Author: Xin Chen

Downloads per author, site-wide

Preprints

Immunogenicity and Safety of a SARS-CoV-2 Inactivated Vaccine in Healthy Adults Aged 18-59 years: Report of the Randomized, Double-blind, and Placebo-controlled Phase 2 Clinical Trial

• Downloaded 27,907 times
• Download rankings, all-time:
  • Site-wide: 382
  • In public and global health: 17
• Year to date:
  • Site-wide: 2,493
• Since beginning of last month:
  • Site-wide: 6,021

Fate mapping via Ms4a3 expression history traces monocyte-derived cells

• Downloaded 3,636 times
• Download rankings, all-time:
  • Site-wide: 5,352
  • In immunology: 207
• Year to date:
  • Site-wide: 53,183
• Since beginning of last month:
  • Site-wide: 29,622

A Novel Triage Tool of Artificial Intelligence Assisted Diagnosis Aid System for Suspected COVID-19 pneumonia In Fever Clinics

• Downloaded 3,189 times
• Download rankings, all-time:
  • Site-wide: 6,527
  • In emergency medicine: 8
• Year to date:
  • Site-wide: 35,905
• Since beginning of last month:
  • Site-wide: 34,519

Unidirectional fork movement coupled with strand-specific histone incorporation ensures asymmetric histone inheritance

• Downloaded 2,422 times
• Download rankings, all-time:
  • Site-wide: 9,743
  • In developmental biology: 104
• Year to date:
  • Site-wide: 117,651
• Since beginning of last month:
  • Site-wide: 54,919

Personalized deep learning of individual immunopeptidomes to identify neoantigens for cancer vaccines

• Downloaded 2,250 times
• Download rankings, all-time:
  • Site-wide: 10,900
  • In bioinformatics: 1,138
• Year to date:
  • Site-wide: 27,114
• Since beginning of last month:
  • Site-wide: 56,952

Allocation of COVID-19 Vaccines Under Limited Supply

• Downloaded 1,871 times
• Download rankings, all-time:
  • Site-wide: 14,397
  • In infectious diseases: 1,954
• Year to date:
  • Site-wide: 33,080
• Since beginning of last month:
  • Site-wide: 26,879

The Big Five, Self-efficacy, and Self-control in Boxers

• Downloaded 1,760 times
• Download rankings, all-time:
  • Site-wide: 15,831
  • In scientific communication and education: 130
• Year to date:
  • Site-wide: 16,822
• Since beginning of last month:
  • Site-wide: 3,629

A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples

• Downloaded 1,688 times
• Download rankings, all-time:
  • Site-wide: 16,847
  • In genomics: 1,549
• Year to date:
  • Site-wide: 81,993
• Since beginning of last month:
  • Site-wide: 109,959

A Comprehensive Multi-Center Cross-platform Benchmarking Study of Single-cell RNA Sequencing Using Reference Samples

• Downloaded 1,546 times
• Download rankings, all-time:
  • Site-wide: 19,380
  • In genomics: 1,750
• Year to date:
  • Site-wide: 64,483
• Since beginning of last month:
  • Site-wide: 20,546

ŌvSim: a Simulation of the Population Dynamics of Mammalian Ovarian Follicles

• Downloaded 1,310 times
• Download rankings, all-time:
  • Site-wide: 25,231
  • In physiology: 78
• Year to date:
  • Site-wide: 155,403
• Since beginning of last month:
  • Site-wide: 105,150

Low-Bias Amplification for Robust DNA Data Readout

• Downloaded 1,276 times
• Download rankings, all-time:
  • Site-wide: 26,308
  • In synthetic biology: 323
• Year to date:
  • Site-wide: 74,716
• Since beginning of last month:
  • Site-wide: 47,771

A Pairwise Distance Distribution Correction (DDC) algorithm to eliminate blinking-caused artifacts in super-resolution microscopy

• Downloaded 1,212 times
• Download rankings, all-time:
  • Site-wide: 28,500
  • In biophysics: 794
• Year to date:
  • Site-wide: 68,677
• Since beginning of last month:
  • Site-wide: 31,720

