Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 53,026 bioRxiv papers from 245,564 authors.

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • In genetics: 11 out of 3,086
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  • Site-wide: 1,508 out of 53,026
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  • Site-wide: 6,333 out of 53,026

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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  • Site-wide: 130 out of 53,026
  • In genetics: 13 out of 3,086
• Year to date:
  • Site-wide: 517 out of 53,026
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  • Site-wide: 964 out of 53,026

Common risk variants identified in autism spectrum disorder

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  • In genetics: 29 out of 3,086
• Year to date:
  • Site-wide: 518 out of 53,026
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  • Site-wide: 3,147 out of 53,026

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 425 out of 53,026
  • In genetics: 46 out of 3,086
• Year to date:
  • Site-wide: 5,700 out of 53,026
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  • Site-wide: 10,410 out of 53,026

Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways

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  • Site-wide: 442 out of 53,026
  • In genetics: 47 out of 3,086
• Year to date:
  • Site-wide: 1,255 out of 53,026
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  • Site-wide: 4,699 out of 53,026

Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • Site-wide: 468 out of 53,026
  • In genetics: 58 out of 3,086
• Year to date:
  • Site-wide: 25,359 out of 53,026
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  • Site-wide: 25,133 out of 53,026

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 3,317 times
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  • Site-wide: 739 out of 53,026
  • In genetics: 74 out of 3,086
• Year to date:
  • Site-wide: 276 out of 53,026
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  • Site-wide: 1,332 out of 53,026

Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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  • In genomics: 209 out of 3,782
• Year to date:
  • Site-wide: 4,084 out of 53,026
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  • Site-wide: 5,765 out of 53,026

Psychiatric Genomics: An Update and an Agenda

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  • In genetics: 91 out of 3,086
• Year to date:
  • Site-wide: 8,641 out of 53,026
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Integrative approaches for large-scale transcriptome-wide association studies

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  • Site-wide: 1,198 out of 53,026
  • In genetics: 117 out of 3,086
• Year to date:
  • Site-wide: 18,220 out of 53,026
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  • Site-wide: 11,828 out of 53,026

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 1,445 out of 53,026
  • In genomics: 338 out of 3,782
• Year to date:
  • Site-wide: 124 out of 53,026
• Since beginning of last month:
  • Site-wide: 691 out of 53,026

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

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  • In genomics: 339 out of 3,782
• Year to date:
  • Site-wide: 19,113 out of 53,026
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  • Site-wide: 22,981 out of 53,026

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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  • In genetics: 152 out of 3,086
• Year to date:
  • Site-wide: 20,106 out of 53,026
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  • Site-wide: 27,917 out of 53,026

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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  • In genetics: 160 out of 3,086
• Year to date:
  • Site-wide: 36,701 out of 53,026
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  • Site-wide: 37,284 out of 53,026

GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways

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  • Site-wide: 2,112 out of 53,026
  • In genetics: 208 out of 3,086
• Year to date:
  • Site-wide: 15,855 out of 53,026
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  • Site-wide: 18,648 out of 53,026

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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  • In genetics: 215 out of 3,086
• Year to date:
  • Site-wide: 26,324 out of 53,026
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  • Site-wide: 27,723 out of 53,026

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

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  • Site-wide: 2,401 out of 53,026
  • In genomics: 501 out of 3,782
• Year to date:
  • Site-wide: 32,612 out of 53,026
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  • Site-wide: 43,566 out of 53,026

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • Site-wide: 2,794 out of 53,026
  • In genetics: 256 out of 3,086
• Year to date:
  • Site-wide: 38,799 out of 53,026
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  • Site-wide: 33,280 out of 53,026

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson's Disease

• Downloaded 1,437 times
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  • Site-wide: 3,208 out of 53,026
  • In genomics: 630 out of 3,782
• Year to date:
  • Site-wide: 319 out of 53,026
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  • Site-wide: 1,587 out of 53,026

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 4,128 out of 53,026
  • In genomics: 758 out of 3,782
• Year to date:
  • Site-wide: 13,306 out of 53,026
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  • Site-wide: 14,013 out of 53,026

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

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  • Site-wide: 5,561 out of 53,026
  • In genomics: 953 out of 3,782
• Year to date:
  • Site-wide: 29,279 out of 53,026
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  • Site-wide: 30,751 out of 53,026

