Author: Yun Li

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Preprints

pVHL regulates protein stability of TCF/LEF transcription factor family via ubiquitin-independent proteasomal degradation

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,110
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Multi-epitope vaccine design using an immunoinformatics approach for 2019 novel coronavirus (SARS-CoV-2)

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  • Site-wide: 4,948
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The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions

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  • Site-wide: 5,124
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An epigenetic biomarker of aging for lifespan and healthspan

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  • Site-wide: 5,129
  • In epidemiology: 488
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Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

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  • Site-wide: 5,281
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  • Site-wide: 4,924
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SAFE-clustering: Single-cell Aggregated (From Ensemble) Clustering for Single-cell RNA-seq Data

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  • Site-wide: 5,345
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Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

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  • Site-wide: 6,621
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The Polygenic and Monogenic Basis of Blood Traits and Diseases

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3D Epigenomic Characterization Reveals Insights Into Gene Regulation and Lineage Specification During Corticogenesis

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  • Site-wide: 9,731
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  • Site-wide: 20,812

Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health traits (n=17,706)

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  • Site-wide: 11,297
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Common genetic variation influencing human white matter microstructure

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Common DNA sequence variation influences 3-dimensional conformation of the human genome

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  • Site-wide: 14,215
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  • Site-wide: 142,999
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  • Site-wide: 126,366

Robust Hi-C chromatin loop maps in human neurogenesis and brain tissues at high-resolution

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  • Site-wide: 22,195

SCDC: Bulk Gene Expression Deconvolution by Multiple Single-Cell RNA Sequencing References

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SMNN: Batch Effect Correction for Single-cell RNA-seq data via Supervised Mutual Nearest Neighbor Detection

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  • Site-wide: 16,752
  • In bioinformatics: 1,911
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The Big Five, Self-efficacy, and Self-control in Boxers

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  • Site-wide: 17,684
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The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3

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  • Site-wide: 18,098
  • In microbiology: 1,052
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  • Site-wide: 57,491

MAPS: model-based analysis of long-range chromatin interactions from PLAC-seq and HiChIP experiments

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  • Site-wide: 20,009
  • In bioinformatics: 2,285
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  • Site-wide: 129,870

Neuronal and glial 3D chromatin architecture illustrates cellular etiology of brain disorders

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  • Site-wide: 22,306
  • In neuroscience: 2,726
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  • Site-wide: 64,322

MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies

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  • Site-wide: 24,436
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  • Site-wide: 55,817
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  • Site-wide: 114,582

A Possible Role Of Microglia In Zika Virus Infection Of The Fetal Human Brain

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  • Site-wide: 24,635
  • In neuroscience: 3,029
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GWAS of 19,629 individuals identifies novel genetic variants for regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits

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  • Site-wide: 27,578
  • In genetics: 1,233
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  • Site-wide: 72,454
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Transcriptome-wide association analysis of 211 neuroimaging traits identifies new genes for brain structures and yields insights into the gene-level pleiotropy with other complex traits

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  • Site-wide: 28,909
  • In genetics: 1,297
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Parallel Characterization of cis-Regulatory Elements for Multiple Genes Using CRISPRpath

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  • Site-wide: 32,525
  • In genomics: 2,784
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  • Site-wide: 3,609

Heritability of regional brain volumes in large-scale neuroimaging and genetic studies

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  • Site-wide: 33,368
  • In genetics: 1,490
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  • Site-wide: 125,873
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  • Site-wide: 136,642

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

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  • Site-wide: 33,690
  • In genetics: 1,509
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  • Site-wide: 146,760
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  • Site-wide: 125,826

MRLocus: identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity

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  • Site-wide: 33,899
  • In bioinformatics: 3,691
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  • Site-wide: 33,002
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  • Site-wide: 94,781

SnapHiC: a computational pipeline to map chromatin contacts from single cell Hi-C data

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  • Site-wide: 37,249
  • In bioinformatics: 4,005
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  • Site-wide: 11,275
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  • Site-wide: 36,572

Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program

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  • Site-wide: 38,493
  • In hematology: 33
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  • Site-wide: 9,625
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  • Site-wide: 28,792

HUGIn: Hi-C Unifying Genomic Interrogator

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  • Site-wide: 39,996
  • In genetics: 1,762
• Year to date:
  • Site-wide: 154,315
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  • Site-wide: 157,533

TWO-SIGMA: a novel TWO-component SInGle cell Model-based Association method for single-cell RNA-seq data

