Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,182 bioRxiv papers from 306,456 authors.

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Preprints

Analysis of protein-coding genetic variation in 60,706 humans

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Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

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  • In genetics: 12 out of 3,896
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • In genetics: 14 out of 3,896
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Genomewide association study identifies 30 loci associated with bipolar disorder

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  • In genetics: 33 out of 3,896
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  • Site-wide: 2,118 out of 70,182

Common risk variants identified in autism spectrum disorder

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  • Site-wide: 321 out of 70,182
  • In genetics: 36 out of 3,896
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  • Site-wide: 2,221 out of 70,182
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Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk

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  • Site-wide: 508 out of 70,182
  • In genetics: 50 out of 3,896
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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 525 out of 70,182
  • In genetics: 52 out of 3,896
• Year to date:
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Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways

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  • In genetics: 53 out of 3,896
• Year to date:
  • Site-wide: 8,407 out of 70,182
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Regulatory variants explain much more heritability than coding variants across 11 common diseases

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  • In genetics: 60 out of 3,896
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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

• Downloaded 3,902 times
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  • Site-wide: 752 out of 70,182
  • In genetics: 69 out of 3,896
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  • Site-wide: 3,523 out of 70,182
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  • Site-wide: 5,491 out of 70,182

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

• Downloaded 3,679 times
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  • In genomics: 217 out of 4,699
• Year to date:
  • Site-wide: 395 out of 70,182
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  • Site-wide: 243 out of 70,182

Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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  • In genomics: 244 out of 4,699
• Year to date:
  • Site-wide: 9,887 out of 70,182
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  • Site-wide: 39,113 out of 70,182

Psychiatric Genomics: An Update and an Agenda

• Downloaded 3,139 times
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  • Site-wide: 1,144 out of 70,182
  • In genetics: 99 out of 3,896
• Year to date:
  • Site-wide: 9,174 out of 70,182
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  • Site-wide: 40,126 out of 70,182

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s Disease

• Downloaded 2,690 times
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  • Site-wide: 1,493 out of 70,182
  • In genomics: 337 out of 4,699
• Year to date:
  • Site-wide: 586 out of 70,182
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  • Site-wide: 439 out of 70,182

Integrative approaches for large-scale transcriptome-wide association studies

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  • Site-wide: 1,528 out of 70,182
  • In genetics: 146 out of 3,896
• Year to date:
  • Site-wide: 27,180 out of 70,182
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  • Site-wide: 36,106 out of 70,182

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

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  • Site-wide: 1,788 out of 70,182
  • In genomics: 395 out of 4,699
• Year to date:
  • Site-wide: 29,376 out of 70,182
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  • Site-wide: 23,011 out of 70,182

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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  • Site-wide: 2,160 out of 70,182
  • In genetics: 200 out of 3,896
• Year to date:
  • Site-wide: 37,540 out of 70,182
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  • Site-wide: 62,459 out of 70,182

GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways

• Downloaded 1,988 times
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  • Site-wide: 2,572 out of 70,182
  • In genetics: 239 out of 3,896
• Year to date:
  • Site-wide: 6,638 out of 70,182
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  • Site-wide: 19,460 out of 70,182

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

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  • In genetics: 252 out of 3,896
• Year to date:
  • Site-wide: 24,036 out of 70,182
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  • Site-wide: 32,164 out of 70,182

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

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  • Site-wide: 3,058 out of 70,182
  • In genomics: 600 out of 4,699
• Year to date:
  • Site-wide: 56,442 out of 70,182
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  • Site-wide: 27,343 out of 70,182

Comparative genetic architectures of schizophrenia in East Asian and European populations

• Downloaded 1,694 times
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  • Site-wide: 3,364 out of 70,182
  • In genetics: 286 out of 3,896
• Year to date:
  • Site-wide: 2,076 out of 70,182
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  • Site-wide: 2,502 out of 70,182

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,628 times
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  • Site-wide: 3,608 out of 70,182
  • In genetics: 308 out of 3,896
• Year to date:
  • Site-wide: 15,754 out of 70,182
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  • Site-wide: 39,321 out of 70,182

Human loss-of-function variants suggest that partial LRRK2 inhibition is a safe therapeutic strategy for Parkinson’s disease

• Downloaded 1,480 times
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  • Site-wide: 4,263 out of 70,182
  • In genomics: 777 out of 4,699
• Year to date:
  • Site-wide: 3,437 out of 70,182
• Since beginning of last month:
  • Site-wide: 4,683 out of 70,182

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,319 times
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  • Site-wide: 5,154 out of 70,182
  • In genomics: 895 out of 4,699
• Year to date:
  • Site-wide: 36,154 out of 70,182
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  • Site-wide: 22,903 out of 70,182

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

• Downloaded 1,296 times
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  • Site-wide: 5,309 out of 70,182
  • In genetics: 425 out of 3,896
• Year to date:
  • Site-wide: 7,052 out of 70,182
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  • Site-wide: 6,088 out of 70,182

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

• Downloaded 1,267 times
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  • Site-wide: 5,506 out of 70,182
  • In genomics: 940 out of 4,699
• Year to date:
  • Site-wide: 10,348 out of 70,182
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  • Site-wide: 31,785 out of 70,182

Evaluation Of Chromatin Accessibility In Prefrontal Cortex Of Schizophrenia Cases And Controls

• Downloaded 1,039 times
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  • Site-wide: 7,658 out of 70,182
  • In genomics: 1,218 out of 4,699
• Year to date:
  • Site-wide: 37,201 out of 70,182
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  • Site-wide: 15,155 out of 70,182

Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.

