Author: Lu Lu

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Preprints

Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications

• Downloaded 142,373 times
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  • Site-wide: 39
  • In infectious diseases: 16
• Year to date:
  • Site-wide: 437
• Since beginning of last month:
  • Site-wide: 382

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

• Downloaded 16,110 times
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  • Site-wide: 701
  • In microbiology: 73
• Year to date:
  • Site-wide: 55,101
• Since beginning of last month:
  • Site-wide: 101,730

Antibody-dependent enhancement (ADE) of SARS-CoV-2 infection in recovered COVID-19 patients: studies based on cellular and structural biology analysis

• Downloaded 12,887 times
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  • Site-wide: 929
  • In infectious diseases: 306
• Year to date:
  • Site-wide: 1,312
• Since beginning of last month:
  • Site-wide: 8,051

Neutralization of SARS-CoV-2 Omicron variant by sera from BNT162b2 or Coronavac vaccine recipients

• Downloaded 8,910 times
• Download rankings, all-time:
  • Site-wide: 1,480
  • In infectious diseases: 472
• Year to date:
  • Site-wide: 486
• Since beginning of last month:
  • Site-wide: 2,901

Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

• Downloaded 6,242 times
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  • Site-wide: 2,346
  • In microbiology: 183
• Year to date:
  • Site-wide: 58,511
• Since beginning of last month:
  • Site-wide: 68,353

Fully human single-domain antibodies against SARS-CoV-2

• Downloaded 5,615 times
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  • Site-wide: 2,705
  • In microbiology: 208
• Year to date:
  • Site-wide: 21,158
• Since beginning of last month:
  • Site-wide: 38,793

Efficient combinatorial targeting of RNA transcripts in single cells with Cas13 RNA Perturb-seq

• Downloaded 4,729 times
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  • Site-wide: 3,411
  • In genomics: 479
• Year to date:
  • Site-wide: 210
• Since beginning of last month:
  • Site-wide: 1,077

Multi-Omic Profiling of the Liver Across Diets and Age in a Diverse Mouse Population

• Downloaded 2,582 times
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  • Site-wide: 8,141
  • In systems biology: 128
• Year to date:
  • Site-wide: 9,937
• Since beginning of last month:
  • Site-wide: 11,682

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

• Downloaded 2,272 times
• Download rankings, all-time:
  • Site-wide: 9,787
  • In microbiology: 672
• Year to date:
  • Site-wide: 539
• Since beginning of last month:
  • Site-wide: 8,606

Monitoring SARS-CoV-2 circulation and diversity through community wastewater sequencing

• Downloaded 2,241 times
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  • Site-wide: 9,970
  • In public and global health: 258
• Year to date:
  • Site-wide: 38,153
• Since beginning of last month:
  • Site-wide: 53,336

Segmentation and shielding of the most vulnerable members of the population as elements of an exit strategy from COVID-19 lockdown

• Downloaded 2,237 times
• Download rankings, all-time:
  • Site-wide: 9,988
  • In epidemiology: 806
• Year to date:
  • Site-wide: 21,477
• Since beginning of last month:
  • Site-wide: 35,363

Interactions between strains govern the eco-evolutionary dynamics of microbial communities

• Downloaded 2,161 times
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  • Site-wide: 10,546
  • In microbiology: 594
• Year to date:
  • Site-wide: 26,880
• Since beginning of last month:
  • Site-wide: 64,197

Adaptation, spread and transmission of SARS-CoV-2 in farmed minks and related humans in the Netherlands

• Downloaded 2,010 times
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  • Site-wide: 11,781
  • In microbiology: 652
• Year to date:
  • Site-wide: 70,287
• Since beginning of last month:
  • Site-wide: 166,379

Systems biology informed deep learning for inferring parameters and hidden dynamics

• Downloaded 1,764 times
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  • Site-wide: 14,309
  • In bioinformatics: 1,503
• Year to date:
  • Site-wide: 49,886
• Since beginning of last month:
  • Site-wide: 80,544

A natural mutator allele shapes mutation spectrum variation in mice

• Downloaded 1,360 times
• Download rankings, all-time:
  • Site-wide: 21,254
  • In genetics: 1,055
• Year to date:
  • Site-wide: 7,335
• Since beginning of last month:
  • Site-wide: 8,489

The expanded BXD family of mice: A cohort for experimental systems genetics and precision medicine

