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Author: Hongyu Zhao

  • ORCiD: http://orcid.org/0000-0003-1195-9607
  • Most recently observed institution: Department of Genetics, Yale School of Medicine, New Haven, CT, USA; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA

Rankings

  • All-time downloads: 73,046 (rank: 3,327 )
  • Categories:
    • bioinformatics: 11,492 (rank: 1,099 )
    • cancer biology: 475 (rank: 34,237 (tie) )
    • cardiovascular medicine: 458 (rank: 3,086 (tie) )
    • cell biology: 5,653 (rank: 1,248 (tie) )
    • epidemiology: 737 (rank: 20,855 (tie) )
    • genetic and genomic medicine: 7,250 (rank: 438 )
    • genetics: 24,072 (rank: 512 )
    • genomics: 7,330 (rank: 4,173 (tie) )
    • immunology: 5,358 (rank: 3,310 (tie) )
    • infectious diseases: 5,394 (rank: 12,777 (tie) )
    • neuroscience: 3,529 (rank: 10,274 (tie) )
    • plant biology: 152 (rank: 27,780 (tie) )

Downloads per author, site-wide

Preprints

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

cell biology more details view paper
  • Downloaded 5,659 times
  • Download rankings, all-time:
    • Site-wide: 2,959
    • In cell biology: 45
  • Year to date:
    • Site-wide: 82,534
  • Since beginning of last month:
    • Site-wide: 45,440

Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19

infectious diseases more details view paper
  • Downloaded 5,420 times
  • Download rankings, all-time:
    • Site-wide: 3,140
    • In infectious diseases: 782
  • Year to date:
    • Site-wide: 37,048
  • Since beginning of last month:
    • Site-wide: 22,097

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

genomics more details view paper
  • Downloaded 3,520 times
  • Download rankings, all-time:
    • Site-wide: 5,781
    • In genomics: 538
  • Year to date:
    • Site-wide: 140,500
  • Since beginning of last month:
    • Site-wide: 30,209

A statistical framework for cross-tissue transcriptome-wide association analysis

genetics more details view paper
  • Downloaded 3,087 times
  • Download rankings, all-time:
    • Site-wide: 7,005
    • In genetics: 255
  • Year to date:
    • Site-wide: 35,419
  • Since beginning of last month:
    • Site-wide: 90,481

AC-PCA: simultaneous dimension reduction and adjustment for confounding variation

bioinformatics more details view paper
  • Downloaded 2,793 times
  • Download rankings, all-time:
    • Site-wide: 8,104
    • In bioinformatics: 808
  • Year to date:
    • Site-wide: 30,003
  • Since beginning of last month:
    • Site-wide: 90,084

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

immunology more details view paper
  • Downloaded 2,594 times
  • Download rankings, all-time:
    • Site-wide: 9,047
    • In immunology: 351
  • Year to date:
    • Site-wide: 14,611
  • Since beginning of last month:
    • Site-wide: 24,966

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

genetics more details view paper
  • Downloaded 2,273 times
  • Download rankings, all-time:
    • Site-wide: 11,064
    • In genetics: 420
  • Year to date:
    • Site-wide: 5,652
  • Since beginning of last month:
    • Site-wide: 13,039

Neoantigen-driven B cell and CD4+ T follicular helper cell collaboration promotes robust anti-tumor CD8+ T cell responses

immunology more details view paper
  • Downloaded 2,133 times
  • Download rankings, all-time:
    • Site-wide: 12,196
    • In immunology: 467
  • Year to date:
    • Site-wide: 47,392
  • Since beginning of last month:
    • Site-wide: 95,326

Single-cell transcriptomic and proteomic analysis of Parkinson's disease Brains

neuroscience more details view paper
  • Downloaded 2,100 times
  • Download rankings, all-time:
    • Site-wide: 12,450
    • In neuroscience: 1,323
  • Year to date:
    • Site-wide: 12,388
  • Since beginning of last month:
    • Site-wide: 4,259

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

genetics more details view paper
  • Downloaded 2,085 times
  • Download rankings, all-time:
    • Site-wide: 12,615
    • In genetics: 466
  • Year to date:
    • Site-wide: 132,539
  • Since beginning of last month:
    • Site-wide: 141,476

Local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits

genetics more details view paper
  • Downloaded 2,054 times
  • Download rankings, all-time:
    • Site-wide: 12,884
    • In genetics: 490
  • Year to date:
    • Site-wide: 14,469
  • Since beginning of last month:
    • Site-wide: 54,742

