Author: Ole Mors

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Preprints

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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  • Site-wide: 974
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  • Site-wide: 8,078
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  • Site-wide: 14,616

Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

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  • Site-wide: 1,154
  • In genetics: 23
• Year to date:
  • Site-wide: 13,088
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  • Site-wide: 8,538

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,320
  • In genetics: 26
• Year to date:
  • Site-wide: 36,946
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  • Site-wide: 25,451

Common risk variants identified in autism spectrum disorder

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  • Site-wide: 1,417
  • In genetics: 28
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  • Site-wide: 27,784
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  • Site-wide: 22,635

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,788
  • In genetics: 41
• Year to date:
  • Site-wide: 61,414
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  • Site-wide: 50,686

A Major Role for Common Genetic Variation in Anxiety Disorders

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  • Site-wide: 3,975
  • In genetics: 124
• Year to date:
  • Site-wide: 10,035
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  • Site-wide: 7,895

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 5,312
  • In psychiatry and clinical psychology: 21
• Year to date:
  • Site-wide: 12,607
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  • Site-wide: 6,474

Genetic Architecture of 11 Major Psychiatric Disorders at Biobehavioral, Functional Genomic, and Molecular Genetic Levels of Analysis

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  • Site-wide: 5,930
  • In genetic and genomic medicine: 40
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  • Site-wide: 2,280
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  • Site-wide: 691

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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  • Site-wide: 7,205
  • In genetics: 265
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  • Site-wide: 104,257
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  • Site-wide: 91,958

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 7,562
  • In genetics: 351
• Year to date:
  • Site-wide: 2,841
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  • Site-wide: 10,075

Minimal phenotyping yields GWAS hits of reduced specificity for major depression

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  • Site-wide: 9,530
  • In genetics: 366
• Year to date:
  • Site-wide: 51,211
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  • Site-wide: 45,156

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 11,006
  • In genetics: 424
• Year to date:
  • Site-wide: 32,501
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  • Site-wide: 30,328

ASD and ADHD have a similar burden of rare protein-truncating variants

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  • Site-wide: 11,786
  • In genetics: 444
• Year to date:
  • Site-wide: 68,865
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  • Site-wide: 61,978

Genome-wide association study implicates CHRNA2 in cannabis use disorder

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  • Site-wide: 12,457
  • In genomics: 1,117
• Year to date:
  • Site-wide: 79,753
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  • Site-wide: 93,185

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 12,499
  • In genetics: 470
• Year to date:
  • Site-wide: 153,544
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  • Site-wide: 115,147

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 17,196
  • In genomics: 1,529
• Year to date:
  • Site-wide: 108,212
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  • Site-wide: 112,183

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 18,399
  • In genetics: 741
• Year to date:
  • Site-wide: 125,661
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  • Site-wide: 77,574

Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort

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  • Site-wide: 19,696
  • In genetics: 793
• Year to date:
  • Site-wide: 110,833
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  • Site-wide: 112,285

Cross-validation of technologies for genotyping CYP2D6 and CYP2C19

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  • Site-wide: 19,728
  • In genetics: 940
• Year to date:
  • Site-wide: 16,213
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  • Site-wide: 12,031

Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

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  • Site-wide: 20,408
  • In genomics: 1,817
• Year to date:
  • Site-wide: 38,918
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  • Site-wide: 39,764

Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

• Downloaded 1,281 times
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  • Site-wide: 23,308
  • In genomics: 1,995
• Year to date:
  • Site-wide: 89,809
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  • Site-wide: 104,839

A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

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  • Site-wide: 23,997
  • In genetics: 944
• Year to date:
  • Site-wide: 160,098
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  • Site-wide: 117,268

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

• Downloaded 1,076 times
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  • Site-wide: 30,478
  • In psychiatry and clinical psychology: 337
• Year to date:
  • Site-wide: 1,506
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  • Site-wide: 1,857

Complex spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes

• Downloaded 1,055 times
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  • Site-wide: 31,351
  • In genomics: 2,577
• Year to date:
  • Site-wide: 105,073
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  • Site-wide: 85,209

Pharmacogenetics of antidepressant response: a polygenic approach

• Downloaded 958 times
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  • Site-wide: 36,190
  • In genetics: 1,431
• Year to date:
  • Site-wide: 163,765
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  • Site-wide: 93,517

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 942 times
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  • Site-wide: 37,142
  • In genetics: 1,450
• Year to date:
  • Site-wide: 173,582
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  • Site-wide: 159,755

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 40,723
  • In genetic and genomic medicine: 211
• Year to date:
  • Site-wide: 92,597
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  • Site-wide: 69,431

Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder and case subgroups.

