Author: Yang Liu

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Preprints

Cross-reactive TCR with alloreactivity for immunodominant HIV-1 epitope Gag TL9 with enhanced control of viral infection

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High-Spatial-Resolution Multi-Omics Atlas Sequencing of Mouse Embryos via Deterministic Barcoding in Tissue

• Downloaded 5,888 times
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  • Site-wide: 1,750
  • In genomics: 153
• Year to date:
  • Site-wide: 1,615
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  • Site-wide: 1,755

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

• Downloaded 4,859 times
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  • Site-wide: 2,265
  • In cell biology: 39
• Year to date:
  • Site-wide: 3,908
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  • Site-wide: 3,991

A portable and cost-effective microfluidic system for massively parallel single-cell transcriptome profiling

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  • Site-wide: 2,284
  • In genomics: 232
• Year to date:
  • Site-wide: 7,352
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  • Site-wide: 5,516

Enhancing Intracellular Accumulation and Target Engagement of PROTACs with Reversible Covalent Chemistry

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  • Site-wide: 3,871
  • In pharmacology and toxicology: 21
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  • Site-wide: 22,040
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  • Site-wide: 34,623

Direct preparation of Cas9 ribonucleoprotein from E. coli for PCR-free seamless DNA assembly

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  • Site-wide: 4,009
  • In synthetic biology: 39
• Year to date:
  • Site-wide: 15,429
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  • Site-wide: 17,089

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers

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  • Site-wide: 4,748
  • In cancer biology: 66
• Year to date:
  • Site-wide: 33,155
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  • Site-wide: 34,299

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

• Downloaded 2,805 times
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  • Site-wide: 4,942
  • In microbiology: 309
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  • Site-wide: 5,767
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  • Site-wide: 8,058

Augmented Reality Powers a Cognitive Prosthesis for the Blind

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  • Site-wide: 5,639
  • In animal behavior and cognition: 34
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  • Site-wide: 37,720
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  • Site-wide: 16,532

Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity

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  • Site-wide: 5,783
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  • Site-wide: 112,205
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  • Site-wide: 117,993

Expanding diversity of Asgard archaea and the elusive ancestry of eukaryotes

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  • Site-wide: 8,624
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  • Site-wide: 3,282
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  • Site-wide: 3,926

Evolutionary context-integrated deep sequence modeling for protein engineering

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  • Site-wide: 8,946
  • In bioinformatics: 1,059
• Year to date:
  • Site-wide: 10,092
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  • Site-wide: 24,559

Cytotoxicity evaluation of chloroquine and hydroxychloroquine in multiple cell lines and tissues by dynamic imaging system and PBPK model

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  • Site-wide: 11,239
  • In pharmacology and toxicology: 63
• Year to date:
  • Site-wide: 9,783
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  • Site-wide: 19,255

Asgard archaea are diverse, ubiquitous, and transcriptionally active microbes

• Downloaded 1,534 times
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  • Site-wide: 11,972
  • In microbiology: 686
• Year to date:
  • Site-wide: 46,687
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  • Site-wide: 32,586

METABOLIC: High-throughput profiling of microbial genomes for functional traits, biogeochemistry, and community-scale metabolic networks

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  • Site-wide: 12,174
  • In bioinformatics: 1,434
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  • Site-wide: 8,466
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  • Site-wide: 10,027

Deep Genomic Signature for early metastasis prediction in prostate cancer

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  • Site-wide: 14,985
  • In bioinformatics: 1,777
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  • Site-wide: 66,089
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  • Site-wide: 48,107

Single-cell microRNA/mRNA co-sequencing reveals non-genetic heterogeneity and novel regulatory mechanisms

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  • Site-wide: 15,163
  • In systems biology: 286
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  • Site-wide: 51,130
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  • Site-wide: 48,124

