Author: Xin Chen

Downloads per author, site-wide

Preprints

Immunogenicity and Safety of a SARS-CoV-2 Inactivated Vaccine in Healthy Adults Aged 18-59 years: Report of the Randomized, Double-blind, and Placebo-controlled Phase 2 Clinical Trial

• Downloaded 23,076 times
• Download rankings, all-time:
  • Site-wide: 330
  • In public and global health: 14
• Year to date:
  • Site-wide: 133
• Since beginning of last month:
  • Site-wide: 104

Fate mapping via Ms4a3 expression history traces monocyte-derived cells

• Downloaded 3,347 times
• Download rankings, all-time:
  • Site-wide: 4,074
  • In immunology: 139
• Year to date:
  • Site-wide: 15,794
• Since beginning of last month:
  • Site-wide: 20,937

A Novel Triage Tool of Artificial Intelligence Assisted Diagnosis Aid System for Suspected COVID-19 pneumonia In Fever Clinics

• Downloaded 2,624 times
• Download rankings, all-time:
  • Site-wide: 5,755
  • In emergency medicine: 9
• Year to date:
  • Site-wide: 7,628
• Since beginning of last month:
  • Site-wide: 10,037

Unidirectional fork movement coupled with strand-specific histone incorporation ensures asymmetric histone inheritance

• Downloaded 2,285 times
• Download rankings, all-time:
  • Site-wide: 7,077
  • In developmental biology: 83
• Year to date:
  • Site-wide: 77,136
• Since beginning of last month:
  • Site-wide: 100,921

Personalized deep learning of individual immunopeptidomes to identify neoantigens for cancer vaccines

• Downloaded 1,722 times
• Download rankings, all-time:
  • Site-wide: 10,735
  • In bioinformatics: 1,248
• Year to date:
  • Site-wide: 31,043
• Since beginning of last month:
  • Site-wide: 39,633

Allocation of COVID-19 Vaccines Under Limited Supply

• Downloaded 1,421 times
• Download rankings, all-time:
  • Site-wide: 14,260
  • In infectious diseases: 1,599
• Year to date:
  • Site-wide: 8,621
• Since beginning of last month:
  • Site-wide: 17,083

A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples

• Downloaded 1,402 times
• Download rankings, all-time:
  • Site-wide: 14,563
  • In genomics: 1,488
• Year to date:
  • Site-wide: 2,423
• Since beginning of last month:
  • Site-wide: 7,253

The Big Five, Self-efficacy, and Self-control in Boxers

• Downloaded 1,248 times
• Download rankings, all-time:
  • Site-wide: 17,341
  • In scientific communication and education: 138
• Year to date:
  • Site-wide: 23,572
• Since beginning of last month:
  • Site-wide: 33,423

ŌvSim: a Simulation of the Population Dynamics of Mammalian Ovarian Follicles

• Downloaded 1,189 times
• Download rankings, all-time:
  • Site-wide: 18,638
  • In physiology: 53
• Year to date:
  • Site-wide: 58,096
• Since beginning of last month:
  • Site-wide: 43,674

A Comprehensive Multi-Center Cross-platform Benchmarking Study of Single-cell RNA Sequencing Using Reference Samples

• Downloaded 1,186 times
• Download rankings, all-time:
  • Site-wide: 18,691
  • In genomics: 1,834
• Year to date:
  • Site-wide: 19,361
• Since beginning of last month:
  • Site-wide: 24,830

Single-cell transcriptome analysis reveals estrogen signaling augments the mitochondrial folate pathway to coordinately fuel purine and polyamine synthesis in breast cancer cells

• Downloaded 1,076 times
• Download rankings, all-time:
  • Site-wide: 21,560
  • In genomics: 2,073
• Year to date:
  • Site-wide: 111,082
• Since beginning of last month:
  • Site-wide: 113,056

Low-Bias Amplification for Robust DNA Data Readout

• Downloaded 1,046 times
• Download rankings, all-time:
  • Site-wide: 22,500
  • In synthetic biology: 288
• Year to date:
  • Site-wide: 43,560
• Since beginning of last month:
  • Site-wide: 37,043

