Author: Xin Chen

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Preprints

Rab7/Retromer-based endolysosomal trafficking facilitates effector secretion and host invasion in rice blast

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Yeast U6 snRNA made by RNA polymerase II is less stable but functional

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Immunogenicity and Safety of a SARS-CoV-2 Inactivated Vaccine in Healthy Adults Aged 18-59 years: Report of the Randomized, Double-blind, and Placebo-controlled Phase 2 Clinical Trial

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  • Site-wide: 367
  • In public and global health: 17
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  • Site-wide: 2,171
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  • Site-wide: 4,185

Fate mapping via Ms4a3 expression history traces monocyte-derived cells

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  • Site-wide: 5,076
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  • Site-wide: 46,402
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A Novel Triage Tool of Artificial Intelligence Assisted Diagnosis Aid System for Suspected COVID-19 pneumonia In Fever Clinics

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  • Site-wide: 6,243
  • In emergency medicine: 8
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  • Site-wide: 49,305

Unidirectional fork movement coupled with strand-specific histone incorporation ensures asymmetric histone inheritance

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  • Site-wide: 9,181
  • In developmental biology: 99
• Year to date:
  • Site-wide: 115,347
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  • Site-wide: 125,301

Personalized deep learning of individual immunopeptidomes to identify neoantigens for cancer vaccines

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  • Site-wide: 10,741
  • In bioinformatics: 1,164
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  • Site-wide: 25,119
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  • Site-wide: 33,459

Allocation of COVID-19 Vaccines Under Limited Supply

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  • Site-wide: 14,516
  • In infectious diseases: 1,870
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  • Site-wide: 37,320
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  • Site-wide: 50,214

A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples

• Downloaded 1,617 times
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  • Site-wide: 16,274
  • In genomics: 1,461
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  • Site-wide: 94,710

The Big Five, Self-efficacy, and Self-control in Boxers

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  • Site-wide: 17,487
  • In scientific communication and education: 137
• Year to date:
  • Site-wide: 25,143
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  • Site-wide: 22,360

A Comprehensive Multi-Center Cross-platform Benchmarking Study of Single-cell RNA Sequencing Using Reference Samples

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  • Site-wide: 19,032
  • In genomics: 1,699
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  • Site-wide: 71,947
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  • Site-wide: 70,731

ŌvSim: a Simulation of the Population Dynamics of Mammalian Ovarian Follicles

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  • Site-wide: 23,485
  • In physiology: 62
• Year to date:
  • Site-wide: 150,399
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  • Site-wide: 138,943

Low-Bias Amplification for Robust DNA Data Readout

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  • Site-wide: 25,428
  • In synthetic biology: 314
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  • Site-wide: 70,343
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  • Site-wide: 59,374

A Pairwise Distance Distribution Correction (DDC) algorithm to eliminate blinking-caused artifacts in super-resolution microscopy

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  • Site-wide: 27,575
  • In biophysics: 736
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  • Site-wide: 59,840
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  • Site-wide: 78,295

Stem cell mitotic drive ensures asymmetric epigenetic inheritance

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  • Site-wide: 28,167
  • In developmental biology: 477
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Identifying strategies to target the metabolic flexibility of tumours

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  • Site-wide: 28,527
  • In cancer biology: 669
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  • Site-wide: 114,128
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Single-cell transcriptome analysis reveals estrogen signaling augments the mitochondrial folate pathway to coordinately fuel purine and polyamine synthesis in breast cancer cells

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  • Site-wide: 28,620
  • In genomics: 2,346
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  • Site-wide: 112,125

Knowledge about benefits and risks of undergoing cataract surgery among cataract patients in Southern China

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  • Site-wide: 38,709
  • In ophthalmology: 16
• Year to date:
  • Site-wide: 39,310
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  • Site-wide: 31,095

Mapping and Inheritance analysis of a novel dominant rice male sterility mutant, OsDMS-1

• Downloaded 859 times
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  • Site-wide: 42,642
  • In genetics: 1,678
• Year to date:
  • Site-wide: 143,931
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  • Site-wide: 138,991

Robust retrieval of data stored in DNA by de Bruijn graph-based de novo strand assembly

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  • Site-wide: 44,282
  • In bioinformatics: 5,658
• Year to date:
  • Site-wide: 17,411
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  • Site-wide: 36,965

Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells

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  • Site-wide: 44,587
  • In biophysics: 1,408
• Year to date:
  • Site-wide: 75,925
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  • Site-wide: 57,592

GeneQC: A quality control tool for gene expression estimation based on RNA-sequencing reads mapping

• Downloaded 817 times
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  • Site-wide: 45,934
  • In bioinformatics: 4,427
• Year to date:
  • Site-wide: 139,121
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  • Site-wide: 153,688

Instructive starPEG-Heparin biohybrid 3D cultures for modeling human neural stem cell plasticity, neurogenesis, and neurodegeneration

• Downloaded 708 times
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  • Site-wide: 56,434
  • In neuroscience: 7,663
• Year to date:
  • Site-wide: 92,931
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  • Site-wide: 62,436

Chest Computed Tomography for the Diagnosis of Patients with Coronavirus Disease 2019 (COVID-19): A Rapid Review and Meta-Analysis

• Downloaded 702 times
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  • Site-wide: 57,141
  • In radiology and imaging: 95
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  • Site-wide: 107,627
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  • Site-wide: 152,528

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

• Downloaded 673 times
• Download rankings, all-time:
  • Site-wide: 60,668
  • In microbiology: 4,299
• Year to date:
  • Site-wide: 36,862
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  • Site-wide: 12,648

Clinically applicable histopathological diagnosis system for gastric cancer detection using deep learning

• Downloaded 665 times
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  • Site-wide: 61,678
  • In pathology: 266
• Year to date:
  • Site-wide: 157,044
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  • Site-wide: 184,537

A novel long noncoding RNA LINC00844 regulates prostate cancer cell migration and invasion through androgen receptor signaling

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  • Site-wide: 63,471
  • In cancer biology: 1,761
• Year to date:
  • Site-wide: 90,878
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  • Site-wide: 112,813

A tale of winglets: evolution of flight morphology in stick insects

• Downloaded 617 times
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  • Site-wide: 68,005
  • In evolutionary biology: 3,006
• Year to date:
  • Site-wide: 147,414
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  • Site-wide: 146,996

Sequence signatures of two IGHV3-53/3-66 public clonotypes to SARS-CoV-2 receptor binding domain

• Downloaded 602 times
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  • Site-wide: 70,283
  • In microbiology: 4,452
• Year to date:
  • Site-wide: 71,128
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  • Site-wide: 96,979

Asymmetric histone inheritance regulates stem cell fate in Drosophila midgut

• Downloaded 596 times
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  • Site-wide: 71,124
  • In developmental biology: 1,814
• Year to date:
  • Site-wide: 66,677
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  • Site-wide: 79,153

A Genetically Encoded Trimethylsilyl 1D 1H-NMR Probe for Conformation Change in Large Membrane Protein Complexes

• Downloaded 583 times
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  • Site-wide: 73,147
  • In biochemistry: 1,824
• Year to date:
  • Site-wide: 157,189
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  • Site-wide: 151,151

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

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  • Site-wide: 76,245
  • In biochemistry: None
• Year to date:
  • Site-wide: 4,258
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  • Site-wide: 566

Circular RNAs regulate cancer stem cells by FMRP against CCAR1 complex in hepatocellular carcinoma

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  • Site-wide: 78,147
  • In cancer biology: 2,110
• Year to date:
  • Site-wide: 166,209
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  • Site-wide: 183,056

A probabilistic model-based bi-clustering method for single-cell transcriptomic data analysis

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  • Site-wide: 82,028
  • In bioinformatics: 7,006
• Year to date:
  • Site-wide: 181,718
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  • Site-wide: 168,536

Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8

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  • Site-wide: 87,436
  • In biochemistry: 2,767
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  • Site-wide: 14,389

RECTA: Regulon Identification Based on Comparative Genomics and Transcriptomics Analysis

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  • Site-wide: 89,896
  • In systems biology: 1,805
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  • Site-wide: 176,474
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  • Site-wide: 172,799

Distinct pattern of autofluorescence of the skin and fingernails of acute ischemic stroke patients: A novel diagnostic biomarker for acute ischemic stroke

