Author: Hongyu Zhao

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Preprints

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

• Downloaded 5,659 times
• Download rankings, all-time:
  • Site-wide: 2,959
  • In cell biology: 45
• Year to date:
  • Site-wide: 82,534
• Since beginning of last month:
  • Site-wide: 45,440

Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19

• Downloaded 5,420 times
• Download rankings, all-time:
  • Site-wide: 3,140
  • In infectious diseases: 782
• Year to date:
  • Site-wide: 37,048
• Since beginning of last month:
  • Site-wide: 22,097

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

• Downloaded 3,520 times
• Download rankings, all-time:
  • Site-wide: 5,781
  • In genomics: 538
• Year to date:
  • Site-wide: 140,500
• Since beginning of last month:
  • Site-wide: 30,209

A statistical framework for cross-tissue transcriptome-wide association analysis

• Downloaded 3,087 times
• Download rankings, all-time:
  • Site-wide: 7,005
  • In genetics: 255
• Year to date:
  • Site-wide: 35,419
• Since beginning of last month:
  • Site-wide: 90,481

AC-PCA: simultaneous dimension reduction and adjustment for confounding variation

• Downloaded 2,793 times
• Download rankings, all-time:
  • Site-wide: 8,104
  • In bioinformatics: 808
• Year to date:
  • Site-wide: 30,003
• Since beginning of last month:
  • Site-wide: 90,084

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

• Downloaded 2,594 times
• Download rankings, all-time:
  • Site-wide: 9,047
  • In immunology: 351
• Year to date:
  • Site-wide: 14,611
• Since beginning of last month:
  • Site-wide: 24,966

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

• Downloaded 2,273 times
• Download rankings, all-time:
  • Site-wide: 11,064
  • In genetics: 420
• Year to date:
  • Site-wide: 5,652
• Since beginning of last month:
  • Site-wide: 13,039

Neoantigen-driven B cell and CD4+ T follicular helper cell collaboration promotes robust anti-tumor CD8+ T cell responses

• Downloaded 2,133 times
• Download rankings, all-time:
  • Site-wide: 12,196
  • In immunology: 467
• Year to date:
  • Site-wide: 47,392
• Since beginning of last month:
  • Site-wide: 95,326

Single-cell transcriptomic and proteomic analysis of Parkinson's disease Brains

• Downloaded 2,100 times
• Download rankings, all-time:
  • Site-wide: 12,450
  • In neuroscience: 1,323
• Year to date:
  • Site-wide: 12,388
• Since beginning of last month:
  • Site-wide: 4,259

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

• Downloaded 2,085 times
• Download rankings, all-time:
  • Site-wide: 12,615
  • In genetics: 466
• Year to date:
  • Site-wide: 132,539
• Since beginning of last month:
  • Site-wide: 141,476

Local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits

• Downloaded 2,054 times
• Download rankings, all-time:
  • Site-wide: 12,884
  • In genetics: 490
• Year to date:
  • Site-wide: 14,469
• Since beginning of last month:
  • Site-wide: 54,742

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

• Downloaded 1,913 times
• Download rankings, all-time:
  • Site-wide: 14,369
  • In genetic and genomic medicine: 89
• Year to date:
  • Site-wide: 28,320
• Since beginning of last month:
  • Site-wide: 23,634

A powerful approach to estimating annotation-stratified genetic covariance using GWAS summary statistics

• Downloaded 1,840 times
• Download rankings, all-time:
  • Site-wide: 15,273
  • In genetics: 603
• Year to date:
  • Site-wide: 118,743
• Since beginning of last month:
  • Site-wide: 51,439

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

• Downloaded 1,674 times
• Download rankings, all-time:
  • Site-wide: 17,699
  • In genetic and genomic medicine: 111
• Year to date:
  • Site-wide: 27,288
• Since beginning of last month:
  • Site-wide: 21,749

