Author: Alexis Battle

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Preprints

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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The GTEx Consortium atlas of genetic regulatory effects across human tissues

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Co-expression networks reveal the tissue-specific regulation of transcription and splicing

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In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer

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  • In immunology: 173
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The impact of rare variation on gene expression across tissues

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Distant regulatory effects of genetic variation in multiple human tissues

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  • Site-wide: 6,865
  • In genomics: 599
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Addressing confounding artifacts in reconstruction of gene co-expression networks

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  • In genomics: 782
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Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

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  • Site-wide: 9,480
  • In genetics: 367
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Diverse transcriptomic signatures across human tissues identify functional rare genetic variation

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ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

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  • In genetic and genomic medicine: 68
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Mechanisms of tissue-specific genetic regulation revealed by latent factors across eQTLs

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The architecture of brain co-expression reveals the brain-wide basis of disease susceptibility

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  • In genetics: 796
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Genome-wide association and multi-omic analyses reveal new mechanisms for Heart Failure

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  • Site-wide: 25,072
  • In genetic and genomic medicine: 122
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GBAT: a gene-based association method for robust trans-gene regulation detection

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Single-Cell Sequencing Reveals Lineage-Specific Dynamic Genetic Regulation of Gene Expression During Human Cardiomyocyte Differentiation

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Novel Aggregative trans-eQTL Association Analysis of Known Genetic Variants Detect Trait-specific Target Gene-sets

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  • In genetic and genomic medicine: 208
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Network reconstruction for trans acting genetic loci using multi-omics data and prior information

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  • In bioinformatics: 4,091
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  • Site-wide: 133,951

Redefining tissue specificity of genetic regulation of gene expression in the presence of allelic heterogeneity

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  • In genetic and genomic medicine: 236
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Imputed gene associations identify replicable trans-acting genes enriched in transcription pathways and complex traits

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  • In genetics: 1,831
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Human embryoid bodies as a novel system for genomic studies of functionally diverse cell types

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  • In genomics: 4,552
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Random Forest Factorization Reveals Latent Structure in Single Cell RNA Sequencing Data

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  • In bioinformatics: 6,291
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OTTERS: A powerful TWAS framework leveraging summary-level reference data

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Genome-Wide Large-Scale Multi-Trait Analysis Characterizes Global Patterns of Pleiotropy and Unique Trait-Specific Variants

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