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Author: Adriano KK Aguzzi

Rankings

  • All-time downloads: 52,525 (rank: 4,057 )
  • Categories:
    • allergy and immunology: 1,541 (rank: 1,238 (tie) )
    • biochemistry: 1,335 (rank: 5,006 (tie) )
    • biophysics: 311 (rank: 20,060 (tie) )
    • epidemiology: 5,923 (rank: 3,084 (tie) )
    • genetic and genomic medicine: 191 (rank: 14,361 (tie) )
    • immunology: 16,941 (rank: 765 (tie) )
    • molecular biology: 1,052 (rank: 7,463 (tie) )
    • neurology: 7,945 (rank: 137 (tie) )
    • neuroscience: 17,286 (rank: 640 )

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Preprints

The channel activities of the full-length prion and truncated proteins

biochemistry more details view paper

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Dendritic integration of sensory and reward information facilitates learning

neuroscience more details view paper

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Systemic and mucosal antibody secretion specific to SARS-CoV-2 during mild versus severe COVID-19

immunology more details view paper
  • Downloaded 16,501 times
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    • Site-wide: 611
    • In immunology: 29
  • Year to date:
    • Site-wide: 3,857
  • Since beginning of last month:
    • Site-wide: 7,116

Autoantibodies against the prion protein in individuals with PRNP mutations

neurology more details view paper
  • Downloaded 7,301 times
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    • Site-wide: 1,694
    • In neurology: 5
  • Year to date:
    • Site-wide: 35,087
  • Since beginning of last month:
    • Site-wide: 2,943

Population-wide evolution of SARS-CoV-2 immunity tracked by a ternary immunoassay

epidemiology more details view paper
  • Downloaded 5,755 times
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    • Site-wide: 2,339
    • In epidemiology: 279
  • Year to date:
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The mesoSPIM initiative: open-source light-sheet mesoscopes for imaging in cleared tissue

neuroscience more details view paper
  • Downloaded 2,031 times
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    • Site-wide: 10,193
    • In neuroscience: 1,007
  • Year to date:
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Pericytes regulate vascular immune homeostasis in the CNS

neuroscience more details view paper
  • Downloaded 1,583 times
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    • Site-wide: 14,795
    • In neuroscience: 1,593
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 69,868

Microfluidic Affinity Profiling reveals a Broad Range of Target Affinities for Anti-SARS-CoV-2 Antibodies in Plasma of Covid Survivors

allergy and immunology more details view paper
  • Downloaded 1,541 times
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    • Site-wide: 15,460
    • In allergy and immunology: 67
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An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of a-synuclein

neuroscience more details view paper
  • Downloaded 1,120 times
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    • In neuroscience: 3,068
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Developmental Divergence of Sensory Stimulus Representation in Cortical Interneurons

neuroscience more details view paper
  • Downloaded 1,002 times
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    • Site-wide: 29,637
    • In neuroscience: 3,710
  • Year to date:
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  • Since beginning of last month:
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LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

neuroscience more details view paper
  • Downloaded 999 times
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    • Site-wide: 29,773
    • In neuroscience: 3,741
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 21,441

Protective anti-prion antibodies in human immunoglobulin repertoires

neuroscience more details view paper
  • Downloaded 944 times
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    • Site-wide: 32,413
    • In neuroscience: 4,162
  • Year to date:
    • Site-wide: 97,004
  • Since beginning of last month:
    • Site-wide: 106,411

Local predictors of anti-Aβ therapy efficacy revealed by quantitative whole-brain microscopy

neuroscience more details view paper
  • Downloaded 922 times
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    • Site-wide: 33,547
    • In neuroscience: 4,325
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 23,645

Loss of PIKfyve drives the spongiform degeneration in prion diseases

neuroscience more details view paper
  • Downloaded 838 times
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    • Site-wide: 38,560
    • In neuroscience: 5,099
  • Year to date:
    • Site-wide: 99,086
  • Since beginning of last month:
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In vitro measurements of protein-protein interactions show that antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum

biochemistry more details view paper
  • Downloaded 765 times
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    • Site-wide: 43,938
    • In biochemistry: 1,106
  • Year to date:
    • Site-wide: 58,592
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    • Site-wide: 77,372

