Author: Yan Chen

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Preprints

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

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  • Site-wide: 6,551
  • In genetics: 253
• Year to date:
  • Site-wide: 13,049
• Since beginning of last month:
  • Site-wide: 20,915

Epidemiological and clinical features of 291 cases with coronavirus disease 2019 in areas adjacent to Hubei, China: a double-center observational study

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  • Site-wide: 7,501
  • In respiratory medicine: 29
• Year to date:
  • Site-wide: 68,447
• Since beginning of last month:
  • Site-wide: 77,093

Distinct mutations and lineages of SARS-CoV-2 virus in the early phase of COVID-19 pandemic and subsequent global expansion

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  • Site-wide: 11,887
  • In genomics: 1,214
• Year to date:
  • Site-wide: 16,640
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  • Site-wide: 2,273

Large-scale chemical-genetics of the human gut bacterium Bacteroides thetaiotaomicron

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  • Site-wide: 13,075
  • In microbiology: 732
• Year to date:
  • Site-wide: 72,155
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  • Site-wide: 60,697

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

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  • Site-wide: 20,049
  • In infectious diseases: 2,704
• Year to date:
  • Site-wide: 5,676
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  • Site-wide: 1,851

Endocytic Clathrin Coats Develop Curvature at Early Stages of Their Formation

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  • Site-wide: 29,018
  • In biophysics: 793
• Year to date:
  • Site-wide: 43,542
• Since beginning of last month:
  • Site-wide: 77,778

Functional connectivity alterations of the temporal lobe and hippocampus in semantic dementia and Alzheimer’s disease

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  • Site-wide: 33,513
  • In neuroscience: 3,974
• Year to date:
  • Site-wide: 119,105
• Since beginning of last month:
  • Site-wide: 158,829

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

• Downloaded 878 times
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  • Site-wide: 41,652
  • In molecular biology: 1,175
• Year to date:
  • Site-wide: 55,522
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  • Site-wide: 16,787

Whole-exome sequencing identified rare variants associated with body length and girth in cattle

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  • Site-wide: 42,347
  • In genetics: 1,758
• Year to date:
  • Site-wide: 68,260
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  • Site-wide: 78,592

Genome-scale metabolic rewiring to achieve predictable titers rates and yield of a non-native product at scale

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  • Site-wide: 44,450
  • In bioengineering: 786
• Year to date:
  • Site-wide: 135,324
• Since beginning of last month:
  • Site-wide: 128,453

Chemoinformatic-guided engineering of polyketide synthases

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  • Site-wide: 49,526
  • In biochemistry: 1,142
• Year to date:
  • Site-wide: 146,471
• Since beginning of last month:
  • Site-wide: 176,711

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

• Downloaded 755 times
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  • Site-wide: 52,052
  • In molecular biology: 1,843
• Year to date:
  • Site-wide: 15,154
• Since beginning of last month:
  • Site-wide: 12,180

Improving the Efficiency of Genomic Selection in Chinese Simmental beef cattle

• Downloaded 743 times
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  • Site-wide: 53,304
  • In genomics: 3,706
• Year to date:
  • Site-wide: 160,213
• Since beginning of last month:
  • Site-wide: 182,382

Genome structure and evolution of Antirrhnum majus L.

• Downloaded 695 times
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  • Site-wide: 58,579
  • In genomics: 4,047
• Year to date:
  • Site-wide: 90,347
• Since beginning of last month:
  • Site-wide: 162,545

Digital polymerase chain reaction in an array of microfluidic printed droplets

• Downloaded 684 times
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  • Site-wide: 59,868
  • In molecular biology: 1,724
• Year to date:
  • Site-wide: 59,705
• Since beginning of last month:
  • Site-wide: 32,456

Incidence and Characteristics of Co-infection and Secondary Infection in Patients with COVID-19

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  • Site-wide: 64,498
  • In microbiology: 4,820
• Year to date:
  • Site-wide: 35,983
• Since beginning of last month:
  • Site-wide: 4,415

Mapping genetic determinants of 184 circulating proteins in 26,494 individuals to connect proteins and disease.