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinsons disease

• Downloaded 973 times
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  • Site-wide: 6,019 out of 53,026
  • In genomics: 1,007 out of 3,782
• Year to date:
  • Site-wide: 700 out of 53,026
• Since beginning of last month:
  • Site-wide: 3,680 out of 53,026

Evaluation Of Chromatin Accessibility In Prefrontal Cortex Of Schizophrenia Cases And Controls

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  • Site-wide: 6,347 out of 53,026
  • In genomics: 1,055 out of 3,782
• Year to date:
  • Site-wide: 34,869 out of 53,026
• Since beginning of last month:
  • Site-wide: 46,701 out of 53,026

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

• Downloaded 883 times
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  • Site-wide: 7,036 out of 53,026
  • In genetics: 566 out of 3,086
• Year to date:
  • Site-wide: 2,291 out of 53,026
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  • Site-wide: 4,480 out of 53,026

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

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  • Site-wide: 7,265 out of 53,026
  • In genomics: 1,154 out of 3,782
• Year to date:
  • Site-wide: 33,821 out of 53,026
• Since beginning of last month:
  • Site-wide: 22,866 out of 53,026

Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.

• Downloaded 833 times
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  • Site-wide: 7,681 out of 53,026
  • In genetics: 604 out of 3,086
• Year to date:
  • Site-wide: 9,528 out of 53,026
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  • Site-wide: 13,646 out of 53,026

Common Variant Associations with Fragile X Syndrome

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  • Site-wide: 9,694 out of 53,026
  • In genetics: 715 out of 3,086
• Year to date:
  • Site-wide: 13,416 out of 53,026
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  • Site-wide: 17,225 out of 53,026

Building a schizophrenia genetic network: Transcription Factor 4 regulates genes involved in neuronal development and schizophrenia risk.

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  • Site-wide: 12,012 out of 53,026
  • In genetics: 874 out of 3,086
• Year to date:
  • Site-wide: 19,497 out of 53,026
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  • Site-wide: 22,528 out of 53,026

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

• Downloaded 508 times
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  • Site-wide: 15,197 out of 53,026
  • In genetics: 1,075 out of 3,086
• Year to date:
  • Site-wide: 13,231 out of 53,026
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  • Site-wide: 19,639 out of 53,026

Proof of concept: Molecular prediction of schizophrenia risk

• Downloaded 473 times
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  • Site-wide: 16,587 out of 53,026
  • In genomics: 2,042 out of 3,782
• Year to date:
  • Site-wide: 45,996 out of 53,026
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  • Site-wide: 45,965 out of 53,026

Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes

• Downloaded 435 times
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  • Site-wide: 18,265 out of 53,026
  • In genomics: 2,165 out of 3,782
• Year to date:
  • Site-wide: 16,539 out of 53,026
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  • Site-wide: 20,409 out of 53,026

The Anorexia Nervosa Genetics Initiative: Overview and Methods

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  • Site-wide: 19,286 out of 53,026
  • In genetics: 1,332 out of 3,086
• Year to date:
  • Site-wide: 28,038 out of 53,026
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  • Site-wide: 36,100 out of 53,026

Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

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  • Site-wide: 25,213 out of 53,026
  • In genetics: 1,674 out of 3,086
• Year to date:
  • Site-wide: 4,845 out of 53,026
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  • Site-wide: 8,842 out of 53,026

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • Site-wide: 26,843 out of 53,026
  • In genetics: 1,776 out of 3,086
• Year to date:
  • Site-wide: 5,429 out of 53,026
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  • Site-wide: 6,756 out of 53,026

Genetic variation in the Major Histocompatibility Complex and association with depression

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  • Site-wide: 32,502 out of 53,026
  • In genetics: 2,076 out of 3,086
• Year to date:
  • Site-wide: 22,785 out of 53,026
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  • Site-wide: 29,762 out of 53,026

mTADA: a framework for analyzing de novo mutations in multiple traits

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  • Site-wide: 39,749 out of 53,026
  • In genomics: 3,330 out of 3,782
• Year to date:
  • Site-wide: 38,183 out of 53,026
• Since beginning of last month:
  • Site-wide: 40,971 out of 53,026

Genetic comorbidity between major depression and cardio-metabolic disease, stratified by age at onset of major depression.

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  • Site-wide: 42,461 out of 53,026
  • In genetics: 2,599 out of 3,086
• Year to date:
  • Site-wide: 15,455 out of 53,026
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  • Site-wide: 2,649 out of 53,026