Identifying strategies to target the metabolic flexibility of tumours

• Downloaded 1,176 times
• Download rankings, all-time:
  • Site-wide: 29,885
  • In cancer biology: 747
• Year to date:
  • Site-wide: 108,353
• Since beginning of last month:
  • Site-wide: 63,676

Stem cell mitotic drive ensures asymmetric epigenetic inheritance

• Downloaded 1,172 times
• Download rankings, all-time:
  • Site-wide: 30,077
  • In developmental biology: 533
• Year to date:
  • Site-wide: 121,843
• Since beginning of last month:
  • Site-wide: 108,443

Single-cell transcriptome analysis reveals estrogen signaling augments the mitochondrial folate pathway to coordinately fuel purine and polyamine synthesis in breast cancer cells

• Downloaded 1,156 times
• Download rankings, all-time:
  • Site-wide: 30,701
  • In genomics: 2,512
• Year to date:
  • Site-wide: 165,270
• Since beginning of last month:
  • Site-wide: 68,446

Knowledge about benefits and risks of undergoing cataract surgery among cataract patients in Southern China

• Downloaded 1,027 times
• Download rankings, all-time:
  • Site-wide: 36,848
  • In ophthalmology: 18
• Year to date:
  • Site-wide: 37,367
• Since beginning of last month:
  • Site-wide: 20,438

Robust retrieval of data stored in DNA by de Bruijn graph-based de novo strand assembly

• Downloaded 940 times
• Download rankings, all-time:
  • Site-wide: 42,238
  • In bioinformatics: 4,458
• Year to date:
  • Site-wide: 22,203
• Since beginning of last month:
  • Site-wide: 40,650

Mapping and Inheritance analysis of a novel dominant rice male sterility mutant, OsDMS-1

• Downloaded 891 times
• Download rankings, all-time:
  • Site-wide: 45,760
  • In genetics: 1,785
• Year to date:
  • Site-wide: 151,983
• Since beginning of last month:
  • Site-wide: 126,443

Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells

• Downloaded 870 times
• Download rankings, all-time:
  • Site-wide: 47,531
  • In biophysics: 1,445
• Year to date:
  • Site-wide: 97,519
• Since beginning of last month:
  • Site-wide: 153,362

GeneQC: A quality control tool for gene expression estimation based on RNA-sequencing reads mapping

• Downloaded 865 times
• Download rankings, all-time:
  • Site-wide: 47,975
  • In bioinformatics: 4,854
• Year to date:
  • Site-wide: 121,605
• Since beginning of last month:
  • Site-wide: 46,431

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

• Downloaded 837 times
• Download rankings, all-time:
  • Site-wide: 50,419
  • In microbiology: 2,984
• Year to date:
  • Site-wide: 26,152
• Since beginning of last month:
  • Site-wide: None

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

• Downloaded 807 times
• Download rankings, all-time:
  • Site-wide: 53,257
  • In biochemistry: 1,582
• Year to date:
  • Site-wide: 4,851
• Since beginning of last month:
  • Site-wide: 12,899

Chest Computed Tomography for the Diagnosis of Patients with Coronavirus Disease 2019 (COVID-19): A Rapid Review and Meta-Analysis

• Downloaded 728 times
• Download rankings, all-time:
  • Site-wide: 61,837
  • In radiology and imaging: 114
• Year to date:
  • Site-wide: 137,364
• Since beginning of last month:
  • Site-wide: 184,086

Instructive starPEG-Heparin biohybrid 3D cultures for modeling human neural stem cell plasticity, neurogenesis, and neurodegeneration

• Downloaded 726 times
• Download rankings, all-time:
  • Site-wide: 62,099
  • In neuroscience: 8,270
• Year to date:
  • Site-wide: 135,706
• Since beginning of last month:
  • Site-wide: 193,324

A novel long noncoding RNA LINC00844 regulates prostate cancer cell migration and invasion through androgen receptor signaling