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

• Downloaded 1,537 times
• Download rankings, all-time:
  • Site-wide: 20,229
  • In genetics: 837
• Year to date:
  • Site-wide: 23,520
• Since beginning of last month:
  • Site-wide: 52,743

Mendelian Randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics

• Downloaded 1,424 times
• Download rankings, all-time:
  • Site-wide: 22,897
  • In genetics: 925
• Year to date:
  • Site-wide: 26,518
• Since beginning of last month:
  • Site-wide: 36,895

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease

• Downloaded 1,409 times
• Download rankings, all-time:
  • Site-wide: 23,303
  • In genetics: 923
• Year to date:
  • Site-wide: 132,635
• Since beginning of last month:
  • Site-wide: 175,222

SCRIBE: a new approach to dropout imputation and batch effects correction for single-cell RNA-seq data

• Downloaded 1,386 times
• Download rankings, all-time:
  • Site-wide: 23,920
  • In bioinformatics: 2,606
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 126,985

Measuring genetic variation in the multi-ethnic Million Veteran Program (MVP)

• Downloaded 1,300 times
• Download rankings, all-time:
  • Site-wide: 26,524
  • In genetics: 1,061
• Year to date:
  • Site-wide: 82,622
• Since beginning of last month:
  • Site-wide: 131,955

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 1,166 times
• Download rankings, all-time:
  • Site-wide: 31,482
  • In genetics: 1,278
• Year to date:
  • Site-wide: 23,248
• Since beginning of last month:
  • Site-wide: 42,659

Mediated pleiotropy between psychiatric disorders and autoimmune disorders revealed by integrative analysis of multiple GWAS

• Downloaded 1,101 times
• Download rankings, all-time:
  • Site-wide: 34,374
  • In genomics: 2,791
• Year to date:
  • Site-wide: 94,102
• Since beginning of last month:
  • Site-wide: 117,063

Leveraging functional annotation to identify genes associated with complex diseases

• Downloaded 1,086 times
• Download rankings, all-time:
  • Site-wide: 35,077
  • In genetics: 1,377
• Year to date:
  • Site-wide: 188,861
• Since beginning of last month:
  • Site-wide: 154,106

Genome-wide Association Study of Alcohol Consumption and Use Disorder in Multiple Populations (N = 274,424)

• Downloaded 1,034 times
• Download rankings, all-time:
  • Site-wide: 37,877
  • In genetics: 1,508
• Year to date:
  • Site-wide: 167,663
• Since beginning of last month:
  • Site-wide: 59,370

Comparison of methods for estimating genetic correlation between complex traits using GWAS summary statistics

• Downloaded 1,019 times
• Download rankings, all-time:
  • Site-wide: 38,746
  • In genetics: 1,534
• Year to date:
  • Site-wide: 66,235
• Since beginning of last month:
  • Site-wide: 162,205

Transcriptomic Organization of Human Posttraumatic Stress Disorder

• Downloaded 921 times
• Download rankings, all-time:
  • Site-wide: 45,226
  • In genomics: 3,427
• Year to date:
  • Site-wide: 119,952
• Since beginning of last month:
  • Site-wide: 188,185

Influence of blood pressure on pneumonia risk: Epidemiological association and Mendelian randomisation in the UK Biobank

• Downloaded 874 times
• Download rankings, all-time:
  • Site-wide: 49,126
  • In genetic and genomic medicine: 312
• Year to date:
  • Site-wide: 46,914
• Since beginning of last month:
  • Site-wide: 66,121

TP53-mediated clonal hematopoiesis confers increased risk for incident peripheral artery disease

• Downloaded 867 times
• Download rankings, all-time:
  • Site-wide: 49,702
  • In genetic and genomic medicine: 366
• Year to date:
  • Site-wide: 1,203
• Since beginning of last month:
  • Site-wide: 20,025

Leveraging Functional Annotations in Genetic Risk Prediction for Human Complex Diseases

