Author: Xin Chen

Downloads per author, site-wide

Preprints

Immunogenicity and Safety of a SARS-CoV-2 Inactivated Vaccine in Healthy Adults Aged 18-59 years: Report of the Randomized, Double-blind, and Placebo-controlled Phase 2 Clinical Trial

• Downloaded 26,428 times
• Download rankings, all-time:
  • Site-wide: 330
  • In public and global health: 16
• Year to date:
  • Site-wide: 187
• Since beginning of last month:
  • Site-wide: 586

Fate mapping via Ms4a3 expression history traces monocyte-derived cells

• Downloaded 3,451 times
• Download rankings, all-time:
  • Site-wide: 4,488
  • In immunology: 159
• Year to date:
  • Site-wide: 21,489
• Since beginning of last month:
  • Site-wide: 47,516

A Novel Triage Tool of Artificial Intelligence Assisted Diagnosis Aid System for Suspected COVID-19 pneumonia In Fever Clinics

• Downloaded 2,921 times
• Download rankings, all-time:
  • Site-wide: 5,727
  • In emergency medicine: 8
• Year to date:
  • Site-wide: 7,486
• Since beginning of last month:
  • Site-wide: 7,290

Unidirectional fork movement coupled with strand-specific histone incorporation ensures asymmetric histone inheritance

• Downloaded 2,342 times
• Download rankings, all-time:
  • Site-wide: 7,902
  • In developmental biology: 93
• Year to date:
  • Site-wide: 91,914
• Since beginning of last month:
  • Site-wide: 97,360

Personalized deep learning of individual immunopeptidomes to identify neoantigens for cancer vaccines

• Downloaded 1,924 times
• Download rankings, all-time:
  • Site-wide: 10,574
  • In bioinformatics: 1,194
• Year to date:
  • Site-wide: 23,849
• Since beginning of last month:
  • Site-wide: 16,228

Allocation of COVID-19 Vaccines Under Limited Supply

• Downloaded 1,598 times
• Download rankings, all-time:
  • Site-wide: 13,900
  • In infectious diseases: 1,715
• Year to date:
  • Site-wide: 10,640
• Since beginning of last month:
  • Site-wide: 18,350

A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples

• Downloaded 1,559 times
• Download rankings, all-time:
  • Site-wide: 14,486
  • In genomics: 1,425
• Year to date:
  • Site-wide: 3,703
• Since beginning of last month:
  • Site-wide: 40,336

A Comprehensive Multi-Center Cross-platform Benchmarking Study of Single-cell RNA Sequencing Using Reference Samples

• Downloaded 1,387 times
• Download rankings, all-time:
  • Site-wide: 17,454
  • In genomics: 1,667
• Year to date:
  • Site-wide: 17,728
• Since beginning of last month:
  • Site-wide: 25,123

The Big Five, Self-efficacy, and Self-control in Boxers

• Downloaded 1,369 times
• Download rankings, all-time:
  • Site-wide: 17,775
  • In scientific communication and education: 136
• Year to date:
  • Site-wide: 27,517
• Since beginning of last month:
  • Site-wide: 27,504

ŌvSim: a Simulation of the Population Dynamics of Mammalian Ovarian Follicles

• Downloaded 1,239 times
• Download rankings, all-time:
  • Site-wide: 20,630
  • In physiology: 57
• Year to date:
  • Site-wide: 79,231
• Since beginning of last month:
  • Site-wide: 92,404

Low-Bias Amplification for Robust DNA Data Readout

• Downloaded 1,120 times
• Download rankings, all-time:
  • Site-wide: 24,057
  • In synthetic biology: 305
• Year to date:
  • Site-wide: 54,729
• Since beginning of last month:
  • Site-wide: 79,510

Single-cell transcriptome analysis reveals estrogen signaling augments the mitochondrial folate pathway to coordinately fuel purine and polyamine synthesis in breast cancer cells

• Downloaded 1,104 times
• Download rankings, all-time:
  • Site-wide: 24,606
  • In genomics: 2,243
• Year to date:
  • Site-wide: 140,897
• Since beginning of last month:
  • Site-wide: 138,107

