Author: Yan Chen

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Preprints

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

• Downloaded 2,513 times
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  • Site-wide: 6,254
  • In genetics: 270
• Year to date:
  • Site-wide: 9,135
• Since beginning of last month:
  • Site-wide: 33,557

Epidemiological and clinical features of 291 cases with coronavirus disease 2019 in areas adjacent to Hubei, China: a double-center observational study

• Downloaded 2,496 times
• Download rankings, all-time:
  • Site-wide: 6,325
  • In respiratory medicine: 29
• Year to date:
  • Site-wide: 24,091
• Since beginning of last month:
  • Site-wide: 26,157

Large-scale chemical-genetics of the human gut bacterium Bacteroides thetaiotaomicron

• Downloaded 1,720 times
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  • Site-wide: 10,945
  • In microbiology: 646
• Year to date:
  • Site-wide: 20,768
• Since beginning of last month:
  • Site-wide: 37,131

Distinct mutations and lineages of SARS-CoV-2 virus in the early phase of COVID-19 pandemic and subsequent global expansion

• Downloaded 1,504 times
• Download rankings, all-time:
  • Site-wide: 13,285
  • In genomics: 1,364
• Year to date:
  • Site-wide: 1,773
• Since beginning of last month:
  • Site-wide: 12,399

Functional connectivity alterations of the temporal lobe and hippocampus in semantic dementia and Alzheimer’s disease

• Downloaded 934 times
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  • Site-wide: 26,996
  • In neuroscience: 3,488
• Year to date:
  • Site-wide: 56,035
• Since beginning of last month:
  • Site-wide: 107,028

Endocytic Clathrin Coats Develop Curvature at Early Stages of Their Formation

• Downloaded 897 times
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  • Site-wide: 28,547
  • In biophysics: 819
• Year to date:
  • Site-wide: 28,402
• Since beginning of last month:
  • Site-wide: 31,086

Genome-scale metabolic rewiring to achieve predictable titers rates and yield of a non-native product at scale

• Downloaded 790 times
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  • Site-wide: 34,134
  • In bioengineering: 618
• Year to date:
  • Site-wide: 104,343
• Since beginning of last month:
  • Site-wide: 34,317

Whole-exome sequencing identified rare variants associated with body length and girth in cattle

• Downloaded 696 times
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  • Site-wide: 40,565
  • In genetics: 1,818
• Year to date:
  • Site-wide: 58,925
• Since beginning of last month:
  • Site-wide: 113,477

Improving the Efficiency of Genomic Selection in Chinese Simmental beef cattle

• Downloaded 676 times
• Download rankings, all-time:
  • Site-wide: 42,150
  • In genomics: 3,397
• Year to date:
  • Site-wide: 119,206
• Since beginning of last month:
  • Site-wide: 48,586

Chemoinformatic-guided engineering of polyketide synthases

• Downloaded 644 times
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  • Site-wide: 44,866
  • In biochemistry: 1,131
• Year to date:
  • Site-wide: 53,130
• Since beginning of last month:
  • Site-wide: 17,347

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

• Downloaded 632 times
• Download rankings, all-time:
  • Site-wide: 45,921
  • In molecular biology: 1,311
• Year to date:
  • Site-wide: 6,046
• Since beginning of last month:
  • Site-wide: 24,207

Genome structure and evolution of Antirrhnum majus L.

• Downloaded 584 times
• Download rankings, all-time:
  • Site-wide: 50,810
  • In genomics: 3,899
• Year to date:
  • Site-wide: 124,969
• Since beginning of last month:
  • Site-wide: 52,024

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

• Downloaded 577 times
• Download rankings, all-time:
  • Site-wide: 51,606
  • In infectious diseases: 3,059
• Year to date:
  • Site-wide: 6,942
• Since beginning of last month:
  • Site-wide: 19,730

Sulfated RaxX, which represents an unclassified group of ribosomally synthesized post-translationally modified peptides, binds a host immune receptor

• Downloaded 540 times
• Download rankings, all-time:
  • Site-wide: 55,862
  • In microbiology: 3,573
• Year to date:
  • Site-wide: 121,667
• Since beginning of last month:
  • Site-wide: 32,753

Digital polymerase chain reaction in an array of microfluidic printed droplets

• Downloaded 500 times
• Download rankings, all-time:
  • Site-wide: 61,125
  • In molecular biology: 1,738
• Year to date:
  • Site-wide: 66,315
• Since beginning of last month:
  • Site-wide: 18,943

Host engineering for improved valerolactam production in Pseudomonas putida

• Downloaded 496 times
• Download rankings, all-time:
  • Site-wide: 61,640
  • In synthetic biology: 743
• Year to date:
  • Site-wide: 97,808
• Since beginning of last month:
  • Site-wide: None

The metabolic response of Pseudomonas taiwanensis to NADH dehydrogenase deficiency

• Downloaded 490 times
• Download rankings, all-time:
  • Site-wide: 62,468
  • In physiology: 388
• Year to date:
  • Site-wide: 82,844
• Since beginning of last month:
  • Site-wide: None

Incidence and Characteristics of Co-infection and Secondary Infection in Patients with COVID-19

• Downloaded 437 times
• Download rankings, all-time:
  • Site-wide: 70,542
  • In microbiology: 4,773
• Year to date:
  • Site-wide: 10,448
• Since beginning of last month:
  • Site-wide: 5,438

A unified neurocognitive model of the anterior temporal lobe contributions to semantics, language, social behaviour & face recognition

