Author: Olav B. Smeland

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Preprints

Genomewide association study identifies 30 loci associated with bipolar disorder

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  • Site-wide: 1,920
  • In genetics: 45
• Year to date:
  • Site-wide: 7,831
• Since beginning of last month:
  • Site-wide: 26,304

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 2,828
  • In genetics: 79
• Year to date:
  • Site-wide: 5,168
• Since beginning of last month:
  • Site-wide: 29,856

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

• Downloaded 3,707 times
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  • Site-wide: 5,348
  • In psychiatry and clinical psychology: 20
• Year to date:
  • Site-wide: 9,333
• Since beginning of last month:
  • Site-wide: 18,379

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

• Downloaded 3,512 times
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  • Site-wide: 5,802
  • In genomics: 540
• Year to date:
  • Site-wide: 94,084
• Since beginning of last month:
  • Site-wide: 90,403

Genetics of brain age suggest an overlap with common brain disorders

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  • Site-wide: 6,807
  • In neuroscience: 586
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 26,145

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 7,443
  • In genetics: 275
• Year to date:
  • Site-wide: 7,748
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  • Site-wide: 8,715

Estimating inflation in GWAS summary statistics due to variance distortion from cryptic relatedness

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  • Site-wide: 9,080
  • In genomics: 870
• Year to date:
  • Site-wide: 4,583
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  • Site-wide: 17,128

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,624 times
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  • Site-wide: 18,558
  • In genomics: 1,676
• Year to date:
  • Site-wide: 112,580
• Since beginning of last month:
  • Site-wide: 51,987

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

• Downloaded 1,396 times
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  • Site-wide: 23,664
  • In genetics: 946
• Year to date:
  • Site-wide: 119,412
• Since beginning of last month:
  • Site-wide: 209,693

Phenotypically independent mental health symptom profiles are genetically related

• Downloaded 1,196 times
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  • Site-wide: 30,228
  • In psychiatry and clinical psychology: 123
• Year to date:
  • Site-wide: 90,631
• Since beginning of last month:
  • Site-wide: 125,012

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 979 times
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  • Site-wide: 41,248
  • In genetics: 1,628
• Year to date:
  • Site-wide: 135,963
• Since beginning of last month:
  • Site-wide: 201,487

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

• Downloaded 938 times
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  • Site-wide: 44,052
  • In genetic and genomic medicine: 273
• Year to date:
  • Site-wide: 83,881
• Since beginning of last month:
  • Site-wide: 112,490

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy and improves prediction

• Downloaded 877 times
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  • Site-wide: 48,814
  • In genetics: 1,971
• Year to date:
  • Site-wide: 11,129
• Since beginning of last month:
  • Site-wide: 21,439

Multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.

• Downloaded 834 times
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  • Site-wide: 52,658
  • In genetics: 2,072
• Year to date:
  • Site-wide: 84,528
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  • Site-wide: 124,274

Making the MOSTest of imaging genetics

• Downloaded 814 times
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  • Site-wide: 54,651
  • In neuroscience: 7,413
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 187,889

Cortico-genetic mapping links individual brain maturity in youths to cognitive and psychiatric traits

• Downloaded 759 times
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  • Site-wide: 60,651
  • In neuroscience: 8,336
• Year to date:
  • Site-wide: 116,227
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  • Site-wide: 142,354

Improved prediction of schizophrenia by leveraging genetic overlap with brain morphology

• Downloaded 700 times
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  • Site-wide: 68,175
  • In psychiatry and clinical psychology: 312
• Year to date:
  • Site-wide: 83,885
• Since beginning of last month:
  • Site-wide: 160,800

The dark side of the mean: brain structural heterogeneity in schizophrenia and its polygenic risk.

• Downloaded 644 times
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  • Site-wide: 76,357
  • In neuroscience: 10,928
• Year to date:
  • Site-wide: 73,699
• Since beginning of last month:
  • Site-wide: 120,136

Genetic control of variability in subcortical and intracranial volumes

• Downloaded 606 times
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  • Site-wide: 82,624
  • In neuroscience: 11,658
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 142,976

Characterization of Age and Polarity at Onset in Bipolar Disorder

• Downloaded 587 times
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  • Site-wide: 86,064
  • In psychiatry and clinical psychology: 418
• Year to date:
  • Site-wide: 145,073
• Since beginning of last month:
  • Site-wide: 56,559

Annotation-Informed Causal Mixture Modeling (AI-MiXeR) reveals phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories

• Downloaded 561 times
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  • Site-wide: 91,033
  • In genetics: 3,511
• Year to date:
  • Site-wide: 61,985
• Since beginning of last month:
  • Site-wide: 186,836

Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank

• Downloaded 496 times
• Download rankings, all-time:
  • Site-wide: 105,181
  • In genetic and genomic medicine: 680
• Year to date:
  • Site-wide: 160,823
• Since beginning of last month:
  • Site-wide: 183,975

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture Model

• Downloaded 489 times
• Download rankings, all-time:
  • Site-wide: 106,904
  • In genetics: 4,066
• Year to date:
  • Site-wide: 112,460
• Since beginning of last month:
  • Site-wide: 180,437

Population-based body-brain mapping links brain morphology and body composition

• Downloaded 427 times
• Download rankings, all-time:
  • Site-wide: 122,422
  • In neuroscience: 17,923
• Year to date:
  • Site-wide: 90,418
• Since beginning of last month:
  • Site-wide: 187,974

Genome-wide association analysis reveals extensive genetic overlap between mood instability and psychiatric disorders but divergent patterns of genetic effects

• Downloaded 425 times
• Download rankings, all-time:
  • Site-wide: 123,080
  • In psychiatry and clinical psychology: 704
• Year to date:
  • Site-wide: 75,391
• Since beginning of last month:
  • Site-wide: 29,445

A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia

• Downloaded 392 times
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  • Site-wide: 132,351
  • In neuroscience: 19,292
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 211,064

Genetic overlap between Alzheimer's disease and depression mapped onto the brain

• Downloaded 374 times
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  • Site-wide: 137,759
  • In genetic and genomic medicine: 961
• Year to date:
  • Site-wide: 89,683
• Since beginning of last month:
  • Site-wide: 194,398

Clustering schizophrenia genes by their temporal expression patterns aids functional interpretation: genetics-based evidence in favor of the two-hit hypothesis

• Downloaded 150 times
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  • Site-wide: 198,125
  • In psychiatry and clinical psychology: 1,385
• Year to date:
  • Site-wide: 130,302
• Since beginning of last month:
  • Site-wide: 89,096

Efficient meta-analysis of multivariate genome-wide association studies with Meta-MOSTest

• Downloaded 138 times
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  • Site-wide: 200,496
  • In bioinformatics: 14,711
• Year to date:
  • Site-wide: 130,380
• Since beginning of last month:
  • Site-wide: 59,148

Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression.

• Downloaded 85 times
• Download rankings, all-time:
  • Site-wide: 210,232
  • In genetic and genomic medicine: 1,700
• Year to date:
  • Site-wide: 67,722
• Since beginning of last month:
  • Site-wide: 70,250

Improved functional mapping with GSA-MiXeR implicates biologically specific gene-sets and estimates enrichment magnitude

• Downloaded 72 times
• Download rankings, all-time:
  • Site-wide: 212,625
  • In psychiatry and clinical psychology: None
• Year to date:
  • Site-wide: 11,866
• Since beginning of last month:
  • Site-wide: 6,426