Stem cell mitotic drive ensures asymmetric epigenetic inheritance

• Downloaded 1,037 times
• Download rankings, all-time:
  • Site-wide: 22,821
  • In developmental biology: 405
• Year to date:
  • Site-wide: 85,402
• Since beginning of last month:
  • Site-wide: 79,933

Identifying strategies to target the metabolic flexibility of tumours

• Downloaded 981 times
• Download rankings, all-time:
  • Site-wide: 24,703
  • In cancer biology: 604
• Year to date:
  • Site-wide: 44,598
• Since beginning of last month:
  • Site-wide: 72,498

A Pairwise Distance Distribution Correction (DDC) algorithm to eliminate blinking-caused artifacts in super-resolution microscopy

• Downloaded 956 times
• Download rankings, all-time:
  • Site-wide: 25,677
  • In biophysics: 713
• Year to date:
  • Site-wide: 30,983
• Since beginning of last month:
  • Site-wide: 24,097

Mapping and Inheritance analysis of a novel dominant rice male sterility mutant, OsDMS-1

• Downloaded 750 times
• Download rankings, all-time:
  • Site-wide: 36,062
  • In genetics: 1,654
• Year to date:
  • Site-wide: 91,425
• Since beginning of last month:
  • Site-wide: 57,516

GeneQC: A quality control tool for gene expression estimation based on RNA-sequencing reads mapping

• Downloaded 733 times
• Download rankings, all-time:
  • Site-wide: 37,196
  • In bioinformatics: 4,040
• Year to date:
  • Site-wide: 107,884
• Since beginning of last month:
  • Site-wide: 134,999

Chest Computed Tomography for the Diagnosis of Patients with Coronavirus Disease 2019 (COVID-19): A Rapid Review and Meta-Analysis

• Downloaded 616 times
• Download rankings, all-time:
  • Site-wide: 46,758
  • In radiology and imaging: 77
• Year to date:
  • Site-wide: 95,423
• Since beginning of last month:
  • Site-wide: 103,028

Clinically applicable histopathological diagnosis system for gastric cancer detection using deep learning

• Downloaded 614 times
• Download rankings, all-time:
  • Site-wide: 46,878
  • In pathology: 216
• Year to date:
  • Site-wide: 79,227
• Since beginning of last month:
  • Site-wide: 119,856

Knowledge about benefits and risks of undergoing cataract surgery among cataract patients in Southern China

• Downloaded 588 times
• Download rankings, all-time:
  • Site-wide: 49,479
  • In ophthalmology: 22
• Year to date:
  • Site-wide: 28,557
• Since beginning of last month:
  • Site-wide: 17,618

Instructive starPEG-Heparin biohybrid 3D cultures for modeling human neural stem cell plasticity, neurogenesis, and neurodegeneration

• Downloaded 584 times
• Download rankings, all-time:
  • Site-wide: 49,977
  • In neuroscience: 7,150
• Year to date:
  • Site-wide: 80,836
• Since beginning of last month:
  • Site-wide: 69,332

A novel long noncoding RNA LINC00844 regulates prostate cancer cell migration and invasion through androgen receptor signaling

• Downloaded 573 times
• Download rankings, all-time:
  • Site-wide: 51,179
  • In cancer biology: 1,437
• Year to date:
  • Site-wide: 96,440
• Since beginning of last month:
  • Site-wide: 61,098

A tale of winglets: evolution of flight morphology in stick insects

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 53,514
  • In evolutionary biology: 2,759
• Year to date:
  • Site-wide: 82,086
• Since beginning of last month:
  • Site-wide: 120,600

Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells

• Downloaded 541 times
• Download rankings, all-time:
  • Site-wide: 54,846
  • In biophysics: 1,843
• Year to date:
  • Site-wide: 19,750
• Since beginning of last month:
  • Site-wide: 19,123

A Genetically Encoded Trimethylsilyl 1D 1H-NMR Probe for Conformation Change in Large Membrane Protein Complexes

