Author: Roy H Perlis

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,393
  • In genetics: 27
• Year to date:
  • Site-wide: 20,576
• Since beginning of last month:
  • Site-wide: 21,548

Genomewide association study identifies 30 loci associated with bipolar disorder

• Downloaded 7,744 times
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  • Site-wide: 1,920
  • In genetics: 45
• Year to date:
  • Site-wide: 7,831
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  • Site-wide: 26,304

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

• Downloaded 3,707 times
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  • Site-wide: 5,348
  • In psychiatry and clinical psychology: 20
• Year to date:
  • Site-wide: 9,333
• Since beginning of last month:
  • Site-wide: 18,379

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

• Downloaded 2,959 times
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  • Site-wide: 7,443
  • In genetics: 275
• Year to date:
  • Site-wide: 7,748
• Since beginning of last month:
  • Site-wide: 8,715

Minimal phenotyping yields GWAS hits of reduced specificity for major depression

• Downloaded 2,390 times
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  • Site-wide: 10,254
  • In genetics: 388
• Year to date:
  • Site-wide: 115,034
• Since beginning of last month:
  • Site-wide: 89,924

Identifying common pharmacotherapies associated with reduced COVID-19 morbidity using electronic health records

• Downloaded 2,382 times
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  • Site-wide: 10,314
  • In infectious diseases: 1,614
• Year to date:
  • Site-wide: 45,052
• Since beginning of last month:
  • Site-wide: 39,260

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 18,558
  • In genomics: 1,676
• Year to date:
  • Site-wide: 112,578
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  • Site-wide: 51,987

Increased microglial synapse elimination in patient-specific models of schizophrenia

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  • Site-wide: 22,435
  • In neuroscience: 2,678
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 141,267

Persistence of symptoms up to 10 months following acute COVID-19 illness

• Downloaded 1,409 times
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  • Site-wide: 23,319
  • In infectious diseases: 2,505
• Year to date:
  • Site-wide: 103,050
• Since beginning of last month:
  • Site-wide: 40,270

Impact of COVID-19 on psychiatric assessment in emergency and outpatient settings measured using electronic health records

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  • Site-wide: 24,355
  • In psychiatry and clinical psychology: 99
• Year to date:
  • Site-wide: 90,595
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  • Site-wide: 53,633

Neurodevelopmental outcomes at one year in offspring of mothers who test positive for SARS-CoV-2 during pregnancy

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  • Site-wide: 28,476
  • In neurology: 90
• Year to date:
  • Site-wide: 78,236
• Since beginning of last month:
  • Site-wide: 37,715

Comparison of post-COVID depression and major depressive disorder

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  • Site-wide: 34,639
  • In psychiatry and clinical psychology: 147
• Year to date:
  • Site-wide: 22,754
• Since beginning of last month:
  • Site-wide: 40,294

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

• Downloaded 1,062 times
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  • Site-wide: 36,305
  • In neuroscience: 4,768
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 24,987

Laboratory findings associated with mechanical ventilation requirement and mortality among hospitalized individuals with Covid-19 in Eastern Massachusetts

• Downloaded 905 times
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  • Site-wide: 46,521
  • In infectious diseases: 3,630
• Year to date:
  • Site-wide: 124,794
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  • Site-wide: 76,915

Single cell profiling of Hofbauer cells and fetal brain microglia reveals shared programs and functions

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  • Site-wide: 49,596
  • In developmental biology: 1,099
• Year to date:
  • Site-wide: 42,901
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  • Site-wide: 13,773

Estimated regional white matter hyperintensity burden, resting state functional connectivity, and cognitive functions in older adults

• Downloaded 825 times
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  • Site-wide: 53,538
  • In neuroscience: 7,167
• Year to date:
  • Site-wide: None
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  • Site-wide: 183,650

New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation

• Downloaded 712 times
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  • Site-wide: 66,576
  • In genomics: 4,554
• Year to date:
  • Site-wide: 187,836
• Since beginning of last month:
  • Site-wide: 152,910

Novel polygenic risk score links depression-related cortical transcriptomic changes to brain morphology and symptom severity

• Downloaded 686 times
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  • Site-wide: 70,181
  • In genetic and genomic medicine: 453
• Year to date:
  • Site-wide: 102,757
• Since beginning of last month:
  • Site-wide: 39,931

Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19

• Downloaded 651 times
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  • Site-wide: 75,334
  • In psychiatry and clinical psychology: 350
• Year to date:
  • Site-wide: 186,126
• Since beginning of last month:
  • Site-wide: 57,073