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  • Site-wide: 42,877
  • In genomics: 3,420
• Year to date:
  • Site-wide: 48,150
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  • Site-wide: 56,516

Multi-SNP Mediation Intersection-Union Test

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  • Site-wide: 44,139
  • In genetics: 1,942
• Year to date:
  • Site-wide: 87,577
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  • Site-wide: 116,064

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

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  • Site-wide: 44,473
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  • Site-wide: 153,421

Association between ApoE polymorphism and type 2 diabetes: A meta-analysis of 59 studies

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  • Site-wide: 48,563
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  • Site-wide: 59,673
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  • Site-wide: 53,355

SAME-clustering: Single-cell Aggregated Clustering via Mixture Model Ensemble

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  • Site-wide: 49,040
  • In bioinformatics: 5,017
• Year to date:
  • Site-wide: 151,092
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  • Site-wide: 129,910

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

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  • Site-wide: 49,142
  • In cell biology: 2,071
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  • Site-wide: 94,303

FIREcaller: Detecting Frequently Interacting Regions from Hi-C Data

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  • Site-wide: 57,496
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Methylome-Wide Association Study Of Central Adiposity Implicates Genes Involved In Immune And Endocrine Systems

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  • Site-wide: 61,637
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Generation of Cynomolgus Monkeys (Macaca fascicularis) Embryos with ICSI Based on the MII-Stage Oocytes Acquired by Personalized Superovulation Protocol

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  • Site-wide: 79,596
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  • Site-wide: 125,462

iSMNN: Batch Effect Correction for Single-cell RNA-seq data via Iterative Supervised Mutual Nearest Neighbor Refinement

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  • Site-wide: 80,306
  • In bioinformatics: 7,333
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  • Site-wide: 80,676

The Characteristic of Auditory Function and Cochlear Pathophysiology in a Noise-exposed Cohort: A Cross-sectional Study

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THUNDER: A reference-free deconvolution method to infer cell type proportions from bulk Hi-C data

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  • Site-wide: 85,590
  • In bioinformatics: 7,668
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Characterizing sensitivity and coverage of clinical WGS as a diagnostic test for genetic disorders

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From GWAS Variant to Function: a Study of ~148,000 Variants for Blood Cell Traits.

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Genetic control of fetal placental genomics contributes to development of health and disease

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Integrative methylome and transcriptome analysis of Japanese flounder (Paralichthys olivaceus) skeletal muscle during development

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TWO-SIGMA-G: A New Competitive Gene Set Testing Framework for scRNA-seq Data Accounting for Inter-Gene and Cell-Cell Correlation

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  • Site-wide: 17,519

A large-scale transcriptome-wide association study (TWAS) of ten blood cell phenotypes reveals complexities of TWAS fine-mapping

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CUE: CpG impUtation Ensemble for DNA Methylation Levels Across the Human Methylation450 (HM450) and EPIC (HM850) BeadChip Platforms

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  • Site-wide: 107,392
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  • Site-wide: 94,838

HiC-ACT: Improved Detection of Chromatin Interactions from Hi-C Data via Aggregated Cauchy Test

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  • Site-wide: 110,870
  • In bioinformatics: 9,252
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  • Site-wide: 88,561

Generalized Multi-SNP Mediation Intersection-Union Test

• Downloaded 277 times
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  • Site-wide: 112,386
  • In genetics: 4,665
• Year to date:
  • Site-wide: 138,520
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  • Site-wide: 121,774

Phased implementation of COVID-19 vaccination: rapid assessment of policy adoption, reach and effectiveness to protect the most vulnerable in the US

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  • Site-wide: 117,705
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  • Site-wide: 34,661

MUNIn (Multiple sample UNifying long-range chromatin Interaction detector): a statistical framework for identifying long-range chromatin interactions from multiple samples

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  • Site-wide: 126,179
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Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types

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HPRep: Quantifying reproducibility in HiChIP and PLAC-seq datasets

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eSCAN: Scan Regulatory Regions for Aggregate Association Testing using Whole Genome Sequencing Data

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  • Site-wide: 130,601
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Genome engineering of Nannochloropsis with large deletions for constructing microalgal minigenomes

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  • Site-wide: 132,923
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  • Site-wide: 119,659

The efficacy and safety of bamlanivimab treatment against COVID-19: A meta-analysis

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  • Site-wide: 134,057
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Genetic influences on the intrinsic and extrinsic functional organizations of the cerebral cortex

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Transcriptome-wide association study in UK Biobank Europeans identifies associations with blood cell traits.

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