• Downloaded 495 times
• Download rankings, all-time:
  • Site-wide: 60,820
  • In biochemistry: 1,610
• Year to date:
  • Site-wide: 78,645
• Since beginning of last month:
  • Site-wide: 53,236

A probabilistic model-based bi-clustering method for single-cell transcriptomic data analysis

• Downloaded 471 times
• Download rankings, all-time:
  • Site-wide: 64,202
  • In bioinformatics: 6,251
• Year to date:
  • Site-wide: 146,583
• Since beginning of last month:
  • Site-wide: 145,647

Circular RNAs regulate cancer stem cells by FMRP against CCAR1 complex in hepatocellular carcinoma

• Downloaded 460 times
• Download rankings, all-time:
  • Site-wide: 65,801
  • In cancer biology: 1,899
• Year to date:
  • Site-wide: 105,964
• Since beginning of last month:
  • Site-wide: 130,571

RECTA: Regulon Identification Based on Comparative Genomics and Transcriptomics Analysis

• Downloaded 440 times
• Download rankings, all-time:
  • Site-wide: 68,993
  • In systems biology: 1,612
• Year to date:
  • Site-wide: 120,610
• Since beginning of last month:
  • Site-wide: 145,269

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 71,901
  • In microbiology: 4,814
• Year to date:
  • Site-wide: 10,097
• Since beginning of last month:
  • Site-wide: 26,956

Asymmetric histone inheritance regulates stem cell fate in Drosophila midgut

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 71,744
  • In developmental biology: 1,813
• Year to date:
  • Site-wide: 74,033
• Since beginning of last month:
  • Site-wide: 71,405

Sequence signatures of two IGHV3-53/3-66 public clonotypes to SARS-CoV-2 receptor binding domain

• Downloaded 417 times
• Download rankings, all-time:
  • Site-wide: 72,857
  • In microbiology: 4,891
• Year to date:
  • Site-wide: 10,321
• Since beginning of last month:
  • Site-wide: 23,853

Distinct pattern of autofluorescence of the skin and fingernails of acute ischemic stroke patients: A novel diagnostic biomarker for acute ischemic stroke

• Downloaded 400 times
• Download rankings, all-time:
  • Site-wide: 75,804
  • In neuroscience: 11,334
• Year to date:
  • Site-wide: 112,478
• Since beginning of last month:
  • Site-wide: 134,888

Characterization of histone inheritance patterns in the Drosophila female germline

• Downloaded 330 times
• Download rankings, all-time:
  • Site-wide: 89,413
  • In developmental biology: 2,375
• Year to date:
  • Site-wide: 69,834
• Since beginning of last month:
  • Site-wide: 77,996

Relationship between ecological stoichiometry and community diversity of plant ecosystems in the upper reaches of the Tarim River, China

• Downloaded 312 times
• Download rankings, all-time:
  • Site-wide: 93,551
  • In ecology: 2,792
• Year to date:
  • Site-wide: 115,871
• Since beginning of last month:
  • Site-wide: 112,174

Green autofluorescence intensity of skin and fingernails: A novel biomarker for non-invasive evaluation of pathological state of blood vessels

• Downloaded 311 times
• Download rankings, all-time:
  • Site-wide: 93,797
  • In pathology: 481
• Year to date:
  • Site-wide: 138,804
• Since beginning of last month:
  • Site-wide: 134,256

Mixed Culture of Bacterial Cell for Large Scale DNA Storage

• Downloaded 296 times
• Download rankings, all-time:
  • Site-wide: 97,077
  • In molecular biology: 2,871
• Year to date:
  • Site-wide: 101,667
• Since beginning of last month:
  • Site-wide: 95,904

A Multi-center Cross-platform Single-cell RNA Sequencing Reference Dataset

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 99,435
  • In bioinformatics: 8,548
• Year to date:
  • Site-wide: 79,029
• Since beginning of last month:
  • Site-wide: 120,354

Trabeculae microstructure parameters serve as effective predictors for marginal bone loss of dental implant in the mandible