Stem cell mitotic drive ensures asymmetric epigenetic inheritance

• Downloaded 1,095 times
• Download rankings, all-time:
  • Site-wide: 24,889
  • In developmental biology: 438
• Year to date:
  • Site-wide: 97,653
• Since beginning of last month:
  • Site-wide: 93,123

Identifying strategies to target the metabolic flexibility of tumours

• Downloaded 1,082 times
• Download rankings, all-time:
  • Site-wide: 25,403
  • In cancer biology: 637
• Year to date:
  • Site-wide: 47,708
• Since beginning of last month:
  • Site-wide: 50,938

A Pairwise Distance Distribution Correction (DDC) algorithm to eliminate blinking-caused artifacts in super-resolution microscopy

• Downloaded 1,061 times
• Download rankings, all-time:
  • Site-wide: 26,187
  • In biophysics: 725
• Year to date:
  • Site-wide: 36,142
• Since beginning of last month:
  • Site-wide: 45,882

Mapping and Inheritance analysis of a novel dominant rice male sterility mutant, OsDMS-1

• Downloaded 831 times
• Download rankings, all-time:
  • Site-wide: 37,397
  • In genetics: 1,633
• Year to date:
  • Site-wide: 86,189
• Since beginning of last month:
  • Site-wide: 50,526

GeneQC: A quality control tool for gene expression estimation based on RNA-sequencing reads mapping

• Downloaded 787 times
• Download rankings, all-time:
  • Site-wide: 40,460
  • In bioinformatics: 4,274
• Year to date:
  • Site-wide: 116,619
• Since beginning of last month:
  • Site-wide: 132,125

Knowledge about benefits and risks of undergoing cataract surgery among cataract patients in Southern China

• Downloaded 767 times
• Download rankings, all-time:
  • Site-wide: 42,023
  • In ophthalmology: 18
• Year to date:
  • Site-wide: 24,805
• Since beginning of last month:
  • Site-wide: 16,870

Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells

• Downloaded 765 times
• Download rankings, all-time:
  • Site-wide: 42,185
  • In biophysics: 1,354
• Year to date:
  • Site-wide: 16,613
• Since beginning of last month:
  • Site-wide: 6,556

Chest Computed Tomography for the Diagnosis of Patients with Coronavirus Disease 2019 (COVID-19): A Rapid Review and Meta-Analysis

• Downloaded 654 times
• Download rankings, all-time:
  • Site-wide: 52,427
  • In radiology and imaging: 91
• Year to date:
  • Site-wide: 121,198
• Since beginning of last month:
  • Site-wide: 136,796

Instructive starPEG-Heparin biohybrid 3D cultures for modeling human neural stem cell plasticity, neurogenesis, and neurodegeneration

• Downloaded 648 times
• Download rankings, all-time:
  • Site-wide: 53,013
  • In neuroscience: 7,476
• Year to date:
  • Site-wide: 90,894
• Since beginning of last month:
  • Site-wide: 106,834

Clinically applicable histopathological diagnosis system for gastric cancer detection using deep learning

• Downloaded 643 times
• Download rankings, all-time:
  • Site-wide: 53,597
  • In pathology: 252
• Year to date:
  • Site-wide: 115,033
• Since beginning of last month:
  • Site-wide: 143,831

A novel long noncoding RNA LINC00844 regulates prostate cancer cell migration and invasion through androgen receptor signaling

• Downloaded 599 times
• Download rankings, all-time:
  • Site-wide: 58,828
  • In cancer biology: 1,691
• Year to date:
  • Site-wide: 133,106
• Since beginning of last month:
  • Site-wide: 152,384

A tale of winglets: evolution of flight morphology in stick insects

• Downloaded 591 times
• Download rankings, all-time:
  • Site-wide: 59,887
  • In evolutionary biology: 2,929
• Year to date:
  • Site-wide: 109,786
• Since beginning of last month:
  • Site-wide: 141,663

A Genetically Encoded Trimethylsilyl 1D 1H-NMR Probe for Conformation Change in Large Membrane Protein Complexes