• Downloaded 831 times
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  • Site-wide: 44,654
  • In psychiatry and clinical psychology: 176
• Year to date:
  • Site-wide: 34,562
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  • Site-wide: 34,003

The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders

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  • Site-wide: 45,404
  • In genetics: 1,750
• Year to date:
  • Site-wide: 181,433
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  • Site-wide: 183,030

The neurobiology of BRD1 implicates sex-biased dysregulation of nuclear receptor signaling in mental disorders

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  • Site-wide: 45,946
  • In neuroscience: 5,954
• Year to date:
  • Site-wide: 107,797
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  • Site-wide: 143,397

Genome-wide association study identifies new locus associated with OCD

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  • Site-wide: 46,329
  • In psychiatry and clinical psychology: 263
• Year to date:
  • Site-wide: 8,855
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  • Site-wide: 8,983

Assessing 42 inflammatory markers in 321 control subjects and 887 major depressive disorder cases: BMI and other confounders and overall predictive ability for current depression

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  • Site-wide: 48,931
  • In neuroscience: 6,391
• Year to date:
  • Site-wide: 105,289
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  • Site-wide: 72,209

Identification of risk variants and characterization of the polygenic architecture of disruptive behavior disorders in the context of ADHD

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  • Site-wide: 55,050
  • In genomics: 3,891
• Year to date:
  • Site-wide: 120,387
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  • Site-wide: 150,972

Exploring contributors to variability in estimates of SNP-heritability and genetic correlations from the iPSYCH case-cohort and published meta-studies of major psychiatric disorders.

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  • Site-wide: 55,776
  • In genetics: 2,173
• Year to date:
  • Site-wide: 117,115
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  • Site-wide: 141,337

Meta-analysis of Scandinavian Schizophrenia Exomes

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  • Site-wide: 57,805
  • In genetics: 2,361
• Year to date:
  • Site-wide: 71,519
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  • Site-wide: 78,217

Elevated polygenic burden for autism is associated with differential DNA methylation at birth.

• Downloaded 686 times
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  • Site-wide: 58,747
  • In genetics: 2,250
• Year to date:
  • Site-wide: 180,431
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  • Site-wide: 175,199

New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation

• Downloaded 674 times
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  • Site-wide: 60,284
  • In genomics: 4,066
• Year to date:
  • Site-wide: 174,835
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  • Site-wide: 183,195

Antidepressant Response in Major Depressive Disorder: A Genome-wide Association Study

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  • Site-wide: 65,036
  • In psychiatry and clinical psychology: 257
• Year to date:
  • Site-wide: 76,924
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  • Site-wide: 154,255

The iPSYCH2015 Case-Cohort sample: updated directions for unravelling genetic and environmental architectures of severe mental disorders

• Downloaded 611 times
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  • Site-wide: 68,597
  • In epidemiology: 3,435
• Year to date:
  • Site-wide: 34,514
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  • Site-wide: 24,075

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies

• Downloaded 602 times
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  • Site-wide: 69,887
  • In genetics: 2,668
• Year to date:
  • Site-wide: 185,639
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  • Site-wide: 175,377

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

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  • Site-wide: 70,743
  • In genetics: 2,696
• Year to date:
  • Site-wide: 181,398
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  • Site-wide: 146,896

Accounting for age-of-onset and family history improves power in genome-wide association studies

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  • Site-wide: 78,770
  • In bioinformatics: 6,993
• Year to date:
  • Site-wide: 60,594
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  • Site-wide: 153,787

Genetic factors underlying the bidirectional relationship between autoimmune and mental disorders – findings from a Danish population-based study

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  • Site-wide: 80,011
  • In bioinformatics: 7,278
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  • Site-wide: 71,745
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  • Site-wide: 57,524

Statin treatment and the risk of depression

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  • Site-wide: 84,537
  • In epidemiology: 3,718
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  • Site-wide: 67,665
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  • Site-wide: 56,810

Genetic variation in the Major Histocompatibility Complex and association with depression

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  • Site-wide: 87,421
  • In genetics: 3,344
• Year to date:
  • Site-wide: 152,582
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  • Site-wide: 117,000

Polygenic prediction of school performance in children with and without psychiatric disorders

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  • Site-wide: 92,497
  • In genetics: 3,576
• Year to date:
  • Site-wide: 132,400
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  • Site-wide: 152,727

Genome-wide association study of febrile seizures identifies seven new loci implicating fever response and neuronal excitability genes

• Downloaded 442 times
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  • Site-wide: 100,101
  • In genetic and genomic medicine: 545
• Year to date:
  • Site-wide: 62,263
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  • Site-wide: 118,695

Polygenic profiles define aspects of clinical heterogeneity in ADHD

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  • Site-wide: 112,551
  • In psychiatry and clinical psychology: 608
• Year to date:
  • Site-wide: 43,680
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  • Site-wide: 53,134

Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention deficit hyperactivity disorder

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  • Site-wide: 121,569
  • In psychiatry and clinical psychology: 613
• Year to date:
  • Site-wide: 60,600
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  • Site-wide: 99,649

Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression

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  • Site-wide: 132,653
  • In psychiatry and clinical psychology: 683
• Year to date:
  • Site-wide: 80,576
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  • Site-wide: 44,566

Polygenic heterogeneity across obsessive-compulsive disorder subgroups defined by a comorbid diagnosis

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  • Site-wide: 157,481
  • In psychiatry and clinical psychology: 875
• Year to date:
  • Site-wide: 100,245
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  • Site-wide: 110,600

Interplay of ADHD polygenic liability with birth-related, somatic and psychosocial factors in ADHD - a nationwide study

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  • Site-wide: 168,112
  • In psychiatry and clinical psychology: 1,019
• Year to date:
  • Site-wide: 77,142
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  • Site-wide: 59,180

Genome-wide by environment interaction study of stressful life events and hospital-treated depression in the iPSYCH2012 sample

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  • Site-wide: 172,690
  • In genetic and genomic medicine: 1,137
• Year to date:
  • Site-wide: 83,847
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  • Site-wide: 98,224