• Downloaded 960 times
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  • Site-wide: 8,758 out of 70,182
  • In genetics: 660 out of 3,896
• Year to date:
  • Site-wide: 15,722 out of 70,182
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  • Site-wide: 27,410 out of 70,182

Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause

• Downloaded 934 times
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  • Site-wide: 9,155 out of 70,182
  • In genetics: 685 out of 3,896
• Year to date:
  • Site-wide: 27,243 out of 70,182
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  • Site-wide: 42,011 out of 70,182

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

• Downloaded 929 times
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  • Site-wide: 9,230 out of 70,182
  • In genomics: 1,404 out of 4,699
• Year to date:
  • Site-wide: 13,355 out of 70,182
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  • Site-wide: 49,528 out of 70,182

Functional consequences of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

• Downloaded 897 times
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  • Site-wide: 9,723 out of 70,182
  • In genomics: 1,452 out of 4,699
• Year to date:
  • Site-wide: 33,743 out of 70,182
• Since beginning of last month:
  • Site-wide: 45,413 out of 70,182

Building a schizophrenia genetic network: Transcription Factor 4 regulates genes involved in neuronal development and schizophrenia risk.

• Downloaded 847 times
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  • Site-wide: 10,666 out of 70,182
  • In genetics: 772 out of 3,896
• Year to date:
  • Site-wide: 17,679 out of 70,182
• Since beginning of last month:
  • Site-wide: 10,839 out of 70,182

Common Variant Associations with Fragile X Syndrome

• Downloaded 836 times
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  • Site-wide: 10,911 out of 70,182
  • In genetics: 794 out of 3,896
• Year to date:
  • Site-wide: 12,378 out of 70,182
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  • Site-wide: 32,545 out of 70,182

Functional partitioning of local and distal gene expression regulation in multiple human tissues

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  • In genomics: 1,695 out of 4,699
• Year to date:
  • Site-wide: 37,010 out of 70,182
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  • Site-wide: 66,941 out of 70,182

Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders

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  • Site-wide: 15,682 out of 70,182
  • In genetics: 1,064 out of 3,896
• Year to date:
  • Site-wide: 4,498 out of 70,182
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  • Site-wide: 5,085 out of 70,182

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • Site-wide: 17,239 out of 70,182
  • In genetics: 1,174 out of 3,896
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  • Site-wide: 58,403 out of 70,182

Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes

• Downloaded 567 times
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  • Site-wide: 19,036 out of 70,182
  • In genomics: 2,269 out of 4,699
• Year to date:
  • Site-wide: 7,819 out of 70,182
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  • Site-wide: 29,960 out of 70,182

Robust Hi-C chromatin loop maps in human neurogenesis and brain tissues at high-resolution

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  • Site-wide: 19,112 out of 70,182
  • In genomics: 2,280 out of 4,699
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  • Site-wide: 9,454 out of 70,182
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  • Site-wide: 5,869 out of 70,182

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

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  • Site-wide: 19,174 out of 70,182
  • In genetics: 1,272 out of 3,896
• Year to date:
  • Site-wide: 41,016 out of 70,182
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  • Site-wide: 41,582 out of 70,182

Proof of concept: Molecular prediction of schizophrenia risk

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  • In genomics: 2,427 out of 4,699
• Year to date:
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  • Site-wide: 25,363 out of 70,182

The Anorexia Nervosa Genetics Initiative: Overview and Methods

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  • In genetics: 1,477 out of 3,896
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  • Site-wide: 34,355 out of 70,182

Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

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  • In genetics: 1,596 out of 3,896
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  • Site-wide: 29,220 out of 70,182

Characterization of single gene copy number variants in schizophrenia

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  • In genetics: 2,127 out of 3,896
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  • Site-wide: 26,022 out of 70,182
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  • Site-wide: 26,768 out of 70,182

Genetic variation in the Major Histocompatibility Complex and association with depression

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  • Site-wide: 38,265 out of 70,182
  • In genetics: 2,347 out of 3,896
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  • Site-wide: 45,644 out of 70,182
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  • Site-wide: 54,810 out of 70,182

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • Site-wide: 39,804 out of 70,182
  • In genetics: 2,429 out of 3,896
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  • Site-wide: 32,699 out of 70,182
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  • Site-wide: 26,873 out of 70,182

Schizophrenia is characterized by age- and sex-specific effects on epigenetic aging

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  • Site-wide: 42,924 out of 70,182
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  • Site-wide: 36,509 out of 70,182

Association Tests Using Copy Number Profile Curves (CONCUR) Enhances Power in Rare Copy Number Variant Analysis

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  • Site-wide: 50,102 out of 70,182
  • In bioinformatics: 5,555 out of 6,883
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  • Site-wide: 18,818 out of 70,182

mTADA: a framework for analyzing de novo mutations in multiple traits

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  • Site-wide: 66,001 out of 70,182

Antipsychotic behavioral phenotypes in the mouse Collaborative Cross recombinant inbred inter-crosses (RIX)

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  • Site-wide: 47,705 out of 70,182