Author: Toni-Kim Clarke

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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Genomewide association study identifies 30 loci associated with bipolar disorder

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

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Minimal phenotyping yields GWAS hits of reduced specificity for major depression

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Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

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Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

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Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

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Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

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Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

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Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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A validation of the diathesis-stress model for depression in Generation Scotland.

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A meta-analysis of genome-wide association studies of epigenetic age acceleration

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Accelerated Epigenetic Ageing in Major Depressive Disorder

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CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

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Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

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Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

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Response to 'Problems in interpreting and using GWAS of conditional phenotypes illustrated by alcohol GWAS'

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Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.

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Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

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Epigenetic signatures of starting and stopping smoking

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Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression

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Expression quantitative trait loci-derived scores and white matter microstructure in UK Biobank: a novel approach to integrating genetics and neuroimaging

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Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

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