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

genetic and genomic medicine more details view paper
  • Downloaded 1,913 times
  • Download rankings, all-time:
    • Site-wide: 14,369
    • In genetic and genomic medicine: 89
  • Year to date:
    • Site-wide: 28,320
  • Since beginning of last month:
    • Site-wide: 23,634

A powerful approach to estimating annotation-stratified genetic covariance using GWAS summary statistics

genetics more details view paper
  • Downloaded 1,840 times
  • Download rankings, all-time:
    • Site-wide: 15,273
    • In genetics: 603
  • Year to date:
    • Site-wide: 118,743
  • Since beginning of last month:
    • Site-wide: 51,439

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

genetic and genomic medicine more details view paper
  • Downloaded 1,674 times
  • Download rankings, all-time:
    • Site-wide: 17,699
    • In genetic and genomic medicine: 111
  • Year to date:
    • Site-wide: 27,288
  • Since beginning of last month:
    • Site-wide: 21,749

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

genetics more details view paper
  • Downloaded 1,537 times
  • Download rankings, all-time:
    • Site-wide: 20,229
    • In genetics: 837
  • Year to date:
    • Site-wide: 23,520
  • Since beginning of last month:
    • Site-wide: 52,743

Mendelian Randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics

genetics more details view paper
  • Downloaded 1,424 times
  • Download rankings, all-time:
    • Site-wide: 22,897
    • In genetics: 925
  • Year to date:
    • Site-wide: 26,518
  • Since beginning of last month:
    • Site-wide: 36,895

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease

genetics more details view paper
  • Downloaded 1,409 times
  • Download rankings, all-time:
    • Site-wide: 23,303
    • In genetics: 923
  • Year to date:
    • Site-wide: 132,635
  • Since beginning of last month:
    • Site-wide: 175,222

SCRIBE: a new approach to dropout imputation and batch effects correction for single-cell RNA-seq data

bioinformatics more details view paper
  • Downloaded 1,386 times
  • Download rankings, all-time:
    • Site-wide: 23,920
    • In bioinformatics: 2,606
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 126,985

Measuring genetic variation in the multi-ethnic Million Veteran Program (MVP)

genetics more details view paper
  • Downloaded 1,300 times
  • Download rankings, all-time:
    • Site-wide: 26,524
    • In genetics: 1,061
  • Year to date:
    • Site-wide: 82,622
  • Since beginning of last month:
    • Site-wide: 131,955

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

genetics more details view paper
  • Downloaded 1,166 times
  • Download rankings, all-time:
    • Site-wide: 31,482
    • In genetics: 1,278
  • Year to date:
    • Site-wide: 23,248
  • Since beginning of last month:
    • Site-wide: 42,659

Mediated pleiotropy between psychiatric disorders and autoimmune disorders revealed by integrative analysis of multiple GWAS

genomics more details view paper
  • Downloaded 1,101 times
  • Download rankings, all-time:
    • Site-wide: 34,374
    • In genomics: 2,791
  • Year to date:
    • Site-wide: 94,102
  • Since beginning of last month:
    • Site-wide: 117,063

Leveraging functional annotation to identify genes associated with complex diseases

genetics more details view paper
  • Downloaded 1,086 times
  • Download rankings, all-time:
    • Site-wide: 35,077
    • In genetics: 1,377
  • Year to date:
    • Site-wide: 188,861
  • Since beginning of last month:
    • Site-wide: 154,106

Genome-wide Association Study of Alcohol Consumption and Use Disorder in Multiple Populations (N = 274,424)

genetics more details view paper
  • Downloaded 1,034 times
  • Download rankings, all-time:
    • Site-wide: 37,877
    • In genetics: 1,508
  • Year to date:
    • Site-wide: 167,663
  • Since beginning of last month:
    • Site-wide: 59,370

Comparison of methods for estimating genetic correlation between complex traits using GWAS summary statistics

genetics more details view paper
  • Downloaded 1,019 times
  • Download rankings, all-time:
    • Site-wide: 38,746
    • In genetics: 1,534
  • Year to date:
    • Site-wide: 66,235
  • Since beginning of last month:
    • Site-wide: 162,205

Transcriptomic Organization of Human Posttraumatic Stress Disorder

genomics more details view paper
  • Downloaded 921 times
  • Download rankings, all-time:
    • Site-wide: 45,226
    • In genomics: 3,427
  • Year to date:
    • Site-wide: 119,952
  • Since beginning of last month:
    • Site-wide: 188,185