• Downloaded 699 times
• Download rankings, all-time:
  • Site-wide: 65,530
  • In cancer biology: 1,882
• Year to date:
  • Site-wide: 96,711
• Since beginning of last month:
  • Site-wide: 68,381

Sequence signatures of two IGHV3-53/3-66 public clonotypes to SARS-CoV-2 receptor binding domain

• Downloaded 688 times
• Download rankings, all-time:
  • Site-wide: 67,056
  • In microbiology: 4,098
• Year to date:
  • Site-wide: 63,547
• Since beginning of last month:
  • Site-wide: 74,967

Clinically applicable histopathological diagnosis system for gastric cancer detection using deep learning

• Downloaded 687 times
• Download rankings, all-time:
  • Site-wide: 67,197
  • In pathology: 295
• Year to date:
  • Site-wide: 183,985
• Since beginning of last month:
  • Site-wide: 152,008

A tale of winglets: evolution of flight morphology in stick insects

• Downloaded 647 times
• Download rankings, all-time:
  • Site-wide: 72,967
  • In evolutionary biology: 3,257
• Year to date:
  • Site-wide: 157,428
• Since beginning of last month:
  • Site-wide: 81,469

Asymmetric histone inheritance regulates stem cell fate in Drosophila midgut

• Downloaded 640 times
• Download rankings, all-time:
  • Site-wide: 74,024
  • In developmental biology: 1,785
• Year to date:
  • Site-wide: 82,871
• Since beginning of last month:
  • Site-wide: 110,538

Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8

• Downloaded 616 times
• Download rankings, all-time:
  • Site-wide: 77,774
  • In biochemistry: 2,115
• Year to date:
  • Site-wide: 39,443
• Since beginning of last month:
  • Site-wide: 86,294

A Genetically Encoded Trimethylsilyl 1D 1H-NMR Probe for Conformation Change in Large Membrane Protein Complexes

• Downloaded 613 times
• Download rankings, all-time:
  • Site-wide: 78,228
  • In biochemistry: 2,027
• Year to date:
  • Site-wide: 163,709
• Since beginning of last month:
  • Site-wide: 197,918

Circular RNAs regulate cancer stem cells by FMRP against CCAR1 complex in hepatocellular carcinoma

• Downloaded 586 times
• Download rankings, all-time:
  • Site-wide: 82,858
  • In cancer biology: 2,396
• Year to date:
  • Site-wide: 160,744
• Since beginning of last month:
  • Site-wide: 106,396

A probabilistic model-based bi-clustering method for single-cell transcriptomic data analysis

• Downloaded 555 times
• Download rankings, all-time:
  • Site-wide: 88,570
  • In bioinformatics: 7,743
• Year to date:
  • Site-wide: 191,769
• Since beginning of last month:
  • Site-wide: 123,490

Differential condensation of sister chromatids coordinates with Cdc6 to ensure distinct cell cycle progression in Drosophila male germline stem cell lineage

• Downloaded 543 times
• Download rankings, all-time:
  • Site-wide: 91,008
  • In developmental biology: 2,285
• Year to date:
  • Site-wide: 45,937
• Since beginning of last month:
  • Site-wide: 136,568

RECTA: Regulon Identification Based on Comparative Genomics and Transcriptomics Analysis

• Downloaded 526 times
• Download rankings, all-time:
  • Site-wide: 94,527
  • In systems biology: 1,965
• Year to date:
  • Site-wide: 161,733
• Since beginning of last month:
  • Site-wide: 80,157

Algorithm optimization for weighted gene co-expression network analysis: accelerating the calculation of Topology Overlap Matrices with OpenMP and SQLite

• Downloaded 508 times
• Download rankings, all-time:
  • Site-wide: 98,372
  • In bioinformatics: 8,537
• Year to date:
  • Site-wide: 24,107
• Since beginning of last month:
  • Site-wide: None

Distinct 'pattern of autofluorescence' of acute ischemic stroke patients' skin and fingernails: A novel diagnostic biomarker for acute ischemic stroke

• Downloaded 498 times
• Download rankings, all-time:
  • Site-wide: 100,554
  • In neuroscience: 13,943
• Year to date:
  • Site-wide: 185,475
• Since beginning of last month:
  • Site-wide: None

