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Author: Michael J Owen

Rankings

  • All-time downloads: 61,753 (rank: 2,650 )
  • Categories:
    • genetic and genomic medicine: 8,058 (rank: 119 )
    • genetics: 33,230 (rank: 178 )
    • genomics: 11,291 (rank: 1,799 )
    • neuroscience: 4,104 (rank: 5,533 (tie) )
    • pharmacology and therapeutics: 322 (rank: 875 (tie) )
    • psychiatry and clinical psychology: 4,748 (rank: 114 )

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Preprints

Alterations in resting-state activity and functional connectivity in children with 22q11.2 deletion syndrome

psychiatry and clinical psychology more details view paper

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

genetics more details view paper
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    • Site-wide: 1,032
    • In genetics: 26
  • Year to date:
    • Site-wide: 51,070
  • Since beginning of last month:
    • Site-wide: 105,850

Genomewide association study identifies 30 loci associated with bipolar disorder

genetics more details view paper
  • Downloaded 7,478 times
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    • Site-wide: 1,403
    • In genetics: 40
  • Year to date:
    • Site-wide: 20,334
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Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

genetic and genomic medicine more details view paper
  • Downloaded 4,806 times
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    • Site-wide: 2,543
    • In genetic and genomic medicine: 11
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Genetic Identification Of Brain Cell Types Underlying Schizophrenia

genomics more details view paper
  • Downloaded 3,628 times
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    • Site-wide: 3,783
    • In genomics: 390
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Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

psychiatry and clinical psychology more details view paper
  • Downloaded 2,959 times
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    • Site-wide: 5,025
    • In psychiatry and clinical psychology: 18
  • Year to date:
    • Site-wide: 1,637
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Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

genomics more details view paper
  • Downloaded 2,542 times
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    • Site-wide: 6,272
    • In genomics: 660
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Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

genetics more details view paper
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    • Site-wide: 6,502
    • In genetics: 281
  • Year to date:
    • Site-wide: 10,737
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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

genetics more details view paper
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    • Site-wide: 10,132
    • In genetics: 448
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Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

genetics more details view paper
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    • Site-wide: 11,646
    • In genetics: 523
  • Year to date:
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

genomics more details view paper
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    • Site-wide: 13,743
    • In genomics: 1,403
  • Year to date:
    • Site-wide: 101,120
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Causal Analyses, Statistical Efficiency And Phenotypic Precision Through Recall-By-Genotype Study Design

genetics more details view paper
  • Downloaded 1,180 times
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    • Site-wide: 19,496
    • In genetics: 900
  • Year to date:
    • Site-wide: 68,972
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    • Site-wide: 21,324

A Genetics-First Approach to Dissecting the Heterogeneity of Autism: Phenotypic Comparison of Autism Risk Copy Number Variants

psychiatry and clinical psychology more details view paper
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    • Site-wide: 22,880
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Rare schizophrenia risk variants are enriched in genes shared with neurodevelopmental disorders

genetics more details view paper
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    • Site-wide: 22,917
    • In genetics: 1,050
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Medical consequences of pathogenic CNVs in adults: Analysis of the UK Biobank

genomics more details view paper
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    • Site-wide: 22,996
    • In genomics: 2,169
  • Year to date:
    • Site-wide: 146,915
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    • Site-wide: 99,338

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

genomics more details view paper
  • Downloaded 1,049 times
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    • Site-wide: 23,185
    • In genomics: 2,186
  • Year to date:
    • Site-wide: 114,060
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Synaptic protein DLG2 controls neurogenic transcriptional programs disrupted in schizophrenia and related disorders

genetics more details view paper
  • Downloaded 929 times
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    • Site-wide: 27,668
    • In genetics: 1,267
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    • Site-wide: 13,271
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Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder

neuroscience more details view paper
  • Downloaded 866 times
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    • Site-wide: 30,533
    • In neuroscience: 3,957
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    • Site-wide: 28,751
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    • Site-wide: 102,143

