Author: Yang Liu

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Preprints

High-Spatial-Resolution Multi-Omics Atlas Sequencing of Mouse Embryos via Deterministic Barcoding in Tissue

• Downloaded 7,717 times
• Download rankings, all-time:
  • Site-wide: 1,761
  • In genomics: 123
• Year to date:
  • Site-wide: 15,580
• Since beginning of last month:
  • Site-wide: 17,669

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

• Downloaded 5,944 times
• Download rankings, all-time:
  • Site-wide: 2,505
  • In cell biology: 35
• Year to date:
  • Site-wide: 6,645
• Since beginning of last month:
  • Site-wide: 15,699

A portable and cost-effective microfluidic system for massively parallel single-cell transcriptome profiling

• Downloaded 5,707 times
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  • Site-wide: 2,637
  • In genomics: 225
• Year to date:
  • Site-wide: 5,713
• Since beginning of last month:
  • Site-wide: 5,741

Enhancing Intracellular Accumulation and Target Engagement of PROTACs with Reversible Covalent Chemistry

• Downloaded 3,723 times
• Download rankings, all-time:
  • Site-wide: 4,751
  • In pharmacology and toxicology: 25
• Year to date:
  • Site-wide: 42,026
• Since beginning of last month:
  • Site-wide: 31,893

Direct preparation of Cas9 ribonucleoprotein from E. coli for PCR-free seamless DNA assembly

• Downloaded 3,658 times
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  • Site-wide: 4,886
  • In synthetic biology: 42
• Year to date:
  • Site-wide: 31,200
• Since beginning of last month:
  • Site-wide: 24,562

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers

• Downloaded 3,112 times
• Download rankings, all-time:
  • Site-wide: 6,172
  • In cancer biology: 82
• Year to date:
  • Site-wide: 47,924
• Since beginning of last month:
  • Site-wide: 40,545

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

• Downloaded 3,042 times
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  • Site-wide: 6,393
  • In microbiology: 385
• Year to date:
  • Site-wide: 59,827
• Since beginning of last month:
  • Site-wide: 70,381

Augmented Reality Powers a Cognitive Prosthesis for the Blind

• Downloaded 2,998 times
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  • Site-wide: 6,519
  • In animal behavior and cognition: 37
• Year to date:
  • Site-wide: 17,011
• Since beginning of last month:
  • Site-wide: 18,408

Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity

• Downloaded 2,620 times
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  • Site-wide: 7,957
  • In genomics: 727
• Year to date:
  • Site-wide: 142,470
• Since beginning of last month:
  • Site-wide: 114,426

Expanding diversity of Asgard archaea and the elusive ancestry of eukaryotes

• Downloaded 2,562 times
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  • Site-wide: 8,221
  • In genomics: 798
• Year to date:
  • Site-wide: 16,503
• Since beginning of last month:
  • Site-wide: 16,991

Evolutionary context-integrated deep sequence modeling for protein engineering

• Downloaded 2,411 times
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  • Site-wide: 8,969
  • In bioinformatics: 943
• Year to date:
  • Site-wide: 27,348
• Since beginning of last month:
  • Site-wide: 29,768

METABOLIC: High-throughput profiling of microbial genomes for functional traits, biogeochemistry, and community-scale metabolic networks

• Downloaded 2,292 times
• Download rankings, all-time:
  • Site-wide: 9,652
  • In bioinformatics: 1,027
• Year to date:
  • Site-wide: 14,087
• Since beginning of last month:
  • Site-wide: 39,747

Cytotoxicity evaluation of chloroquine and hydroxychloroquine in multiple cell lines and tissues by dynamic imaging system and PBPK model

• Downloaded 1,923 times
• Download rankings, all-time:
  • Site-wide: 12,561
  • In pharmacology and toxicology: 71
• Year to date:
  • Site-wide: 54,697
• Since beginning of last month:
  • Site-wide: 29,833

Asgard archaea are diverse, ubiquitous, and transcriptionally active microbes

• Downloaded 1,675 times
• Download rankings, all-time:
  • Site-wide: 15,399
  • In microbiology: 855
• Year to date:
  • Site-wide: 79,873
• Since beginning of last month:
  • Site-wide: 45,145

Single-cell microRNA/mRNA co-sequencing reveals non-genetic heterogeneity and novel regulatory mechanisms