• Downloaded 558 times
• Download rankings, all-time:
  • Site-wide: 64,244
  • In biochemistry: 1,711
• Year to date:
  • Site-wide: 89,524
• Since beginning of last month:
  • Site-wide: 88,654

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

• Downloaded 538 times
• Download rankings, all-time:
  • Site-wide: 67,125
  • In microbiology: 4,304
• Year to date:
  • Site-wide: 14,223
• Since beginning of last month:
  • Site-wide: 76,566

Circular RNAs regulate cancer stem cells by FMRP against CCAR1 complex in hepatocellular carcinoma

• Downloaded 528 times
• Download rankings, all-time:
  • Site-wide: 68,601
  • In cancer biology: 1,974
• Year to date:
  • Site-wide: 103,319
• Since beginning of last month:
  • Site-wide: 68,041

Sequence signatures of two IGHV3-53/3-66 public clonotypes to SARS-CoV-2 receptor binding domain

• Downloaded 524 times
• Download rankings, all-time:
  • Site-wide: 69,200
  • In microbiology: 4,466
• Year to date:
  • Site-wide: 14,813
• Since beginning of last month:
  • Site-wide: 63,137

A probabilistic model-based bi-clustering method for single-cell transcriptomic data analysis

• Downloaded 515 times
• Download rankings, all-time:
  • Site-wide: 70,649
  • In bioinformatics: 6,668
• Year to date:
  • Site-wide: 148,774
• Since beginning of last month:
  • Site-wide: 117,348

Asymmetric histone inheritance regulates stem cell fate in Drosophila midgut

• Downloaded 505 times
• Download rankings, all-time:
  • Site-wide: 72,216
  • In developmental biology: 1,823
• Year to date:
  • Site-wide: 75,307
• Since beginning of last month:
  • Site-wide: 47,999

RECTA: Regulon Identification Based on Comparative Genomics and Transcriptomics Analysis

• Downloaded 471 times
• Download rankings, all-time:
  • Site-wide: 78,077
  • In systems biology: 1,750
• Year to date:
  • Site-wide: 144,308
• Since beginning of last month:
  • Site-wide: 134,136

Distinct pattern of autofluorescence of the skin and fingernails of acute ischemic stroke patients: A novel diagnostic biomarker for acute ischemic stroke

• Downloaded 453 times
• Download rankings, all-time:
  • Site-wide: 81,485
  • In neuroscience: 12,024
• Year to date:
  • Site-wide: 119,213
• Since beginning of last month:
  • Site-wide: 78,520

Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8

• Downloaded 390 times
• Download rankings, all-time:
  • Site-wide: 94,606
  • In biochemistry: 2,725
• Year to date:
  • Site-wide: 23,449
• Since beginning of last month:
  • Site-wide: 46,971

Characterization of histone inheritance patterns in the Drosophila female germline

• Downloaded 381 times
• Download rankings, all-time:
  • Site-wide: 96,533
  • In developmental biology: 2,611
• Year to date:
  • Site-wide: 90,294
• Since beginning of last month:
  • Site-wide: 118,066

Relationship between ecological stoichiometry and community diversity of plant ecosystems in the upper reaches of the Tarim River, China

• Downloaded 372 times
• Download rankings, all-time:
  • Site-wide: 98,540
  • In ecology: 2,808
• Year to date:
  • Site-wide: 115,709
• Since beginning of last month:
  • Site-wide: 117,427

Green autofluorescence intensity of skin and fingernails: A novel biomarker for non-invasive evaluation of pathological state of blood vessels

• Downloaded 357 times
• Download rankings, all-time:
  • Site-wide: 102,088
  • In pathology: 541
• Year to date:
  • Site-wide: 141,661
• Since beginning of last month:
  • Site-wide: 121,376

Mixed Culture of Bacterial Cell for Large Scale DNA Storage

• Downloaded 350 times
• Download rankings, all-time:
  • Site-wide: 103,941
  • In molecular biology: 3,089
• Year to date:
  • Site-wide: 112,241
• Since beginning of last month:
  • Site-wide: 108,423

A Multi-center Cross-platform Single-cell RNA Sequencing Reference Dataset

• Downloaded 346 times
• Download rankings, all-time:
  • Site-wide: 104,711
  • In bioinformatics: 8,873
• Year to date:
  • Site-wide: 92,187
• Since beginning of last month:
  • Site-wide: 108,839