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

genetics more details view paper
  • Downloaded 866 times
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    • Site-wide: 30,552
    • In genetics: 1,400
  • Year to date:
    • Site-wide: 110,661
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Genetic association study of psychotic experiences in UK Biobank

genetics more details view paper
  • Downloaded 825 times
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    • Site-wide: 32,624
    • In genetics: 1,502
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    • Site-wide: 88,288
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Association between schizophrenia and both loss of function and missense mutations in paralog conserved sites of voltage-gated sodium channels

genetics more details view paper
  • Downloaded 804 times
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    • Site-wide: 33,846
    • In genetics: 1,557
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    • Site-wide: 84,317
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Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia

genetics more details view paper
  • Downloaded 793 times
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    • Site-wide: 34,553
    • In genetics: 1,576
  • Year to date:
    • Site-wide: 83,972
  • Since beginning of last month:
    • Site-wide: 57,878

Exome sequencing in bipolar disorder reveals shared risk gene AKAP11 with schizophrenia

genetic and genomic medicine more details view paper
  • Downloaded 751 times
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    • Site-wide: 37,270
    • In genetic and genomic medicine: 147
  • Year to date:
    • Site-wide: 5,110
  • Since beginning of last month:
    • Site-wide: 3,639

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

genetics more details view paper
  • Downloaded 727 times
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    • Site-wide: 38,997
    • In genetics: 1,754
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    • Site-wide: 120,377
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Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

genetic and genomic medicine more details view paper
  • Downloaded 658 times
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    • Site-wide: 44,460
    • In genetic and genomic medicine: 181
  • Year to date:
    • Site-wide: 15,351
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    • Site-wide: 54,976

A Transcriptome Wide Association Study implicates specific pre- and post-synaptic abnormalities in Schizophrenia

genetics more details view paper
  • Downloaded 657 times
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    • Site-wide: 44,588
    • In genetics: 1,992
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    • Site-wide: 121,915
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    • Site-wide: 99,315

Analyses of rare and common alleles in parent-proband trios implicate rare missense variants in SLC6A1 in schizophrenia and confirm the involvement of loss of function intolerant and neurodevelopmental disorder genes.

genetics more details view paper
  • Downloaded 634 times
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    • Site-wide: 46,662
    • In genetics: 2,084
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    • Site-wide: 84,030
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    • Site-wide: 112,327

Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

genetics more details view paper
  • Downloaded 602 times
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    • Site-wide: 49,770
    • In genetics: 2,205
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    • Site-wide: 43,891
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The general impact of haploinsufficiency on brain connectivity underlies the pleiotropic effect of neuropsychiatric CNVs

genetic and genomic medicine more details view paper
  • Downloaded 596 times
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    • Site-wide: 50,408
    • In genetic and genomic medicine: 202
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    • Site-wide: 70,539
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    • Site-wide: 68,384

Genetic association of FMRP targets with psychiatric disorders

neuroscience more details view paper
  • Downloaded 581 times
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    • Site-wide: 52,073
    • In neuroscience: 7,389
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    • Site-wide: 76,375
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    • Site-wide: 68,872

Haploinsufficiency of the psychiatric risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms

neuroscience more details view paper
  • Downloaded 536 times
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    • Site-wide: 57,453
    • In neuroscience: 8,271
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    • Site-wide: 81,576
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Meta-analysis of Scandinavian Schizophrenia Exomes

genetics more details view paper
  • Downloaded 526 times
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    • Site-wide: 58,786
    • In genetics: 2,595
  • Year to date:
    • Site-wide: 57,818
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    • Site-wide: 13,311

Neuropsychiatric copy number variants exert shared effects on human brain structure

genetic and genomic medicine more details view paper
  • Downloaded 516 times
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    • Site-wide: 60,170
    • In genetic and genomic medicine: 249
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    • Site-wide: 46,596
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Dynamic expression of risk genes for schizophrenia and bipolar disorder across development

neuroscience more details view paper
  • Downloaded 506 times
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    • Site-wide: 61,443
    • In neuroscience: 8,907
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    • Site-wide: 136,794
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    • Site-wide: 86,677

The role of rare copy number variants in depression

neuroscience more details view paper
  • Downloaded 484 times
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    • Site-wide: 64,612
    • In neuroscience: 9,392
  • Year to date:
    • Site-wide: 108,123
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    • Site-wide: 86,942