• Downloaded 829 times
• Download rankings, all-time:
  • Site-wide: 53,190
  • In bioinformatics: 5,242
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 201,506

A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics

• Downloaded 824 times
• Download rankings, all-time:
  • Site-wide: 53,725
  • In bioinformatics: 5,310
• Year to date:
  • Site-wide: 126,177
• Since beginning of last month:
  • Site-wide: 156,892

OTTERS: A powerful TWAS framework leveraging summary-level reference data

• Downloaded 821 times
• Download rankings, all-time:
  • Site-wide: 53,997
  • In genetics: 2,360
• Year to date:
  • Site-wide: 2,059
• Since beginning of last month:
  • Site-wide: 2,035

ResPAN: a powerful batch correction model forscRNA-seq data through residual adversarialnetworks

• Downloaded 763 times
• Download rankings, all-time:
  • Site-wide: 60,137
  • In bioinformatics: 5,904
• Year to date:
  • Site-wide: 109,696
• Since beginning of last month:
  • Site-wide: 21,704

Three distinct velocities of elongating RNA polymerase define exons and introns

• Downloaded 748 times
• Download rankings, all-time:
  • Site-wide: 61,966
  • In genomics: 4,288
• Year to date:
  • Site-wide: 168,910
• Since beginning of last month:
  • Site-wide: 210,412

Application of a Novel Machine Learning Method to Big Data Infers a Relationship Between Asthma and the Development of Neoplasia

• Downloaded 747 times
• Download rankings, all-time:
  • Site-wide: 62,122
  • In epidemiology: 2,980
• Year to date:
  • Site-wide: 92,297
• Since beginning of last month:
  • Site-wide: 90,030

A Markov Random Field Model for Network-based Differential Expression Analysis of Single-cell RNA-seq Data

• Downloaded 746 times
• Download rankings, all-time:
  • Site-wide: 62,197
  • In bioinformatics: 6,062
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 34,237

Benchmarking Automated Cell Type Annotation Tools for Single-cell ATAC-seq Data

• Downloaded 731 times
• Download rankings, all-time:
  • Site-wide: 64,154
  • In bioinformatics: 6,424
• Year to date:
  • Site-wide: 98,233
• Since beginning of last month:
  • Site-wide: 7,616

Circadian Rhythm Analysis Using Wearable Device Data: A Novel Penalized Machine Learning Approach

• Downloaded 724 times
• Download rankings, all-time:
  • Site-wide: 64,994
  • In neuroscience: 9,203
• Year to date:
  • Site-wide: 37,070
• Since beginning of last month:
  • Site-wide: 65,111

Identifying Combinations of Cancer Drivers in Individual Patients

• Downloaded 715 times
• Download rankings, all-time:
  • Site-wide: 66,199
  • In bioinformatics: 6,280
• Year to date:
  • Site-wide: 171,574
• Since beginning of last month:
  • Site-wide: 117,660

A Statistical Framework to Identify Cell Types Whose Genetically Regulated Proportions are Associated with Complex Diseases

• Downloaded 686 times
• Download rankings, all-time:
  • Site-wide: 70,188
  • In genetic and genomic medicine: 451
• Year to date:
  • Site-wide: 109,224
• Since beginning of last month:
  • Site-wide: 51,063

Simultaneous and sequential multi-species coronavirus vaccination

• Downloaded 663 times
• Download rankings, all-time:
  • Site-wide: 73,419
  • In immunology: 2,411
• Year to date:
  • Site-wide: 147,321
• Since beginning of last month:
  • Site-wide: 41,825

Genetic Association of Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease

• Downloaded 660 times
• Download rankings, all-time:
  • Site-wide: 74,010
  • In bioinformatics: 6,969
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 210,225

Estimating cell-type-specific gene co-expression networks from bulk gene expression data with an application to Alzheimer's disease