• Downloaded 1,510 times
• Download rankings, all-time:
  • Site-wide: 18,063
  • In systems biology: 302
• Year to date:
  • Site-wide: 67,646
• Since beginning of last month:
  • Site-wide: 91,818

Deep Genomic Signature for early metastasis prediction in prostate cancer

• Downloaded 1,448 times
• Download rankings, all-time:
  • Site-wide: 19,282
  • In bioinformatics: 2,005
• Year to date:
  • Site-wide: 117,744
• Since beginning of last month:
  • Site-wide: 161,193

COVID-19 Neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital

• Downloaded 1,410 times
• Download rankings, all-time:
  • Site-wide: 20,103
  • In pathology: 97
• Year to date:
  • Site-wide: 22,092
• Since beginning of last month:
  • Site-wide: 11,372

RISC: robust integration of single-cell RNA-seq datasets with different extents of cell cluster overlap

• Downloaded 1,364 times
• Download rankings, all-time:
  • Site-wide: 21,135
  • In bioinformatics: 2,220
• Year to date:
  • Site-wide: 96,924
• Since beginning of last month:
  • Site-wide: 147,986

Comparative genomics identified a genetic locus in plant-associated Pseudomonas spp. that is necessary for induced systemic susceptibility

• Downloaded 1,358 times
• Download rankings, all-time:
  • Site-wide: 21,297
  • In plant biology: 260
• Year to date:
  • Site-wide: 71,949
• Since beginning of last month:
  • Site-wide: 114,235

Learning Structural Motif Representations For Efficient Protein Structure Search

• Downloaded 1,313 times
• Download rankings, all-time:
  • Site-wide: 22,452
  • In bioinformatics: 2,321
• Year to date:
  • Site-wide: 149,735
• Since beginning of last month:
  • Site-wide: 143,272

A trans-complementation system for SARS-CoV-2

• Downloaded 1,207 times
• Download rankings, all-time:
  • Site-wide: 25,590
  • In microbiology: 1,446
• Year to date:
  • Site-wide: 58,190
• Since beginning of last month:
  • Site-wide: 74,632

Deciphering signaling specificity with interpretable deep neural networks

• Downloaded 1,198 times
• Download rankings, all-time:
  • Site-wide: 25,895
  • In bioinformatics: 2,680
• Year to date:
  • Site-wide: 111,268
• Since beginning of last month:
  • Site-wide: 104,021

Optimizing CRISPR/Cas9 System to Precisely Model Plasminogen Activator Inhibitor-1 Point Mutations in Mice

• Downloaded 1,193 times
• Download rankings, all-time:
  • Site-wide: 26,066
  • In genetics: 1,022
• Year to date:
  • Site-wide: 126,024
• Since beginning of last month:
  • Site-wide: 139,527

Massively parallel genomic perturbations with multi-target CRISPR reveal new insights on Cas9 activity and DNA damage responses at endogenous sites

• Downloaded 1,175 times
• Download rankings, all-time:
  • Site-wide: 26,631
  • In cell biology: 1,499
• Year to date:
  • Site-wide: 1,313
• Since beginning of last month:
  • Site-wide: 4,999

Mitigating Data Scarcity in Protein Binding Prediction Using Meta-Learning

• Downloaded 1,162 times
• Download rankings, all-time:
  • Site-wide: 27,117
  • In bioinformatics: 2,816
• Year to date:
  • Site-wide: 117,288
• Since beginning of last month:
  • Site-wide: 114,240

Single-nucleus RNA-seq identifies Huntington disease astrocyte states

• Downloaded 1,146 times
• Download rankings, all-time:
  • Site-wide: 27,713
  • In neuroscience: 3,158
• Year to date:
  • Site-wide: 147,231
• Since beginning of last month:
  • Site-wide: 126,494

Cyclic-di-GMP is required for corneal infection by Pseudomonas aeruginosa and modulates host immunity

• Downloaded 1,025 times
• Download rankings, all-time:
  • Site-wide: 32,726
  • In microbiology: 1,793
• Year to date:
  • Site-wide: 149,349
• Since beginning of last month:
  • Site-wide: 112,100

Highly diverse Asgard archaea participate in organic matter degradation in coastal sediments

• Downloaded 996 times
• Download rankings, all-time:
  • Site-wide: 34,202
  • In microbiology: 2,019
• Year to date:
  • Site-wide: 57,518
• Since beginning of last month:
  • Site-wide: 53,704

