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Author: Michael J Owen

Rankings

  • All-time downloads: 79,017 (rank: 2,998 )
  • Categories:
    • genetic and genomic medicine: 14,072 (rank: 53 )
    • genetics: 36,236 (rank: 190 )
    • genomics: 11,934 (rank: 2,058 )
    • neuroscience: 5,055 (rank: 5,971 )
    • pharmacology and therapeutics: 679 (rank: 750 (tie) )
    • psychiatry and clinical psychology: 7,240 (rank: 104 )

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

genetics more details view paper
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Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

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    • In genetic and genomic medicine: 9
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Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Downloaded 7,684 times
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    • Site-wide: 1,902
    • In genetics: 42
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Genetic Identification Of Brain Cell Types Underlying Schizophrenia

genomics more details view paper
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Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

psychiatry and clinical psychology more details view paper
  • Downloaded 3,654 times
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Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

genetics more details view paper
  • Downloaded 3,186 times
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    • Site-wide: 6,527
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Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

genomics more details view paper
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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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Exome sequencing in bipolar disorder reveals shared risk gene AKAP11 with schizophrenia

genetic and genomic medicine more details view paper
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    • In genetic and genomic medicine: 105
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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    • In genomics: 1,618
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Synaptic protein DLG2 controls neurogenic transcriptional programs disrupted in schizophrenia and related disorders

genetics more details view paper
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    • In genetics: 934
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A Genetics-First Approach to Dissecting the Heterogeneity of Autism: Phenotypic Comparison of Autism Risk Copy Number Variants

psychiatry and clinical psychology more details view paper
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Causal Analyses, Statistical Efficiency And Phenotypic Precision Through Recall-By-Genotype Study Design

genetics more details view paper
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Rare schizophrenia risk variants are enriched in genes shared with neurodevelopmental disorders

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    • In genetics: 1,204
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Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder

neuroscience more details view paper
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Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

genomics more details view paper
  • Downloaded 1,146 times
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    • Site-wide: 31,080
    • In genomics: 2,528
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Medical consequences of pathogenic CNVs in adults: Analysis of the UK Biobank

genomics more details view paper
  • Downloaded 1,114 times
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    • Site-wide: 32,487
    • In genomics: 2,620
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Association between schizophrenia and both loss of function and missense mutations in paralog conserved sites of voltage-gated sodium channels

genetics more details view paper
  • Downloaded 1,003 times
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    • Site-wide: 38,137
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Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

genetics more details view paper
  • Downloaded 973 times
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    • Site-wide: 39,959
    • In genetics: 1,579
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Genetic association study of psychotic experiences in UK Biobank

genetics more details view paper
  • Downloaded 965 times
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    • Site-wide: 40,455
    • In genetics: 1,645
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Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Downloaded 924 times
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    • Site-wide: 43,269
    • In genetic and genomic medicine: 249
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Atlas of functional connectivity relationships across rare and common genetic variants, traits, and psychiatric conditions

genetic and genomic medicine more details view paper
  • Downloaded 900 times
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    • Site-wide: 45,010
    • In genetic and genomic medicine: 263
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Rare schizophrenia risk variant burden is conserved in diverse human populations

genetic and genomic medicine more details view paper
  • Downloaded 890 times
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    • Site-wide: 45,785
    • In genetic and genomic medicine: 315
  • Year to date:
    • Site-wide: 4,094
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Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia

genetics more details view paper
  • Downloaded 888 times
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    • Site-wide: 45,921
    • In genetics: 1,848
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Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

genetics more details view paper
  • Downloaded 878 times
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    • Site-wide: 46,773
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Clozapine metabolism is associated with Absolute Neutrophil Count in individuals with treatment-resistant schizophrenia

pharmacology and therapeutics more details view paper
  • Downloaded 790 times
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    • In pharmacology and therapeutics: 85
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The general impact of haploinsufficiency on brain connectivity underlies the pleiotropic effect of neuropsychiatric CNVs

genetic and genomic medicine more details view paper
  • Downloaded 765 times
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Meta-analysis of Scandinavian Schizophrenia Exomes

genetics more details view paper
  • Downloaded 752 times
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    • In genetics: 2,364
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Analyses of rare and common alleles in parent-proband trios implicate rare missense variants in SLC6A1 in schizophrenia and confirm the involvement of loss of function intolerant and neurodevelopmental disorder genes.