• Downloaded 1,345 times
• Download rankings, all-time:
  • Site-wide: 21,633
  • In genomics: 1,971
• Year to date:
  • Site-wide: 30,688
• Since beginning of last month:
  • Site-wide: 25,329

Epidemic waves of COVID-19 in Scotland: a genomic perspective on the impact of the introduction and relaxation of lockdown on SARS-CoV-2

• Downloaded 974 times
• Download rankings, all-time:
  • Site-wide: 35,383
  • In epidemiology: 1,932
• Year to date:
  • Site-wide: 40,437
• Since beginning of last month:
  • Site-wide: 41,210

Gene-by-environmental modulation of longevity and weight gain in the murine BXD family

• Downloaded 942 times
• Download rankings, all-time:
  • Site-wide: 37,211
  • In genetics: 1,519
• Year to date:
  • Site-wide: 74,742
• Since beginning of last month:
  • Site-wide: 120,648

Engineered Trimeric ACE2 Binds and Locks “Three-up” Spike Protein to Potently Inhibit SARS-CoVs and Mutants

• Downloaded 894 times
• Download rankings, all-time:
  • Site-wide: 40,147
  • In bioengineering: 724
• Year to date:
  • Site-wide: 98,802
• Since beginning of last month:
  • Site-wide: 128,283

Public good exploitation in natural bacterioplankton communities

• Downloaded 853 times
• Download rankings, all-time:
  • Site-wide: 43,076
  • In microbiology: 2,464
• Year to date:
  • Site-wide: 86,425
• Since beginning of last month:
  • Site-wide: 124,901

An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge

• Downloaded 845 times
• Download rankings, all-time:
  • Site-wide: 43,660
  • In immunology: 1,739
• Year to date:
  • Site-wide: 2,241
• Since beginning of last month:
  • Site-wide: 14,573

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

• Downloaded 697 times
• Download rankings, all-time:
  • Site-wide: 57,575
  • In microbiology: 3,298
• Year to date:
  • Site-wide: 131,917
• Since beginning of last month:
  • Site-wide: 152,063

Evolutionary origins of epidemic potential among human RNA viruses

• Downloaded 607 times
• Download rankings, all-time:
  • Site-wide: 69,304
  • In evolutionary biology: 3,082
• Year to date:
  • Site-wide: 141,287
• Since beginning of last month:
  • Site-wide: 125,655

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

• Downloaded 601 times
• Download rankings, all-time:
  • Site-wide: 70,236
  • In immunology: 3,608
• Year to date:
  • Site-wide: 5,008
• Since beginning of last month:
  • Site-wide: 48,198

Computational approaches towards reducing contamination in single-cell RNA-seq data

• Downloaded 561 times
• Download rankings, all-time:
  • Site-wide: 76,419
  • In bioinformatics: 6,968
• Year to date:
  • Site-wide: 88,710
• Since beginning of last month:
  • Site-wide: 112,755

Identification of a functional non-coding variant in the GABAA receptor α2 subunit of the C57BL/6J mouse reference genome: Major implications for neuroscience research

• Downloaded 547 times
• Download rankings, all-time:
  • Site-wide: 78,778
  • In genetics: 3,005
• Year to date:
  • Site-wide: 184,733
• Since beginning of last month:
  • Site-wide: 163,349

Small-scale soil microbial community heterogeneity linked to landforms on King George Island, maritime Antarctica

• Downloaded 485 times
• Download rankings, all-time:
  • Site-wide: 90,611
  • In microbiology: 5,529
• Year to date:
  • Site-wide: 163,866
• Since beginning of last month:
  • Site-wide: 141,037

Genome-wide discovery of hidden genes mediating known drug-disease association using KDDANet

• Downloaded 483 times
• Download rankings, all-time:
  • Site-wide: 91,132
  • In bioinformatics: 7,711
• Year to date:
  • Site-wide: 129,878
• Since beginning of last month:
  • Site-wide: 131,328

Copper(II) Gluconate Boosts the Anti-SARS-CoV-2 Effect of Disulfiram in Vitro

• Downloaded 444 times
• Download rankings, all-time:
  • Site-wide: 99,934
  • In biochemistry: 2,825
• Year to date:
  • Site-wide: 76,324
• Since beginning of last month:
  • Site-wide: 69,960