• Downloaded 656 times
• Download rankings, all-time:
  • Site-wide: 74,589
  • In bioinformatics: 7,073
• Year to date:
  • Site-wide: 35,237
• Since beginning of last month:
  • Site-wide: 28,688

Non-linear Archetypal Analysis of Single-cell RNA-seq Data by Deep Autoencoders

• Downloaded 626 times
• Download rankings, all-time:
  • Site-wide: 79,247
  • In bioinformatics: 7,419
• Year to date:
  • Site-wide: 32,888
• Since beginning of last month:
  • Site-wide: 37,121

Comprehensive Analysis of Ubiquitously Expressed Genes in Human, From a Data-Driven Perspective

• Downloaded 622 times
• Download rankings, all-time:
  • Site-wide: 79,819
  • In genomics: 5,229
• Year to date:
  • Site-wide: 48,302
• Since beginning of last month:
  • Site-wide: 26,728

Correcting statistical bias in correlation-based kinship estimators

• Downloaded 525 times
• Download rankings, all-time:
  • Site-wide: 98,541
  • In genetics: 3,770
• Year to date:
  • Site-wide: 64,387
• Since beginning of last month:
  • Site-wide: 86,374

microRNA seedless sites attenuate strong-seed-site-mediated target repression

• Downloaded 515 times
• Download rankings, all-time:
  • Site-wide: 100,797
  • In bioinformatics: 8,952
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 211,157

Identifying Modules of Cooperating Cancer Drivers

• Downloaded 479 times
• Download rankings, all-time:
  • Site-wide: 109,231
  • In cancer biology: 3,303
• Year to date:
  • Site-wide: 85,919
• Since beginning of last month:
  • Site-wide: 122,795

Hemodynamic Differences Between Women and Men with Elevated Blood Pressure in China: A Non-Invasive Assessment of 45,082 Adults Using Impedance Cardiography

• Downloaded 464 times
• Download rankings, all-time:
  • Site-wide: 112,906
  • In cardiovascular medicine: 292
• Year to date:
  • Site-wide: 100,016
• Since beginning of last month:
  • Site-wide: 96,687

Integrative Analyses Reveal Novel Disease-associated Loci and Genes for Idiopathic Pulmonary Fibrosis

• Downloaded 452 times
• Download rankings, all-time:
  • Site-wide: 115,910
  • In genetic and genomic medicine: 770
• Year to date:
  • Site-wide: 56,814
• Since beginning of last month:
  • Site-wide: 45,133

Genomic Influences on Self-Reported Childhood Maltreatment

• Downloaded 450 times
• Download rankings, all-time:
  • Site-wide: 116,509
  • In genomics: 6,665
• Year to date:
  • Site-wide: 193,691
• Since beginning of last month:
  • Site-wide: 199,622

Retrospective Association Analysis of Longitudinal Binary Traits Identifies Important Loci and Pathways in Cocaine Use

• Downloaded 441 times
• Download rankings, all-time:
  • Site-wide: 118,831
  • In genetics: 4,469
• Year to date:
  • Site-wide: 93,208
• Since beginning of last month:
  • Site-wide: 195,741

Motor nuclei innervating eye muscles spared in mouse model of SOD1-linked ALS

• Downloaded 432 times
• Download rankings, all-time:
  • Site-wide: 121,132
  • In neuroscience: 17,622
• Year to date:
  • Site-wide: 92,173
• Since beginning of last month:
  • Site-wide: 149,801

Quantifying concordant genetic effects of de novo mutations on multiple disorders

• Downloaded 426 times
• Download rankings, all-time:
  • Site-wide: 122,741
  • In genetics: 4,606
• Year to date:
  • Site-wide: 107,694
• Since beginning of last month:
  • Site-wide: 84,720

Estimating genetic correlation jointly using individual-level and summary-level GWAS data

