Author: Min Shen

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Preprints

An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19

• Downloaded 3,311 times
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  • Site-wide: 5,647
  • In biochemistry: 90
• Year to date:
  • Site-wide: 27,336
• Since beginning of last month:
  • Site-wide: 23,005

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

• Downloaded 3,172 times
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  • Site-wide: 6,001
  • In pharmacology and toxicology: 34
• Year to date:
  • Site-wide: 22,464
• Since beginning of last month:
  • Site-wide: 22,518

A retrospective study of the clinical characteristics of COVID-19 infection in 26 children

• Downloaded 2,734 times
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  • Site-wide: 7,448
  • In infectious diseases: 1,291
• Year to date:
  • Site-wide: 52,947
• Since beginning of last month:
  • Site-wide: 103,343

Small Molecule Inhibitors of the Human Histone Lysine Methyltransferase NSD2 / WHSC1 / MMSET Identified from a Quantitative High-Throughput Screen with Nucleosome Substrate

• Downloaded 2,673 times
• Download rankings, all-time:
  • Site-wide: 7,703
  • In cancer biology: 107
• Year to date:
  • Site-wide: 39,711
• Since beginning of last month:
  • Site-wide: 36,704

An OpenData portal to share COVID-19 drug repurposing data in real time

• Downloaded 1,667 times
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  • Site-wide: 15,523
  • In microbiology: 936
• Year to date:
  • Site-wide: 20,554
• Since beginning of last month:
  • Site-wide: 16,967

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

• Downloaded 1,538 times
• Download rankings, all-time:
  • Site-wide: 17,582
  • In cell biology: 530
• Year to date:
  • Site-wide: 34,660
• Since beginning of last month:
  • Site-wide: 27,853

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening

• Downloaded 1,496 times
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  • Site-wide: 18,290
  • In pharmacology and toxicology: 101
• Year to date:
  • Site-wide: 35,333
• Since beginning of last month:
  • Site-wide: 51,198

Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay

• Downloaded 1,426 times
• Download rankings, all-time:
  • Site-wide: 19,734
  • In biochemistry: 412
• Year to date:
  • Site-wide: 50,051
• Since beginning of last month:
  • Site-wide: 55,263

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles

• Downloaded 1,285 times
• Download rankings, all-time:
  • Site-wide: 23,199
  • In pharmacology and toxicology: 130
• Year to date:
  • Site-wide: 58,816
• Since beginning of last month:
  • Site-wide: 39,740

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

• Downloaded 1,198 times
• Download rankings, all-time:
  • Site-wide: 25,877
  • In microbiology: 1,448
• Year to date:
  • Site-wide: 79,277
• Since beginning of last month:
  • Site-wide: 53,695

Assessing Inhibitors Of Mutant Isocitrate Dehydrogenase Using A Suite Of Pre-Clinical Discovery Assays

• Downloaded 1,165 times
• Download rankings, all-time:
  • Site-wide: 26,994
  • In cancer biology: 600
• Year to date:
  • Site-wide: 175,170
• Since beginning of last month:
  • Site-wide: 184,638

Discovery of TMPRSS2 inhibitors from virtual screening

• Downloaded 1,041 times
• Download rankings, all-time:
  • Site-wide: 31,962
  • In bioinformatics: 3,909
• Year to date:
  • Site-wide: 18,738
• Since beginning of last month:
  • Site-wide: 9,137

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

• Downloaded 1,030 times
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  • Site-wide: 32,502
  • In cancer biology: 764
• Year to date:
  • Site-wide: 143,334
• Since beginning of last month:
  • Site-wide: 175,134

Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening

• Downloaded 643 times
• Download rankings, all-time:
  • Site-wide: 64,186
  • In cell biology: 2,695
• Year to date:
  • Site-wide: 108,202
• Since beginning of last month:
  • Site-wide: 93,475

A High-Throughput Screen of a Library of Therapeutics Identifies Substrates of P-glycoprotein

• Downloaded 640 times
• Download rankings, all-time:
  • Site-wide: 64,534
  • In pharmacology and toxicology: 385
• Year to date:
  • Site-wide: 111,289
• Since beginning of last month:
  • Site-wide: 105,744

Machine learning on drug-specific data to predict small molecule teratogenicity

• Downloaded 493 times
• Download rankings, all-time:
  • Site-wide: 88,927
  • In bioinformatics: 7,385
• Year to date:
  • Site-wide: 184,055
• Since beginning of last month:
  • Site-wide: 188,925

Identification of activators of human fumarate hydratase by quantitative high-throughput screening

• Downloaded 473 times
• Download rankings, all-time:
  • Site-wide: 93,022
  • In biochemistry: 2,478
• Year to date:
  • Site-wide: 160,761
• Since beginning of last month:
  • Site-wide: 129,455

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

• Downloaded 470 times
• Download rankings, all-time:
  • Site-wide: 93,853
  • In pharmacology and toxicology: 631
• Year to date:
  • Site-wide: 45,248
• Since beginning of last month:
  • Site-wide: 49,873

Minimal information for Chemosensitivity assays (MICHA): A next-generation pipeline to enable the FAIRification of drug screening experiments

• Downloaded 468 times
• Download rankings, all-time:
  • Site-wide: 94,136
  • In bioinformatics: 7,975
• Year to date:
  • Site-wide: 112,039
• Since beginning of last month:
  • Site-wide: 90,733

A Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 116,296
  • In biochemistry: 4,449
• Year to date:
  • Site-wide: 7,637
• Since beginning of last month:
  • Site-wide: 33,818

A hybrid in silico approach reveals novel inhibitors of multiple SARS-CoV-2 variants

• Downloaded 322 times
• Download rankings, all-time:
  • Site-wide: 131,672
  • In cell biology: 5,769
• Year to date:
  • Site-wide: 151,093
• Since beginning of last month:
  • Site-wide: 155,028

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

• Downloaded 285 times
• Download rankings, all-time:
  • Site-wide: 142,522
  • In pharmacology and toxicology: 1,016
• Year to date:
  • Site-wide: 131,434
• Since beginning of last month:
  • Site-wide: 153,986

Temporal Metabolic Characteristics and Transcriptomic Landscape of Islets and Liver Reveal Dynamic Pathophysiology and Interorgan Crosstalk in High-fat Diet-induced Diabetes

• Downloaded 276 times
• Download rankings, all-time:
  • Site-wide: 145,224
  • In cell biology: 6,283
• Year to date:
  • Site-wide: 156,824
• Since beginning of last month:
  • Site-wide: 151,528

A Graph Convolutional Network-based screening strategy for rapid identification of SARS-CoV-2 cell-entry inhibitors

• Downloaded 257 times
• Download rankings, all-time:
  • Site-wide: 150,979
  • In bioinformatics: 11,478
• Year to date:
  • Site-wide: 47,119
• Since beginning of last month:
  • Site-wide: 122,038

Target Class Profiling of Small Molecule Methyltransferases

• Downloaded 236 times
• Download rankings, all-time:
  • Site-wide: 157,078
  • In biochemistry: None
• Year to date:
  • Site-wide: 15,320
• Since beginning of last month:
  • Site-wide: 39,416