Author: Mohammad Arfan Ikram

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Preprints

The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,386
  • In genetics: 35
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  • Site-wide: 23,011
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  • Site-wide: 42,776

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 2,364
  • In genetics: 70
• Year to date:
  • Site-wide: 23,022
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  • Site-wide: 33,376

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 4,648
  • In genetics: 168
• Year to date:
  • Site-wide: 64,899
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  • Site-wide: 128,557

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,312 times
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  • Site-wide: 4,777
  • In genomics: 469
• Year to date:
  • Site-wide: 109,472
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  • Site-wide: 143,780

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• Downloaded 2,546 times
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  • Site-wide: 7,018
  • In genetics: 287
• Year to date:
  • Site-wide: 148,965
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  • Site-wide: 160,470

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

• Downloaded 1,967 times
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  • Site-wide: 10,247
  • In neuroscience: 1,038
• Year to date:
  • Site-wide: 85,484
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  • Site-wide: 134,748

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

• Downloaded 1,829 times
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  • Site-wide: 11,441
  • In genetics: 480
• Year to date:
  • Site-wide: 105,720
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  • Site-wide: 136,411

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 11,487
  • In genetics: 485
• Year to date:
  • Site-wide: 90,782
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  • Site-wide: 84,772

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 11,958
  • In genetics: 509
• Year to date:
  • Site-wide: 79,631
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  • Site-wide: 132,578

Equivalence of LD-Score Regression and Individual-Level-Data Methods

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  • Site-wide: 12,863
  • In genetics: 554
• Year to date:
  • Site-wide: 37,033
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  • Site-wide: 49,763

GenNet framework: interpretable neural networks for phenotype prediction

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  • Site-wide: 13,670
  • In bioinformatics: 1,520
• Year to date:
  • Site-wide: 4,619
• Since beginning of last month:
  • Site-wide: 11,600

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

• Downloaded 1,491 times
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  • Site-wide: 15,627
  • In genomics: 1,520
• Year to date:
  • Site-wide: 37,896
• Since beginning of last month:
  • Site-wide: 98,015

Grey Matter Age Prediction as a Biomarker for Risk of Dementia: A Population-based Study

• Downloaded 1,411 times
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  • Site-wide: 17,012
  • In epidemiology: 1,145
• Year to date:
  • Site-wide: 98,067
• Since beginning of last month:
  • Site-wide: 93,942

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,322 times
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  • Site-wide: 18,760
  • In genomics: 1,759
• Year to date:
  • Site-wide: 111,643
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  • Site-wide: 115,020

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 1,250 times
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  • Site-wide: 20,405
  • In genetic and genomic medicine: 96
• Year to date:
  • Site-wide: 8,003
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  • Site-wide: 18,089

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 21,885
  • In genetics: 956
• Year to date:
  • Site-wide: 13,348
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  • Site-wide: 80,528

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

• Downloaded 925 times
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  • Site-wide: 32,085
  • In genetics: 1,406
• Year to date:
  • Site-wide: 41,765
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  • Site-wide: 100,468

Planar cell polarity pathway and development of the human visual cortex

• Downloaded 881 times
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  • Site-wide: 34,418
  • In neuroscience: 4,511
• Year to date:
  • Site-wide: 78,907
• Since beginning of last month:
  • Site-wide: 95,125

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

• Downloaded 804 times
• Download rankings, all-time:
  • Site-wide: 39,369
  • In bioinformatics: 4,199
• Year to date:
  • Site-wide: 119,380
• Since beginning of last month:
  • Site-wide: 93,753

Novel genetic loci affecting facial shape variation in humans

• Downloaded 777 times
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  • Site-wide: 41,283
  • In genomics: 3,286
• Year to date:
  • Site-wide: 97,176
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  • Site-wide: 105,130

Relationship between gut microbiota and circulating metabolites in population-based cohorts

• Downloaded 729 times
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  • Site-wide: 45,288
  • In epidemiology: 2,242
• Year to date:
  • Site-wide: 157,384
• Since beginning of last month:
  • Site-wide: 161,850

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

• Downloaded 571 times
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  • Site-wide: 62,582
  • In genomics: 4,471
• Year to date:
  • Site-wide: 140,102
• Since beginning of last month:
  • Site-wide: 157,318

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 569 times
• Download rankings, all-time:
  • Site-wide: 62,851
  • In genomics: 4,483
• Year to date:
  • Site-wide: 136,691
• Since beginning of last month:
  • Site-wide: 84,288

Genetic variants for head size share genes and pathways with cancer

• Downloaded 561 times
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  • Site-wide: 63,881
  • In genomics: 4,542
• Year to date:
  • Site-wide: 42,836
• Since beginning of last month:
  • Site-wide: 49,341

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 529 times
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  • Site-wide: 68,644
  • In genetics: 2,917
• Year to date:
  • Site-wide: 143,981
• Since beginning of last month:
  • Site-wide: 95,592

High-dimensional mapping of cognition to the brain using voxel-based morphometry and subcortical shape analysis.

• Downloaded 503 times
• Download rankings, all-time:
  • Site-wide: 72,706
  • In neuroscience: 10,629
• Year to date:
  • Site-wide: 68,091
• Since beginning of last month:
  • Site-wide: 42,952

Metabolome-wide association study on ABCA7 demonstrates a role for ceramide metabolism in impaired cognitive performance and Alzheimer's disease

• Downloaded 479 times
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  • Site-wide: 76,991
  • In neurology: 232
• Year to date:
  • Site-wide: 17,188
• Since beginning of last month:
  • Site-wide: 19,455

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 463 times
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  • Site-wide: 79,795
  • In genomics: 5,232
• Year to date:
  • Site-wide: 39,125
• Since beginning of last month:
  • Site-wide: 18,268

Choosing questions before methods in dementia research with competing events and causal goals

• Downloaded 370 times
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  • Site-wide: 99,309
  • In neurology: 337
• Year to date:
  • Site-wide: 25,636
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  • Site-wide: 29,206

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

• Downloaded 323 times
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  • Site-wide: 110,895
  • In bioinformatics: 9,232
• Year to date:
  • Site-wide: 146,192
• Since beginning of last month:
  • Site-wide: 156,867

KCND3 is a novel susceptibility locus for early repolarization

• Downloaded 307 times
• Download rankings, all-time:
  • Site-wide: 114,880
  • In genetics: 4,682
• Year to date:
  • Site-wide: 145,502
• Since beginning of last month:
  • Site-wide: 120,171

Investigating the relationships between unfavorable sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses

• Downloaded 264 times
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  • Site-wide: 126,336
  • In epidemiology: 5,338
• Year to date:
  • Site-wide: 77,694
• Since beginning of last month:
  • Site-wide: 82,701

MiR-139-5p is a causal biomarker for type 2 diabetes; Results from genome-wide microRNA profiling and Mendelian randomization analysis in a population-based study

• Downloaded 147 times
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  • Site-wide: 153,803
  • In epidemiology: 6,366
• Year to date:
  • Site-wide: 82,671
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  • Site-wide: 46,365

Genetic variants link lower segregation of brain networks to higher blood pressure and worse cognition within the general aging population

• Downloaded 146 times
• Download rankings, all-time:
  • Site-wide: 154,022
  • In neurology: 888
• Year to date:
  • Site-wide: 82,753
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  • Site-wide: 106,484

Challenges at the APOE locus: A robust quality control approach for accurate APOE genotyping

• Downloaded 107 times
• Download rankings, all-time:
  • Site-wide: 159,735
  • In neurology: 958
• Year to date:
  • Site-wide: 109,023
• Since beginning of last month:
  • Site-wide: 16,031