Author: Myriam Fornage

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Preprints

Recovery of trait heritability from whole genome sequence data

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  • Site-wide: 1,534
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  • Site-wide: 31,783

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • Site-wide: 1,202
  • In genomics: 97
• Year to date:
  • Site-wide: 3,936
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  • Site-wide: 57,857

The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,252
  • In genetics: 32
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  • Site-wide: 17,170
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  • Site-wide: 9,682

The PAGE Study: How Genetic Diversity Improves Our Understanding of the Architecture of Complex Traits

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  • Site-wide: 4,374
  • In genetics: 167
• Year to date:
  • Site-wide: 43,193
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  • Site-wide: 40,372

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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  • Site-wide: 4,719
  • In genomics: 488
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  • Site-wide: 10,255
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  • Site-wide: 88,996

Large-scale association analyses identify host factors influencing human gut microbiome composition

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  • Site-wide: 6,749
  • In genetics: 296
• Year to date:
  • Site-wide: 5,196
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  • Site-wide: 26,304

Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

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  • Site-wide: 9,066
  • In genetics: 386
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  • Site-wide: 4,659
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  • Site-wide: 1,917

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 10,576
  • In genetics: 465
• Year to date:
  • Site-wide: 75,884
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  • Site-wide: 45,865

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 10,834
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  • Site-wide: 54,153
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  • Site-wide: 19,806

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • Site-wide: 13,875
  • In genetic and genomic medicine: 62
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  • Site-wide: 6,258
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  • Site-wide: 9,608

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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  • Site-wide: 14,420
  • In genetics: 657
• Year to date:
  • Site-wide: 7,515
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  • Site-wide: 124,932

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

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  • Site-wide: 14,577
  • In genomics: 1,478
• Year to date:
  • Site-wide: 28,686
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  • Site-wide: 96,204

Mitochondrial DNA Copy Number (mtDNA-CN) Can Influence Mortality and Cardiovascular Disease via Methylation of Nuclear DNA CpGs

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  • Site-wide: 29,094
  • In genomics: 2,582
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  • Site-wide: 53,525
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  • Site-wide: 13,475

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

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  • Site-wide: 29,748
  • In genetics: 1,355
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  • Site-wide: 29,230
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  • Site-wide: 13,581

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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  • Site-wide: 30,806
  • In genetics: 1,416
• Year to date:
  • Site-wide: 86,936
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  • Site-wide: 87,471

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

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  • Site-wide: 31,461
  • In genetics: 1,447
• Year to date:
  • Site-wide: 7,471
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  • Site-wide: 4,474

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 33,244
  • In neuroscience: 4,364
• Year to date:
  • Site-wide: 78,166
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  • Site-wide: 113,710

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

• Downloaded 753 times
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  • Site-wide: 37,127
  • In bioinformatics: 4,015
• Year to date:
  • Site-wide: 121,917
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  • Site-wide: 100,436

Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program

• Downloaded 698 times
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  • Site-wide: 41,185
  • In hematology: 34
• Year to date:
  • Site-wide: 8,773
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  • Site-wide: 43,311

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

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  • Site-wide: 41,605
  • In genomics: 3,358
• Year to date:
  • Site-wide: 107,152
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  • Site-wide: 57,718

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

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  • Site-wide: 46,921
  • In genetics: 2,093
• Year to date:
  • Site-wide: 125,881
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  • Site-wide: 64,907

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality

• Downloaded 586 times
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  • Site-wide: 51,464
  • In genetics: 2,273
• Year to date:
  • Site-wide: 7,305
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  • Site-wide: 77,100

Methylome-Wide Association Study Of Central Adiposity Implicates Genes Involved In Immune And Endocrine Systems

• Downloaded 524 times
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  • Site-wide: 59,032
  • In genomics: 4,342
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  • Site-wide: 47,084
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  • Site-wide: 15,036

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 518 times
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  • Site-wide: 59,883
  • In genomics: 4,377
• Year to date:
  • Site-wide: 146,771
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  • Site-wide: None

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

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  • Site-wide: 62,408
  • In genetics: 2,758
• Year to date:
  • Site-wide: 23,513
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  • Site-wide: 44,323

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

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  • Site-wide: 66,028
  • In neuroscience: 9,675
• Year to date:
  • Site-wide: 106,663
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  • Site-wide: 115,160

Large Meta-Analysis in the CHARGE Consortium Provides Evidence For an Association of Serum Vitamin D With Pulmonary Function

• Downloaded 458 times
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  • Site-wide: 68,578
  • In epidemiology: 3,028
• Year to date:
  • Site-wide: 132,360
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  • Site-wide: 45,532

Genetic variants for head size share genes and pathways with cancer

• Downloaded 455 times
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  • Site-wide: 68,974
  • In genomics: 4,814
• Year to date:
  • Site-wide: 45,942
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  • Site-wide: 86,346

Polygenic Risk Prediction using Gradient Boosted Trees Captures Non-Linear Genetic Effects and Allele Interactions in Complex Phenotypes

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  • Site-wide: 84,193
  • In genetic and genomic medicine: 367
• Year to date:
  • Site-wide: 14,261
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  • Site-wide: 2,010

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

• Downloaded 334 times
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  • Site-wide: 91,832
  • In epidemiology: 3,876
• Year to date:
  • Site-wide: 64,303
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  • Site-wide: 120,547

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

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  • Site-wide: 92,294
  • In epidemiology: 3,893
• Year to date:
  • Site-wide: 101,640
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  • Site-wide: 56,968

Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential

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  • Site-wide: 93,322
  • In genetic and genomic medicine: 422
• Year to date:
  • Site-wide: 17,090
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  • Site-wide: 67,796

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 289 times
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  • Site-wide: 102,059
  • In genomics: 6,123
• Year to date:
  • Site-wide: 68,550
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  • Site-wide: 81,981

Differential Host Gene Signatures in Response to Mycobacterium tuberculosis Infection

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  • Site-wide: 118,076
  • In microbiology: 8,607
• Year to date:
  • Site-wide: 126,875
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  • Site-wide: 123,946

Polygenic Risk Scores for Alzheimer's Disease and Mild Cognitive Impairment in Hispanics/Latinos in the U.S: The Study of Latinos - Investigation ofNeurocognitive Aging

• Downloaded 213 times
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  • Site-wide: 120,821
  • In genetic and genomic medicine: 639
• Year to date:
  • Site-wide: 30,269
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  • Site-wide: 66,459

find-tfbs: a tool to identify functional non-coding variants associated with complex human traits using open chromatin maps and phased whole-genome sequences

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  • Site-wide: 122,540
  • In genomics: 6,791
• Year to date:
  • Site-wide: 71,262
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  • Site-wide: 93,340

Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sex

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  • Site-wide: 145,374
  • In genetic and genomic medicine: 843
• Year to date:
  • Site-wide: 66,340
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  • Site-wide: 3,200

Blood metabolites predicting Mild Cognitive Impairment in the Study of Latinos-Investigation of Neurocognitive Aging (HCHS/SOL)

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  • Site-wide: 148,540
  • In epidemiology: 6,133
• Year to date:
  • Site-wide: 80,638
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  • Site-wide: 132,465