• Downloaded 589 times
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  • Site-wide: 72,924
  • In genetic and genomic medicine: 473
• Year to date:
  • Site-wide: 18,906
• Since beginning of last month:
  • Site-wide: 28,503

Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor

• Downloaded 584 times
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  • Site-wide: 73,640
  • In biophysics: 2,635
• Year to date:
  • Site-wide: 68,879
• Since beginning of last month:
  • Site-wide: 74,165

Sulfated RaxX, which represents an unclassified group of ribosomally synthesized post-translationally modified peptides, binds a host immune receptor

• Downloaded 579 times
• Download rankings, all-time:
  • Site-wide: 74,486
  • In microbiology: 4,309
• Year to date:
  • Site-wide: 172,717
• Since beginning of last month:
  • Site-wide: 97,864

The metabolic response of Pseudomonas taiwanensis to NADH dehydrogenase deficiency

• Downloaded 570 times
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  • Site-wide: 75,943
  • In physiology: 455
• Year to date:
  • Site-wide: 105,680
• Since beginning of last month:
  • Site-wide: 117,384

Host engineering for improved valerolactam production in Pseudomonas putida

• Downloaded 566 times
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  • Site-wide: 76,694
  • In synthetic biology: 845
• Year to date:
  • Site-wide: 160,169
• Since beginning of last month:
  • Site-wide: 111,719

Structural mechanism of regioselectivity in an unusual bacterial acyl-CoA dehydrogenase

• Downloaded 541 times
• Download rankings, all-time:
  • Site-wide: 80,934
  • In biochemistry: 2,197
• Year to date:
  • Site-wide: 91,869
• Since beginning of last month:
  • Site-wide: 70,234

Single-cell transcriptomics reveal cell type-specific molecular changes and altered intercellular communications in chronic obstructive pulmonary disease

• Downloaded 526 times
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  • Site-wide: 83,759
  • In pathology: 428
• Year to date:
  • Site-wide: 48,990
• Since beginning of last month:
  • Site-wide: 34,550

A unified neurocognitive model of the anterior temporal lobe contributions to semantics, language, social behaviour & face recognition

• Downloaded 500 times
• Download rankings, all-time:
  • Site-wide: 88,892
  • In neuroscience: 11,915
• Year to date:
  • Site-wide: 184,332
• Since beginning of last month:
  • Site-wide: 183,413

Methyl ketone production by Pseudomonas putida is enhanced by plant-derived amino acids

• Downloaded 472 times
• Download rankings, all-time:
  • Site-wide: 94,631
  • In bioengineering: 1,768
• Year to date:
  • Site-wide: 126,581
• Since beginning of last month:
  • Site-wide: 49,025

IL-18 and Lower Risk for Lung Cancer: Triangulated Evidence from Germline Predictions, Pre-Diagnostic Measurements, and Tumor Expression

• Downloaded 461 times
• Download rankings, all-time:
  • Site-wide: 97,114
  • In genetic and genomic medicine: 693
• Year to date:
  • Site-wide: 36,933
• Since beginning of last month:
  • Site-wide: 8,240

Allosteric priming of E. coli CheY by the flagellar motor protein FliM

• Downloaded 457 times
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  • Site-wide: 98,136
  • In biophysics: 3,348
• Year to date:
  • Site-wide: 159,318
• Since beginning of last month:
  • Site-wide: 128,243

The response of Pseudomonas putida to a complex lignolysate

• Downloaded 437 times
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  • Site-wide: 102,778
  • In microbiology: 6,703
• Year to date:
  • Site-wide: 94,778
• Since beginning of last month:
  • Site-wide: 181,223

B Cell Receptor-Responsive miR-141 and viral miR-BART9 promote Epstein-Barr Virus Reactivation Through FOXO3 Inhibition

• Downloaded 374 times
• Download rankings, all-time:
  • Site-wide: 118,621
  • In molecular biology: 3,216
• Year to date:
  • Site-wide: 183,794
• Since beginning of last month:
  • Site-wide: 174,027

Structure and mechanism of a mitochondrial AAA+ disaggregase CLBP

• Downloaded 322 times
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  • Site-wide: 133,406
  • In molecular biology: None
• Year to date:
  • Site-wide: 10,633
• Since beginning of last month:
  • Site-wide: 42,636

Blood flow coordinates collective endothelial cell migration during vascular plexus formation and promotes angiogenic sprout regression via vegfr3/flt4

• Downloaded 296 times
• Download rankings, all-time:
  • Site-wide: 140,901
  • In developmental biology: 3,625
• Year to date:
  • Site-wide: 105,310
• Since beginning of last month:
  • Site-wide: 99,912

Transcription factor determines the sources of extracellular vesicle DNA

• Downloaded 295 times
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  • Site-wide: 141,477
  • In cell biology: 6,765
• Year to date:
  • Site-wide: 12,099
• Since beginning of last month:
  • Site-wide: 71,303