Influence of blood pressure on pneumonia risk: Epidemiological association and Mendelian randomisation in the UK Biobank

genetic and genomic medicine more details view paper
  • Downloaded 874 times
  • Download rankings, all-time:
    • Site-wide: 49,126
    • In genetic and genomic medicine: 312
  • Year to date:
    • Site-wide: 46,914
  • Since beginning of last month:
    • Site-wide: 66,121

TP53-mediated clonal hematopoiesis confers increased risk for incident peripheral artery disease

genetic and genomic medicine more details view paper
  • Downloaded 867 times
  • Download rankings, all-time:
    • Site-wide: 49,702
    • In genetic and genomic medicine: 366
  • Year to date:
    • Site-wide: 1,203
  • Since beginning of last month:
    • Site-wide: 20,025

Leveraging Functional Annotations in Genetic Risk Prediction for Human Complex Diseases

bioinformatics more details view paper
  • Downloaded 829 times
  • Download rankings, all-time:
    • Site-wide: 53,190
    • In bioinformatics: 5,242
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 201,506

A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics

bioinformatics more details view paper
  • Downloaded 824 times
  • Download rankings, all-time:
    • Site-wide: 53,725
    • In bioinformatics: 5,310
  • Year to date:
    • Site-wide: 126,177
  • Since beginning of last month:
    • Site-wide: 156,892

OTTERS: A powerful TWAS framework leveraging summary-level reference data

genetics more details view paper
  • Downloaded 821 times
  • Download rankings, all-time:
    • Site-wide: 53,997
    • In genetics: 2,360
  • Year to date:
    • Site-wide: 2,059
  • Since beginning of last month:
    • Site-wide: 2,035

ResPAN: a powerful batch correction model forscRNA-seq data through residual adversarialnetworks

bioinformatics more details view paper
  • Downloaded 763 times
  • Download rankings, all-time:
    • Site-wide: 60,137
    • In bioinformatics: 5,904
  • Year to date:
    • Site-wide: 109,696
  • Since beginning of last month:
    • Site-wide: 21,704

Three distinct velocities of elongating RNA polymerase define exons and introns

genomics more details view paper
  • Downloaded 748 times
  • Download rankings, all-time:
    • Site-wide: 61,966
    • In genomics: 4,288
  • Year to date:
    • Site-wide: 168,910
  • Since beginning of last month:
    • Site-wide: 210,412

Application of a Novel Machine Learning Method to Big Data Infers a Relationship Between Asthma and the Development of Neoplasia

epidemiology more details view paper
  • Downloaded 747 times
  • Download rankings, all-time:
    • Site-wide: 62,122
    • In epidemiology: 2,980
  • Year to date:
    • Site-wide: 92,297
  • Since beginning of last month:
    • Site-wide: 90,030

A Markov Random Field Model for Network-based Differential Expression Analysis of Single-cell RNA-seq Data

bioinformatics more details view paper
  • Downloaded 746 times
  • Download rankings, all-time:
    • Site-wide: 62,197
    • In bioinformatics: 6,062
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 34,237

Benchmarking Automated Cell Type Annotation Tools for Single-cell ATAC-seq Data

bioinformatics more details view paper
  • Downloaded 731 times
  • Download rankings, all-time:
    • Site-wide: 64,154
    • In bioinformatics: 6,424
  • Year to date:
    • Site-wide: 98,233
  • Since beginning of last month:
    • Site-wide: 7,616

Circadian Rhythm Analysis Using Wearable Device Data: A Novel Penalized Machine Learning Approach

neuroscience more details view paper
  • Downloaded 724 times
  • Download rankings, all-time:
    • Site-wide: 64,994
    • In neuroscience: 9,203
  • Year to date:
    • Site-wide: 37,070
  • Since beginning of last month:
    • Site-wide: 65,111

Identifying Combinations of Cancer Drivers in Individual Patients

bioinformatics more details view paper
  • Downloaded 715 times
  • Download rankings, all-time:
    • Site-wide: 66,199
    • In bioinformatics: 6,280
  • Year to date:
    • Site-wide: 171,574
  • Since beginning of last month:
    • Site-wide: 117,660

A Statistical Framework to Identify Cell Types Whose Genetically Regulated Proportions are Associated with Complex Diseases

genetic and genomic medicine more details view paper
  • Downloaded 686 times
  • Download rankings, all-time:
    • Site-wide: 70,188
    • In genetic and genomic medicine: 451
  • Year to date:
    • Site-wide: 109,224
  • Since beginning of last month:
    • Site-wide: 51,063

Simultaneous and sequential multi-species coronavirus vaccination

immunology more details view paper
  • Downloaded 663 times
  • Download rankings, all-time:
    • Site-wide: 73,419
    • In immunology: 2,411
  • Year to date:
    • Site-wide: 147,321
  • Since beginning of last month:
    • Site-wide: 41,825