Integrative proteomics reveals exceptional diversity and versatility of mammalian humoral immunity

• Downloaded 971 times
• Download rankings, all-time:
  • Site-wide: 35,445
  • In bioengineering: 639
• Year to date:
  • Site-wide: 64,732
• Since beginning of last month:
  • Site-wide: 151,242

Divergence in the face of gene flow in two Charadrius plovers along the Chinese coast

• Downloaded 960 times
• Download rankings, all-time:
  • Site-wide: 36,088
  • In evolutionary biology: 1,379
• Year to date:
  • Site-wide: 99,643
• Since beginning of last month:
  • Site-wide: 93,473

Discovery of the Quiescent Body that Functions as a Biological Timer for Growth Resumption of Non-growing Bacterial Cells

• Downloaded 936 times
• Download rankings, all-time:
  • Site-wide: 37,511
  • In microbiology: 2,087
• Year to date:
  • Site-wide: 153,822
• Since beginning of last month:
  • Site-wide: 105,162

Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

• Downloaded 921 times
• Download rankings, all-time:
  • Site-wide: 38,406
  • In cancer biology: 958
• Year to date:
  • Site-wide: 129,845
• Since beginning of last month:
  • Site-wide: 130,837

A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth

• Downloaded 864 times
• Download rankings, all-time:
  • Site-wide: 42,154
  • In genomics: 3,214
• Year to date:
  • Site-wide: 87,574
• Since beginning of last month:
  • Site-wide: 130,938

Tapping into non-English-language science for the conservation of global biodiversity

• Downloaded 840 times
• Download rankings, all-time:
  • Site-wide: 43,988
  • In scientific communication and education: 268
• Year to date:
  • Site-wide: 56,091
• Since beginning of last month:
  • Site-wide: 98,996

Comparative analyses of 3654 chloroplast genomes unraveled new insights into the evolutionary mechanism of green plants

• Downloaded 831 times
• Download rankings, all-time:
  • Site-wide: 44,682
  • In plant biology: 840
• Year to date:
  • Site-wide: 87,315
• Since beginning of last month:
  • Site-wide: 160,554

WindSTORM: Robust online image processing for high-throughput nanoscopy

• Downloaded 822 times
• Download rankings, all-time:
  • Site-wide: 45,406
  • In bioinformatics: 4,374
• Year to date:
  • Site-wide: 179,153
• Since beginning of last month:
  • Site-wide: 164,761

Enhanced super-resolution microscopy by extreme value based emitter recovery

• Downloaded 815 times
• Download rankings, all-time:
  • Site-wide: 45,950
  • In cell biology: 1,701
• Year to date:
  • Site-wide: 166,005
• Since beginning of last month:
  • Site-wide: 143,737

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

• Downloaded 803 times
• Download rankings, all-time:
  • Site-wide: 47,008
  • In genomics: 3,364
• Year to date:
  • Site-wide: 189,029
• Since beginning of last month:
  • Site-wide: 169,956

Spatiotemporal Gene Coexpression and Regulation in Mouse Cardiomyocytes of Early Cardiac Morphogenesis

• Downloaded 779 times
• Download rankings, all-time:
  • Site-wide: 49,168
  • In genetics: 1,922
• Year to date:
  • Site-wide: 163,005
• Since beginning of last month:
  • Site-wide: 129,227

The histone chaperone FACT modulates nucleosome structure by tethering its components

• Downloaded 763 times
• Download rankings, all-time:
  • Site-wide: 50,604
  • In biochemistry: 1,203
• Year to date:
  • Site-wide: 166,296
• Since beginning of last month:
  • Site-wide: 141,322

High-Spatial-Resolution Multi-Omics Atlas Sequencing of Mouse Embryos via Deterministic Barcoding in Tissue

• Downloaded 751 times
• Download rankings, all-time:
  • Site-wide: 51,826
  • In genomics: 3,675
• Year to date:
  • Site-wide: 106,622
• Since beginning of last month:
  • Site-wide: 134,407

Neo-sex chromosomes, genetic diversity and demographic history in the Critically Endangered Raso lark

• Downloaded 744 times
• Download rankings, all-time:
  • Site-wide: 52,480
  • In genomics: 3,719
• Year to date:
  • Site-wide: 129,843
• Since beginning of last month:
  • Site-wide: 114,628

