Author: Patrick F Sullivan

Downloads per author, site-wide

Preprints

Analysis of protein-coding genetic variation in 60,706 humans

• Downloaded 22,018 times
• Download rankings, all-time:
  • Site-wide: 307
  • In genomics: 11
• Year to date:
  • Site-wide: 23,912
• Since beginning of last month:
  • Site-wide: 19,435

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

• Downloaded 11,275 times
• Download rankings, all-time:
  • Site-wide: 681
  • In genetics: 18
• Year to date:
  • Site-wide: 2,673
• Since beginning of last month:
  • Site-wide: 1,300

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,392 times
• Download rankings, all-time:
  • Site-wide: 870
  • In genetics: 26
• Year to date:
  • Site-wide: 31,379
• Since beginning of last month:
  • Site-wide: 33,428

Common risk variants identified in autism spectrum disorder

• Downloaded 7,982 times
• Download rankings, all-time:
  • Site-wide: 1,070
  • In genetics: 32
• Year to date:
  • Site-wide: 2,250
• Since beginning of last month:
  • Site-wide: 2,190

Genomewide association study identifies 30 loci associated with bipolar disorder

• Downloaded 7,323 times
• Download rankings, all-time:
  • Site-wide: 1,202
  • In genetics: 38
• Year to date:
  • Site-wide: 18,472
• Since beginning of last month:
  • Site-wide: 18,114

Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways

• Downloaded 5,261 times
• Download rankings, all-time:
  • Site-wide: 1,855
  • In genetics: 66
• Year to date:
  • Site-wide: 20,192
• Since beginning of last month:
  • Site-wide: 16,026

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

• Downloaded 5,211 times
• Download rankings, all-time:
  • Site-wide: 1,875
  • In genetics: 68
• Year to date:
  • Site-wide: 33,272
• Since beginning of last month:
  • Site-wide: 38,740

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

• Downloaded 5,203 times
• Download rankings, all-time:
  • Site-wide: 1,881
  • In genetics: 69
• Year to date:
  • Site-wide: 21,438
• Since beginning of last month:
  • Site-wide: 21,527

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

• Downloaded 4,757 times
• Download rankings, all-time:
  • Site-wide: 2,137
  • In genomics: 225
• Year to date:
  • Site-wide: 16,132
• Since beginning of last month:
  • Site-wide: 20,746

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 4,537 times
• Download rankings, all-time:
  • Site-wide: 2,276
  • In genetics: 85
• Year to date:
  • Site-wide: 30,876
• Since beginning of last month:
  • Site-wide: 29,027

Regulatory variants explain much more heritability than coding variants across 11 common diseases

• Downloaded 4,463 times
• Download rankings, all-time:
  • Site-wide: 2,330
  • In genetics: 87
• Year to date:
  • Site-wide: 83,091
• Since beginning of last month:
  • Site-wide: 71,983

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s Disease

• Downloaded 4,176 times
• Download rankings, all-time:
  • Site-wide: 2,558
  • In genomics: 287
• Year to date:
  • Site-wide: 10,812
• Since beginning of last month:
  • Site-wide: 11,310

Genetic Identification Of Brain Cell Types Underlying Schizophrenia

• Downloaded 3,600 times
• Download rankings, all-time:
  • Site-wide: 3,193
  • In genomics: 361
• Year to date:
  • Site-wide: 72,289
• Since beginning of last month:
  • Site-wide: 56,012

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

• Downloaded 3,367 times
• Download rankings, all-time:
  • Site-wide: 3,509
  • In genetic and genomic medicine: 11
• Year to date:
  • Site-wide: 975
• Since beginning of last month:
  • Site-wide: 1,028

Psychiatric Genomics: An Update and an Agenda

• Downloaded 3,361 times
• Download rankings, all-time:
  • Site-wide: 3,523
  • In genetics: 138
• Year to date:
  • Site-wide: 65,582
• Since beginning of last month:
  • Site-wide: 63,116

Integrative approaches for large-scale transcriptome-wide association studies

• Downloaded 2,907 times
• Download rankings, all-time:
  • Site-wide: 4,318
  • In genetics: 191
• Year to date:
  • Site-wide: 38,024
• Since beginning of last month:
  • Site-wide: 37,050

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathways

• Downloaded 2,577 times
• Download rankings, all-time:
  • Site-wide: 5,131
  • In genetics: 231
• Year to date:
  • Site-wide: 69,852
• Since beginning of last month:
  • Site-wide: 66,276

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

• Downloaded 2,569 times
• Download rankings, all-time:
  • Site-wide: 5,161
  • In genomics: 579
• Year to date:
  • Site-wide: 118,774
• Since beginning of last month:
  • Site-wide: 112,376

