Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,616 bioRxiv papers from 308,268 authors.

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • In genetics: 14 out of 3,908
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  • Site-wide: 8,310 out of 70,482
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  • Site-wide: 8,639 out of 70,482

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 287 out of 70,482
  • In genetics: 32 out of 3,908
• Year to date:
  • Site-wide: 1,574 out of 70,482
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  • Site-wide: 2,118 out of 70,482

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 3,902 times
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  • Site-wide: 757 out of 70,482
  • In genetics: 70 out of 3,908
• Year to date:
  • Site-wide: 7,006 out of 70,482
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  • Site-wide: 5,489 out of 70,482

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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  • In genetics: 183 out of 3,908
• Year to date:
  • Site-wide: 63,451 out of 70,482
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  • Site-wide: 15,083 out of 70,482

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

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  • In genetics: 255 out of 3,908
• Year to date:
  • Site-wide: 54,816 out of 70,482
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  • Site-wide: 31,283 out of 70,482

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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  • Site-wide: 3,661 out of 70,482
  • In genetics: 312 out of 3,908
• Year to date:
  • Site-wide: 64,270 out of 70,482
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  • Site-wide: 27,969 out of 70,482

Minimal phenotyping yields GWAS hits of reduced specificity for major depression

• Downloaded 1,485 times
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  • In genetics: 360 out of 3,908
• Year to date:
  • Site-wide: 11,391 out of 70,482
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  • Site-wide: 4,650 out of 70,482

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

• Downloaded 1,428 times
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  • In genetics: 381 out of 3,908
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  • Site-wide: 12,088 out of 70,482
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  • Site-wide: 15,464 out of 70,482

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

• Downloaded 1,147 times
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  • In genetics: 510 out of 3,908
• Year to date:
  • Site-wide: 33,603 out of 70,482
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  • Site-wide: 26,856 out of 70,482

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

• Downloaded 954 times
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  • Site-wide: 8,938 out of 70,482
  • In genetics: 669 out of 3,908
• Year to date:
  • Site-wide: 18,585 out of 70,482
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  • Site-wide: 18,517 out of 70,482

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • In genetics: 676 out of 3,908
• Year to date:
  • Site-wide: 10,451 out of 70,482
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  • Site-wide: 41,197 out of 70,482

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

• Downloaded 729 times
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  • Site-wide: 13,459 out of 70,482
  • In genetics: 924 out of 3,908
• Year to date:
  • Site-wide: 20,731 out of 70,482
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  • Site-wide: 58,981 out of 70,482

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 641 times
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  • Site-wide: 16,219 out of 70,482
  • In genetics: 1,104 out of 3,908
• Year to date:
  • Site-wide: 37,482 out of 70,482
• Since beginning of last month:
  • Site-wide: 48,569 out of 70,482

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

• Downloaded 624 times
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  • Site-wide: 16,821 out of 70,482
  • In genetics: 1,147 out of 3,908
• Year to date:
  • Site-wide: 67,192 out of 70,482
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  • Site-wide: 59,265 out of 70,482

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

• Downloaded 608 times
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  • Site-wide: 17,466 out of 70,482
  • In genetics: 1,183 out of 3,908
• Year to date:
  • Site-wide: 36,655 out of 70,482
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  • Site-wide: 59,471 out of 70,482

Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

• Downloaded 565 times
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  • Site-wide: 19,334 out of 70,482
  • In genomics: 2,295 out of 4,710
• Year to date:
  • Site-wide: 50,034 out of 70,482
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  • Site-wide: 62,333 out of 70,482

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

• Downloaded 529 times
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  • Site-wide: 21,099 out of 70,482
  • In genetics: 1,411 out of 3,908
• Year to date:
  • Site-wide: 7,577 out of 70,482
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  • Site-wide: 6,993 out of 70,482

A validation of the diathesis-stress model for depression in Generation Scotland.