genetics more details view paper
  • Downloaded 742 times
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    • Site-wide: 59,952
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Neuropsychiatric copy number variants exert shared effects on human brain structure

genetic and genomic medicine more details view paper
  • Downloaded 738 times
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    • Site-wide: 60,454
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Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

genetics more details view paper
  • Downloaded 721 times
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    • Site-wide: 62,548
    • In genetics: 2,422
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A Transcriptome Wide Association Study implicates specific pre- and post-synaptic abnormalities in Schizophrenia

genetics more details view paper
  • Downloaded 720 times
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    • In genetics: 2,376
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Haploinsufficiency of the psychiatric risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms

neuroscience more details view paper
  • Downloaded 675 times
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Genetic association of FMRP targets with psychiatric disorders

neuroscience more details view paper
  • Downloaded 636 times
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    • Site-wide: 74,483
    • In neuroscience: 10,245
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The role of rare copy number variants in depression

neuroscience more details view paper
  • Downloaded 590 times
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    • Site-wide: 81,901
    • In neuroscience: 11,519
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Dynamic expression of risk genes for schizophrenia and bipolar disorder across development

neuroscience more details view paper
  • Downloaded 587 times
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    • In neuroscience: 11,331
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Characterization of Age and Polarity at Onset in Bipolar Disorder

psychiatry and clinical psychology more details view paper
  • Downloaded 570 times
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    • In psychiatry and clinical psychology: 398
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Effects of pathogenic CNVs on physical traits in participants of the UK Biobank

genetics more details view paper
  • Downloaded 545 times
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Cyfip1 haploinsufficiency is associated with white matter changes, myelin thinning, reduction of mature oligodendrocytes and behavioural inflexibility

neuroscience more details view paper
  • Downloaded 526 times
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Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: A longitudinal analysis and GWAS using clinical monitoring data from the UK

pharmacology and therapeutics more details view paper
  • Downloaded 501 times
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    • Site-wide: 99,802
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Differences in Genetic Liability for Insomnia and Hypersomnia in Bipolar Disorder Subtypes

genomics more details view paper
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Effects of pathogenic CNVs on biochemical markers: a study on the UK Biobank

genomics more details view paper
  • Downloaded 469 times
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Novel Insight into the Aetiology of Autism Spectrum Disorder Gained by Integrating Expression Data with Genome-wide Association Statistics

genomics more details view paper
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The rate of de novo CNVs in healthy controls

genomics more details view paper
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Emotional and behavioural phenotypes in young people with neurodevelopmental CNVs

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  • Downloaded 429 times
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    • Site-wide: 116,938
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Electrophysiological network alterations in adults with copy number variants associated with high neurodevelopmental risk

neuroscience more details view paper
  • Downloaded 409 times
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    • Site-wide: 122,192
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Psychopathology in mothers of children with pathogenic Copy Number Variants

psychiatry and clinical psychology more details view paper
  • Downloaded 396 times
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Sleep EEG in young people with 22q11.2 deletion syndrome: a cross-sectional study of slow-waves, spindles and correlations with memory and neurodevelopmental symptoms

psychiatry and clinical psychology more details view paper
  • Downloaded 395 times
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A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder

genetic and genomic medicine more details view paper
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Alterations in resting-state activity and functional connectivity in children with 22q11.2 deletion syndrome

psychiatry and clinical psychology more details view paper
  • Downloaded 345 times
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DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts

psychiatry and clinical psychology more details view paper
  • Downloaded 336 times
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Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by mutation of the psychiatric risk gene Cacna1c

neuroscience more details view paper
  • Downloaded 333 times
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Coordination difficulties, IQ and psychopathology in children with high-risk Copy Number Variants

genetics more details view paper
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Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

genetics more details view paper
  • Downloaded 279 times
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    • Site-wide: 160,580
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The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases

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Rare Maternally Inherited Coding Variants on Chromosome X Carry Predominantly Male Risk in Autism, Tourette Syndrome, and Attention-deficit/Hyperactivity Disorder

genetic and genomic medicine more details view paper
  • Downloaded 212 times
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    • Site-wide: 178,627
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Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scores

psychiatry and clinical psychology more details view paper
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Developmental profile of psychiatric risk associated with voltage-gated cation channel activity

neuroscience more details view paper
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Pathogenic mis-splicing of CPEB4 in schizophrenia

neuroscience more details view paper
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Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS and sporadic congenital heart disease

genetics more details view paper
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