Author: Andrew Ward

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Preprints

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

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  • Site-wide: 76,067
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  • Site-wide: 110,096

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

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  • Site-wide: 3,981
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  • Site-wide: 56,764
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  • Site-wide: 67,216

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

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  • Site-wide: 4,417
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• Year to date:
  • Site-wide: 7,272
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  • Site-wide: 14,138

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

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  • Site-wide: 5,693
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  • Site-wide: 49,386
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  • Site-wide: 156,917

Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

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  • Site-wide: 7,201
  • In immunology: 265
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  • Site-wide: 47,610
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  • Site-wide: 61,027

Cryo-EM structure of the mechanically activated ion channel OSCA1.2

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  • Site-wide: 10,445
  • In biophysics: 194
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  • Site-wide: 66,329
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  • Site-wide: 66,436

Structure of the SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors

• Downloaded 1,908 times
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  • Site-wide: 12,715
  • In biophysics: 258
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  • Site-wide: 95,956
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  • Site-wide: 94,168

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

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  • Site-wide: 13,984
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• Year to date:
  • Site-wide: 14,881
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  • Site-wide: 27,724

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

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  • Site-wide: 14,250
  • In immunology: 645
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  • Site-wide: 2,264
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  • Site-wide: 6,142

Structure of the hepatitis C virus E1E2 glycoprotein complex

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  • Site-wide: 16,150
  • In immunology: 835
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  • Site-wide: 2,531
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  • Site-wide: 3,346

OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels

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  • Site-wide: 16,238
  • In biophysics: 361
• Year to date:
  • Site-wide: 95,990
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  • Site-wide: 129,653

Tailored Design of Protein Nanoparticle Scaffolds for Multivalent Presentation of Viral Glycoprotein Antigens

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  • Site-wide: 17,197
  • In synthetic biology: 178
• Year to date:
  • Site-wide: 112,027
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  • Site-wide: 67,781

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

• Downloaded 1,543 times
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  • Site-wide: 17,501
  • In microbiology: 1,044
• Year to date:
  • Site-wide: 28,657
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  • Site-wide: 25,302

Structures of the Otopetrin Proton Channels Otop1 and Otop3

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  • Site-wide: 19,655
  • In biochemistry: 401
• Year to date:
  • Site-wide: 114,055
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  • Site-wide: 94,238

Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

• Downloaded 1,326 times
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  • Site-wide: 22,112
  • In microbiology: 1,272
• Year to date:
  • Site-wide: 47,670
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  • Site-wide: 46,214

Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

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  • Site-wide: 23,116
  • In immunology: 871
• Year to date:
  • Site-wide: 26,053
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  • Site-wide: 17,770

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

• Downloaded 1,280 times
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  • Site-wide: 23,366
  • In immunology: 778
• Year to date:
  • Site-wide: 163,717
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  • Site-wide: 150,335

Visualization of the HIV-1 Env Glycan Shield Across Scales

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  • Site-wide: 25,852
  • In biophysics: 646
• Year to date:
  • Site-wide: 103,973
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  • Site-wide: 95,780

An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain

• Downloaded 1,198 times
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  • Site-wide: 25,904
  • In microbiology: 1,441
• Year to date:
  • Site-wide: 63,237
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  • Site-wide: 90,590

Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

• Downloaded 1,103 times
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  • Site-wide: 29,330
  • In biochemistry: 614
• Year to date:
  • Site-wide: 149,001
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  • Site-wide: 150,325

Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses

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  • Site-wide: 30,138
  • In immunology: 1,249
• Year to date:
  • Site-wide: 4,840
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  • Site-wide: 13,301

Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

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  • Site-wide: 30,167
  • In biophysics: 790
• Year to date:
  • Site-wide: 119,677
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  • Site-wide: 110,195

Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

• Downloaded 1,060 times
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  • Site-wide: 31,150
  • In immunology: 1,016
• Year to date:
  • Site-wide: 149,133
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  • Site-wide: 130,758

HIV-1 vaccine design through minimizing envelope metastability

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  • Site-wide: 32,667
  • In microbiology: 1,761
• Year to date:
  • Site-wide: 167,065
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  • Site-wide: 161,276

From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

• Downloaded 1,011 times
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  • Site-wide: 33,480
  • In immunology: 1,119
• Year to date:
  • Site-wide: 33,653
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  • Site-wide: 52,672

A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

• Downloaded 851 times
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  • Site-wide: 43,139
  • In immunology: 1,453
• Year to date:
  • Site-wide: 52,434
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  • Site-wide: 29,932

A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection

• Downloaded 849 times
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  • Site-wide: 43,352
  • In microbiology: 2,554
• Year to date:
  • Site-wide: 65,664
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  • Site-wide: 40,228

