Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,594 bioRxiv papers from 298,341 authors.

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • In genetics: 14 out of 3,799
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Genomewide association study identifies 30 loci associated with bipolar disorder

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Common risk variants identified in autism spectrum disorder

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Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways

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  • In genetics: 53 out of 3,799
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Regulatory variants explain much more heritability than coding variants across 11 common diseases

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

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  • Site-wide: 4,818 out of 67,594

Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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• Year to date:
  • Site-wide: 6,357 out of 67,594
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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • In genomics: 252 out of 4,581
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  • Site-wide: 215 out of 67,594
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  • Site-wide: 1,222 out of 67,594

Psychiatric Genomics: An Update and an Agenda

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  • In genetics: 97 out of 3,799
• Year to date:
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Integrative approaches for large-scale transcriptome-wide association studies

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  • In genetics: 143 out of 3,799
• Year to date:
  • Site-wide: 23,063 out of 67,594
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  • Site-wide: 63,465 out of 67,594

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

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  • In genomics: 386 out of 4,581
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  • Site-wide: 40,504 out of 67,594

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson's Disease

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  • In genomics: 403 out of 4,581
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  • Site-wide: 402 out of 67,594
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  • Site-wide: 1,902 out of 67,594

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

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  • In genetics: 177 out of 3,799
• Year to date:
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  • Site-wide: 21,909 out of 67,594

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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  • Site-wide: 60,073 out of 67,594

GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways

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  • In genetics: 234 out of 3,799
• Year to date:
  • Site-wide: 19,223 out of 67,594
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  • Site-wide: 22,010 out of 67,594

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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  • In genetics: 250 out of 3,799
• Year to date:
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  • Site-wide: 59,083 out of 67,594

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

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  • In genomics: 583 out of 4,581
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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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  • In genetics: 302 out of 3,799
• Year to date:
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  • Site-wide: 61,517 out of 67,594

Comparative genetic architectures of schizophrenia in East Asian and European populations

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  • In genetics: 313 out of 3,799
• Year to date:
  • Site-wide: 2,321 out of 67,594
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  • Site-wide: 1,291 out of 67,594

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

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  • In genomics: 809 out of 4,581
• Year to date:
  • Site-wide: 1,104 out of 67,594
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  • Site-wide: 7,309 out of 67,594

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • In genomics: 889 out of 4,581
• Year to date:
  • Site-wide: 22,173 out of 67,594
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  • Site-wide: 55,104 out of 67,594

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

• Downloaded 1,256 times
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  • In genetics: 429 out of 3,799
• Year to date:
  • Site-wide: 2,527 out of 67,594
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  • Site-wide: 5,120 out of 67,594

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

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  • In genomics: 932 out of 4,581
• Year to date:
  • Site-wide: 15,472 out of 67,594
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  • Site-wide: 17,264 out of 67,594

Evaluation Of Chromatin Accessibility In Prefrontal Cortex Of Schizophrenia Cases And Controls

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  • Site-wide: 13,141 out of 67,594

Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.

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  • In genetics: 649 out of 3,799
• Year to date:
  • Site-wide: 14,002 out of 67,594
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  • Site-wide: 37,662 out of 67,594

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

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  • In genetics: 661 out of 3,799
• Year to date:
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  • Site-wide: 15,674 out of 67,594

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

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  • In genomics: 1,384 out of 4,581
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  • Site-wide: 60,937 out of 67,594

Functional consequences of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

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  • In genomics: 1,433 out of 4,581
• Year to date:
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  • Site-wide: 57,604 out of 67,594

Building a schizophrenia genetic network: Transcription Factor 4 regulates genes involved in neuronal development and schizophrenia risk.

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  • In genetics: 771 out of 3,799
• Year to date:
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  • Site-wide: 16,712 out of 67,594

Common Variant Associations with Fragile X Syndrome

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  • In genetics: 788 out of 3,799
• Year to date:
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Functional partitioning of local and distal gene expression regulation in multiple human tissues

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Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • Site-wide: 48,317 out of 67,594

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • In genetics: 1,196 out of 3,799
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  • Site-wide: 4,757 out of 67,594

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes

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Proof of concept: Molecular prediction of schizophrenia risk

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The Anorexia Nervosa Genetics Initiative: Overview and Methods

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Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

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Genetic variation in the Major Histocompatibility Complex and association with depression

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Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • Site-wide: 23,499 out of 67,594

Schizophrenia is characterized by age- and sex-specific effects on epigenetic aging

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  • Site-wide: 8,996 out of 67,594

mTADA: a framework for analyzing de novo mutations in multiple traits

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Association Tests Using Copy Number Profile Curves (CONCUR) Enhances Power in Rare Copy Number Variant Analysis

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