Author: M. Arfan Ikram

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Preprints

The genetic architecture of the human cerebral cortex

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  • Site-wide: 942
  • In genetics: 30
• Year to date:
  • Site-wide: 9,162
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  • Site-wide: 12,902

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 1,670
  • In genetics: 66
• Year to date:
  • Site-wide: 8,888
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  • Site-wide: 17,218

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 3,288
  • In genetics: 146
• Year to date:
  • Site-wide: 20,223
• Since beginning of last month:
  • Site-wide: 40,423

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,206 times
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  • Site-wide: 3,295
  • In genomics: 391
• Year to date:
  • Site-wide: 98,332
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  • Site-wide: 86,008

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• Downloaded 2,489 times
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  • Site-wide: 4,712
  • In genetics: 230
• Year to date:
  • Site-wide: 70,785
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  • Site-wide: 88,449

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

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  • Site-wide: 7,369
  • In neuroscience: 785
• Year to date:
  • Site-wide: 20,772
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  • Site-wide: 54,147

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

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  • Site-wide: 8,133
  • In genetics: 410
• Year to date:
  • Site-wide: 87,353
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  • Site-wide: 67,762

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 8,334
  • In genetics: 423
• Year to date:
  • Site-wide: 72,018
• Since beginning of last month:
  • Site-wide: 54,505

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 8,874
  • In genetics: 455
• Year to date:
  • Site-wide: 58,783
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  • Site-wide: 34,984

Equivalence of LD-Score Regression and Individual-Level-Data Methods

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  • Site-wide: 10,982
  • In genetics: 558
• Year to date:
  • Site-wide: 51,054
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  • Site-wide: 24,948

Grey Matter Age Prediction as a Biomarker for Risk of Dementia: A Population-based Study

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  • Site-wide: 12,399
  • In epidemiology: 804
• Year to date:
  • Site-wide: 23,793
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  • Site-wide: 69,631

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

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  • Site-wide: 13,538
  • In genomics: 1,482
• Year to date:
  • Site-wide: 14,439
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  • Site-wide: 20,673

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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  • Site-wide: 13,605
  • In genomics: 1,488
• Year to date:
  • Site-wide: 49,258
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  • Site-wide: 91,629

Exome sequencing identifies novel AD-associated genes.

• Downloaded 902 times
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  • Site-wide: 21,331
  • In genetic and genomic medicine: 57
• Year to date:
  • Site-wide: 13,806
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  • Site-wide: 4,851

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 28,479
  • In neuroscience: 3,947
• Year to date:
  • Site-wide: 32,109
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  • Site-wide: 43,825

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

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  • Site-wide: 29,779
  • In bioinformatics: 3,474
• Year to date:
  • Site-wide: 64,911
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  • Site-wide: 64,111

Relationship between gut microbiota and circulating metabolites in population-based cohorts

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  • Site-wide: 31,338
  • In epidemiology: 1,532
• Year to date:
  • Site-wide: 71,380
• Since beginning of last month:
  • Site-wide: 100,454

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

• Downloaded 662 times
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  • Site-wide: 32,931
  • In genetics: 1,651
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  • Site-wide: None
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  • Site-wide: None

Novel genetic loci affecting facial shape variation in humans

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  • Site-wide: 33,021
  • In genomics: 2,956
• Year to date:
  • Site-wide: 47,845
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  • Site-wide: 50,911

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 645 times
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  • Site-wide: 34,062
  • In genetics: 1,711
• Year to date:
  • Site-wide: 17,528
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  • Site-wide: 10,281

GenNet framework: interpretable neural networks for phenotype prediction

• Downloaded 544 times
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  • Site-wide: 42,266
  • In bioinformatics: 4,598
• Year to date:
  • Site-wide: 5,419
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  • Site-wide: 19,025

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 507 times
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  • Site-wide: 45,873
  • In genetic and genomic medicine: 113
• Year to date:
  • Site-wide: 5,446
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  • Site-wide: 8,706

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

• Downloaded 506 times
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  • Site-wide: 46,015
  • In genomics: 3,740
• Year to date:
  • Site-wide: 44,062
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  • Site-wide: 85,577

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 497 times
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  • Site-wide: 47,056
  • In genomics: 3,798
• Year to date:
  • Site-wide: 69,630
• Since beginning of last month:
  • Site-wide: 110,357

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 468 times
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  • Site-wide: 50,423
  • In genetics: 2,454
• Year to date:
  • Site-wide: 45,122
• Since beginning of last month:
  • Site-wide: 107,710

High-dimensional mapping of cognition to the brain using voxel-based morphometry and subcortical shape analysis.

• Downloaded 329 times
• Download rankings, all-time:
  • Site-wide: 70,937
  • In neuroscience: 11,051
• Year to date:
  • Site-wide: 92,662
• Since beginning of last month:
  • Site-wide: 55,945

Genetic variants for head size share genes and pathways with cancer

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  • Site-wide: 72,798
  • In genomics: 4,986
• Year to date:
  • Site-wide: 18,924
• Since beginning of last month:
  • Site-wide: 43,095

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

• Downloaded 262 times
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  • Site-wide: 83,876
  • In bioinformatics: 7,614
• Year to date:
  • Site-wide: 72,786
• Since beginning of last month:
  • Site-wide: 55,552

KCND3 is a novel susceptibility locus for early repolarization

• Downloaded 243 times
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  • Site-wide: 87,825
  • In genetics: 4,084
• Year to date:
  • Site-wide: 100,298
• Since beginning of last month:
  • Site-wide: 95,289

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 193 times
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  • Site-wide: 98,403
  • In genomics: 5,900
• Year to date:
  • Site-wide: 67,823
• Since beginning of last month:
  • Site-wide: 69,668

Investigating the relationships between unfavorable sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses

• Downloaded 104 times
• Download rankings, all-time:
  • Site-wide: 114,835
  • In epidemiology: 4,578
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 103,540