Author: Min Shen

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Preprints

An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19

• Downloaded 3,003 times
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  • Site-wide: 4,858
  • In biochemistry: 75
• Year to date:
  • Site-wide: 6,542
• Since beginning of last month:
  • Site-wide: 65,914

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

• Downloaded 2,708 times
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  • Site-wide: 5,638
  • In pharmacology and toxicology: 33
• Year to date:
  • Site-wide: 5,269
• Since beginning of last month:
  • Site-wide: 13,391

Small Molecule Inhibitors of the Human Histone Lysine Methyltransferase NSD2 / WHSC1 / MMSET Identified from a Quantitative High-Throughput Screen with Nucleosome Substrate

• Downloaded 2,477 times
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  • Site-wide: 6,450
  • In cancer biology: 98
• Year to date:
  • Site-wide: 14,036
• Since beginning of last month:
  • Site-wide: 4,067

A retrospective study of the clinical characteristics of COVID-19 infection in 26 children

• Downloaded 2,464 times
• Download rankings, all-time:
  • Site-wide: 6,507
  • In infectious diseases: 1,067
• Year to date:
  • Site-wide: 24,203
• Since beginning of last month:
  • Site-wide: 57,710

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

• Downloaded 1,334 times
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  • Site-wide: 16,123
  • In cell biology: 477
• Year to date:
  • Site-wide: 12,868
• Since beginning of last month:
  • Site-wide: 4,213

An OpenData portal to share COVID-19 drug repurposing data in real time

• Downloaded 1,292 times
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  • Site-wide: 16,927
  • In microbiology: 984
• Year to date:
  • Site-wide: 8,094
• Since beginning of last month:
  • Site-wide: 20,194

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening

• Downloaded 1,229 times
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  • Site-wide: 18,192
  • In pharmacology and toxicology: 99
• Year to date:
  • Site-wide: 10,809
• Since beginning of last month:
  • Site-wide: 7,861

Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay

• Downloaded 1,204 times
• Download rankings, all-time:
  • Site-wide: 18,747
  • In biochemistry: 375
• Year to date:
  • Site-wide: 15,044
• Since beginning of last month:
  • Site-wide: 3,349

Assessing Inhibitors Of Mutant Isocitrate Dehydrogenase Using A Suite Of Pre-Clinical Discovery Assays

• Downloaded 1,129 times
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  • Site-wide: 20,635
  • In cancer biology: 481
• Year to date:
  • Site-wide: 101,342
• Since beginning of last month:
  • Site-wide: 13,079

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles

• Downloaded 1,103 times
• Download rankings, all-time:
  • Site-wide: 21,350
  • In pharmacology and toxicology: 120
• Year to date:
  • Site-wide: 25,002
• Since beginning of last month:
  • Site-wide: 19,821

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

• Downloaded 1,028 times
• Download rankings, all-time:
  • Site-wide: 23,657
  • In microbiology: 1,396
• Year to date:
  • Site-wide: 17,341
• Since beginning of last month:
  • Site-wide: 65,951

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

• Downloaded 938 times
• Download rankings, all-time:
  • Site-wide: 27,038
  • In cancer biology: 671
• Year to date:
  • Site-wide: 43,948
• Since beginning of last month:
  • Site-wide: None

Discovery of TMPRSS2 inhibitors from virtual screening

• Downloaded 631 times
• Download rankings, all-time:
  • Site-wide: 46,499
  • In bioinformatics: 4,851
• Year to date:
  • Site-wide: 8,184
• Since beginning of last month:
  • Site-wide: 57,930

A High-Throughput Screen of a Library of Therapeutics Identifies Substrates of P-glycoprotein

• Downloaded 556 times
• Download rankings, all-time:
  • Site-wide: 54,563
  • In pharmacology and toxicology: 326
• Year to date:
  • Site-wide: 86,520
• Since beginning of last month:
  • Site-wide: 39,069

Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening

• Downloaded 509 times
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  • Site-wide: 60,483
  • In cell biology: 2,651
• Year to date:
  • Site-wide: 53,387
• Since beginning of last month:
  • Site-wide: 9,257

Machine learning on drug-specific data to predict small molecule teratogenicity

• Downloaded 444 times
• Download rankings, all-time:
  • Site-wide: 70,204
  • In bioinformatics: 6,648
• Year to date:
  • Site-wide: 65,715
• Since beginning of last month:
  • Site-wide: 107,246

Identification of activators of human fumarate hydratase by quantitative high-throughput screening

• Downloaded 380 times
• Download rankings, all-time:
  • Site-wide: 81,473
  • In biochemistry: 2,278
• Year to date:
  • Site-wide: 120,419
• Since beginning of last month:
  • Site-wide: 121,763

Minimal information for Chemosensitivity assays (MICHA): A next-generation pipeline to enable the FAIRification of drug screening experiments

• Downloaded 312 times
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  • Site-wide: 96,018
  • In bioinformatics: 8,351
• Year to date:
  • Site-wide: 38,181
• Since beginning of last month:
  • Site-wide: 51,601

A hybrid in silico approach reveals novel inhibitors of multiple SARS-CoV-2 variants

• Downloaded 211 times
• Download rankings, all-time:
  • Site-wide: 120,444
  • In cell biology: 5,536
• Year to date:
  • Site-wide: 29,513
• Since beginning of last month:
  • Site-wide: 59,761

Temporal Metabolic Characteristics and Transcriptomic Landscape of Islets and Liver Reveal Dynamic Pathophysiology and Interorgan Crosstalk in High-fat Diet-induced Diabetes

• Downloaded 205 times
• Download rankings, all-time:
  • Site-wide: 121,749
  • In cell biology: 5,587
• Year to date:
  • Site-wide: 98,898
• Since beginning of last month:
  • Site-wide: None

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

• Downloaded 119 times
• Download rankings, all-time:
  • Site-wide: 141,299
  • In pharmacology and toxicology: 1,215
• Year to date:
  • Site-wide: 56,014
• Since beginning of last month:
  • Site-wide: 102,162