  • In immunology: 932 out of 3,123
• Year to date:
  • Site-wide: 64,039 out of 100,621
• Since beginning of last month:
  • Site-wide: 41,993 out of 100,621

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

• Downloaded 494 times
• Download rankings, all-time:
  • Site-wide: 35,743 out of 100,621
  • In immunology: 982 out of 3,123
• Year to date:
  • Site-wide: 56,085 out of 100,621
• Since beginning of last month:
  • Site-wide: 28,473 out of 100,621

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

• Downloaded 486 times
• Download rankings, all-time:
  • Site-wide: 36,461 out of 100,621
  • In immunology: 1,014 out of 3,123
• Year to date:
  • Site-wide: 27,657 out of 100,621
• Since beginning of last month:
  • Site-wide: None out of 100,621

Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

• Downloaded 433 times
• Download rankings, all-time:
  • Site-wide: 41,661 out of 100,621
  • In microbiology: 2,924 out of 8,911
• Year to date:
  • Site-wide: 8,474 out of 100,621
• Since beginning of last month:
  • Site-wide: None out of 100,621

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

• Downloaded 427 times
• Download rankings, all-time:
  • Site-wide: 42,386 out of 100,621
  • In immunology: 1,183 out of 3,123
• Year to date:
  • Site-wide: 82,365 out of 100,621
• Since beginning of last month:
  • Site-wide: 53,845 out of 100,621

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

• Downloaded 425 times
• Download rankings, all-time:
  • Site-wide: 42,642 out of 100,621
  • In immunology: 1,190 out of 3,123
• Year to date:
  • Site-wide: 78,709 out of 100,621
• Since beginning of last month:
  • Site-wide: 40,040 out of 100,621

Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail

• Downloaded 424 times
• Download rankings, all-time:
  • Site-wide: 42,773 out of 100,621
  • In biophysics: 1,736 out of 4,433
• Year to date:
  • Site-wide: 13,825 out of 100,621
• Since beginning of last month:
  • Site-wide: 9,093 out of 100,621

EMHP: An accurate automated hole masking algorithm for single-particle cryo-EM image processing

• Downloaded 381 times
• Download rankings, all-time:
  • Site-wide: 47,910 out of 100,621
  • In bioinformatics: 5,580 out of 9,245
• Year to date:
  • Site-wide: 90,388 out of 100,621
• Since beginning of last month:
  • Site-wide: 55,351 out of 100,621

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 57,886 out of 100,621
  • In microbiology: 4,321 out of 8,911
• Year to date:
  • Site-wide: 14,142 out of 100,621
• Since beginning of last month:
  • Site-wide: 755 out of 100,621

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

• Downloaded 302 times
• Download rankings, all-time:
  • Site-wide: 59,096 out of 100,621
  • In immunology: 1,643 out of 3,123
• Year to date:
  • Site-wide: 42,588 out of 100,621
• Since beginning of last month:
  • Site-wide: 48,142 out of 100,621

Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

• Downloaded 263 times
• Download rankings, all-time:
  • Site-wide: 65,485 out of 100,621
  • In molecular biology: 2,119 out of 3,492
• Year to date:
  • Site-wide: 17,910 out of 100,621
• Since beginning of last month:
  • Site-wide: 991 out of 100,621

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

• Downloaded 261 times
• Download rankings, all-time:
  • Site-wide: 65,734 out of 100,621
  • In immunology: 1,853 out of 3,123
• Year to date:
  • Site-wide: 48,807 out of 100,621
• Since beginning of last month:
  • Site-wide: None out of 100,621

An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain

• Downloaded 247 times
• Download rankings, all-time:
  • Site-wide: 68,254 out of 100,621
  • In microbiology: 5,306 out of 8,911
• Year to date:
  • Site-wide: 19,660 out of 100,621
• Since beginning of last month:
  • Site-wide: None out of 100,621

Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

• Downloaded 223 times
• Download rankings, all-time:
  • Site-wide: 72,479 out of 100,621
  • In immunology: 2,086 out of 3,123
• Year to date:
  • Site-wide: 22,635 out of 100,621
• Since beginning of last month:
  • Site-wide: None out of 100,621

Polyclonal epitope cartography reveals the temporal dynamics and diversity of human antibody responses to H5N1 vaccination

• Downloaded 202 times
• Download rankings, all-time:
  • Site-wide: 76,121 out of 100,621
  • In immunology: 2,201 out of 3,123
• Year to date:
  • Site-wide: 25,936 out of 100,621
• Since beginning of last month:
  • Site-wide: None out of 100,621

A strain-specific inhibitor of receptor-bound HIV-1 targets a pocket near the fusion peptide and offers a template for drug design

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 80,422 out of 100,621
  • In biophysics: 3,514 out of 4,433
• Year to date:
  • Site-wide: 30,534 out of 100,621
• Since beginning of last month:
  • Site-wide: 11,970 out of 100,621

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

• Downloaded 150 times
• Download rankings, all-time:
  • Site-wide: 84,962 out of 100,621
  • In biochemistry: 2,861 out of 3,441
• Year to date:
  • Site-wide: 37,699 out of 100,621
• Since beginning of last month:
  • Site-wide: 20,385 out of 100,621

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

• Downloaded 80 times
• Download rankings, all-time:
  • Site-wide: 93,692 out of 100,621
  • In immunology: 2,794 out of 3,123
• Year to date:
  • Site-wide: 69,832 out of 100,621
• Since beginning of last month:
  • Site-wide: 6,065 out of 100,621