Rice NIN-LIKE PROTEIN 4 is a master regulator of nitrogen use efficiency

• Downloaded 719 times
• Download rankings, all-time:
  • Site-wide: 55,045
  • In plant biology: 1,122
• Year to date:
  • Site-wide: 124,290
• Since beginning of last month:
  • Site-wide: 94,931

Functional and molecular early enteric biomarkers for Parkinson's disease in mice and men

• Downloaded 706 times
• Download rankings, all-time:
  • Site-wide: 56,426
  • In neuroscience: 7,812
• Year to date:
  • Site-wide: 88,875
• Since beginning of last month:
  • Site-wide: 53,454

DeepMOCCA: A pan-cancer prognostic model identifies personalized prognostic markers through graph attention and multi-omics data integration

• Downloaded 635 times
• Download rankings, all-time:
  • Site-wide: 65,271
  • In bioinformatics: 7,000
• Year to date:
  • Site-wide: 26,606
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  • Site-wide: 47,098

Genome and community-level interaction insights on wide carbon utilizing and element cycling function of Hydrothermarchaeota from hydrothermal sediment

• Downloaded 578 times
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  • Site-wide: 73,555
  • In ecology: 1,698
• Year to date:
  • Site-wide: 136,440
• Since beginning of last month:
  • Site-wide: 109,182

Treatment of Graft-versus-Host Disease by Echinomycin in a New Humanized Mouse Model

• Downloaded 576 times
• Download rankings, all-time:
  • Site-wide: 73,953
  • In immunology: 2,176
• Year to date:
  • Site-wide: 144,740
• Since beginning of last month:
  • Site-wide: 131,266

Widespread Inter-Chromosomal Epistasis Regulates Glucose Homeostasis And Gene Expression

• Downloaded 551 times
• Download rankings, all-time:
  • Site-wide: 77,885
  • In genetics: 2,973
• Year to date:
  • Site-wide: 185,271
• Since beginning of last month:
  • Site-wide: 160,294

Draft genome of the aquatic moss Fontinalis antipyretica (Fontinalaceae, Bryophyta)

• Downloaded 537 times
• Download rankings, all-time:
  • Site-wide: 80,413
  • In genomics: 5,001
• Year to date:
  • Site-wide: 183,491
• Since beginning of last month:
  • Site-wide: 179,467

Measurement of the torque in braided DNAs using a thermodynamic Maxwell relation

• Downloaded 529 times
• Download rankings, all-time:
  • Site-wide: 81,792
  • In biophysics: 2,755
• Year to date:
  • Site-wide: 152,069
• Since beginning of last month:
  • Site-wide: 179,017

Molecular basis of P[6] and P[8] major human rotavirus VP8* domain interactions with histo-blood group antigens

• Downloaded 513 times
• Download rankings, all-time:
  • Site-wide: 85,001
  • In biochemistry: 2,264
• Year to date:
  • Site-wide: 125,445
• Since beginning of last month:
  • Site-wide: 76,391

Screening of FDA-approved Drugs and Identification of Novel Lassa Virus Entry Inhibitors

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 86,148
  • In microbiology: 5,305
• Year to date:
  • Site-wide: 152,615
• Since beginning of last month:
  • Site-wide: 141,989

Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 87,314
  • In microbiology: 5,257
• Year to date:
  • Site-wide: 182,876
• Since beginning of last month:
  • Site-wide: 185,909

Cdc42 is required for lymphatic branching, maturation and valve formation during embryonic development

• Downloaded 487 times
• Download rankings, all-time:
  • Site-wide: 90,047
  • In developmental biology: 2,241
• Year to date:
  • Site-wide: 123,715
• Since beginning of last month:
  • Site-wide: 156,139

Separating an allele associated with late flowering and slow maturation of Arabidopsis thaliana from population structure

• Downloaded 472 times
• Download rankings, all-time:
  • Site-wide: 93,360
  • In genetics: 3,538
• Year to date:
  • Site-wide: 174,810
• Since beginning of last month:
  • Site-wide: 175,029

The closed-loop pathways of signaling molecules

• Downloaded 470 times
• Download rankings, all-time:
  • Site-wide: 93,745
  • In bioinformatics: 7,685
• Year to date:
  • Site-wide: 188,354
• Since beginning of last month:
  • Site-wide: 169,555

Mammalian CST averts replication failure by preventing G-quadruplex accumulation

• Downloaded 465 times
• Download rankings, all-time:
  • Site-wide: 94,951
  • In molecular biology: 2,664
• Year to date:
  • Site-wide: 143,585
• Since beginning of last month:
  • Site-wide: 85,271

