Author: T-K Clarke

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Preprints

Genomewide association study identifies 30 loci associated with bipolar disorder

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 2,461
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  • Site-wide: 35,073
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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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  • Site-wide: 5,514
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Minimal phenotyping yields GWAS hits of reduced specificity for major depression

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  • Site-wide: 7,703
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Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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  • Site-wide: 10,104
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 12,850
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  • Site-wide: 90,488
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  • Site-wide: 134,652

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

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  • Site-wide: 13,546
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Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • Site-wide: 16,777
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  • Site-wide: 75,499
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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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  • Site-wide: 17,198
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Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

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  • Site-wide: 19,329
  • In genetics: 922
• Year to date:
  • Site-wide: 41,784
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  • Site-wide: 36,356

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

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  • Site-wide: 27,304
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  • Site-wide: 105,712
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  • Site-wide: 92,509

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants

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  • Site-wide: 32,266
  • In epidemiology: 1,659
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  • Site-wide: 52,570
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Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

• Downloaded 749 times
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  • Site-wide: 34,329
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• Year to date:
  • Site-wide: 127,095
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  • Site-wide: 123,913

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

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  • Site-wide: 35,187
  • In genetics: 1,651
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  • Site-wide: 130,366
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  • Site-wide: 124,544

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • Site-wide: 35,652
  • In genetics: 1,670
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  • Site-wide: 119,367
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  • Site-wide: 102,164

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

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  • Site-wide: 37,998
  • In genetics: 1,762
• Year to date:
  • Site-wide: 80,275
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Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

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  • Site-wide: 42,216
  • In genomics: 3,451
• Year to date:
  • Site-wide: 140,486
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  • Site-wide: 122,802

A meta-analysis of genome-wide association studies of epigenetic age acceleration

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  • Site-wide: 48,213
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  • Site-wide: 137,415
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  • Site-wide: 115,386

CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

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Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder

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  • Site-wide: 56,499
  • In neuroscience: 8,286
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  • Site-wide: 98,334
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Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

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  • Site-wide: 58,361
  • In genomics: 4,325
• Year to date:
  • Site-wide: 113,212
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  • Site-wide: 72,135

Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.

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  • Site-wide: 63,260
  • In genetics: 2,864
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  • Site-wide: 72,814
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  • Site-wide: 77,317

Cognitive functioning and lifetime Major Depressive Disorder in UK Biobank

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  • Site-wide: 64,232
  • In psychiatry and clinical psychology: 219
• Year to date:
  • Site-wide: 61,583
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  • Site-wide: 42,791

Multivariate GWAS elucidates the genetic architecture of alcohol consumption and misuse, corrects biases, and reveals novel associations with disease

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  • Site-wide: 67,041
  • In genetics: 3,034
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Epigenetic prediction of major depressive disorder

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  • Site-wide: 67,549
  • In psychiatry and clinical psychology: 227
• Year to date:
  • Site-wide: 112,393
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  • Site-wide: 79,833

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

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  • Site-wide: 80,925
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  • Site-wide: 136,985
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  • Site-wide: 133,347

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

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  • Site-wide: 82,163
  • In genetics: 3,670
• Year to date:
  • Site-wide: 137,982
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  • Site-wide: 123,469

Epigenetic signatures of starting and stopping smoking

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  • Site-wide: 93,462
  • In genomics: 5,772
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  • Site-wide: 140,572
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  • Site-wide: 111,857

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

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  • Site-wide: 107,997
  • In neuroscience: 16,549
• Year to date:
  • Site-wide: 140,133
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  • Site-wide: 124,718

Associations between alcohol use and accelerated biological ageing

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  • Site-wide: 29,334