Genetic Association of Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease

bioinformatics more details view paper
  • Downloaded 660 times
  • Download rankings, all-time:
    • Site-wide: 74,010
    • In bioinformatics: 6,969
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 210,225

Estimating cell-type-specific gene co-expression networks from bulk gene expression data with an application to Alzheimer's disease

bioinformatics more details view paper
  • Downloaded 656 times
  • Download rankings, all-time:
    • Site-wide: 74,589
    • In bioinformatics: 7,073
  • Year to date:
    • Site-wide: 35,237
  • Since beginning of last month:
    • Site-wide: 28,688

Non-linear Archetypal Analysis of Single-cell RNA-seq Data by Deep Autoencoders

bioinformatics more details view paper
  • Downloaded 626 times
  • Download rankings, all-time:
    • Site-wide: 79,247
    • In bioinformatics: 7,419
  • Year to date:
    • Site-wide: 32,888
  • Since beginning of last month:
    • Site-wide: 37,121

Comprehensive Analysis of Ubiquitously Expressed Genes in Human, From a Data-Driven Perspective

genomics more details view paper
  • Downloaded 622 times
  • Download rankings, all-time:
    • Site-wide: 79,819
    • In genomics: 5,229
  • Year to date:
    • Site-wide: 48,302
  • Since beginning of last month:
    • Site-wide: 26,728

Correcting statistical bias in correlation-based kinship estimators

genetics more details view paper
  • Downloaded 525 times
  • Download rankings, all-time:
    • Site-wide: 98,541
    • In genetics: 3,770
  • Year to date:
    • Site-wide: 64,387
  • Since beginning of last month:
    • Site-wide: 86,374

microRNA seedless sites attenuate strong-seed-site-mediated target repression

bioinformatics more details view paper
  • Downloaded 515 times
  • Download rankings, all-time:
    • Site-wide: 100,797
    • In bioinformatics: 8,952
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 211,157

Identifying Modules of Cooperating Cancer Drivers

cancer biology more details view paper
  • Downloaded 479 times
  • Download rankings, all-time:
    • Site-wide: 109,231
    • In cancer biology: 3,303
  • Year to date:
    • Site-wide: 85,919
  • Since beginning of last month:
    • Site-wide: 122,795

Hemodynamic Differences Between Women and Men with Elevated Blood Pressure in China: A Non-Invasive Assessment of 45,082 Adults Using Impedance Cardiography

cardiovascular medicine more details view paper
  • Downloaded 464 times
  • Download rankings, all-time:
    • Site-wide: 112,906
    • In cardiovascular medicine: 292
  • Year to date:
    • Site-wide: 100,016
  • Since beginning of last month:
    • Site-wide: 96,687

Integrative Analyses Reveal Novel Disease-associated Loci and Genes for Idiopathic Pulmonary Fibrosis

genetic and genomic medicine more details view paper
  • Downloaded 452 times
  • Download rankings, all-time:
    • Site-wide: 115,910
    • In genetic and genomic medicine: 770
  • Year to date:
    • Site-wide: 56,814
  • Since beginning of last month:
    • Site-wide: 45,133

Genomic Influences on Self-Reported Childhood Maltreatment

genomics more details view paper
  • Downloaded 450 times
  • Download rankings, all-time:
    • Site-wide: 116,509
    • In genomics: 6,665
  • Year to date:
    • Site-wide: 193,691
  • Since beginning of last month:
    • Site-wide: 199,622

Retrospective Association Analysis of Longitudinal Binary Traits Identifies Important Loci and Pathways in Cocaine Use

genetics more details view paper
  • Downloaded 441 times
  • Download rankings, all-time:
    • Site-wide: 118,831
    • In genetics: 4,469
  • Year to date:
    • Site-wide: 93,208
  • Since beginning of last month:
    • Site-wide: 195,741

Motor nuclei innervating eye muscles spared in mouse model of SOD1-linked ALS

neuroscience more details view paper
  • Downloaded 432 times
  • Download rankings, all-time:
    • Site-wide: 121,132
    • In neuroscience: 17,622
  • Year to date:
    • Site-wide: 92,173
  • Since beginning of last month:
    • Site-wide: 149,801

Quantifying concordant genetic effects of de novo mutations on multiple disorders

genetics more details view paper
  • Downloaded 426 times
  • Download rankings, all-time:
    • Site-wide: 122,741
    • In genetics: 4,606
  • Year to date:
    • Site-wide: 107,694
  • Since beginning of last month:
    • Site-wide: 84,720