Demographic histories and genome-wide patterns of divergence in incipient species of shorebirds

• Downloaded 451 times
• Download rankings, all-time:
  • Site-wide: 98,126
  • In evolutionary biology: 4,418
• Year to date:
  • Site-wide: 187,845
• Since beginning of last month:
  • Site-wide: 175,293

Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth

• Downloaded 439 times
• Download rankings, all-time:
  • Site-wide: 100,700
  • In microbiology: 9,940
• Year to date:
  • Site-wide: 5,997
• Since beginning of last month:
  • Site-wide: 28,112

Ectomycorrhizal fungi induce systemic resistance against insects on a non-mycorrhizal plant in a CERK1-dependent manner

• Downloaded 434 times
• Download rankings, all-time:
  • Site-wide: 102,017
  • In plant biology: 2,471
• Year to date:
  • Site-wide: 182,921
• Since beginning of last month:
  • Site-wide: 167,903

Out of the Qinghai-Tibetan Plateau and get flourishing - the evolution of Neodon voles (Rodentia: Cricetidae) revealed by systematic sampling and low coverage whole genome sequencing

• Downloaded 426 times
• Download rankings, all-time:
  • Site-wide: 103,833
  • In zoology: 349
• Year to date:
  • Site-wide: 106,771
• Since beginning of last month:
  • Site-wide: 128,159

The genome assembly and annotation of Magnolia biondii Pamp., a phylogenetically, economically, and medicinally important ornamental tree species

• Downloaded 404 times
• Download rankings, all-time:
  • Site-wide: 109,163
  • In plant biology: 2,731
• Year to date:
  • Site-wide: 113,754
• Since beginning of last month:
  • Site-wide: 84,762

Co-evolution of Eukaryotic-like Vps4 and ESCRT-III Subunits in the Asgard Archaea

• Downloaded 391 times
• Download rankings, all-time:
  • Site-wide: 112,383
  • In microbiology: 7,317
• Year to date:
  • Site-wide: 152,275
• Since beginning of last month:
  • Site-wide: 108,382

Extrasynaptic volume transmission: A novel route for neuropeptide signaling in nematodes

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 116,129
  • In neuroscience: 16,356
• Year to date:
  • Site-wide: 112,664
• Since beginning of last month:
  • Site-wide: 134,500

Novel Asgard archaea phylum Hermodarchaeota degrade alkanes and aromatics via alkyl/benzyl-succinate synthase and benzoyl-CoA pathway

• Downloaded 354 times
• Download rankings, all-time:
  • Site-wide: 122,436
  • In genomics: 6,625
• Year to date:
  • Site-wide: 148,267
• Since beginning of last month:
  • Site-wide: 150,769

Population disruption: estimating changes in population distribution in the UK during the COVID-19 pandemic

• Downloaded 347 times
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  • Site-wide: 124,502
  • In public and global health: 1,753
• Year to date:
  • Site-wide: 72,338
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  • Site-wide: 46,304

SPINK1-induced amelioration of impaired autophagy contributes to suppression of trypsinogen activation in a model of acute pancreatitis

• Downloaded 336 times
• Download rankings, all-time:
  • Site-wide: 127,508
  • In molecular biology: 3,632
• Year to date:
  • Site-wide: 136,473
• Since beginning of last month:
  • Site-wide: 128,871

Emergence of Zika virus: Direct reversion of mutations and fitness restoration prior to spread to the Americas

• Downloaded 330 times
• Download rankings, all-time:
  • Site-wide: 129,134
  • In microbiology: 8,661
• Year to date:
  • Site-wide: 151,121
• Since beginning of last month:
  • Site-wide: 107,317

IgY antibodies against Ebola virus possess post-exposure protection and excellent thermostability

• Downloaded 311 times
• Download rankings, all-time:
  • Site-wide: 134,786
  • In immunology: 3,941
• Year to date:
  • Site-wide: 129,299
• Since beginning of last month:
  • Site-wide: 83,781

Predicting Collaborative Learning Quality through Physiological Synchrony Recorded by Wearable Biosensors

• Downloaded 303 times
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  • Site-wide: 137,290
  • In neuroscience: 20,429
• Year to date:
  • Site-wide: 72,608
• Since beginning of last month:
  • Site-wide: 88,905