Trabeculae microstructure parameters serve as effective predictors for marginal bone loss of dental implant in the mandible

• Downloaded 321 times
• Download rankings, all-time:
  • Site-wide: 111,173
  • In dentistry and oral medicine: 85
• Year to date:
  • Site-wide: 74,938
• Since beginning of last month:
  • Site-wide: 131,403

Differential condensation of sister chromatids coordinates with Cdc6 to ensure distinct cell cycle progression in Drosophila male germline stem cell lineage

• Downloaded 320 times
• Download rankings, all-time:
  • Site-wide: 111,236
  • In developmental biology: 3,038
• Year to date:
  • Site-wide: 31,356
• Since beginning of last month:
  • Site-wide: 21,513

Associated habitat and suitability modeling of goldenseal (Hydrastis canadensis L.) in Pennsylvania: explaining and predicting species distribution in a northern edge of range state

• Downloaded 312 times
• Download rankings, all-time:
  • Site-wide: 113,276
  • In ecology: 3,465
• Year to date:
  • Site-wide: 119,581
• Since beginning of last month:
  • Site-wide: 102,952

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

• Downloaded 305 times
• Download rankings, all-time:
  • Site-wide: 115,165
  • In cancer biology: 3,486
• Year to date:
  • Site-wide: 75,386
• Since beginning of last month:
  • Site-wide: 99,441

Prevalence, incidence and risk factors for myopia among urban and rural children in southern China: protocol for a school-based cohort study

• Downloaded 298 times
• Download rankings, all-time:
  • Site-wide: 116,994
  • In ophthalmology: 128
• Year to date:
  • Site-wide: 34,578
• Since beginning of last month:
  • Site-wide: 63,204

RASSF1A independence and early Galectin-1 upregulation in PIK3CA induced hepatocarcinogenesis: new therapeutic venues

• Downloaded 221 times
• Download rankings, all-time:
  • Site-wide: 137,205
  • In pathology: 795
• Year to date:
  • Site-wide: 51,431
• Since beginning of last month:
  • Site-wide: 111,085

Algorithm optimization for weighted gene co-expression network analysis: accelerating the calculation of Topology Overlap Matrices with OpenMP and SQLite

• Downloaded 197 times
• Download rankings, all-time:
  • Site-wide: 143,035
  • In bioinformatics: 11,077
• Year to date:
  • Site-wide: 59,105
• Since beginning of last month:
  • Site-wide: 100,723

The Human walking kinematic model combined with upper and lower limb movement

• Downloaded 189 times
• Download rankings, all-time:
  • Site-wide: 145,059
  • In biophysics: 5,527
• Year to date:
  • Site-wide: 62,334
• Since beginning of last month:
  • Site-wide: 49,159

Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina

• Downloaded 186 times
• Download rankings, all-time:
  • Site-wide: 145,571
  • In genomics: 7,504
• Year to date:
  • Site-wide: 137,273
• Since beginning of last month:
  • Site-wide: 151,221

Sleep disturbances and related factors among preschool children in rural areas of China: a cross-sectional study

• Downloaded 181 times
• Download rankings, all-time:
  • Site-wide: 146,737
  • In epidemiology: 6,101
• Year to date:
  • Site-wide: 91,056
• Since beginning of last month:
  • Site-wide: 76,707

Trends and Patterns of Opioid Epidemic: A Large-Scale Retrospective Study of Hospital Visits with Opioid Poisoning in New York State, 2010-2016

• Downloaded 171 times
• Download rankings, all-time:
  • Site-wide: 148,941
  • In public and global health: 2,053
• Year to date:
  • Site-wide: 108,299
• Since beginning of last month:
  • Site-wide: 95,027

Does Obstructive sleep apnea increase the risk of Parkinson Disease? A systematic review and meta-analysis.

• Downloaded 156 times
• Download rankings, all-time:
  • Site-wide: 151,885
  • In epidemiology: 6,290
• Year to date:
  • Site-wide: 112,055
• Since beginning of last month:
  • Site-wide: 85,050