• Downloaded 387 times
• Download rankings, all-time:
  • Site-wide: 133,900
  • In genetics: 5,018
• Year to date:
  • Site-wide: 109,735
• Since beginning of last month:
  • Site-wide: 49,564

Inferring time-lagged causality using the derivative of single-cell expression

• Downloaded 375 times
• Download rankings, all-time:
  • Site-wide: 137,379
  • In bioinformatics: 10,983
• Year to date:
  • Site-wide: 149,711
• Since beginning of last month:
  • Site-wide: 135,606

TRPV5, TRPV6, TRPM6, and TRPM7 do not contribute to hair-cell mechanotransduction

• Downloaded 359 times
• Download rankings, all-time:
  • Site-wide: 141,928
  • In neuroscience: 20,731
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 196,987

M-DATA: A Statistical Approach to Jointly Analyzing De Novo Mutations for Multiple Traits

• Downloaded 336 times
• Download rankings, all-time:
  • Site-wide: 149,148
  • In genetic and genomic medicine: 1,052
• Year to date:
  • Site-wide: 180,621
• Since beginning of last month:
  • Site-wide: 158,627

Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression in the VA Health Care System

• Downloaded 314 times
• Download rankings, all-time:
  • Site-wide: 155,704
  • In genetic and genomic medicine: 1,120
• Year to date:
  • Site-wide: 42,843
• Since beginning of last month:
  • Site-wide: 104,786

Automated Feature Extraction from Population Wearable Device Data Identified Novel Loci Associated with Sleep and Circadian Rhythms

• Downloaded 312 times
• Download rankings, all-time:
  • Site-wide: 156,269
  • In genetics: 5,781
• Year to date:
  • Site-wide: 89,026
• Since beginning of last month:
  • Site-wide: 186,072

Cell-type-specific co-expression inference from single cell RNA-sequencing data

• Downloaded 193 times
• Download rankings, all-time:
  • Site-wide: 189,064
  • In bioinformatics: 15,309
• Year to date:
  • Site-wide: 3,547
• Since beginning of last month:
  • Site-wide: 1,218

Network Assisted Analysis of De Novo Variants Using Protein-Protein Interaction Information Identified 46 Candidate Genes for Congenital Heart Disease

• Downloaded 163 times
• Download rankings, all-time:
  • Site-wide: 195,509
  • In genetic and genomic medicine: 1,510
• Year to date:
  • Site-wide: 103,120
• Since beginning of last month:
  • Site-wide: 137,401

AIM1-dependent high basal SA accumulation modulates stomatal aperture in rice

• Downloaded 162 times
• Download rankings, all-time:
  • Site-wide: 195,781
  • In plant biology: 5,524
• Year to date:
  • Site-wide: 31,227
• Since beginning of last month:
  • Site-wide: 28,106

Quantifying constraint in human mitochondrial DNA

• Downloaded 147 times
• Download rankings, all-time:
  • Site-wide: 198,808
  • In genetics: None
• Year to date:
  • Site-wide: 2,002
• Since beginning of last month:
  • Site-wide: 2,963

Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program

• Downloaded 114 times
• Download rankings, all-time:
  • Site-wide: 204,915
  • In genetics: 7,143
• Year to date:
  • Site-wide: 68,007
• Since beginning of last month:
  • Site-wide: 41,649

Whole Exome Sequencing Analyses Support a Role of Vitamin D Metabolism in Ischemic Stroke

• Downloaded 103 times
• Download rankings, all-time:
  • Site-wide: 206,954
  • In genetic and genomic medicine: 1,655
• Year to date:
  • Site-wide: 98,981
• Since beginning of last month:
  • Site-wide: 69,628

Statistical Assessment of Biomarker Replicability using MAJAR Method

• Downloaded 67 times
• Download rankings, all-time:
  • Site-wide: 213,453
  • In genetic and genomic medicine: 1,740
• Year to date:
  • Site-wide: 31,260
• Since beginning of last month:
  • Site-wide: 5,721