• Downloaded 469 times
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  • Site-wide: 24,517 out of 70,482
  • In genomics: 2,638 out of 4,710
• Year to date:
  • Site-wide: 33,995 out of 70,482
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  • Site-wide: 33,355 out of 70,482

A meta-analysis of genome-wide association studies of epigenetic age acceleration

• Downloaded 463 times
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  • Site-wide: 24,866 out of 70,482
  • In genetics: 1,626 out of 3,908
• Year to date:
  • Site-wide: 19,047 out of 70,482
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  • Site-wide: 23,658 out of 70,482

Educational attainment causally impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study in ~ 780,000 study participants

• Downloaded 460 times
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  • Site-wide: 25,052 out of 70,482
  • In epidemiology: 332 out of 1,556
• Year to date:
  • Site-wide: 10,070 out of 70,482
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  • Site-wide: 28,176 out of 70,482

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

• Downloaded 433 times
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  • Site-wide: 26,879 out of 70,482
  • In genetics: 1,739 out of 3,908
• Year to date:
  • Site-wide: 34,016 out of 70,482
• Since beginning of last month:
  • Site-wide: 41,917 out of 70,482

Accelerated Epigenetic Ageing in Major Depressive Disorder

• Downloaded 426 times
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  • Site-wide: 27,342 out of 70,482
  • In genomics: 2,843 out of 4,710
• Year to date:
  • Site-wide: 51,592 out of 70,482
• Since beginning of last month:
  • Site-wide: 60,178 out of 70,482

CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

• Downloaded 364 times
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  • Site-wide: 32,466 out of 70,482
  • In genetics: 2,032 out of 3,908
• Year to date:
  • Site-wide: 21,526 out of 70,482
• Since beginning of last month:
  • Site-wide: 4,447 out of 70,482

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

• Downloaded 339 times
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  • Site-wide: 34,813 out of 70,482
  • In genetics: 2,155 out of 3,908
• Year to date:
  • Site-wide: 42,280 out of 70,482
• Since beginning of last month:
  • Site-wide: 41,305 out of 70,482

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 287 times
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  • Site-wide: 40,257 out of 70,482
  • In genetics: 2,451 out of 3,908
• Year to date:
  • Site-wide: 53,469 out of 70,482
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  • Site-wide: 26,880 out of 70,482

Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder

• Downloaded 283 times
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  • Site-wide: 40,778 out of 70,482
  • In neuroscience: 7,149 out of 12,671
• Year to date:
  • Site-wide: 45,416 out of 70,482
• Since beginning of last month:
  • Site-wide: 26,646 out of 70,482

Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.

• Downloaded 273 times
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  • Site-wide: 42,011 out of 70,482
  • In genetics: 2,525 out of 3,908
• Year to date:
  • Site-wide: 35,854 out of 70,482
• Since beginning of last month:
  • Site-wide: 65,003 out of 70,482

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 269 times
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  • Site-wide: 42,461 out of 70,482
  • In genetics: 2,556 out of 3,908
• Year to date:
  • Site-wide: 62,852 out of 70,482
• Since beginning of last month:
  • Site-wide: 48,910 out of 70,482

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

• Downloaded 263 times
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  • Site-wide: 43,160 out of 70,482
  • In genetics: 2,599 out of 3,908
• Year to date:
  • Site-wide: 66,283 out of 70,482
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  • Site-wide: 67,818 out of 70,482

Epigenetic signatures of starting and stopping smoking

• Downloaded 222 times
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  • Site-wide: 48,670 out of 70,482
  • In genomics: 3,969 out of 4,710
• Year to date:
  • Site-wide: 62,514 out of 70,482
• Since beginning of last month:
  • Site-wide: 63,945 out of 70,482

Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

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  • Site-wide: 48,791 out of 70,482
  • In genomics: 3,972 out of 4,710
• Year to date:
  • Site-wide: 33,460 out of 70,482
• Since beginning of last month:
  • Site-wide: 35,671 out of 70,482

Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression

• Downloaded 200 times
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  • Site-wide: 51,716 out of 70,482
  • In genetics: 3,060 out of 3,908
• Year to date:
  • Site-wide: 60,964 out of 70,482
• Since beginning of last month:
  • Site-wide: 66,136 out of 70,482

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

• Downloaded 155 times
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  • Site-wide: 58,403 out of 70,482
  • In neuroscience: 10,437 out of 12,671
• Year to date:
  • Site-wide: 54,531 out of 70,482
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  • Site-wide: 20,423 out of 70,482

Expression quantitative trait loci-derived scores and white matter microstructure in UK Biobank: a novel approach to integrating genetics and neuroimaging

• Downloaded 148 times
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  • Site-wide: 59,558 out of 70,482
  • In bioinformatics: 6,233 out of 6,905
• Year to date:
  • Site-wide: 29,489 out of 70,482
• Since beginning of last month:
  • Site-wide: 48,955 out of 70,482