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

• Downloaded 2,489 times
• Download rankings, all-time:
  • Site-wide: 5,422
  • In genetics: 249
• Year to date:
  • Site-wide: 15,745
• Since beginning of last month:
  • Site-wide: 18,128

Comparative genetic architectures of schizophrenia in East Asian and European populations

• Downloaded 2,303 times
• Download rankings, all-time:
  • Site-wide: 6,084
  • In genetics: 286
• Year to date:
  • Site-wide: 27,227
• Since beginning of last month:
  • Site-wide: 23,968

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

• Downloaded 2,301 times
• Download rankings, all-time:
  • Site-wide: 6,093
  • In genetics: 287
• Year to date:
  • Site-wide: 106,059
• Since beginning of last month:
  • Site-wide: 89,354

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

• Downloaded 2,269 times
• Download rankings, all-time:
  • Site-wide: 6,218
  • In genetics: 295
• Year to date:
  • Site-wide: 8,411
• Since beginning of last month:
  • Site-wide: 8,755

GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways

• Downloaded 2,246 times
• Download rankings, all-time:
  • Site-wide: 6,306
  • In genetics: 300
• Year to date:
  • Site-wide: 44,732
• Since beginning of last month:
  • Site-wide: 33,609

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

• Downloaded 2,120 times
• Download rankings, all-time:
  • Site-wide: 6,861
  • In psychiatry and clinical psychology: 23
• Year to date:
  • Site-wide: 1,382
• Since beginning of last month:
  • Site-wide: 772

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

• Downloaded 1,980 times
• Download rankings, all-time:
  • Site-wide: 7,579
  • In genomics: 825
• Year to date:
  • Site-wide: 86,222
• Since beginning of last month:
  • Site-wide: 89,225

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

• Downloaded 1,967 times
• Download rankings, all-time:
  • Site-wide: 7,663
  • In genomics: 836
• Year to date:
  • Site-wide: 44,587
• Since beginning of last month:
  • Site-wide: 62,298

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,791 times
• Download rankings, all-time:
  • Site-wide: 8,817
  • In genetics: 414
• Year to date:
  • Site-wide: 47,910
• Since beginning of last month:
  • Site-wide: 56,252

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

• Downloaded 1,497 times
• Download rankings, all-time:
  • Site-wide: 11,449
  • In genetics: 552
• Year to date:
  • Site-wide: 17,494
• Since beginning of last month:
  • Site-wide: 20,739

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

• Downloaded 1,467 times
• Download rankings, all-time:
  • Site-wide: 11,803
  • In genomics: 1,287
• Year to date:
  • Site-wide: 75,321
• Since beginning of last month:
  • Site-wide: 112,549

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,458 times
• Download rankings, all-time:
  • Site-wide: 11,925
  • In genomics: 1,296
• Year to date:
  • Site-wide: 74,651
• Since beginning of last month:
  • Site-wide: 75,484

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

• Downloaded 1,214 times
• Download rankings, all-time:
  • Site-wide: 15,785
  • In genetics: 780
• Year to date:
  • Site-wide: 64,942
• Since beginning of last month:
  • Site-wide: 56,563

Evaluation Of Chromatin Accessibility In Prefrontal Cortex Of Schizophrenia Cases And Controls

• Downloaded 1,163 times
• Download rankings, all-time:
  • Site-wide: 16,829
  • In genomics: 1,740
• Year to date:
  • Site-wide: 103,025
• Since beginning of last month:
  • Site-wide: 108,073

Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.

• Downloaded 1,128 times
• Download rankings, all-time:
  • Site-wide: 17,600
  • In genetics: 860
• Year to date:
  • Site-wide: 82,993
• Since beginning of last month:
  • Site-wide: 71,902

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

• Downloaded 1,070 times
• Download rankings, all-time:
  • Site-wide: 19,018
  • In genetics: 924
• Year to date:
  • Site-wide: 3,734
• Since beginning of last month:
  • Site-wide: 3,712

Functional consequences of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

• Downloaded 1,033 times
• Download rankings, all-time:
  • Site-wide: 20,040
  • In genomics: 2,010
• Year to date:
  • Site-wide: 98,515
• Since beginning of last month:
  • Site-wide: 96,639

Building a schizophrenia genetic network: Transcription Factor 4 regulates genes involved in neuronal development and schizophrenia risk.

