Author: Christopher Cottrell

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Preprints

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

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Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

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Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens

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Visualization of the HIV-1 Env Glycan Shield Across Scales

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  • In biophysics: 646
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Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

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  • Site-wide: 29,334
  • In biochemistry: 614
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Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

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From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

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  • Site-wide: 33,470
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Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

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Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

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  • Site-wide: 96,369
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Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

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Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

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  • In immunology: 1,718
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  • Site-wide: 127,553
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  • Site-wide: 117,934

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

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  • In immunology: 1,779
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Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

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  • Site-wide: 164,152

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

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A broad and potent neutralization epitope in SARS-related coronaviruses

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  • Site-wide: 77,037
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Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics

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  • Site-wide: 141,127

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor binding head domains

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Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

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  • In immunology: 3,320
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  • Site-wide: 148,369
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HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

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  • In immunology: 3,561
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Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

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  • In biochemistry: 3,527
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Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

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High-resolution mapping of the neutralizing and binding specificities of polyclonal rabbit serum elicited by HIV Env trimer immunization

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  • In microbiology: 8,581
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Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

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  • In immunology: 4,253
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Efficient isolation of rare B cells using next-generation antigen barcoding

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  • Site-wide: 149,896
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• Year to date:
  • Site-wide: 13,230
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  • Site-wide: 1,703