Author: Hongyu Zhao

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Preprints

Network Assisted Analysis of De Novo Variants Using Protein-Protein Interaction Information Identified 46 Candidate Genes for Congenital Heart Disease

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Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

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Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19

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Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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A statistical framework for cross-tissue transcriptome-wide association analysis

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AC-PCA: simultaneous dimension reduction and adjustment for confounding variation

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A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

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Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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Local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits

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A powerful approach to estimating annotation-stratified genetic covariance using GWAS summary statistics

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Neoantigen-driven B cell and CD4+ T follicular helper cell collaboration promotes robust anti-tumor CD8+ T cell responses

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Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

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Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease

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Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

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SCRIBE: a new approach to dropout imputation and batch effects correction for single-cell RNA-seq data

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Measuring genetic variation in the multi-ethnic Million Veteran Program (MVP)

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Mediated pleiotropy between psychiatric disorders and autoimmune disorders revealed by integrative analysis of multiple GWAS

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Leveraging functional annotation to identify genes associated with complex diseases

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Genome-wide Association Study of Alcohol Consumption and Use Disorder in Multiple Populations (N = 274,424)

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A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

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Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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Comparison of methods for estimating genetic correlation between complex traits using GWAS summary statistics

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Transcriptomic Organization of Human Posttraumatic Stress Disorder

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Leveraging Functional Annotations in Genetic Risk Prediction for Human Complex Diseases

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A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics

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Influence of blood pressure on pneumonia risk: Epidemiological association and Mendelian randomisation in the UK Biobank

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Three distinct velocities of elongating RNA polymerase define exons and introns

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Application of a Novel Machine Learning Method to Big Data Infers a Relationship Between Asthma and the Development of Neoplasia

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Identifying Combinations of Cancer Drivers in Individual Patients

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Genetic Association of Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease

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Circadian Rhythm Analysis Using Wearable Device Data: A Novel Penalized Machine Learning Approach

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MR-APSS: a unified approach to Mendelian Randomization accounting for pleiotropy and sample structure using genome-wide summary statistics

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A Markov Random Field Model for Network-based Differential Expression Analysis of Single-cell RNA-seq Data

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microRNA seedless sites attenuate strong-seed-site-mediated target repression

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Genomic Influences on Self-Reported Childhood Maltreatment

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A Statistical Framework to Identify Cell Types Whose Genetically Regulated Proportions are Associated with Complex Diseases

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Non-linear Archetypal Analysis of Single-cell RNA-seq Data by Deep Autoencoders

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Identifying Modules of Cooperating Cancer Drivers

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Motor nuclei innervating eye muscles spared in mouse model of SOD1-linked ALS

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Retrospective Association Analysis of Longitudinal Binary Traits Identifies Important Loci and Pathways in Cocaine Use

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Comprehensive Analysis of Ubiquitously Expressed Genes in Human, From a Data-Driven Perspective

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TP53-mediated clonal hematopoiesis confers increased risk for incident peripheral artery disease

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TRPV5, TRPV6, TRPM6, and TRPM7 do not contribute to hair-cell mechanotransduction

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Inferring time-lagged causality using the derivative of single-cell expression

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Quantifying concordant genetic effects of de novo mutations on multiple disorders

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Integrative Analyses Reveal Novel Disease-associated Loci and Genes for Idiopathic Pulmonary Fibrosis

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M-DATA: A Statistical Approach to Jointly Analyzing De Novo Mutations for Multiple Traits

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Correcting statistical bias in correlation-based kinship estimators

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Automated Feature Extraction from Population Wearable Device Data Identified Novel Loci Associated with Sleep and Circadian Rhythms

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Hemodynamic Differences Between Women and Men with Elevated Blood Pressure in China

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Estimating genetic correlation jointly using individual-level and summary-level GWAS data

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