Author: Min Shen

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Preprints

An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19

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  • Site-wide: 4,709
  • In biochemistry: 72
• Year to date:
  • Site-wide: 5,552
• Since beginning of last month:
  • Site-wide: 6,856

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

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  • Site-wide: 5,723
  • In pharmacology and toxicology: 32
• Year to date:
  • Site-wide: 5,148
• Since beginning of last month:
  • Site-wide: 3,102

A retrospective study of the clinical characteristics of COVID-19 infection in 26 children

• Downloaded 2,415 times
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  • Site-wide: 6,267
  • In infectious diseases: 995
• Year to date:
  • Site-wide: 22,685
• Since beginning of last month:
  • Site-wide: 17,854

Small Molecule Inhibitors of the Human Histone Lysine Methyltransferase NSD2 / WHSC1 / MMSET Identified from a Quantitative High-Throughput Screen with Nucleosome Substrate

• Downloaded 2,379 times
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  • Site-wide: 6,395
  • In cancer biology: 99
• Year to date:
  • Site-wide: 15,209
• Since beginning of last month:
  • Site-wide: 14,052

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

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  • Site-wide: 17,310
  • In cell biology: 543
• Year to date:
  • Site-wide: 15,044
• Since beginning of last month:
  • Site-wide: 14,271

An OpenData portal to share COVID-19 drug repurposing data in real time

• Downloaded 1,210 times
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  • Site-wide: 17,424
  • In microbiology: 1,010
• Year to date:
  • Site-wide: 7,196
• Since beginning of last month:
  • Site-wide: 2,314

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening

• Downloaded 1,130 times
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  • Site-wide: 19,278
  • In pharmacology and toxicology: 107
• Year to date:
  • Site-wide: 10,814
• Since beginning of last month:
  • Site-wide: 10,090

Assessing Inhibitors Of Mutant Isocitrate Dehydrogenase Using A Suite Of Pre-Clinical Discovery Assays

• Downloaded 1,102 times
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  • Site-wide: 20,000
  • In cancer biology: 470
• Year to date:
  • Site-wide: 114,152
• Since beginning of last month:
  • Site-wide: 118,339

Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay

• Downloaded 1,077 times
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  • Site-wide: 20,697
  • In biochemistry: 441
• Year to date:
  • Site-wide: 19,440
• Since beginning of last month:
  • Site-wide: 16,963

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles

• Downloaded 1,047 times
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  • Site-wide: 21,541
  • In pharmacology and toxicology: 117
• Year to date:
  • Site-wide: 24,751
• Since beginning of last month:
  • Site-wide: 32,235

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

• Downloaded 969 times
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  • Site-wide: 24,160
  • In microbiology: 1,419
• Year to date:
  • Site-wide: 16,023
• Since beginning of last month:
  • Site-wide: 45,117

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

• Downloaded 909 times
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  • Site-wide: 26,466
  • In cancer biology: 663
• Year to date:
  • Site-wide: 39,416
• Since beginning of last month:
  • Site-wide: 39,510

Discovery of TMPRSS2 inhibitors from virtual screening

• Downloaded 573 times
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  • Site-wide: 49,078
  • In bioinformatics: 5,075
• Year to date:
  • Site-wide: 6,762
• Since beginning of last month:
  • Site-wide: 9,493

A High-Throughput Screen of a Library of Therapeutics Identifies Substrates of P-glycoprotein

• Downloaded 527 times
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  • Site-wide: 54,244
  • In pharmacology and toxicology: 325
• Year to date:
  • Site-wide: 95,211
• Since beginning of last month:
  • Site-wide: 95,154

Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening

• Downloaded 461 times
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  • Site-wide: 62,987
  • In cell biology: 2,774
• Year to date:
  • Site-wide: 61,107
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  • Site-wide: 66,459

Machine learning on drug-specific data to predict small molecule teratogenicity

• Downloaded 431 times
• Download rankings, all-time:
  • Site-wide: 67,693
  • In bioinformatics: 6,473
• Year to date:
  • Site-wide: 54,236
• Since beginning of last month:
  • Site-wide: 65,789

Identification of activators of human fumarate hydratase by quantitative high-throughput screening

• Downloaded 373 times
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  • Site-wide: 77,653
  • In biochemistry: 2,172
• Year to date:
  • Site-wide: 104,563
• Since beginning of last month:
  • Site-wide: 80,273

Minimal information for Chemosensitivity assays (MICHA): A next-generation pipeline to enable the FAIRification of drug screening experiments

• Downloaded 235 times
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  • Site-wide: 107,448
  • In bioinformatics: 9,052
• Year to date:
  • Site-wide: 51,423
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  • Site-wide: None

Temporal Metabolic Characteristics and Transcriptomic Landscape of Islets and Liver Reveal Dynamic Pathophysiology and Interorgan Crosstalk in High-fat Diet-induced Diabetes

• Downloaded 193 times
• Download rankings, all-time:
  • Site-wide: 117,493
  • In cell biology: 5,420
• Year to date:
  • Site-wide: 88,336
• Since beginning of last month:
  • Site-wide: 97,207

A hybrid in silico approach reveals novel inhibitors of multiple SARS-CoV-2 variants

• Downloaded 173 times
• Download rankings, all-time:
  • Site-wide: 121,992
  • In cell biology: 5,622
• Year to date:
  • Site-wide: 26,670
• Since beginning of last month:
  • Site-wide: 4,536

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

• Downloaded 102 times
• Download rankings, all-time:
  • Site-wide: 136,793
  • In pharmacology and toxicology: 1,195
• Year to date:
  • Site-wide: 47,204
• Since beginning of last month:
  • Site-wide: 42,110