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies

• Downloaded 645 times
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  • Site-wide: 76,310
  • In genetics: 2,922
• Year to date:
  • Site-wide: 193,979
• Since beginning of last month:
  • Site-wide: 152,043

N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells

• Downloaded 630 times
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  • Site-wide: 78,541
  • In neuroscience: 12,257
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 38,703

Umbilical cord blood derived microglia-like cells to model COVID-19 exposure

• Downloaded 571 times
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  • Site-wide: 89,092
  • In neuroscience: 12,728
• Year to date:
  • Site-wide: 186,173
• Since beginning of last month:
  • Site-wide: 162,354

Case-control study of neuropsychiatric symptoms following COVID-19 hospitalization in 2 academic health systems

• Downloaded 563 times
• Download rankings, all-time:
  • Site-wide: 90,750
  • In psychiatry and clinical psychology: 449
• Year to date:
  • Site-wide: 106,620
• Since beginning of last month:
  • Site-wide: 74,107

Persistence of neuropsychiatric symptoms associated with SARS-CoV-2 positivity among a cohort of children and adolescents

• Downloaded 421 times
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  • Site-wide: 123,944
  • In psychiatry and clinical psychology: 710
• Year to date:
  • Site-wide: 59,097
• Since beginning of last month:
  • Site-wide: 71,087

Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records

• Downloaded 405 times
• Download rankings, all-time:
  • Site-wide: 128,603
  • In genetics: 4,800
• Year to date:
  • Site-wide: 190,149
• Since beginning of last month:
  • Site-wide: 198,407

Generating interpretable predictions about antidepressant treatment stability using supervised topic models

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 136,763
  • In psychiatry and clinical psychology: 801
• Year to date:
  • Site-wide: 184,306
• Since beginning of last month:
  • Site-wide: 124,983

Consistency of performance of adverse outcome prediction models for hospitalized COVID-19 patients

• Downloaded 374 times
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  • Site-wide: 137,784
  • In infectious diseases: 6,545
• Year to date:
  • Site-wide: 102,606
• Since beginning of last month:
  • Site-wide: 111,664

Tissue and cell-type specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models

• Downloaded 348 times
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  • Site-wide: 145,288
  • In genomics: 7,842
• Year to date:
  • Site-wide: 59,953
• Since beginning of last month:
  • Site-wide: 28,601

Association between long COVID symptoms and employment status

• Downloaded 323 times
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  • Site-wide: 153,065
  • In public and global health: 2,336
• Year to date:
  • Site-wide: 17,615
• Since beginning of last month:
  • Site-wide: 4,057

Human Cerebral Spheroids Undergo Activity Dependent Changes In Cellular Composition And MicroRNA Expression

• Downloaded 321 times
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  • Site-wide: 153,561
  • In neuroscience: 23,203
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 108,356

Cerebrospinal fluid concentration of complement component 4A is increased in first-episode schizophrenia

• Downloaded 309 times
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  • Site-wide: 157,280
  • In psychiatry and clinical psychology: 969
• Year to date:
  • Site-wide: 103,267
• Since beginning of last month:
  • Site-wide: 98,669

Genome-wide association study of treatment resistant depression highlights shared biology with metabolic traits

• Downloaded 238 times
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  • Site-wide: 177,978
  • In genetic and genomic medicine: 1,357
• Year to date:
  • Site-wide: 20,811
• Since beginning of last month:
  • Site-wide: 35,652

Accuracy of Attestation Among Mohs and Dermatologic Surgery Diplomates

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  • Site-wide: 188,696
  • In medical ethics: 45
• Year to date:
  • Site-wide: 55,277
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  • Site-wide: 140,050

Association between social media use and self-reported symptoms of depression in US adults

• Downloaded 194 times
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  • Site-wide: 188,906
  • In psychiatry and clinical psychology: 1,279
• Year to date:
  • Site-wide: 102,006
• Since beginning of last month:
  • Site-wide: 71,067

Loss of function in the autism and schizophrenia-associated gene CYFIP1 in human microglia supports a role in synaptic pruning

• Downloaded 159 times
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  • Site-wide: 196,441
  • In neuroscience: 29,233
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 21,009

Sex-specific neurodevelopmental outcomes in offspring of mothers with SARS-CoV-2 in pregnancy: an electronic health records cohort

• Downloaded 144 times
• Download rankings, all-time:
  • Site-wide: 199,425
  • In psychiatry and clinical psychology: 1,468
• Year to date:
  • Site-wide: 10,500
• Since beginning of last month:
  • Site-wide: 9,080