Effects of pathogenic CNVs on physical traits in participants of the UK Biobank

genetics more details view paper
  • Downloaded 472 times
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    • Site-wide: 66,376
    • In genetics: 2,916
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    • Site-wide: 111,604
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Atlas of functional connectivity relationships across rare and common genetic variants, traits, and psychiatric conditions

genetic and genomic medicine more details view paper
  • Downloaded 453 times
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    • Site-wide: 69,352
    • In genetic and genomic medicine: 285
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    • Site-wide: 10,677
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    • Site-wide: 76,585

Cyfip1 haploinsufficiency is associated with white matter changes, myelin thinning, reduction of mature oligodendrocytes and behavioural inflexibility

neuroscience more details view paper
  • Downloaded 446 times
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    • Site-wide: 70,518
    • In neuroscience: 10,375
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    • Site-wide: 146,675
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Novel Insight into the Aetiology of Autism Spectrum Disorder Gained by Integrating Expression Data with Genome-wide Association Statistics

genomics more details view paper
  • Downloaded 411 times
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    • Site-wide: 76,429
    • In genomics: 5,138
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    • Site-wide: 147,517
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    • Site-wide: 72,297

Differences in Genetic Liability for Insomnia and Hypersomnia in Bipolar Disorder Subtypes

genomics more details view paper
  • Downloaded 399 times
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    • Site-wide: 78,557
    • In genomics: 5,218
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The rate of de novo CNVs in healthy controls

genomics more details view paper
  • Downloaded 367 times
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    • Site-wide: 84,822
    • In genomics: 5,489
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    • Site-wide: 120,937
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    • Site-wide: 106,701

Effects of pathogenic CNVs on biochemical markers: a study on the UK Biobank

genomics more details view paper
  • Downloaded 354 times
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    • Site-wide: 87,437
    • In genomics: 5,592
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    • Site-wide: 78,892
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    • Site-wide: 17,240

Emotional and behavioural phenotypes in young people with neurodevelopmental CNVs

psychiatry and clinical psychology more details view paper
  • Downloaded 331 times
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    • Site-wide: 92,514
    • In psychiatry and clinical psychology: 365
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    • Site-wide: 96,459
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Electrophysiological network alterations in adults with copy number variants associated with high neurodevelopmental risk

neuroscience more details view paper
  • Downloaded 328 times
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    • Site-wide: 93,133
    • In neuroscience: 13,943
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    • Site-wide: 141,558
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Clozapine metabolism is associated with Absolute Neutrophil Count in individuals with treatment-resistant schizophrenia

pharmacology and therapeutics more details view paper
  • Downloaded 322 times
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    • Site-wide: 94,371
    • In pharmacology and therapeutics: 104
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    • Site-wide: 127,086

A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder

genetic and genomic medicine more details view paper
  • Downloaded 278 times
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    • Site-wide: 104,656
    • In genetic and genomic medicine: 510
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    • Site-wide: 47,675

Coordination difficulties, IQ and psychopathology in children with high-risk Copy Number Variants

genetics more details view paper
  • Downloaded 261 times
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    • Site-wide: 108,762
    • In genetics: 4,602
  • Year to date:
    • Site-wide: 108,165
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    • Site-wide: 39,339

Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by mutation of the psychiatric risk gene Cacna1c

neuroscience more details view paper
  • Downloaded 237 times
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    • Site-wide: 114,936
    • In neuroscience: 17,363
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    • Site-wide: 100,739
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Characterization of Age and Polarity at Onset in Bipolar Disorder

psychiatry and clinical psychology more details view paper
  • Downloaded 229 times
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    • Site-wide: 116,803
    • In psychiatry and clinical psychology: 525
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Psychopathology in mothers of children with pathogenic Copy Number Variants

psychiatry and clinical psychology more details view paper
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    • In psychiatry and clinical psychology: 647
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    • Site-wide: 73,954
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Developmental profile of psychiatric risk associated with voltage-gated cation channel activity

neuroscience more details view paper
  • Downloaded 120 times
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    • Site-wide: 142,162
    • In neuroscience: 21,326
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