Apoptotic Extracellular Vesicles (ApoEVs) Safeguard Liver Homeostasis and Regeneration via Assembling an ApoEV-Golgi Organelle

• Downloaded 416 times
• Download rankings, all-time:
  • Site-wide: 106,499
  • In cell biology: 5,327
• Year to date:
  • Site-wide: 49,601
• Since beginning of last month:
  • Site-wide: 22,821

Association of maternal hepatitis B virus infection with adverse pregnancy outcomes and prenatal screening result of second-trimester: a retrospective cohort study

• Downloaded 401 times
• Download rankings, all-time:
  • Site-wide: 110,093
  • In obstetrics and gynecology: 126
• Year to date:
  • Site-wide: 89,298
• Since beginning of last month:
  • Site-wide: 112,240

Two key events associated with a transposable element burst occurred during rice domestication

• Downloaded 389 times
• Download rankings, all-time:
  • Site-wide: 113,067
  • In genomics: 6,229
• Year to date:
  • Site-wide: 177,305
• Since beginning of last month:
  • Site-wide: 115,795

Tripterygium glycosides as a potential treatment for CAR-T induced cytokine release syndrome: implication of monocyte depletion

• Downloaded 385 times
• Download rankings, all-time:
  • Site-wide: 114,080
  • In hematology: 111
• Year to date:
  • Site-wide: 111,909
• Since beginning of last month:
  • Site-wide: 107,801

Genetic dissection of femoral and tibial microarchitecture

• Downloaded 354 times
• Download rankings, all-time:
  • Site-wide: 122,690
  • In genetics: 4,538
• Year to date:
  • Site-wide: 164,732
• Since beginning of last month:
  • Site-wide: 147,099

High-Resolution Maps of Mouse Reference Populations

• Downloaded 312 times
• Download rankings, all-time:
  • Site-wide: 134,706
  • In genetics: 4,996
• Year to date:
  • Site-wide: 158,692
• Since beginning of last month:
  • Site-wide: 141,702

Genomic diversity generated by a transposable element burst in a rice recombinant inbred population

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 151,690
  • In genetics: 5,499
• Year to date:
  • Site-wide: 184,408
• Since beginning of last month:
  • Site-wide: 170,389

Plant endophytic bacteria: a potential resource pool of electroactive microorganisms

• Downloaded 236 times
• Download rankings, all-time:
  • Site-wide: 157,161
  • In microbiology: 11,218
• Year to date:
  • Site-wide: 112,432
• Since beginning of last month:
  • Site-wide: 65,534

Selective cleavage of ncRNA and antiviral activity by human RNase2/EDN in a macrophage infection model

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 162,182
  • In cell biology: 7,562
• Year to date:
  • Site-wide: 50,639
• Since beginning of last month:
  • Site-wide: 39,349

System genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose

• Downloaded 208 times
• Download rankings, all-time:
  • Site-wide: 164,696
  • In neuroscience: 22,913
• Year to date:
  • Site-wide: 125,912
• Since beginning of last month:
  • Site-wide: 167,398

Deciphering the heterogeneous niche in the tumor progression of hepatocellular carcinoma: a Spatial single-cell landscape and multi-omics atlas analysis

• Downloaded 203 times
• Download rankings, all-time:
  • Site-wide: 165,960
  • In oncology: None
• Year to date:
  • Site-wide: 19,327
• Since beginning of last month:
  • Site-wide: 32,009

Prognosis-related molecular subtypes and immune features associated with hepatocellular carcinoma

• Downloaded 100 times
• Download rankings, all-time:
  • Site-wide: 185,805
  • In oncology: 671
• Year to date:
  • Site-wide: 46,819
• Since beginning of last month:
  • Site-wide: 100,823

Private and sub-family specific mutations of founder haplotypes in the BXD family reveal phenotypic consequences relevant to health and disease

• Downloaded 83 times
• Download rankings, all-time:
  • Site-wide: 187,645
  • In genomics: None
• Year to date:
  • Site-wide: 56,693
• Since beginning of last month:
  • Site-wide: 29,433

A novel molecular subtype of hepatocellular carcinoma based on the tumor purity and tumor microenvironment-related polygenic risk scores

• Downloaded 79 times
• Download rankings, all-time:
  • Site-wide: 188,102
  • In oncology: 691
• Year to date:
  • Site-wide: 59,647
• Since beginning of last month:
  • Site-wide: 113,392