• Downloaded 278 times
• Download rankings, all-time:
  • Site-wide: 101,117
  • In dentistry and oral medicine: 72
• Year to date:
  • Site-wide: 50,812
• Since beginning of last month:
  • Site-wide: 108,972

Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8

• Downloaded 271 times
• Download rankings, all-time:
  • Site-wide: 102,832
  • In biochemistry: 2,994
• Year to date:
  • Site-wide: 18,855
• Since beginning of last month:
  • Site-wide: 27,254

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

• Downloaded 256 times
• Download rankings, all-time:
  • Site-wide: 106,580
  • In cancer biology: 3,218
• Year to date:
  • Site-wide: 54,097
• Since beginning of last month:
  • Site-wide: 44,866

Associated habitat and suitability modeling of goldenseal (Hydrastis canadensis L.) in Pennsylvania: explaining and predicting species distribution in a northern edge of range state

• Downloaded 256 times
• Download rankings, all-time:
  • Site-wide: 106,378
  • In ecology: 3,375
• Year to date:
  • Site-wide: 116,206
• Since beginning of last month:
  • Site-wide: 80,536

Differential condensation of sister chromatids coordinates with Cdc6 to ensure distinct cell cycle progression in Drosophila male germline stem cell lineage

• Downloaded 206 times
• Download rankings, all-time:
  • Site-wide: 118,690
  • In developmental biology: 3,206
• Year to date:
  • Site-wide: 27,008
• Since beginning of last month:
  • Site-wide: 51,325

Prevalence, incidence and risk factors for myopia among urban and rural children in southern China: protocol for a school-based cohort study

• Downloaded 192 times
• Download rankings, all-time:
  • Site-wide: 122,303
  • In ophthalmology: 131
• Year to date:
  • Site-wide: 29,386
• Since beginning of last month:
  • Site-wide: 14,634

Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina

• Downloaded 164 times
• Download rankings, all-time:
  • Site-wide: 128,806
  • In genomics: 6,938
• Year to date:
  • Site-wide: 97,499
• Since beginning of last month:
  • Site-wide: 96,287

RASSF1A independence and early Galectin-1 upregulation in PIK3CA induced hepatocarcinogenesis: new therapeutic venues

• Downloaded 142 times
• Download rankings, all-time:
  • Site-wide: 133,661
  • In pathology: 780
• Year to date:
  • Site-wide: 41,712
• Since beginning of last month:
  • Site-wide: 6,564

Algorithm optimization for weighted gene co-expression network analysis: accelerating the calculation of Topology Overlap Matrices with OpenMP and SQLite

• Downloaded 129 times
• Download rankings, all-time:
  • Site-wide: 136,366
  • In bioinformatics: 10,645
• Year to date:
  • Site-wide: 46,017
• Since beginning of last month:
  • Site-wide: 141,464

Trends and Patterns of Opioid Epidemic: A Large-Scale Retrospective Study of Hospital Visits with Opioid Poisoning in New York State, 2010-2016

• Downloaded 110 times
• Download rankings, all-time:
  • Site-wide: 140,124
  • In public and global health: 1,842
• Year to date:
  • Site-wide: 104,543
• Since beginning of last month:
  • Site-wide: 109,036

Sleep disturbances and related factors among preschool children in rural areas of China: a cross-sectional study

• Downloaded 102 times
• Download rankings, all-time:
  • Site-wide: 141,554
  • In epidemiology: 5,805
• Year to date:
  • Site-wide: 96,972
• Since beginning of last month:
  • Site-wide: 80,804

The Human walking kinematic model combined with upper and lower limb movement

• Downloaded 92 times
• Download rankings, all-time:
  • Site-wide: 143,207
  • In biophysics: 5,498
• Year to date:
  • Site-wide: 63,459
• Since beginning of last month:
  • Site-wide: 49,304

Does Obstructive sleep apnea increase the risk of Parkinson Disease? A systematic review and meta-analysis.

• Downloaded 89 times
• Download rankings, all-time:
  • Site-wide: 143,769
  • In epidemiology: 5,900
• Year to date:
  • Site-wide: 119,067
• Since beginning of last month:
  • Site-wide: 87,513