Author: T-K Clarke

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Preprints

Genomewide association study identifies 30 loci associated with bipolar disorder

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 2,917
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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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  • Site-wide: 6,514
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Minimal phenotyping yields GWAS hits of reduced specificity for major depression

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  • Site-wide: 8,667
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• Year to date:
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Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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  • Site-wide: 14,256
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 93,542
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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

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  • Site-wide: 20,916
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Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

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• Year to date:
  • Site-wide: 140,225
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  • Site-wide: 132,411

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

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  • Site-wide: 35,052
  • In epidemiology: 1,847
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  • Site-wide: 69,648
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Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • Site-wide: 40,623
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Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

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  • Site-wide: 41,547
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  • Site-wide: 157,709
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  • Site-wide: 157,251

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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  • Site-wide: 99,293

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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  • Site-wide: 42,978
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  • Site-wide: 160,308
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Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

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  • Site-wide: 47,992
  • In genomics: 3,683
• Year to date:
  • Site-wide: 141,728
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A meta-analysis of genome-wide association studies of epigenetic age acceleration

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CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

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Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder

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  • Site-wide: 61,410
  • In neuroscience: 8,818
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Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

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  • In genomics: 4,629
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  • Site-wide: 115,896

Cognitive functioning and lifetime Major Depressive Disorder in UK Biobank

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  • Site-wide: 66,321
  • In psychiatry and clinical psychology: 256
• Year to date:
  • Site-wide: 71,495
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  • Site-wide: 85,945

Multivariate GWAS elucidates the genetic architecture of alcohol consumption and misuse, corrects biases, and reveals novel associations with disease

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  • Site-wide: 69,990
  • In genetics: 2,970
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  • Site-wide: 55,629
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  • Site-wide: 76,856

Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.

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  • Site-wide: 71,912
  • In genetics: 3,055
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  • Site-wide: 106,491
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  • Site-wide: 133,907

Epigenetic prediction of major depressive disorder

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  • Site-wide: 77,720
  • In psychiatry and clinical psychology: 314
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  • Site-wide: 135,982
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  • Site-wide: 132,781

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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  • Site-wide: 88,699
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  • Site-wide: 125,476
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  • Site-wide: 122,591

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

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  • Site-wide: 97,202
  • In genetics: 4,020
• Year to date:
  • Site-wide: 159,475
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  • Site-wide: 146,895

Epigenetic signatures of starting and stopping smoking

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  • In genomics: 6,489
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  • Site-wide: 147,126

Associations between alcohol use and accelerated biological ageing

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  • In psychiatry and clinical psychology: 527
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  • Site-wide: 63,525

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

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  • Site-wide: 150,487