Personalized in-silico drug response prediction based on the genetic landscape of muscle-invasive bladder cancer

• Downloaded 300 times
• Download rankings, all-time:
  • Site-wide: 138,152
  • In bioinformatics: 10,409
• Year to date:
  • Site-wide: 156,742
• Since beginning of last month:
  • Site-wide: 150,490

Regrowth-delay Body as a Bacterial Subcellular Structure marking multidrug tolerant Persisters

• Downloaded 292 times
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  • Site-wide: 140,516
  • In microbiology: 9,429
• Year to date:
  • Site-wide: 175,221
• Since beginning of last month:
  • Site-wide: 116,700

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 141,873
  • In genetics: 5,256
• Year to date:
  • Site-wide: 152,808
• Since beginning of last month:
  • Site-wide: 115,522

Comparative genomics identified a genetic locus in plant-associated Pseudomonas spp. that is necessary for induced systemic susceptibility

• Downloaded 283 times
• Download rankings, all-time:
  • Site-wide: 143,083
  • In microbiology: 9,482
• Year to date:
  • Site-wide: 187,152
• Since beginning of last month:
  • Site-wide: 188,871

Genome diversity and quorum sensing variations in laboratory strains of Pseudomonas aeruginosa PAO1

• Downloaded 282 times
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  • Site-wide: 143,496
  • In microbiology: 9,970
• Year to date:
  • Site-wide: 107,010
• Since beginning of last month:
  • Site-wide: 102,797

High-throughput living-cell protein crosslinking analysis uncovers the physiological relevance of forming the "inserted" state of the ATP synthase ϵ-subunit

• Downloaded 280 times
• Download rankings, all-time:
  • Site-wide: 144,068
  • In biochemistry: 4,105
• Year to date:
  • Site-wide: 153,140
• Since beginning of last month:
  • Site-wide: 93,965

A Na2CO3-responsive chitinase gene from Chinese wildrye improve pathogen resistance and saline-alkali stress tolerance in transgenic tobacco and maize

• Downloaded 280 times
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  • Site-wide: 144,041
  • In plant biology: 3,769
• Year to date:
  • Site-wide: 155,955
• Since beginning of last month:
  • Site-wide: 130,809

Identification of novel tetracycline resistance gene tet(X14) and its co-occurrence with tet(X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris

• Downloaded 269 times
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  • Site-wide: 147,257
  • In genetics: 5,426
• Year to date:
  • Site-wide: 162,544
• Since beginning of last month:
  • Site-wide: 181,898

Meta-16S rRNA gene phylogenetic reconstruction reveals astonishing diversity of the cosmopolitan myxobacteria

• Downloaded 268 times
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  • Site-wide: 147,517
  • In microbiology: 9,909
• Year to date:
  • Site-wide: 178,556
• Since beginning of last month:
  • Site-wide: 158,877

Src/FAK complex phosphorylates cardiac myosin binding protein c (cMyBP-C) in vitro and in vivo

• Downloaded 261 times
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  • Site-wide: 149,885
  • In molecular biology: 4,231
• Year to date:
  • Site-wide: 156,947
• Since beginning of last month:
  • Site-wide: 83,876

Population genomic analyses of schistosome parasites highlight critical challenges facing end-game elimination efforts

• Downloaded 259 times
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  • Site-wide: 150,299
  • In evolutionary biology: 6,659
• Year to date:
  • Site-wide: 169,176
• Since beginning of last month:
  • Site-wide: 166,144

Increase in weighting of vision vs. proprioception associated with force field adaptation

• Downloaded 256 times
• Download rankings, all-time:
  • Site-wide: 151,230
  • In neuroscience: 20,987
• Year to date:
  • Site-wide: 179,481
• Since beginning of last month:
  • Site-wide: 175,511

Prototheca zopfii Genotype II induces mitochondrial apoptosis in models of bovine mastitis

• Downloaded 229 times
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  • Site-wide: 158,959
  • In microbiology: 10,888
• Year to date:
  • Site-wide: 186,378
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  • Site-wide: 173,234

Impacted Spike Frequency Adaptation Associated with Reduction of KCNQ2/3 Promotes Seizure Activity in Temporal Lobe Epilepsy

• Downloaded 228 times
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  • Site-wide: 159,286
  • In neuroscience: 23,096
• Year to date:
  • Site-wide: 86,783
• Since beginning of last month:
  • Site-wide: 96,604