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

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  • Site-wide: 43,511
  • In immunology: 1,555
• Year to date:
  • Site-wide: 31,048
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  • Site-wide: 27,482

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

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  • Site-wide: 43,969
  • In immunology: 1,496
• Year to date:
  • Site-wide: 42,472
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  • Site-wide: 36,009

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

• Downloaded 821 times
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  • Site-wide: 45,513
  • In immunology: 1,437
• Year to date:
  • Site-wide: 97,482
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  • Site-wide: 109,786

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

• Downloaded 818 times
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  • Site-wide: 45,717
  • In microbiology: 2,567
• Year to date:
  • Site-wide: 116,034
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  • Site-wide: 169,162

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

• Downloaded 803 times
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  • Site-wide: 47,017
  • In immunology: 1,436
• Year to date:
  • Site-wide: 126,890
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  • Site-wide: 152,853

Structure of the Ebola virus nucleoprotein - RNA complex

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  • Site-wide: 47,984
  • In biophysics: 1,423
• Year to date:
  • Site-wide: 165,928
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  • Site-wide: 164,744

A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spike

• Downloaded 780 times
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  • Site-wide: 49,133
  • In immunology: 2,307
• Year to date:
  • Site-wide: 6,826
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  • Site-wide: 5,513

Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

• Downloaded 722 times
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  • Site-wide: 54,776
  • In immunology: 1,636
• Year to date:
  • Site-wide: 171,787
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  • Site-wide: 154,110

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

• Downloaded 707 times
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  • Site-wide: 56,309
  • In immunology: 1,934
• Year to date:
  • Site-wide: 27,960
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  • Site-wide: 27,418

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

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  • Site-wide: 57,063
  • In immunology: 1,718
• Year to date:
  • Site-wide: 126,976
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  • Site-wide: 120,788

Polyclonal epitope cartography reveals the temporal dynamics and diversity of human antibody responses to H5N1 vaccination

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  • Site-wide: 57,546
  • In immunology: 1,767
• Year to date:
  • Site-wide: 75,937
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  • Site-wide: 96,620

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

• Downloaded 695 times
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  • Site-wide: 57,702
  • In bioengineering: 1,447
• Year to date:
  • Site-wide: 3,014
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  • Site-wide: 12,324

Murine monoclonal antibodies against RBD of SARS-CoV-2 neutralize authentic wild type SARS-CoV-2 as well as B.1.1.7 and B.1.351 viruses and protect in vivo in a mouse model in a neutralization dependent manner

• Downloaded 695 times
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  • Site-wide: 57,708
  • In microbiology: 3,349
• Year to date:
  • Site-wide: 125,585
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  • Site-wide: 122,752

HIV-1 Envelope and MPER antibody structures in lipid assemblies

• Downloaded 682 times
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  • Site-wide: 59,381
  • In immunology: 1,758
• Year to date:
  • Site-wide: 150,628
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  • Site-wide: 125,328

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

• Downloaded 681 times
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  • Site-wide: 59,430
  • In immunology: 1,779
• Year to date:
  • Site-wide: 115,562
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  • Site-wide: 100,574

Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

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  • Site-wide: 65,102
  • In molecular biology: 1,746
• Year to date:
  • Site-wide: 142,150
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  • Site-wide: 121,798

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

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  • Site-wide: 66,148
  • In immunology: 1,908
• Year to date:
  • Site-wide: 186,885
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  • Site-wide: 164,673

Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail

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  • Site-wide: 72,891
  • In biophysics: 2,413
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  • Site-wide: 132,121
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  • Site-wide: 75,490

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

• Downloaded 575 times
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  • Site-wide: 74,145
  • In immunology: 2,146
• Year to date:
  • Site-wide: 168,921
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  • Site-wide: 118,081

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

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  • Site-wide: 74,727
  • In immunology: 2,448
• Year to date:
  • Site-wide: 55,220
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  • Site-wide: 20,281

Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface

• Downloaded 553 times
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  • Site-wide: 77,665
  • In immunology: 2,542
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  • Site-wide: 59,468
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  • Site-wide: 20,000

One dose of COVID-19 nanoparticle vaccine REVC-128 provides protection against SARS-CoV-2 challenge at two weeks post immunization

• Downloaded 552 times
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  • Site-wide: 77,853
  • In microbiology: 4,748
• Year to date:
  • Site-wide: 125,596
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  • Site-wide: 134,985

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

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  • Site-wide: 81,639
  • In immunology: 2,388
• Year to date:
  • Site-wide: 137,713
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  • Site-wide: 143,579

Structural Insights into the Venus flytrap Mechanosensitive Ion Channel Flycatcher1

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  • Site-wide: 83,679
  • In biochemistry: 2,233
• Year to date:
  • Site-wide: 49,142
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  • Site-wide: 185,779

