Author: Thomas Werge

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Preprints

Genetic correlates of vitamin D-binding protein and 25 hydroxyvitamin D in neonatal dried blood spots

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Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

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  • Site-wide: 1,154
  • In genetics: 23
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  • Site-wide: 13,222
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Population Genomics of Stone Age Eurasia

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  • Site-wide: 1,402
  • In evolutionary biology: None
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Common risk variants identified in autism spectrum disorder

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  • Site-wide: 1,420
  • In genetics: 28
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Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

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  • Site-wide: 1,692
  • In genetic and genomic medicine: 10
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  • Site-wide: 678
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  • Site-wide: 2,678

A Major Role for Common Genetic Variation in Anxiety Disorders

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  • Site-wide: 3,979
  • In genetics: 124
• Year to date:
  • Site-wide: 10,147
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Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 5,316
  • In psychiatry and clinical psychology: 21
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Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • Site-wide: 6,518
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Genome-wide association study identifies 48 common genetic variants associated with handedness

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  • Site-wide: 6,868
  • In genetics: 250
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Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 7,565
  • In genetics: 351
• Year to date:
  • Site-wide: 2,860
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  • Site-wide: 10,784

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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  • Site-wide: 8,145
  • In genetics: 303
• Year to date:
  • Site-wide: 121,242
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  • Site-wide: 129,356

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

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  • Site-wide: 8,574
  • In genetics: 324
• Year to date:
  • Site-wide: 101,432
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  • Site-wide: 132,659

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 11,010
  • In genetics: 424
• Year to date:
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  • Site-wide: 32,208

Genome-wide association study implicates CHRNA2 in cannabis use disorder

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  • Site-wide: 12,350
  • In genomics: 1,117
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  • Site-wide: 66,967
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  • Site-wide: 49,022

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 12,513
  • In genetics: 470
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Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

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  • Site-wide: 14,743
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 17,222
  • In genomics: 1,529
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  • Site-wide: 114,574

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 18,433
  • In genetics: 741
• Year to date:
  • Site-wide: 129,098
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  • Site-wide: 78,701

Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort

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  • Site-wide: 19,670
  • In genetics: 793
• Year to date:
  • Site-wide: 104,369
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  • Site-wide: 93,143

Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

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  • Site-wide: 20,427
  • In genomics: 1,817
• Year to date:
  • Site-wide: 39,559
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  • Site-wide: 41,602

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 21,950
  • In genetics: 877
• Year to date:
  • Site-wide: 133,547
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  • Site-wide: 117,349

Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

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  • Site-wide: 23,338
  • In genomics: 1,995
• Year to date:
  • Site-wide: 91,718
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  • Site-wide: 104,607

A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

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  • Site-wide: 24,019
  • In genetics: 944
• Year to date:
  • Site-wide: 158,719
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  • Site-wide: 116,827

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

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  • Site-wide: 30,515
  • In psychiatry and clinical psychology: 337
• Year to date:
  • Site-wide: 1,521
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  • Site-wide: 1,937

Complex spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes

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  • Site-wide: 31,376
  • In genomics: 2,577
• Year to date:
  • Site-wide: 107,135
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  • Site-wide: 85,525

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • Site-wide: 33,027
  • In genetics: 1,534
• Year to date:
  • Site-wide: 29,883
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  • Site-wide: 32,188

Cross-trait assortative mating is widespread and inflates genetic correlation estimates

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  • Site-wide: 36,371
  • In genetics: None
• Year to date:
  • Site-wide: 1,812
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  • Site-wide: 3,617

The genetic structure of Norway

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  • Site-wide: 37,650
  • In genetics: 1,548
• Year to date:
  • Site-wide: 74,625
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  • Site-wide: 90,948

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 40,775
  • In genetic and genomic medicine: 211
• Year to date:
  • Site-wide: 92,547
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  • Site-wide: 73,875

Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder and case subgroups.

• Downloaded 831 times
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  • Site-wide: 44,728
  • In psychiatry and clinical psychology: 176
• Year to date:
  • Site-wide: 34,945
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  • Site-wide: 35,701

Low frequency and rare coding variation contributes to multiple sclerosis risk

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  • Site-wide: 45,151
  • In genetics: 1,756
• Year to date:
  • Site-wide: 167,512
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  • Site-wide: 149,751

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • Site-wide: 45,392
  • In genetics: 1,775
• Year to date:
  • Site-wide: 117,708
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  • Site-wide: 95,001

The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders

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  • Site-wide: 45,507
  • In genetics: 1,750
• Year to date:
  • Site-wide: 183,490
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  • Site-wide: 183,799

Genome-wide association study identifies new locus associated with OCD

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  • Site-wide: 46,390
  • In psychiatry and clinical psychology: 263
• Year to date:
  • Site-wide: 8,961
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  • Site-wide: 9,474

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 46,799
  • In genetics: 1,806
• Year to date:
  • Site-wide: 141,542
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  • Site-wide: 168,684

Gestational-age-dependent development of the neonatal metabolome

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  • Site-wide: 48,572
  • In pediatrics: 88
• Year to date:
  • Site-wide: 45,990
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  • Site-wide: 42,501

Impute.me: an open source, non-profit tool for using data from DTC genetic testing to calculate and interpret polygenic risk scores.

