Author: Hongyu Zhao

Downloads per author, site-wide

Preprints

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

• Downloaded 4,589 times
• Download rankings, all-time:
  • Site-wide: 2,245
  • In cell biology: 39
• Year to date:
  • Site-wide: 5,171
• Since beginning of last month:
  • Site-wide: 4,668

Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19

• Downloaded 3,844 times
• Download rankings, all-time:
  • Site-wide: 2,903
  • In infectious diseases: 576
• Year to date:
  • Site-wide: 3,217
• Since beginning of last month:
  • Site-wide: 3,648

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

• Downloaded 2,917 times
• Download rankings, all-time:
  • Site-wide: 4,301
  • In genomics: 478
• Year to date:
  • Site-wide: 6,605
• Since beginning of last month:
  • Site-wide: 6,577

A statistical framework for cross-tissue transcriptome-wide association analysis

• Downloaded 2,767 times
• Download rankings, all-time:
  • Site-wide: 4,639
  • In genetics: 205
• Year to date:
  • Site-wide: 53,761
• Since beginning of last month:
  • Site-wide: 57,009

AC-PCA: simultaneous dimension reduction and adjustment for confounding variation

• Downloaded 2,553 times
• Download rankings, all-time:
  • Site-wide: 5,208
  • In bioinformatics: 567
• Year to date:
  • Site-wide: 48,415
• Since beginning of last month:
  • Site-wide: 61,419

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

• Downloaded 1,884 times
• Download rankings, all-time:
  • Site-wide: 8,189
  • In genetics: 376
• Year to date:
  • Site-wide: 65,945
• Since beginning of last month:
  • Site-wide: 62,410

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

• Downloaded 1,723 times
• Download rankings, all-time:
  • Site-wide: 9,374
  • In genetics: 448
• Year to date:
  • Site-wide: 18,172
• Since beginning of last month:
  • Site-wide: 15,913

A powerful approach to estimating annotation-stratified genetic covariance using GWAS summary statistics

• Downloaded 1,603 times
• Download rankings, all-time:
  • Site-wide: 10,419
  • In genetics: 503
• Year to date:
  • Site-wide: 62,132
• Since beginning of last month:
  • Site-wide: 44,291

Local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits

• Downloaded 1,395 times
• Download rankings, all-time:
  • Site-wide: 12,794
  • In genetics: 629
• Year to date:
  • Site-wide: 8,914
• Since beginning of last month:
  • Site-wide: 9,410

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease

• Downloaded 1,306 times
• Download rankings, all-time:
  • Site-wide: 14,139
  • In genetics: 691
• Year to date:
  • Site-wide: 116,077
• Since beginning of last month:
  • Site-wide: 110,064

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

• Downloaded 1,155 times
• Download rankings, all-time:
  • Site-wide: 17,026
  • In immunology: 497
• Year to date:
  • Site-wide: 940
• Since beginning of last month:
  • Site-wide: 5,801

SCRIBE: a new approach to dropout imputation and batch effects correction for single-cell RNA-seq data

• Downloaded 1,090 times
• Download rankings, all-time:
  • Site-wide: 18,509
  • In bioinformatics: 2,214
• Year to date:
  • Site-wide: 45,673
• Since beginning of last month:
  • Site-wide: 85,162

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

• Downloaded 1,084 times
• Download rankings, all-time:
  • Site-wide: 18,675
  • In genetics: 914
• Year to date:
  • Site-wide: 10,096
• Since beginning of last month:
  • Site-wide: 13,681

Neoantigen-driven B cell and CD4+ T follicular helper cell collaboration promotes robust anti-tumor CD8+ T cell responses

• Downloaded 1,011 times
• Download rankings, all-time:
  • Site-wide: 20,697
  • In immunology: 600
• Year to date:
  • Site-wide: 2,676
• Since beginning of last month:
  • Site-wide: 12,775

Leveraging functional annotation to identify genes associated with complex diseases

• Downloaded 965 times
• Download rankings, all-time:
  • Site-wide: 22,084
  • In genetics: 1,064
• Year to date:
  • Site-wide: 63,727
• Since beginning of last month:
  • Site-wide: 75,596

Mediated pleiotropy between psychiatric disorders and autoimmune disorders revealed by integrative analysis of multiple GWAS