• Downloaded 476 times
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  • Site-wide: 92,865
  • In neuroscience: 12,730
• Year to date:
  • Site-wide: 160,144
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  • Site-wide: 143,222

Differential condensation of sister chromatids coordinates with Cdc6 to ensure distinct cell cycle progression in Drosophila male germline stem cell lineage

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  • Site-wide: 103,904
  • In developmental biology: 2,958
• Year to date:
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  • Site-wide: 32,975

Characterization of histone inheritance patterns in the Drosophila female germline

• Downloaded 408 times
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  • Site-wide: 108,581
  • In developmental biology: 2,739
• Year to date:
  • Site-wide: 143,069
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  • Site-wide: 131,404

Relationship between ecological stoichiometry and community diversity of plant ecosystems in the upper reaches of the Tarim River, China

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  • Site-wide: 110,890
  • In ecology: 2,916
• Year to date:
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  • Site-wide: 136,195

Green autofluorescence intensity of skin and fingernails: A novel biomarker for non-invasive evaluation of pathological state of blood vessels

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  • Site-wide: 116,877
  • In pathology: 574
• Year to date:
  • Site-wide: 170,262
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  • Site-wide: 171,666

A Multi-center Cross-platform Single-cell RNA Sequencing Reference Dataset

• Downloaded 372 times
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  • Site-wide: 117,940
  • In bioinformatics: 9,262
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  • Site-wide: 156,661
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  • Site-wide: 163,782

Mixed Culture of Bacterial Cell for Large Scale DNA Storage

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  • Site-wide: 118,730
  • In molecular biology: 3,266
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  • Site-wide: 151,593

Prevalence, incidence and risk factors for myopia among urban and rural children in southern China: protocol for a school-based cohort study

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  • Site-wide: 119,153
  • In ophthalmology: 131
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Developmentally programmed epigenome regulates cellular plasticity at the parental-to-zygote transition

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  • Site-wide: 122,277
  • In developmental biology: None
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  • Site-wide: 8,488
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Associated habitat and suitability modeling of goldenseal (Hydrastis canadensis L.) in Pennsylvania: explaining and predicting species distribution in a northern edge of range state

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  • Site-wide: 122,699
  • In ecology: 3,512
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Trabeculae microstructure parameters serve as effective predictors for marginal bone loss of dental implant in the mandible

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  • Site-wide: 123,465
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Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

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  • Site-wide: 131,770
  • In cancer biology: 3,717
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  • Site-wide: 161,234

The Human walking kinematic model combined with upper and lower limb movement

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  • Site-wide: 149,447
  • In biophysics: 5,913
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  • Site-wide: 22,777

Sleep disturbances and related factors among preschool children in rural areas of China: a cross-sectional study

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  • Site-wide: 149,894
  • In epidemiology: 6,108
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RASSF1A independence and early Galectin-1 upregulation in PIK3CA induced hepatocarcinogenesis: new therapeutic venues

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  • Site-wide: 152,563
  • In pathology: 843
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Modulation of glucose metabolism by 2-Deoxy-D-Glucose (2DG) promotes IL-17 producing human T cell subsets

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  • Site-wide: 153,915
  • In immunology: None
• Year to date:
  • Site-wide: 14,605
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Algorithm optimization for weighted gene co-expression network analysis: accelerating the calculation of Topology Overlap Matrices with OpenMP and SQLite

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  • Site-wide: 154,206
  • In bioinformatics: 11,612
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  • Site-wide: 96,592
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  • Site-wide: 50,137

Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina

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  • Site-wide: 165,960
  • In genomics: 7,818
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  • Site-wide: 160,607

Trends and Patterns of Opioid Epidemic: A Large-Scale Retrospective Study of Hospital Visits with Opioid Poisoning in New York State, 2010-2016

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  • Site-wide: 170,131
  • In public and global health: 2,282
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Does Obstructive sleep apnea increase the risk of Parkinson Disease? A systematic review and meta-analysis.

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  • Site-wide: 171,977
  • In epidemiology: 6,687
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  • Site-wide: 117,833

Testing the link between isoaspartate and Alzheimer's disease etiology

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  • Site-wide: 187,997
  • In neuroscience: None
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  • Site-wide: 58,820
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Multifaceted role of RIMBP2 in promoting hearing in murine cochlear hair cells

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  • Site-wide: 188,934
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