Author: T-K Clarke

Downloads per author, site-wide

Preprints

Genomewide association study identifies 30 loci associated with bipolar disorder

• Downloaded 7,744 times
• Download rankings, all-time:
  • Site-wide: 1,920
  • In genetics: 45
• Year to date:
  • Site-wide: 7,831
• Since beginning of last month:
  • Site-wide: 26,304

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,875 times
• Download rankings, all-time:
  • Site-wide: 3,617
  • In genetics: 100
• Year to date:
  • Site-wide: 114,409
• Since beginning of last month:
  • Site-wide: 206,684

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

• Downloaded 2,813 times
• Download rankings, all-time:
  • Site-wide: 7,999
  • In genetics: 298
• Year to date:
  • Site-wide: 36,125
• Since beginning of last month:
  • Site-wide: 60,627

Minimal phenotyping yields GWAS hits of reduced specificity for major depression

• Downloaded 2,390 times
• Download rankings, all-time:
  • Site-wide: 10,254
  • In genetics: 388
• Year to date:
  • Site-wide: 115,034
• Since beginning of last month:
  • Site-wide: 89,924

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

• Downloaded 2,085 times
• Download rankings, all-time:
  • Site-wide: 12,615
  • In genetics: 466
• Year to date:
  • Site-wide: 132,539
• Since beginning of last month:
  • Site-wide: 141,476

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

• Downloaded 2,043 times
• Download rankings, all-time:
  • Site-wide: 12,997
  • In genetics: 488
• Year to date:
  • Site-wide: 168,857
• Since beginning of last month:
  • Site-wide: 60,045

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,805 times
• Download rankings, all-time:
  • Site-wide: 15,742
  • In genetics: 635
• Year to date:
  • Site-wide: 118,717
• Since beginning of last month:
  • Site-wide: 32,783

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,624 times
• Download rankings, all-time:
  • Site-wide: 18,558
  • In genomics: 1,676
• Year to date:
  • Site-wide: 112,578
• Since beginning of last month:
  • Site-wide: 51,987

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

• Downloaded 1,405 times
• Download rankings, all-time:
  • Site-wide: 23,426
  • In genetics: 938
• Year to date:
  • Site-wide: 74,151
• Since beginning of last month:
  • Site-wide: 32,706

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

• Downloaded 1,395 times
• Download rankings, all-time:
  • Site-wide: 23,693
  • In genetics: 957
• Year to date:
  • Site-wide: 25,809
• Since beginning of last month:
  • Site-wide: 90,610

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

• Downloaded 1,311 times
• Download rankings, all-time:
  • Site-wide: 26,154
  • In genetics: 1,048
• Year to date:
  • Site-wide: 50,740
• Since beginning of last month:
  • Site-wide: 146,531

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 1,166 times
• Download rankings, all-time:
  • Site-wide: 31,482
  • In genetics: 1,278
• Year to date:
  • Site-wide: 23,248
• Since beginning of last month:
  • Site-wide: 42,659

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

• Downloaded 998 times
• Download rankings, all-time:
  • Site-wide: 39,980
  • In genetics: 1,582
• Year to date:
  • Site-wide: 93,525
• Since beginning of last month:
  • Site-wide: 208,849

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

• Downloaded 949 times
• Download rankings, all-time:
  • Site-wide: 43,276
  • In epidemiology: 2,258
• Year to date:
  • Site-wide: 70,760
• Since beginning of last month:
  • Site-wide: 89,552

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

• Downloaded 865 times
• Download rankings, all-time:
  • Site-wide: 49,902
  • In genetics: 1,942
• Year to date:
  • Site-wide: 137,571
• Since beginning of last month:
  • Site-wide: 116,160

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

• Downloaded 849 times
• Download rankings, all-time:
  • Site-wide: 51,378
  • In genetics: 1,993
• Year to date:
  • Site-wide: 171,114
• Since beginning of last month:
  • Site-wide: 120,170

