Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 63,093 bioRxiv papers from 279,869 authors.

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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Genomewide association study identifies 30 loci associated with bipolar disorder

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  • In genetics: 32 out of 3,582
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Common risk variants identified in autism spectrum disorder

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Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • In genetics: 51 out of 3,582
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Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways

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  • In genetics: 53 out of 3,582
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Regulatory variants explain much more heritability than coding variants across 11 common diseases

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • In genetics: 71 out of 3,582
• Year to date:
  • Site-wide: 424 out of 63,093
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  • Site-wide: 1,965 out of 63,093

Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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  • In genomics: 228 out of 4,333
• Year to date:
  • Site-wide: 5,138 out of 63,093
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  • Site-wide: 14,232 out of 63,093

Psychiatric Genomics: An Update and an Agenda

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  • In genetics: 91 out of 3,582
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  • Site-wide: 8,571 out of 63,093
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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • In genomics: 264 out of 4,333
• Year to date:
  • Site-wide: 182 out of 63,093
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  • Site-wide: 976 out of 63,093

Integrative approaches for large-scale transcriptome-wide association studies

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  • In genetics: 134 out of 3,582
• Year to date:
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  • Site-wide: 26,300 out of 63,093

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

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• Year to date:
  • Site-wide: 20,293 out of 63,093
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Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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  • In genetics: 169 out of 3,582
• Year to date:
  • Site-wide: 23,545 out of 63,093
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  • Site-wide: 27,091 out of 63,093

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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  • In genetics: 184 out of 3,582
• Year to date:
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  • Site-wide: 45,611 out of 63,093

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson's Disease

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  • In genomics: 418 out of 4,333
• Year to date:
  • Site-wide: 335 out of 63,093
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  • Site-wide: 1,513 out of 63,093

GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways

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  • In genetics: 226 out of 3,582
• Year to date:
  • Site-wide: 17,787 out of 63,093
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  • Site-wide: 19,859 out of 63,093

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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  • In genetics: 236 out of 3,582
• Year to date:
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  • Site-wide: 19,483 out of 63,093

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

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  • In genomics: 561 out of 4,333
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  • Site-wide: 41,007 out of 63,093

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • In genetics: 288 out of 3,582
• Year to date:
  • Site-wide: 46,517 out of 63,093
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  • Site-wide: 51,762 out of 63,093

Comparative genetic architectures of schizophrenia in East Asian and European populations

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  • In genetics: 380 out of 3,582
• Year to date:
  • Site-wide: 3,201 out of 63,093
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  • Site-wide: 4,798 out of 63,093

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

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  • In genomics: 835 out of 4,333
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  • Site-wide: 963 out of 63,093
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  • Site-wide: 1,793 out of 63,093

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • In genomics: 841 out of 4,333
• Year to date:
  • Site-wide: 19,430 out of 63,093
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  • Site-wide: 37,485 out of 63,093

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

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  • In genomics: 901 out of 4,333
• Year to date:
  • Site-wide: 15,129 out of 63,093
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  • Site-wide: 9,189 out of 63,093

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

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  • In genetics: 466 out of 3,582
• Year to date:
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  • Site-wide: 4,637 out of 63,093

Evaluation Of Chromatin Accessibility In Prefrontal Cortex Of Schizophrenia Cases And Controls

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  • In genomics: 1,158 out of 4,333
• Year to date:
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  • Site-wide: 60,465 out of 63,093

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

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  • In genomics: 1,294 out of 4,333
• Year to date:
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  • Site-wide: 41,423 out of 63,093

Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.

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  • In genetics: 631 out of 3,582
• Year to date:
  • Site-wide: 13,045 out of 63,093
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  • Site-wide: 29,345 out of 63,093

Functional consequences of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

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  • In genomics: 1,338 out of 4,333
• Year to date:
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  • Site-wide: 46,483 out of 63,093

Building a schizophrenia genetic network: Transcription Factor 4 regulates genes involved in neuronal development and schizophrenia risk.

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  • In genetics: 747 out of 3,582
• Year to date:
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  • Site-wide: 20,242 out of 63,093

Common Variant Associations with Fragile X Syndrome

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  • In genetics: 754 out of 3,582
• Year to date:
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Functional partitioning of local and distal gene expression regulation in multiple human tissues

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Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • In genetics: 945 out of 3,582
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Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • In genetics: 1,087 out of 3,582
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  • Site-wide: 22,286 out of 63,093

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • Site-wide: 30,831 out of 63,093

Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes

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  • Site-wide: 18,211 out of 63,093

Proof of concept: Molecular prediction of schizophrenia risk

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  • Site-wide: 59,585 out of 63,093

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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The Anorexia Nervosa Genetics Initiative: Overview and Methods

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Robust Hi-C chromatin loop maps in human neurogenesis and brain tissues at high-resolution

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Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

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  • Site-wide: 21,089 out of 63,093

Genetic variation in the Major Histocompatibility Complex and association with depression

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  • Site-wide: 53,573 out of 63,093

mTADA: a framework for analyzing de novo mutations in multiple traits

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Schizophrenia is characterized by age- and sex-specific effects on epigenetic aging

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Association Tests Using Copy Number Profile Curves (CONCUR) Enhances Power in Rare Copy Number Variant Analysis

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