• Downloaded 952 times
• Download rankings, all-time:
  • Site-wide: 22,522
  • In genomics: 2,202
• Year to date:
  • Site-wide: 107,131
• Since beginning of last month:
  • Site-wide: 118,790

Measuring genetic variation in the multi-ethnic Million Veteran Program (MVP)

• Downloaded 914 times
• Download rankings, all-time:
  • Site-wide: 23,964
  • In genetics: 1,161
• Year to date:
  • Site-wide: 20,925
• Since beginning of last month:
  • Site-wide: 19,457

Genome-wide Association Study of Alcohol Consumption and Use Disorder in Multiple Populations (N = 274,424)

• Downloaded 843 times
• Download rankings, all-time:
  • Site-wide: 26,804
  • In genetics: 1,295
• Year to date:
  • Site-wide: 84,942
• Since beginning of last month:
  • Site-wide: 80,935

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

• Downloaded 813 times
• Download rankings, all-time:
  • Site-wide: 28,210
  • In genetic and genomic medicine: 88
• Year to date:
  • Site-wide: 5,581
• Since beginning of last month:
  • Site-wide: 7,354

Leveraging Functional Annotations in Genetic Risk Prediction for Human Complex Diseases

• Downloaded 740 times
• Download rankings, all-time:
  • Site-wide: 32,194
  • In bioinformatics: 3,623
• Year to date:
  • Site-wide: 111,261
• Since beginning of last month:
  • Site-wide: 75,690

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 733 times
• Download rankings, all-time:
  • Site-wide: 32,633
  • In genetics: 1,580
• Year to date:
  • Site-wide: 12,470
• Since beginning of last month:
  • Site-wide: 8,624

Transcriptomic Organization of Human Posttraumatic Stress Disorder

• Downloaded 704 times
• Download rankings, all-time:
  • Site-wide: 34,415
  • In genomics: 2,999
• Year to date:
  • Site-wide: 34,607
• Since beginning of last month:
  • Site-wide: 48,269

Three distinct velocities of elongating RNA polymerase define exons and introns

• Downloaded 614 times
• Download rankings, all-time:
  • Site-wide: 41,153
  • In genomics: 3,404
• Year to date:
  • Site-wide: 104,067
• Since beginning of last month:
  • Site-wide: 91,243

Influence of blood pressure on pneumonia risk: Epidemiological association and Mendelian randomisation in the UK Biobank

• Downloaded 589 times
• Download rankings, all-time:
  • Site-wide: 43,436
  • In genetic and genomic medicine: 133
• Year to date:
  • Site-wide: 54,580
• Since beginning of last month:
  • Site-wide: 36,271

Identifying Combinations of Cancer Drivers in Individual Patients

• Downloaded 553 times
• Download rankings, all-time:
  • Site-wide: 46,907
  • In bioinformatics: 4,917
• Year to date:
  • Site-wide: 93,923
• Since beginning of last month:
  • Site-wide: 67,046

Genetic Association of Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease

• Downloaded 535 times
• Download rankings, all-time:
  • Site-wide: 48,777
  • In bioinformatics: 5,072
• Year to date:
  • Site-wide: 61,614
• Since beginning of last month:
  • Site-wide: 76,232

Application of a Novel Machine Learning Method to Big Data Infers a Relationship Between Asthma and the Development of Neoplasia

• Downloaded 533 times
• Download rankings, all-time:
  • Site-wide: 48,992
  • In epidemiology: 2,217
• Year to date:
  • Site-wide: 16,499
• Since beginning of last month:
  • Site-wide: 12,469

Comparison of methods for estimating genetic correlation between complex traits using GWAS summary statistics

• Downloaded 500 times
• Download rankings, all-time:
  • Site-wide: 52,886
  • In genetics: 2,451
• Year to date:
  • Site-wide: 17,382
• Since beginning of last month:
  • Site-wide: 17,614

Genomic Influences on Self-Reported Childhood Maltreatment

• Downloaded 380 times
• Download rankings, all-time:
  • Site-wide: 70,010
  • In genomics: 4,864
• Year to date:
  • Site-wide: 112,050
• Since beginning of last month:
  • Site-wide: 96,739

Circadian Rhythm Analysis Using Wearable Device Data: A Novel Penalized Machine Learning Approach