Learning Structural Motif Representations For Efficient Protein Structure Search

• Downloaded 1,257 times
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  • Site-wide: 16,241
  • In bioinformatics: 1,922
• Year to date:
  • Site-wide: 110,900
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  • Site-wide: 87,654

Comparative genomics identified a genetic locus in plant-associated Pseudomonas spp. that is necessary for induced systemic susceptibility

• Downloaded 1,191 times
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  • Site-wide: 17,582
  • In plant biology: 239
• Year to date:
  • Site-wide: 47,230
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  • Site-wide: 36,730

RISC: robust integration of single-cell RNA-seq datasets with different extents of cell cluster overlap

• Downloaded 1,167 times
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  • Site-wide: 18,129
  • In bioinformatics: 2,125
• Year to date:
  • Site-wide: 27,760
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  • Site-wide: 15,371

Deciphering signaling specificity with interpretable deep neural networks

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  • Site-wide: 19,951
  • In bioinformatics: 2,338
• Year to date:
  • Site-wide: 100,020
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  • Site-wide: 103,821

Optimizing CRISPR/Cas9 System to Precisely Model Plasminogen Activator Inhibitor-1 Point Mutations in Mice

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  • Site-wide: 20,399
  • In genetics: 963
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  • Site-wide: 50,139
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  • Site-wide: 55,999

Single-nucleus RNA-seq identifies Huntington disease astrocyte states

• Downloaded 1,038 times
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  • Site-wide: 21,542
  • In neuroscience: 2,689
• Year to date:
  • Site-wide: 40,302
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  • Site-wide: 83,780

Mitigating Data Scarcity in Protein Binding Prediction Using Meta-Learning

• Downloaded 986 times
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  • Site-wide: 23,129
  • In bioinformatics: 2,685
• Year to date:
  • Site-wide: 48,696
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  • Site-wide: 38,709

Cyclic-di-GMP is required for corneal infection by Pseudomonas aeruginosa and modulates host immunity

• Downloaded 945 times
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  • Site-wide: 24,741
  • In microbiology: 1,434
• Year to date:
  • Site-wide: 104,972
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  • Site-wide: 79,753

Discovery of the Quiescent Body that Functions as a Biological Timer for Growth Resumption of Non-growing Bacterial Cells

• Downloaded 848 times
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  • Site-wide: 28,818
  • In microbiology: 1,695
• Year to date:
  • Site-wide: 97,216
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  • Site-wide: 100,066

A trans-complementation system for SARS-CoV-2

• Downloaded 847 times
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  • Site-wide: 28,867
  • In microbiology: 1,700
• Year to date:
  • Site-wide: 2,680
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  • Site-wide: 19,543

Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

• Downloaded 816 times
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  • Site-wide: 30,391
  • In cancer biology: 798
• Year to date:
  • Site-wide: 92,546
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  • Site-wide: 56,092

Divergence in the face of gene flow in two Charadrius plovers along the Chinese coast

• Downloaded 788 times
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  • Site-wide: 31,889
  • In evolutionary biology: 1,495
• Year to date:
  • Site-wide: 44,556
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  • Site-wide: 100,435

COVID-19 Neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital

• Downloaded 786 times
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  • Site-wide: 32,017
  • In pathology: 142
• Year to date:
  • Site-wide: 2,941
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  • Site-wide: 1,094

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

• Downloaded 771 times
• Download rankings, all-time:
  • Site-wide: 32,862
  • In genomics: 2,870
• Year to date:
  • Site-wide: 113,654
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  • Site-wide: 119,668

WindSTORM: Robust online image processing for high-throughput nanoscopy

• Downloaded 760 times
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  • Site-wide: 33,497
  • In bioinformatics: 3,716
• Year to date:
  • Site-wide: 106,679
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  • Site-wide: 123,198

Highly diverse Asgard archaea participate in organic matter degradation in coastal sediments

• Downloaded 756 times
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  • Site-wide: 33,732
  • In microbiology: 2,021
• Year to date:
  • Site-wide: 73,872
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  • Site-wide: 68,909