Genome-wide transcriptomics identifies an early preclinical signature of prion infection

neuroscience more details view paper
  • Downloaded 732 times
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    • Site-wide: 46,746
    • In neuroscience: 6,405
  • Year to date:
    • Site-wide: 56,144
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    • Site-wide: 128,473

Whole brain optoacoustic tomography reveals strain-specific regional beta-amyloid densities in Alzheimer`s disease amyloidosis models

neuroscience more details view paper
  • Downloaded 683 times
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    • Site-wide: 51,438
    • In neuroscience: 7,174
  • Year to date:
    • Site-wide: 52,850
  • Since beginning of last month:
    • Site-wide: 50,589

The uptake of tau amyloid fibrils is facilitated by the cellular prion protein and hampers prion propagation in cultured cells

neuroscience more details view paper
  • Downloaded 664 times
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    • Site-wide: 53,427
    • In neuroscience: 7,505
  • Year to date:
    • Site-wide: 90,964
  • Since beginning of last month:
    • Site-wide: 129,592

NG2 glia are required for maintaining microglia homeostatic state

neuroscience more details view paper
  • Downloaded 663 times
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    • Site-wide: 53,530
    • In neuroscience: 7,525
  • Year to date:
    • Site-wide: 76,890
  • Since beginning of last month:
    • Site-wide: 102,511

Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference

neuroscience more details view paper
  • Downloaded 657 times
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    • Site-wide: 54,195
    • In neuroscience: 7,618
  • Year to date:
    • Site-wide: 123,614
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Genome-wide association study identifies risk variants for sporadic Creutzfeldt-Jakob disease in STX6 and GAL3ST1

neurology more details view paper
  • Downloaded 644 times
  • Download rankings, all-time:
    • Site-wide: 55,790
    • In neurology: 149
  • Year to date:
    • Site-wide: 35,847
  • Since beginning of last month:
    • Site-wide: 43,589

Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression

neuroscience more details view paper
  • Downloaded 598 times
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    • Site-wide: 61,369
    • In neuroscience: 8,738
  • Year to date:
    • Site-wide: 60,745
  • Since beginning of last month:
    • Site-wide: 123,420

Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape

biochemistry more details view paper
  • Downloaded 570 times
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    • Site-wide: 65,144
    • In biochemistry: 1,734
  • Year to date:
    • Site-wide: 14,592
  • Since beginning of last month:
    • Site-wide: 34,218

A conformational switch controlling the toxicity of the prion protein

molecular biology more details view paper
  • Downloaded 516 times
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    • Site-wide: 73,404
    • In molecular biology: 2,099
  • Year to date:
    • Site-wide: 19,970
  • Since beginning of last month:
    • Site-wide: 29,205

Glial activation in prion diseases is strictly nonautonomous and requires neuronal PrPSc

neuroscience more details view paper
  • Downloaded 485 times
  • Download rankings, all-time:
    • Site-wide: 78,718
    • In neuroscience: 11,497
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 38,777

Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins

immunology more details view paper
  • Downloaded 440 times
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    • Site-wide: 87,471
    • In immunology: 2,686
  • Year to date:
    • Site-wide: 33,158
  • Since beginning of last month:
    • Site-wide: 66,526

SARM1 deficiency, which prevents Wallerian degeneration, upregulates XAF1 and accelerates prion disease

neuroscience more details view paper
  • Downloaded 429 times
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    • Site-wide: 89,684
    • In neuroscience: 13,254
  • Year to date:
    • Site-wide: 139,763
  • Since beginning of last month:
    • Site-wide: 97,659

Ligands binding to the cellular prion protein induce its protective proteolytic release with therapeutic potential in neurodegenerative proteinopathies

neuroscience more details view paper
  • Downloaded 423 times
  • Download rankings, all-time:
    • Site-wide: 90,992
    • In neuroscience: 13,427
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 65,126

Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD

neuroscience more details view paper
  • Downloaded 394 times
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    • Site-wide: 97,335
    • In neuroscience: 14,421
  • Year to date:
    • Site-wide: 22,914
  • Since beginning of last month:
    • Site-wide: 806

Unaltered prion disease in mice lacking developmental endothelial locus-1 (Del 1)

neuroscience more details view paper
  • Downloaded 375 times
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    • Site-wide: 101,706
    • In neuroscience: 15,077
  • Year to date:
    • Site-wide: 137,174
  • Since beginning of last month:
    • Site-wide: 159,235

Prions induce minor genome-wide translational changes in neurons compared to glia

neuroscience more details view paper
  • Downloaded 353 times
  • Download rankings, all-time:
    • Site-wide: 107,198
    • In neuroscience: 15,965
  • Year to date:
    • Site-wide: 155,406
  • Since beginning of last month:
    • Site-wide: 134,180

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity

molecular biology more details view paper
  • Downloaded 334 times
  • Download rankings, all-time:
    • Site-wide: 112,003
    • In molecular biology: 3,313
  • Year to date:
    • Site-wide: 126,685
  • Since beginning of last month:
    • Site-wide: 120,844

Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2

biophysics more details view paper
  • Downloaded 311 times
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    • Site-wide: 117,953
    • In biophysics: 4,510
  • Year to date:
    • Site-wide: 15,898
  • Since beginning of last month:
    • Site-wide: 19,184

Transmission of prion infectivity from blood by peptoid-conjugated beads

neuroscience more details view paper
  • Downloaded 296 times
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    • Site-wide: 121,963
    • In neuroscience: 18,280
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
    • Site-wide: 161,475

Prion infection, transmission and cytopathology modelled in a low-biohazard human cell line

neuroscience more details view paper
  • Downloaded 294 times
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    • Site-wide: 122,712
    • In neuroscience: 18,374
  • Year to date:
    • Site-wide: None
  • Since beginning of last month:
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Behavioral deficits, learning impairment, and enhanced hippocampal excitability in co-isogenic PrnpZH3/ZH3 mice

neuroscience more details view paper
  • Downloaded 264 times
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    • Site-wide: 130,745
    • In neuroscience: 19,585
  • Year to date:
    • Site-wide: 87,287
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    • Site-wide: 66,252

Dimeric prion protein ligand activates Adgrg6 but does not rescue myelinopathy of PrP-deficient mice

neuroscience more details view paper
  • Downloaded 234 times
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    • Site-wide: 138,767
    • In neuroscience: 20,695
  • Year to date:
    • Site-wide: 98,783
  • Since beginning of last month:
    • Site-wide: 83,842

The ASC Protein Controls the Severity of Systemic AA Amyloidosis in Mice

molecular biology more details view paper
  • Downloaded 202 times
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    • Site-wide: 147,147
    • In molecular biology: 4,394
  • Year to date:
    • Site-wide: 32,837
  • Since beginning of last month:
    • Site-wide: 37,203

Genome-wide association study of autopsy-confirmed Multiple System Atrophy identifies common variants near ZIC1 and ZIC4

genetic and genomic medicine more details view paper
  • Downloaded 191 times
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    • Site-wide: 149,795
    • In genetic and genomic medicine: 955
  • Year to date:
    • Site-wide: 6,878
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    • Site-wide: 22,240

Large-scale seroepidemiology identifies a nephro-vascular syndrome associated with autoimmune reactivity to tau

epidemiology more details view paper
  • Downloaded 168 times
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    • Site-wide: 154,873
    • In epidemiology: 6,449
  • Year to date:
    • Site-wide: 50,740
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    • Site-wide: 12,963

The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis

neuroscience more details view paper
  • Downloaded 168 times
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    • Site-wide: 155,006
    • In neuroscience: 23,000
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    • Site-wide: 110,372

The prion protein is not required for peripheral nerve repair after crush injury

neuroscience more details view paper
  • Downloaded 135 times
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    • Site-wide: 161,257
    • In neuroscience: 23,888
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