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 74,853
  • In neuroscience: 11,441
• Year to date:
  • Site-wide: 35,349
• Since beginning of last month:
  • Site-wide: 30,220

microRNA seedless sites attenuate strong-seed-site-mediated target repression

• Downloaded 350 times
• Download rankings, all-time:
  • Site-wide: 75,396
  • In bioinformatics: 7,018
• Year to date:
  • Site-wide: 64,884
• Since beginning of last month:
  • Site-wide: 65,006

Retrospective Association Analysis of Longitudinal Binary Traits Identifies Important Loci and Pathways in Cocaine Use

• Downloaded 336 times
• Download rankings, all-time:
  • Site-wide: 78,149
  • In genetics: 3,556
• Year to date:
  • Site-wide: 75,310
• Since beginning of last month:
  • Site-wide: 74,797

A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics

• Downloaded 307 times
• Download rankings, all-time:
  • Site-wide: 83,699
  • In bioinformatics: 7,574
• Year to date:
  • Site-wide: 19,633
• Since beginning of last month:
  • Site-wide: 30,556

Motor nuclei innervating eye muscles spared in mouse model of SOD1-linked ALS

• Downloaded 298 times
• Download rankings, all-time:
  • Site-wide: 85,637
  • In neuroscience: 13,193
• Year to date:
  • Site-wide: 87,916
• Since beginning of last month:
  • Site-wide: 63,232

Identifying Modules of Cooperating Cancer Drivers

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 90,650
  • In cancer biology: 2,721
• Year to date:
  • Site-wide: 59,880
• Since beginning of last month:
  • Site-wide: 44,340

TRPV5, TRPV6, TRPM6, and TRPM7 do not contribute to hair-cell mechanotransduction

• Downloaded 268 times
• Download rankings, all-time:
  • Site-wide: 92,190
  • In neuroscience: 14,279
• Year to date:
  • Site-wide: 99,060
• Since beginning of last month:
  • Site-wide: 108,855

A Markov Random Field Model for Network-based Differential Expression Analysis of Single-cell RNA-seq Data

• Downloaded 224 times
• Download rankings, all-time:
  • Site-wide: 101,897
  • In bioinformatics: 8,693
• Year to date:
  • Site-wide: 56,171
• Since beginning of last month:
  • Site-wide: 44,904

Automated Feature Extraction from Population Wearable Device Data Identified Novel Loci Associated with Sleep and Circadian Rhythms

• Downloaded 184 times
• Download rankings, all-time:
  • Site-wide: 110,759
  • In genetics: 4,828
• Year to date:
  • Site-wide: 83,990
• Since beginning of last month:
  • Site-wide: 102,783

MR-APSS: a unified approach to Mendelian Randomization accounting for pleiotropy and sample structure using genome-wide summary statistics

• Downloaded 166 times
• Download rankings, all-time:
  • Site-wide: 114,475
  • In genetics: 4,952
• Year to date:
  • Site-wide: 14,110
• Since beginning of last month:
  • Site-wide: 4,171

Inferring time-lagged causality using the derivative of single-cell expression

• Downloaded 159 times
• Download rankings, all-time:
  • Site-wide: 116,085
  • In bioinformatics: 9,523
• Year to date:
  • Site-wide: 14,912
• Since beginning of last month:
  • Site-wide: 41,140

A Statistical Framework to Identify Cell Types Whose Genetically Regulated Proportions are Associated with Complex Diseases

• Downloaded 119 times
• Download rankings, all-time:
  • Site-wide: 124,094
  • In genetic and genomic medicine: 593
• Year to date:
  • Site-wide: 21,399
• Since beginning of last month:
  • Site-wide: 6,581

Correcting statistical bias in correlation-based kinship estimators

• Downloaded 115 times
• Download rankings, all-time:
  • Site-wide: 124,722
  • In genetics: 5,265
• Year to date:
  • Site-wide: 22,383
• Since beginning of last month:
  • Site-wide: 49,121

Hemodynamic Differences Between Women and Men with Elevated Blood Pressure in China

• Downloaded 61 times
• Download rankings, all-time:
  • Site-wide: 132,778
  • In cardiovascular medicine: 391
• Year to date:
  • Site-wide: 43,133
• Since beginning of last month:
  • Site-wide: 15,751

Comprehensive Analysis of Ubiquitously Expressed Genes in Human, From a Data-Driven Perspective

• Downloaded 51 times
• Download rankings, all-time:
  • Site-wide: 133,632
  • In genomics: 6,953
• Year to date:
  • Site-wide: 51,250
• Since beginning of last month:
  • Site-wide: 41,129