Prevalence, incidence and risk factors for myopia among urban and rural children in southern China: protocol for a school-based cohort study

• Downloaded 472 times
• Download rankings, all-time:
  • Site-wide: 106,720
  • In ophthalmology: 93
• Year to date:
  • Site-wide: 57,816
• Since beginning of last month:
  • Site-wide: 175,301

Relationship between ecological stoichiometry and community diversity of plant ecosystems in the upper reaches of the Tarim River, China

• Downloaded 447 times
• Download rankings, all-time:
  • Site-wide: 112,547
  • In ecology: 3,174
• Year to date:
  • Site-wide: 123,835
• Since beginning of last month:
  • Site-wide: 51,368

Characterization of histone inheritance patterns in the Drosophila female germline

• Downloaded 429 times
• Download rankings, all-time:
  • Site-wide: 117,219
  • In developmental biology: 2,990
• Year to date:
  • Site-wide: 176,953
• Since beginning of last month:
  • Site-wide: 196,188

Developmentally programmed epigenome regulates cellular plasticity at the parental-to-zygote transition

• Downloaded 414 times
• Download rankings, all-time:
  • Site-wide: 121,162
  • In developmental biology: 3,287
• Year to date:
  • Site-wide: 14,790
• Since beginning of last month:
  • Site-wide: 42,241

Mixed Culture of Bacterial Cell for Large Scale DNA Storage

• Downloaded 405 times
• Download rankings, all-time:
  • Site-wide: 123,544
  • In molecular biology: 3,589
• Year to date:
  • Site-wide: 159,924
• Since beginning of last month:
  • Site-wide: 150,702

Green autofluorescence intensity of skin and fingernails: A novel biomarker for non-invasive evaluation of pathological state of blood vessels

• Downloaded 403 times
• Download rankings, all-time:
  • Site-wide: 124,277
  • In pathology: 640
• Year to date:
  • Site-wide: 180,791
• Since beginning of last month:
  • Site-wide: 126,586

Associated habitat and suitability modeling of goldenseal (Hydrastis canadensis L.) in Pennsylvania: explaining and predicting species distribution in a northern edge of range state

• Downloaded 401 times
• Download rankings, all-time:
  • Site-wide: 124,759
  • In ecology: 3,669
• Year to date:
  • Site-wide: 108,553
• Since beginning of last month:
  • Site-wide: 56,764

A Multi-center Cross-platform Single-cell RNA Sequencing Reference Dataset

• Downloaded 397 times
• Download rankings, all-time:
  • Site-wide: 125,770
  • In bioinformatics: 9,918
• Year to date:
  • Site-wide: 177,160
• Since beginning of last month:
  • Site-wide: 188,381

Trabeculae microstructure parameters serve as effective predictors for marginal bone loss of dental implant in the mandible

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 131,543
  • In dentistry and oral medicine: 90
• Year to date:
  • Site-wide: 165,821
• Since beginning of last month:
  • Site-wide: 155,203

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

• Downloaded 374 times
• Download rankings, all-time:
  • Site-wide: 132,551
  • In cancer biology: 3,911
• Year to date:
  • Site-wide: 135,196
• Since beginning of last month:
  • Site-wide: 189,338

The Human walking kinematic model combined with upper and lower limb movement

• Downloaded 371 times
• Download rankings, all-time:
  • Site-wide: 133,294
  • In biophysics: 5,060
• Year to date:
  • Site-wide: 51,634
• Since beginning of last month:
  • Site-wide: 140,334

Modulation of glucose metabolism by 2-Deoxy-D-Glucose (2DG) promotes IL-17 producing human T cell subsets

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 136,111
  • In immunology: 4,754
• Year to date:
  • Site-wide: 18,450
• Since beginning of last month:
  • Site-wide: 20,782

Engineering human Mucosal Associated Invariant T (MAIT) cells with chimeric antigen receptors for cancer immunotherapy