• Downloaded 746 times
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  • Site-wide: 52,363
  • In genetics: 2,070
• Year to date:
  • Site-wide: 98,250
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  • Site-wide: 96,748

Identification of risk variants and characterization of the polygenic architecture of disruptive behavior disorders in the context of ADHD

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  • Site-wide: 54,826
  • In genomics: 3,891
• Year to date:
  • Site-wide: 115,844
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  • Site-wide: 121,911

Exploring contributors to variability in estimates of SNP-heritability and genetic correlations from the iPSYCH case-cohort and published meta-studies of major psychiatric disorders.

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  • Site-wide: 55,826
  • In genetics: 2,173
• Year to date:
  • Site-wide: 117,128
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  • Site-wide: 144,094

Meta-analysis of Scandinavian Schizophrenia Exomes

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  • Site-wide: 57,942
  • In genetics: 2,361
• Year to date:
  • Site-wide: 72,128
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  • Site-wide: 80,039

Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction

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  • Site-wide: 59,550
  • In genetics: 2,307
• Year to date:
  • Site-wide: 140,038
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  • Site-wide: 134,428

The iPSYCH2015 Case-Cohort sample: updated directions for unravelling genetic and environmental architectures of severe mental disorders

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  • Site-wide: 66,454
  • In epidemiology: 3,435
• Year to date:
  • Site-wide: 30,365
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  • Site-wide: 17,060

Accounting for age-of-onset and family history improves power in genome-wide association studies

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  • Site-wide: 79,059
  • In bioinformatics: 6,993
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  • Site-wide: 62,114
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  • Site-wide: 155,997

Genetic factors underlying the bidirectional relationship between autoimmune and mental disorders – findings from a Danish population-based study

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  • Site-wide: 80,118
  • In bioinformatics: 7,278
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  • Site-wide: 58,421

Polygenic prediction of school performance in children with and without psychiatric disorders

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  • Site-wide: 92,678
  • In genetics: 3,576
• Year to date:
  • Site-wide: 132,458
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  • Site-wide: 153,380

Genome-wide association study of febrile seizures identifies seven new loci implicating fever response and neuronal excitability genes

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  • Site-wide: 100,384
  • In genetic and genomic medicine: 545
• Year to date:
  • Site-wide: 64,004
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  • Site-wide: 120,117

Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention deficit hyperactivity disorder

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  • Site-wide: 121,911
  • In psychiatry and clinical psychology: 613
• Year to date:
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  • Site-wide: 107,835

AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance

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  • Site-wide: 127,886
  • In neuroscience: 18,051
• Year to date:
  • Site-wide: 148,331
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  • Site-wide: 131,965

Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci

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  • Site-wide: 138,806
  • In genetic and genomic medicine: 849
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  • Site-wide: 66,132
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  • Site-wide: 81,600

A dominant-negative variant in the dopamine transporter PDZ-binding motif is linked to parkinsonism and neuropsychiatric disease

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  • Site-wide: 149,384
  • In neuroscience: 20,911
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  • Site-wide: 150,895
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  • Site-wide: 154,009

Acute COVID-19 severity and 16-month mental morbidity trajectories in patient populations of six nations

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  • Site-wide: 154,043
  • In public and global health: 2,251
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  • Site-wide: 72,807

Polygenic heterogeneity across obsessive-compulsive disorder subgroups defined by a comorbid diagnosis

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  • Site-wide: 157,702
  • In psychiatry and clinical psychology: 875
• Year to date:
  • Site-wide: 100,200
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  • Site-wide: 108,631

Elevated DNA Methylation Gestational Age is associated with the Risk of Later Bipolar Disorder and Anorexia Nervosa in Twins

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  • Site-wide: 158,872
  • In epidemiology: 6,249
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  • Site-wide: 151,511
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  • Site-wide: 152,764

Mendelian randomization study of spermine oxidase and cancer risk

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  • Site-wide: 168,371
  • In genetic and genomic medicine: 1,089
• Year to date:
  • Site-wide: 135,056
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  • Site-wide: 87,482

Interplay of ADHD polygenic liability with birth-related, somatic and psychosocial factors in ADHD - a nationwide study

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  • Site-wide: 168,434
  • In psychiatry and clinical psychology: 1,019
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  • Site-wide: 79,081
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  • Site-wide: 60,294

Genome-wide by environment interaction study of stressful life events and hospital-treated depression in the iPSYCH2012 sample

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  • Site-wide: 172,838
  • In genetic and genomic medicine: 1,137
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  • Site-wide: 84,431
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  • Site-wide: 99,592

The genetic background of hydrocephalus in a population-based cohort: implication of ciliary involvement

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  • Site-wide: 186,480
  • In genetic and genomic medicine: None
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  • Site-wide: 23,342