Structural mapping of antibody landscapes to human betacoronavirus spike proteins

• Downloaded 483 times
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  • Site-wide: 91,015
  • In immunology: 3,111
• Year to date:
  • Site-wide: 22,645
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  • Site-wide: 40,560

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

• Downloaded 482 times
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  • Site-wide: 91,303
  • In immunology: 2,608
• Year to date:
  • Site-wide: 180,032
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  • Site-wide: 176,166

EMHP: An accurate automated hole masking algorithm for single-particle cryo-EM image processing

• Downloaded 457 times
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  • Site-wide: 96,690
  • In bioinformatics: 7,970
• Year to date:
  • Site-wide: 163,282
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  • Site-wide: 130,224

Protective pan-ebolavirus combination therapy by two multifunctional human antibodies

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  • Site-wide: 108,032
  • In immunology: 3,282
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  • Site-wide: 78,203
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  • Site-wide: 59,224

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

• Downloaded 398 times
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  • Site-wide: 110,643
  • In immunology: 3,606
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  • Site-wide: 17,405
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  • Site-wide: 45,465

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

• Downloaded 381 times
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  • Site-wide: 115,086
  • In immunology: 3,320
• Year to date:
  • Site-wide: 151,098
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  • Site-wide: 158,863

Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

• Downloaded 379 times
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  • Site-wide: 115,693
  • In microbiology: 8,087
• Year to date:
  • Site-wide: 73,536
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  • Site-wide: 134,269

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

• Downloaded 347 times
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  • Site-wide: 124,481
  • In immunology: 3,561
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  • Site-wide: 176,180
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  • Site-wide: 158,833

High-resolution structural analysis of enterovirus-reactive polyclonal antibodies in complex with whole virions

• Downloaded 344 times
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  • Site-wide: 125,218
  • In immunology: 5,015
• Year to date:
  • Site-wide: 8,776
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  • Site-wide: 10,537

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

• Downloaded 342 times
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  • Site-wide: 125,840
  • In biochemistry: 3,527
• Year to date:
  • Site-wide: 142,186
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  • Site-wide: 96,705

Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

• Downloaded 339 times
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  • Site-wide: 126,673
  • In immunology: 3,702
• Year to date:
  • Site-wide: 151,113
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  • Site-wide: 121,959

High-resolution mapping of the neutralizing and binding specificities of polyclonal rabbit serum elicited by HIV Env trimer immunization

• Downloaded 330 times
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  • Site-wide: 129,139
  • In microbiology: 8,581
• Year to date:
  • Site-wide: 141,460
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  • Site-wide: 152,637

Lassa virus glycoprotein nanoparticles elicit a neutralizing antibody that defines a new site of vulnerability

• Downloaded 298 times
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  • Site-wide: 138,868
  • In immunology: None
• Year to date:
  • Site-wide: 10,858
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  • Site-wide: 15,535

Convergence of a common solution to broad ebolavirus neutralization by glycan cap directed human antibodies

• Downloaded 297 times
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  • Site-wide: 139,004
  • In immunology: 3,982
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  • Site-wide: 181,059
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  • Site-wide: 170,088

A strain-specific inhibitor of receptor-bound HIV-1 targets a pocket near the fusion peptide and offers a template for drug design

• Downloaded 291 times
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  • Site-wide: 140,849
  • In biophysics: 5,113
• Year to date:
  • Site-wide: 144,845
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  • Site-wide: 100,808

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

• Downloaded 268 times
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  • Site-wide: 147,838
  • In immunology: 4,253
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  • Site-wide: 145,427
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  • Site-wide: 137,697

Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

• Downloaded 224 times
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  • Site-wide: 160,419
  • In immunology: 4,734
• Year to date:
  • Site-wide: 97,179
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  • Site-wide: 86,510

Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens

• Downloaded 183 times
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  • Site-wide: 170,911
  • In molecular biology: 5,047
• Year to date:
  • Site-wide: 75,221
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  • Site-wide: 46,653

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

• Downloaded 173 times
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  • Site-wide: 173,266
  • In microbiology: 12,194
• Year to date:
  • Site-wide: 175,462
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  • Site-wide: 181,609

Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels

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  • Site-wide: 173,854
  • In biophysics: None
• Year to date:
  • Site-wide: 24,487
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  • Site-wide: 41,128

The pre-existing human antibody repertoire to computationally optimized influenza H1 hemagglutinin vaccines

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  • Site-wide: 174,204
  • In immunology: 5,284
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  • Site-wide: 63,079
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  • Site-wide: 82,112

CD4 binding-site antibodies induced by a subtype B HIV-1 envelope trimer

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  • Site-wide: 182,860
  • In immunology: None
• Year to date:
  • Site-wide: 37,132
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  • Site-wide: 92,019