Author: Christopher A Cottrell

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Preprints

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

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Visualization of the HIV-1 Env Glycan Shield Across Scales

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  • In biophysics: 442
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Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

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  • In biochemistry: 401
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Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

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Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

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Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

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Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

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Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

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Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

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Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

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Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

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  • In immunology: 1,424
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Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

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HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

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Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

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Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

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  • In biochemistry: 2,899
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  • Site-wide: 34,306

High-resolution mapping of the neutralizing and binding specificities of polyclonal rabbit serum elicited by HIV Env trimer immunization

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  • Site-wide: 100,803
  • In microbiology: 7,467
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Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

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  • In immunology: 2,995
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