A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth

• Downloaded 755 times
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  • Site-wide: 33,826
  • In genomics: 2,923
• Year to date:
  • Site-wide: 93,120
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  • Site-wide: 97,260

Enhanced super-resolution microscopy by extreme value based emitter recovery

• Downloaded 717 times
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  • Site-wide: 36,277
  • In cell biology: 1,424
• Year to date:
  • Site-wide: 61,477
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  • Site-wide: 89,198

Comparative analyses of 3654 chloroplast genomes unraveled new insights into the evolutionary mechanism of green plants

• Downloaded 688 times
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  • Site-wide: 38,388
  • In plant biology: 797
• Year to date:
  • Site-wide: 62,524
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  • Site-wide: 73,571

The histone chaperone FACT modulates nucleosome structure by tethering its components

• Downloaded 687 times
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  • Site-wide: 38,501
  • In biochemistry: 950
• Year to date:
  • Site-wide: 81,549
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  • Site-wide: 98,072

Spatiotemporal Gene Coexpression and Regulation in Mouse Cardiomyocytes of Early Cardiac Morphogenesis

• Downloaded 684 times
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  • Site-wide: 38,743
  • In genetics: 1,793
• Year to date:
  • Site-wide: 101,549
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  • Site-wide: 108,049

Integrative proteomics reveals exceptional diversity and versatility of mammalian humoral immunity

• Downloaded 672 times
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  • Site-wide: 39,576
  • In bioengineering: 724
• Year to date:
  • Site-wide: 24,947
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  • Site-wide: 69,061

Neo-sex chromosomes, genetic diversity and demographic history in the Critically Endangered Raso lark

• Downloaded 638 times
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  • Site-wide: 42,371
  • In genomics: 3,459
• Year to date:
  • Site-wide: 74,418
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  • Site-wide: 83,546

High-Spatial-Resolution Multi-Omics Atlas Sequencing of Mouse Embryos via Deterministic Barcoding in Tissue

• Downloaded 601 times
• Download rankings, all-time:
  • Site-wide: 45,639
  • In genomics: 3,644
• Year to date:
  • Site-wide: 47,159
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  • Site-wide: 44,495

Rice NIN-LIKE PROTEIN 4 is a master regulator of nitrogen use efficiency

• Downloaded 596 times
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  • Site-wide: 46,092
  • In plant biology: 1,037
• Year to date:
  • Site-wide: 56,236
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  • Site-wide: 27,896

Functional and molecular early enteric biomarkers for Parkinson's disease in mice and men

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  • Site-wide: 55,892
  • In neuroscience: 8,209
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  • Site-wide: 29,579
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  • Site-wide: 31,448

Genome and community-level interaction insights on wide carbon utilizing and element cycling function of Hydrothermarchaeota from hydrothermal sediment

• Downloaded 494 times
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  • Site-wide: 57,691
  • In ecology: 1,510
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  • Site-wide: 96,114
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  • Site-wide: 85,216

Widespread Inter-Chromosomal Epistasis Regulates Glucose Homeostasis And Gene Expression

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  • Site-wide: 57,810
  • In genetics: 2,632
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  • Site-wide: 130,260
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  • Site-wide: 82,580

Treatment of Graft-versus-Host Disease by Echinomycin in a New Humanized Mouse Model

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  • Site-wide: 59,789
  • In immunology: 1,729
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  • Site-wide: 40,904

Measurement of the torque in braided DNAs using a thermodynamic Maxwell relation

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  • Site-wide: 64,656
  • In biophysics: 2,294
• Year to date:
  • Site-wide: 101,225
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  • Site-wide: 44,420

Screening of FDA-approved Drugs and Identification of Novel Lassa Virus Entry Inhibitors

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  • Site-wide: 64,942
  • In microbiology: 4,290
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  • Site-wide: 126,059
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  • Site-wide: 126,221