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 828 times
• Download rankings, all-time:
  • Site-wide: 53,303
  • In genetics: 2,071
• Year to date:
  • Site-wide: 188,454
• Since beginning of last month:
  • Site-wide: 198,273

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

• Downloaded 804 times
• Download rankings, all-time:
  • Site-wide: 55,687
  • In genetics: 2,148
• Year to date:
  • Site-wide: 132,645
• Since beginning of last month:
  • Site-wide: 208,814

Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

• Downloaded 750 times
• Download rankings, all-time:
  • Site-wide: 61,739
  • In genomics: 4,268
• Year to date:
  • Site-wide: 168,876
• Since beginning of last month:
  • Site-wide: 198,700

CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

• Downloaded 681 times
• Download rankings, all-time:
  • Site-wide: 70,913
  • In genetics: 2,733
• Year to date:
  • Site-wide: 112,755
• Since beginning of last month:
  • Site-wide: 60,836

Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder

• Downloaded 676 times
• Download rankings, all-time:
  • Site-wide: 71,591
  • In neuroscience: 9,995
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 180,930

A meta-analysis of genome-wide association studies of epigenetic age acceleration

• Downloaded 665 times
• Download rankings, all-time:
  • Site-wide: 73,107
  • In genetics: 2,789
• Year to date:
  • Site-wide: 138,004
• Since beginning of last month:
  • Site-wide: 207,242

Multivariate GWAS elucidates the genetic architecture of alcohol consumption and misuse, corrects biases, and reveals novel associations with disease

• Downloaded 659 times
• Download rankings, all-time:
  • Site-wide: 74,104
  • In genetics: 2,880
• Year to date:
  • Site-wide: 36,968
• Since beginning of last month:
  • Site-wide: 12,265

Cognitive functioning and lifetime Major Depressive Disorder in UK Biobank

• Downloaded 617 times
• Download rankings, all-time:
  • Site-wide: 80,722
  • In psychiatry and clinical psychology: 388
• Year to date:
  • Site-wide: 159,954
• Since beginning of last month:
  • Site-wide: 100,266

Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

• Downloaded 615 times
• Download rankings, all-time:
  • Site-wide: 80,999
  • In genomics: 5,286
• Year to date:
  • Site-wide: 62,382
• Since beginning of last month:
  • Site-wide: 103,987

Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.

• Downloaded 586 times
• Download rankings, all-time:
  • Site-wide: 86,220
  • In genetics: 3,294
• Year to date:
  • Site-wide: 112,260
• Since beginning of last month:
  • Site-wide: 180,144

Epigenetic prediction of major depressive disorder

• Downloaded 550 times
• Download rankings, all-time:
  • Site-wide: 93,326
  • In psychiatry and clinical psychology: 460
• Year to date:
  • Site-wide: 184,973
• Since beginning of last month:
  • Site-wide: 190,638

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

• Downloaded 475 times
• Download rankings, all-time:
  • Site-wide: 110,204
  • In genetics: 4,166
• Year to date:
  • Site-wide: 132,538
• Since beginning of last month:
  • Site-wide: 141,484

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 417 times
• Download rankings, all-time:
  • Site-wide: 125,285
  • In genetics: 4,677
• Year to date:
  • Site-wide: 190,482
• Since beginning of last month:
  • Site-wide: 209,766

Associations between alcohol use and accelerated biological ageing

• Downloaded 400 times
• Download rankings, all-time:
  • Site-wide: 129,939
  • In psychiatry and clinical psychology: 748
• Year to date:
  • Site-wide: 85,586
• Since beginning of last month:
  • Site-wide: 190,524

Epigenetic signatures of starting and stopping smoking

• Downloaded 354 times
• Download rankings, all-time:
  • Site-wide: 143,646
  • In genomics: 7,592
• Year to date:
  • Site-wide: 135,763
• Since beginning of last month:
  • Site-wide: 206,191

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

• Downloaded 312 times
• Download rankings, all-time:
  • Site-wide: 156,446
  • In neuroscience: 22,841
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 209,189