Verification of SARS-CoV-2-Encoded small RNAs and contribution to Infection-Associated lung inflammation

• Downloaded 290 times
• Download rankings, all-time:
  • Site-wide: 142,786
  • In microbiology: 10,024
• Year to date:
  • Site-wide: 97,675
• Since beginning of last month:
  • Site-wide: 136,627

Pulmonary B cells ameliorate Alzheimer's disease-like neuropathology

• Downloaded 281 times
• Download rankings, all-time:
  • Site-wide: 145,461
  • In neuroscience: 21,253
• Year to date:
  • Site-wide: 94,056
• Since beginning of last month:
  • Site-wide: 105,247

LncRNA SNHG1 suppresses LPS-induced acute lung injury by regulating miR-421/TIMP3 axis

• Downloaded 270 times
• Download rankings, all-time:
  • Site-wide: 148,923
  • In immunology: 4,571
• Year to date:
  • Site-wide: 80,943
• Since beginning of last month:
  • Site-wide: 17,732

Environment-wide association study (EWAS) on cardiometabolic traits: A systematic assessment of the association of lifestyle variables on a longitudinal setting

• Downloaded 259 times
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  • Site-wide: 152,049
  • In epidemiology: 6,594
• Year to date:
  • Site-wide: 58,589
• Since beginning of last month:
  • Site-wide: 12,600

Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages

• Downloaded 240 times
• Download rankings, all-time:
  • Site-wide: 157,512
  • In immunology: 4,634
• Year to date:
  • Site-wide: 84,144
• Since beginning of last month:
  • Site-wide: 53,896

Multiple viral microRNAs regulate interferon release and signaling early during infection with Epstein-Barr virus

• Downloaded 231 times
• Download rankings, all-time:
  • Site-wide: 160,092
  • In microbiology: 10,963
• Year to date:
  • Site-wide: 175,220
• Since beginning of last month:
  • Site-wide: 189,528

Uncertainty quantification in cerebral circulation simulations focusing on the collateral flow: Surrogate model approach with machine learning

• Downloaded 220 times
• Download rankings, all-time:
  • Site-wide: 163,049
  • In bioengineering: None
• Year to date:
  • Site-wide: 18,852
• Since beginning of last month:
  • Site-wide: 19,547

Prohibitin protects against cigarette smoke extract-induced cell apoptosis in cultured human pulmonary microvascular endothelial cells

• Downloaded 192 times
• Download rankings, all-time:
  • Site-wide: 170,022
  • In pharmacology and toxicology: 1,343
• Year to date:
  • Site-wide: 129,521
• Since beginning of last month:
  • Site-wide: 149,887

Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer

• Downloaded 184 times
• Download rankings, all-time:
  • Site-wide: 171,959
  • In systems biology: 3,272
• Year to date:
  • Site-wide: 146,088
• Since beginning of last month:
  • Site-wide: 94,137

Genetic Analysis of Bphse: a Novel Gene Complementing Resistance to Bordetella pertussis-Induced Histamine Sensitization

• Downloaded 139 times
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  • Site-wide: 181,237
  • In genetics: 6,383
• Year to date:
  • Site-wide: 102,303
• Since beginning of last month:
  • Site-wide: 75,249

Genetic Encoding of A Nonhydrolyzable Phosphotyrosine Analog in Mammalian Cells

• Downloaded 138 times
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  • Site-wide: 181,302
  • In bioengineering: 3,706
• Year to date:
  • Site-wide: 69,003
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  • Site-wide: 82,166

Serum Amyloid A promotes Acetaminophen-induced liverinjury by damaging sinusoidal endothelial cell and exacerbating platelet aggregation in liver

• Downloaded 129 times
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  • Site-wide: 182,758
  • In pharmacology and toxicology: 1,517
• Year to date:
  • Site-wide: 74,075
• Since beginning of last month:
  • Site-wide: 93,080

Sex-specific effects of aging on the humoral immune response to repeat vaccination with the high-dose seasonal influenza vaccine in older adults

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  • Site-wide: 183,021
  • In infectious diseases: 7,206
• Year to date:
  • Site-wide: 121,124
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  • Site-wide: 120,201

Estimating the burden of foodborne gastroenteritis due to nontyphoidal Salmonella enterica, Shigella and Vibrio parahaemolyticus in China

• Downloaded 109 times
• Download rankings, all-time:
  • Site-wide: 185,654
  • In epidemiology: None
• Year to date:
  • Site-wide: 47,204
• Since beginning of last month:
  • Site-wide: 71,375