Molecular basis of P[6] and P[8] major human rotavirus VP8* domain interactions with histo-blood group antigens

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  • Site-wide: 67,625
  • In biochemistry: 1,850
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  • Site-wide: 110,653

Draft genome of the aquatic moss Fontinalis antipyretica (Fontinalaceae, Bryophyta)

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  • Site-wide: 69,421
  • In genomics: 4,827
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  • Site-wide: 52,618

Mammalian CST averts replication failure by preventing G-quadruplex accumulation

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  • Site-wide: 70,744
  • In molecular biology: 2,054
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The closed-loop pathways of signaling molecules

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  • Site-wide: 70,782
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  • Site-wide: 91,156
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Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer

• Downloaded 405 times
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  • Site-wide: 70,981
  • In microbiology: 4,772
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  • Site-wide: 41,118
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  • Site-wide: 64,174

Separating an allele associated with late flowering and slow maturation of Arabidopsis thaliana from population structure

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  • Site-wide: 70,999
  • In genetics: 3,194
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  • Site-wide: 116,169
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  • Site-wide: 126,468

Ectomycorrhizal fungi induce systemic resistance against insects on a non-mycorrhizal plant in a CERK1-dependent manner

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  • Site-wide: 71,951
  • In plant biology: 1,860
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  • Site-wide: 114,807

Demographic histories and genome-wide patterns of divergence in incipient species of shorebirds

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  • Site-wide: 72,240
  • In evolutionary biology: 3,850
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  • Site-wide: 108,782
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  • Site-wide: 81,519

Cdc42 is required for lymphatic branching, maturation and valve formation during embryonic development

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  • Site-wide: 83,157
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  • Site-wide: 77,060
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  • Site-wide: 53,384

Out of the Qinghai-Tibetan Plateau and get flourishing - the evolution of Neodon voles (Rodentia: Cricetidae) revealed by systematic sampling and low coverage whole genome sequencing

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  • Site-wide: 88,082
  • In zoology: 342
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  • Site-wide: 93,949
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  • Site-wide: 92,125

Co-evolution of Eukaryotic-like Vps4 and ESCRT-III Subunits in the Asgard Archaea

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  • Site-wide: 91,622
  • In microbiology: 6,494
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  • Site-wide: 137,100

Tapping into non-English-language science for the conservation of global biodiversity

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  • Site-wide: 92,155
  • In scientific communication and education: 528
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  • Site-wide: 12,008
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  • Site-wide: 1,452

The genome assembly and annotation of Magnolia biondii Pamp., a phylogenetically, economically, and medicinally important ornamental tree species

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  • Site-wide: 94,902
  • In plant biology: 2,538
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  • Site-wide: 113,152

Novel Asgard archaea phylum Hermodarchaeota degrade alkanes and aromatics via alkyl/benzyl-succinate synthase and benzoyl-CoA pathway

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  • Site-wide: 99,950
  • In genomics: 5,999
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  • Site-wide: 85,090

Regrowth-delay Body as a Bacterial Subcellular Structure marking multidrug tolerant Persisters

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  • Site-wide: 101,173
  • In microbiology: 7,288
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  • Site-wide: 142,005
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  • Site-wide: 138,779

Emergence of Zika virus: Direct reversion of mutations and fitness restoration prior to spread to the Americas

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  • Site-wide: 103,108
  • In microbiology: 7,461
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  • Site-wide: 92,176
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  • Site-wide: 113,047

Extrasynaptic volume transmission: A novel route for neuropeptide signaling in nematodes

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  • Site-wide: 103,407
  • In neuroscience: 15,875
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  • Site-wide: 55,930
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  • Site-wide: 62,318

Comparative genomics identified a genetic locus in plant-associated Pseudomonas spp. that is necessary for induced systemic susceptibility

• Downloaded 244 times
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  • Site-wide: 104,176
  • In microbiology: 7,545
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  • Site-wide: 121,043
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  • Site-wide: 117,248