Genetic diversity and evolution of Hantaan virus in China and its neighbors

• Downloaded 227 times
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  • Site-wide: 159,422
  • In evolutionary biology: 7,076
• Year to date:
  • Site-wide: 156,558
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  • Site-wide: 152,554

Cross-reactive TCR with alloreactivity for immunodominant HIV-1 epitope Gag TL9 with enhanced control of viral infection

• Downloaded 222 times
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  • Site-wide: 160,856
  • In immunology: 4,876
• Year to date:
  • Site-wide: 73,403
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  • Site-wide: 99,358

Silent dissemination of plasmid-borne tigecycline resistance gene tet(X6) in livestock-associated Acinetobacter towneri

• Downloaded 212 times
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  • Site-wide: 163,408
  • In genetics: 5,910
• Year to date:
  • Site-wide: 148,039
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  • Site-wide: 87,631

Exploration of Chemical Space with Partial Labeled Noisy Student Self-Training for Improving Deep Learning: Application to Drug Metabolism

• Downloaded 203 times
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  • Site-wide: 165,774
  • In bioinformatics: 12,003
• Year to date:
  • Site-wide: 137,819
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  • Site-wide: 166,432

The gut microbiome is a significant risk factor for future chronic lung disease

• Downloaded 196 times
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  • Site-wide: 167,540
  • In respiratory medicine: None
• Year to date:
  • Site-wide: 20,078
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  • Site-wide: 39,047

The complete plastid genomes of two Fabaceae orphan crops from Africa

• Downloaded 192 times
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  • Site-wide: 168,764
  • In genomics: 7,866
• Year to date:
  • Site-wide: 188,903
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  • Site-wide: 183,338

Screening and Identification of Lassa Virus Endonuclease-targeting Inhibitors from a Fragment-based Drug Development Library

• Downloaded 181 times
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  • Site-wide: 171,341
  • In microbiology: 12,588
• Year to date:
  • Site-wide: 75,408
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  • Site-wide: 69,647

Mechanism and consequence of daily modulation of cortical parvalbumin-positive inhibitory neurons

• Downloaded 176 times
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  • Site-wide: 172,523
  • In neuroscience: None
• Year to date:
  • Site-wide: 23,184
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  • Site-wide: 35,567

Screening of Botanical Drugs Against Lassa Virus Entry

• Downloaded 154 times
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  • Site-wide: 177,230
  • In microbiology: 12,684
• Year to date:
  • Site-wide: 142,107
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  • Site-wide: 134,309

ERp44 is Required for Endocardial Cushion Development by Regulating VEGFA Secretion in Myocardium

• Downloaded 152 times
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  • Site-wide: 177,582
  • In developmental biology: 4,374
• Year to date:
  • Site-wide: 118,803
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  • Site-wide: 122,520

Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment and confers resistance to immunotherapy

• Downloaded 151 times
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  • Site-wide: 177,768
  • In cancer biology: None
• Year to date:
  • Site-wide: 28,394
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  • Site-wide: 4,060

Effects of N-linked glycan of Lassa Virus Envelope Glycoprotein on the Immune Response

• Downloaded 142 times
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  • Site-wide: 179,464
  • In microbiology: 12,743
• Year to date:
  • Site-wide: 183,497
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  • Site-wide: 180,323

LPS-TLR4 pathway exaggerates alcohol-induced acute-on-chronic liver failure via provoking NETs formation

• Downloaded 140 times
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  • Site-wide: 179,873
  • In pathology: 1,105
• Year to date:
  • Site-wide: 31,124
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  • Site-wide: 67,488

Within and between classroom transmission patterns of seasonal influenza among primary school students in Matsumoto city, Japan

• Downloaded 132 times
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  • Site-wide: 181,200
  • In infectious diseases: 7,153
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  • Site-wide: 115,592
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  • Site-wide: 155,751

Global dissemination of tet(X3) and tet(X6) among livestock-associated Acinetobacter is sporadically mediated by highly diverse plasmidomes

• Downloaded 130 times
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  • Site-wide: 181,512
  • In microbiology: 13,268
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  • Site-wide: 97,455
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  • Site-wide: 74,691

Genome dynamics in mosses: Extensive synteny coexists with a highly dynamic gene space

• Downloaded 119 times
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  • Site-wide: 183,235
  • In genomics: None
• Year to date:
  • Site-wide: 37,921
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  • Site-wide: 6,000