Estimating genetic correlation jointly using individual-level and summary-level GWAS data

genetics more details view paper
  • Downloaded 387 times
  • Download rankings, all-time:
    • Site-wide: 133,900
    • In genetics: 5,018
  • Year to date:
    • Site-wide: 109,735
  • Since beginning of last month:
    • Site-wide: 49,564

Inferring time-lagged causality using the derivative of single-cell expression

bioinformatics more details view paper
  • Downloaded 375 times
  • Download rankings, all-time:
    • Site-wide: 137,379
    • In bioinformatics: 10,983
  • Year to date:
    • Site-wide: 149,711
  • Since beginning of last month:
    • Site-wide: 135,606

TRPV5, TRPV6, TRPM6, and TRPM7 do not contribute to hair-cell mechanotransduction

neuroscience more details view paper
  • Downloaded 359 times
  • Download rankings, all-time:
    • Site-wide: 141,928
    • In neuroscience: 20,731
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 196,987

M-DATA: A Statistical Approach to Jointly Analyzing De Novo Mutations for Multiple Traits

genetic and genomic medicine more details view paper
  • Downloaded 336 times
  • Download rankings, all-time:
    • Site-wide: 149,148
    • In genetic and genomic medicine: 1,052
  • Year to date:
    • Site-wide: 180,621
  • Since beginning of last month:
    • Site-wide: 158,627

Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression in the VA Health Care System

genetic and genomic medicine more details view paper
  • Downloaded 314 times
  • Download rankings, all-time:
    • Site-wide: 155,704
    • In genetic and genomic medicine: 1,120
  • Year to date:
    • Site-wide: 42,843
  • Since beginning of last month:
    • Site-wide: 104,786

Automated Feature Extraction from Population Wearable Device Data Identified Novel Loci Associated with Sleep and Circadian Rhythms

genetics more details view paper
  • Downloaded 312 times
  • Download rankings, all-time:
    • Site-wide: 156,269
    • In genetics: 5,781
  • Year to date:
    • Site-wide: 89,026
  • Since beginning of last month:
    • Site-wide: 186,072

Cell-type-specific co-expression inference from single cell RNA-sequencing data

bioinformatics more details view paper
  • Downloaded 193 times
  • Download rankings, all-time:
    • Site-wide: 189,064
    • In bioinformatics: 15,309
  • Year to date:
    • Site-wide: 3,547
  • Since beginning of last month:
    • Site-wide: 1,218

Network Assisted Analysis of De Novo Variants Using Protein-Protein Interaction Information Identified 46 Candidate Genes for Congenital Heart Disease

genetic and genomic medicine more details view paper
  • Downloaded 163 times
  • Download rankings, all-time:
    • Site-wide: 195,509
    • In genetic and genomic medicine: 1,510
  • Year to date:
    • Site-wide: 103,120
  • Since beginning of last month:
    • Site-wide: 137,401

AIM1-dependent high basal SA accumulation modulates stomatal aperture in rice

plant biology more details view paper
  • Downloaded 162 times
  • Download rankings, all-time:
    • Site-wide: 195,781
    • In plant biology: 5,524
  • Year to date:
    • Site-wide: 31,227
  • Since beginning of last month:
    • Site-wide: 28,106

Quantifying constraint in human mitochondrial DNA

genetics more details view paper
  • Downloaded 147 times
  • Download rankings, all-time:
    • Site-wide: 198,808
    • In genetics: None
  • Year to date:
    • Site-wide: 2,002
  • Since beginning of last month:
    • Site-wide: 2,963

Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program

genetics more details view paper
  • Downloaded 114 times
  • Download rankings, all-time:
    • Site-wide: 204,915
    • In genetics: 7,143
  • Year to date:
    • Site-wide: 68,007
  • Since beginning of last month:
    • Site-wide: 41,649

Whole Exome Sequencing Analyses Support a Role of Vitamin D Metabolism in Ischemic Stroke

genetic and genomic medicine more details view paper
  • Downloaded 103 times
  • Download rankings, all-time:
    • Site-wide: 206,954
    • In genetic and genomic medicine: 1,655
  • Year to date:
    • Site-wide: 98,981
  • Since beginning of last month:
    • Site-wide: 69,628

Statistical Assessment of Biomarker Replicability using MAJAR Method

genetic and genomic medicine more details view paper
  • Downloaded 67 times
  • Download rankings, all-time:
    • Site-wide: 213,453
    • In genetic and genomic medicine: 1,740
  • Year to date:
    • Site-wide: 31,260
  • Since beginning of last month:
    • Site-wide: 5,721

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