• Downloaded 326 times
• Download rankings, all-time:
  • Site-wide: 146,896
  • In immunology: 6,002
• Year to date:
  • Site-wide: 21,778
• Since beginning of last month:
  • Site-wide: 8,182

Sleep disturbances and related factors among preschool children in rural areas of China: a cross-sectional study

• Downloaded 302 times
• Download rankings, all-time:
  • Site-wide: 153,737
  • In epidemiology: 6,313
• Year to date:
  • Site-wide: 92,418
• Since beginning of last month:
  • Site-wide: 100,875

RASSF1A independence and early Galectin-1 upregulation in PIK3CA induced hepatocarcinogenesis: new therapeutic venues

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 158,237
  • In pathology: 890
• Year to date:
  • Site-wide: 138,876
• Since beginning of last month:
  • Site-wide: 159,675

Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina

• Downloaded 220 times
• Download rankings, all-time:
  • Site-wide: 176,947
  • In genomics: 8,400
• Year to date:
  • Site-wide: 205,201
• Since beginning of last month:
  • Site-wide: 186,718

In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma

• Downloaded 212 times
• Download rankings, all-time:
  • Site-wide: 179,123
  • In cancer biology: 6,011
• Year to date:
  • Site-wide: 41,560
• Since beginning of last month:
  • Site-wide: 11,474

Trends and Patterns of Opioid Epidemic: A Large-Scale Retrospective Study of Hospital Visits with Opioid Poisoning in New York State, 2010-2016

• Downloaded 210 times
• Download rankings, all-time:
  • Site-wide: 179,630
  • In public and global health: 2,562
• Year to date:
  • Site-wide: 196,166
• Since beginning of last month:
  • Site-wide: 149,494

Does Obstructive sleep apnea increase the risk of Parkinson Disease? A systematic review and meta-analysis.

• Downloaded 207 times
• Download rankings, all-time:
  • Site-wide: 180,299
  • In epidemiology: 7,163
• Year to date:
  • Site-wide: 172,774
• Since beginning of last month:
  • Site-wide: 176,626

Rab7/Retromer-based endolysosomal trafficking facilitates effector secretion and host invasion in rice blast

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 182,077
  • In plant biology: 5,131
• Year to date:
  • Site-wide: 45,384
• Since beginning of last month:
  • Site-wide: 37,734

Equalizing epigenetically imprinted centromeres in early mammalian embryos

• Downloaded 182 times
• Download rankings, all-time:
  • Site-wide: 185,959
  • In developmental biology: None
• Year to date:
  • Site-wide: 51,289
• Since beginning of last month:
  • Site-wide: 2,232

Monoallelically-expressed Noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression

• Downloaded 166 times
• Download rankings, all-time:
  • Site-wide: 189,448
  • In cell biology: 8,737
• Year to date:
  • Site-wide: 57,596
• Since beginning of last month:
  • Site-wide: 34,049

Testing the link between isoaspartate and Alzheimer's disease etiology

• Downloaded 165 times
• Download rankings, all-time:
  • Site-wide: 189,663
  • In neuroscience: 27,343
• Year to date:
  • Site-wide: 58,052
• Since beginning of last month:
  • Site-wide: 129,306

Yeast U6 snRNA made by RNA polymerase II is less stable but functional

• Downloaded 123 times
• Download rankings, all-time:
  • Site-wide: 197,301
  • In molecular biology: 5,753
• Year to date:
  • Site-wide: 78,413
• Since beginning of last month:
  • Site-wide: 129,850

Roles of the distinct N-terminal amino acid between H3 and H3.3 in Drosophila male germline stem cell lineage

• Downloaded 100 times
• Download rankings, all-time:
  • Site-wide: 201,085
  • In developmental biology: None
• Year to date:
  • Site-wide: 94,459
• Since beginning of last month:
  • Site-wide: 41,839

Multifaceted role of RIMBP2 in promoting hearing in murine cochlear hair cells

• Downloaded 87 times
• Download rankings, all-time:
  • Site-wide: 203,109
  • In neuroscience: 28,346
• Year to date:
  • Site-wide: 106,853
• Since beginning of last month:
  • Site-wide: 203,915