• Downloaded 1,030 times
• Download rankings, all-time:
  • Site-wide: 20,106
  • In genetics: 968
• Year to date:
  • Site-wide: 101,955
• Since beginning of last month:
  • Site-wide: 79,466

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

• Downloaded 1,023 times
• Download rankings, all-time:
  • Site-wide: 20,312
  • In genomics: 2,031
• Year to date:
  • Site-wide: 90,243
• Since beginning of last month:
  • Site-wide: 87,382

Functional partitioning of local and distal gene expression regulation in multiple human tissues

• Downloaded 856 times
• Download rankings, all-time:
  • Site-wide: 26,213
  • In genomics: 2,457
• Year to date:
  • Site-wide: 132,160
• Since beginning of last month:
  • Site-wide: 117,281

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

• Downloaded 838 times
• Download rankings, all-time:
  • Site-wide: 26,994
  • In genetics: 1,308
• Year to date:
  • Site-wide: 72,025
• Since beginning of last month:
  • Site-wide: 62,252

Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes

• Downloaded 765 times
• Download rankings, all-time:
  • Site-wide: 30,716
  • In genomics: 2,764
• Year to date:
  • Site-wide: 65,240
• Since beginning of last month:
  • Site-wide: 90,757

Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

• Downloaded 759 times
• Download rankings, all-time:
  • Site-wide: 31,066
  • In genetics: 1,500
• Year to date:
  • Site-wide: 95,090
• Since beginning of last month:
  • Site-wide: 109,460

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 733 times
• Download rankings, all-time:
  • Site-wide: 32,629
  • In genetics: 1,580
• Year to date:
  • Site-wide: 12,356
• Since beginning of last month:
  • Site-wide: 8,423

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

• Downloaded 717 times
• Download rankings, all-time:
  • Site-wide: 33,558
  • In genetics: 1,624
• Year to date:
  • Site-wide: 114,927
• Since beginning of last month:
  • Site-wide: 95,301

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

• Downloaded 711 times
• Download rankings, all-time:
  • Site-wide: 33,922
  • In genetics: 1,641
• Year to date:
  • Site-wide: 79,770
• Since beginning of last month:
  • Site-wide: 71,916

Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.

• Downloaded 670 times
• Download rankings, all-time:
  • Site-wide: 36,785
  • In genomics: 3,139
• Year to date:
  • Site-wide: 27,772
• Since beginning of last month:
  • Site-wide: 25,095

Proof of concept: Molecular prediction of schizophrenia risk

• Downloaded 639 times
• Download rankings, all-time:
  • Site-wide: 39,097
  • In genomics: 3,279
• Year to date:
  • Site-wide: 110,523
• Since beginning of last month:
  • Site-wide: 89,184

Schizophrenia is characterized by age- and sex-specific effects on epigenetic aging

• Downloaded 591 times
• Download rankings, all-time:
  • Site-wide: 43,166
  • In genomics: 3,518
• Year to date:
  • Site-wide: 14,288
• Since beginning of last month:
  • Site-wide: 13,937

Characterization of single gene copy number variants in schizophrenia

• Downloaded 459 times
• Download rankings, all-time:
  • Site-wide: 58,071
  • In genetics: 2,698
• Year to date:
  • Site-wide: 120,271
• Since beginning of last month:
  • Site-wide: 129,030

Genetic variation in the Major Histocompatibility Complex and association with depression

• Downloaded 429 times
• Download rankings, all-time:
  • Site-wide: 62,181
  • In genetics: 2,879
• Year to date:
  • Site-wide: 114,327
• Since beginning of last month:
  • Site-wide: 91,073

Association Tests Using Copy Number Profile Curves (CONCUR) Enhances Power in Rare Copy Number Variant Analysis

• Downloaded 329 times
• Download rankings, all-time:
  • Site-wide: 79,325
  • In bioinformatics: 7,292
• Year to date:
  • Site-wide: 119,056
• Since beginning of last month:
  • Site-wide: 112,281

mTADA: a framework for analyzing de novo mutations in multiple traits

• Downloaded 326 times
• Download rankings, all-time:
  • Site-wide: 79,978
  • In genomics: 5,254
• Year to date:
  • Site-wide: 115,023
• Since beginning of last month:
  • Site-wide: 121,502

Genetic heterogeneity and subtypes of major depression

• Downloaded 166 times
• Download rankings, all-time:
  • Site-wide: 114,434
  • In psychiatry and clinical psychology: 488
• Year to date:
  • Site-wide: 14,007
• Since beginning of last month:
  • Site-wide: 4,067

Labile carbon limits late winter microbial activity near Arctic treeline

• Downloaded 139 times
• Download rankings, all-time:
  • Site-wide: 120,024
  • In ecology: 4,284
• Year to date:
  • Site-wide: 122,209
• Since beginning of last month:
  • Site-wide: 133,000

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

• Downloaded 101 times
• Download rankings, all-time:
  • Site-wide: 127,210
  • In genetic and genomic medicine: 618
• Year to date:
  • Site-wide: 25,762
• Since beginning of last month:
  • Site-wide: 8,022