SPINK1-induced amelioration of impaired autophagy contributes to suppression of trypsinogen activation in a model of acute pancreatitis

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  • Site-wide: 104,552
  • In molecular biology: 3,107
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  • Site-wide: 105,612

Identification of novel tetracycline resistance gene tet(X14) and its co-occurrence with tet(X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris

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  • Site-wide: 108,512
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  • Site-wide: 74,931

Increase in weighting of vision vs. proprioception associated with force field adaptation

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  • Site-wide: 108,901
  • In neuroscience: 16,723
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  • Site-wide: 142,463
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  • Site-wide: 131,781

Meta-16S rRNA gene phylogenetic reconstruction reveals astonishing diversity of the cosmopolitan myxobacteria

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  • Site-wide: 109,224
  • In microbiology: 7,989
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  • Site-wide: 136,665

Personalized in-silico drug response prediction based on the genetic landscape of muscle-invasive bladder cancer

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  • Site-wide: 110,550
  • In bioinformatics: 9,211
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  • Site-wide: 129,677

IgY antibodies against Ebola virus possess post-exposure protection and excellent thermostability

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  • Site-wide: 110,940
  • In immunology: 3,212
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Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish

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  • Site-wide: 112,801
  • In genetics: 4,827
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A Na2CO3-responsive chitinase gene from Chinese wildrye improve pathogen resistance and saline-alkali stress tolerance in transgenic tobacco and maize

• Downloaded 202 times
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  • Site-wide: 113,879
  • In plant biology: 3,155
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  • Site-wide: 136,638
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  • Site-wide: 126,739

Prototheca zopfii Genotype II induces mitochondrial apoptosis in models of bovine mastitis

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  • Site-wide: 114,579
  • In microbiology: 8,501
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  • Site-wide: 136,132
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  • Site-wide: 141,122

Population genomic analyses of schistosome parasites highlight critical challenges facing end-game elimination efforts

• Downloaded 197 times
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  • Site-wide: 115,215
  • In evolutionary biology: 5,918
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  • Site-wide: 75,800
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High-throughput living-cell protein crosslinking analysis uncovers the physiological relevance of forming the "inserted" state of the ATP synthase ϵ-subunit

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  • Site-wide: 115,677
  • In biochemistry: 3,432
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  • Site-wide: 100,933

DeepMOCCA: A pan-cancer prognostic model identifies personalized prognostic markers through graph attention and multi-omics data integration

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  • In bioinformatics: 9,509
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  • Site-wide: 21,276
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  • Site-wide: 43,081

Src/FAK complex phosphorylates cardiac myosin binding protein c (cMyBP-C) in vitro and in vivo

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  • Site-wide: 118,278
  • In molecular biology: 3,513
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Genetic diversity and evolution of Hantaan virus in China and its neighbors

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  • Site-wide: 120,019
  • In evolutionary biology: 6,108
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  • Site-wide: 120,660
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Predicting Collaborative Learning Quality through Physiological Synchrony Recorded by Wearable Biosensors

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  • Site-wide: 123,652
  • In neuroscience: 18,843
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  • Site-wide: 104,580

The complete plastid genomes of two Fabaceae orphan crops from Africa

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  • Site-wide: 124,161
  • In genomics: 6,746
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Genome diversity and quorum sensing variations in laboratory strains of Pseudomonas aeruginosa PAO1

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Silent dissemination of plasmid-borne tigecycline resistance gene tet(X6) in livestock-associated Acinetobacter towneri

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Impacted Spike Frequency Adaptation Associated with Reduction of KCNQ2/3 Promotes Seizure Activity in Temporal Lobe Epilepsy

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Exploration of Chemical Space with Partial Labeled Noisy Student Self-Training for Improving Deep Learning: Application to Drug Metabolism

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Screening of Botanical Drugs Against Lassa Virus Entry

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Effects of N-linked glycan of Lassa Virus Envelope Glycoprotein on the Immune Response

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