• Downloaded 432 times
• Download rankings, all-time:
  • Site-wide: 71,512
  • In neuroscience: 10,710
• Year to date:
  • Site-wide: 88,964
• Since beginning of last month:
  • Site-wide: None

Methyl ketone production by Pseudomonas putida is enhanced by plant-derived amino acids

• Downloaded 388 times
• Download rankings, all-time:
  • Site-wide: 79,148
  • In bioengineering: 1,475
• Year to date:
  • Site-wide: 119,618
• Since beginning of last month:
  • Site-wide: None

Structural mechanism of regioselectivity in an unusual bacterial acyl-CoA dehydrogenase

• Downloaded 384 times
• Download rankings, all-time:
  • Site-wide: 79,978
  • In biochemistry: 2,216
• Year to date:
  • Site-wide: 88,788
• Since beginning of last month:
  • Site-wide: 22,291

Allosteric priming of E. coli CheY by the flagellar motor protein FliM

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 88,584
  • In biophysics: 3,309
• Year to date:
  • Site-wide: 68,946
• Since beginning of last month:
  • Site-wide: 96,883

The response of Pseudomonas putida to a complex lignolysate

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 88,607
  • In microbiology: 6,212
• Year to date:
  • Site-wide: 99,574
• Since beginning of last month:
  • Site-wide: 37,783

B Cell Receptor-Responsive miR-141 and viral miR-BART9 promote Epstein-Barr Virus Reactivation Through FOXO3 Inhibition

• Downloaded 308 times
• Download rankings, all-time:
  • Site-wide: 95,866
  • In molecular biology: 2,806
• Year to date:
  • Site-wide: 97,373
• Since beginning of last month:
  • Site-wide: None

Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 100,923
  • In biophysics: 3,846
• Year to date:
  • Site-wide: 18,937
• Since beginning of last month:
  • Site-wide: 24,440

Single-cell transcriptomics reveal cell type-specific molecular changes and altered intercellular communications in chronic obstructive pulmonary disease

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 108,410
  • In pathology: 596
• Year to date:
  • Site-wide: 22,113
• Since beginning of last month:
  • Site-wide: None

IL-18 and Lower Risk for Lung Cancer: Triangulated Evidence from Germline Predictions, Pre-Diagnostic Measurements, and Tumor Expression

• Downloaded 175 times
• Download rankings, all-time:
  • Site-wide: 128,064
  • In genetic and genomic medicine: 684
• Year to date:
  • Site-wide: 35,457
• Since beginning of last month:
  • Site-wide: 65,647

Pulmonary B cells ameliorate Alzheimer's disease-like neuropathology

• Downloaded 162 times
• Download rankings, all-time:
  • Site-wide: 130,954
  • In neuroscience: 19,956
• Year to date:
  • Site-wide: 60,873
• Since beginning of last month:
  • Site-wide: 67,362

Multiple viral microRNAs regulate interferon release and signaling early during infection with Epstein-Barr virus

• Downloaded 149 times
• Download rankings, all-time:
  • Site-wide: 133,847
  • In microbiology: 10,204
• Year to date:
  • Site-wide: 74,853
• Since beginning of last month:
  • Site-wide: None

Verification of SARS-CoV-2-Encoded small RNAs and contribution to Infection-Associated lung inflammation

• Downloaded 138 times
• Download rankings, all-time:
  • Site-wide: 136,280
  • In microbiology: 10,404
• Year to date:
  • Site-wide: 46,241
• Since beginning of last month:
  • Site-wide: 85,937

Blood flow coordinates collective endothelial cell migration during vascular plexus formation and promotes angiogenic sprout regression via vegfr3/flt4

• Downloaded 127 times
• Download rankings, all-time:
  • Site-wide: 138,626
  • In developmental biology: 3,678
• Year to date:
  • Site-wide: 50,362
• Since beginning of last month:
  • Site-wide: 7,186

Prohibitin protects against cigarette smoke extract-induced cell apoptosis in cultured human pulmonary microvascular endothelial cells

• Downloaded 114 times
• Download rankings, all-time:
  • Site-wide: 141,241
  • In pharmacology and toxicology: 1,213
• Year to date:
  • Site-wide: 124,078
• Since beginning of last month:
  • Site-wide: 37,218

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

• Downloaded 113 times
• Download rankings, all-time:
  • Site-wide: 141,404
  • In molecular biology: 4,208
• Year to date:
  • Site-wide: 56,733
• Since beginning of last month:
  • Site-wide: 25,499

Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages

• Downloaded 103 times
• Download rankings, all-time:
  • Site-wide: 143,290
  • In immunology: 4,267
• Year to date:
  • Site-wide: 61,570
• Since beginning of last month:
  • Site-wide: None

Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer

• Downloaded 95 times
• Download rankings, all-time:
  • Site-wide: 144,710
  • In systems biology: 3,029
• Year to date:
  • Site-wide: 66,583
• Since beginning of last month:
  • Site-wide: 86,143

Environment-wide association study (EWAS) on cardiometabolic traits: A systematic assessment of the association of lifestyle variables on a longitudinal setting

• Downloaded 78 times
• Download rankings, all-time:
  • Site-wide: 147,239
  • In epidemiology: 6,046
• Year to date:
  • Site-wide: 78,254
• Since beginning of last month:
  • Site-wide: None

LncRNA SNHG1 suppresses LPS-induced acute lung injury by regulating miR-421/TIMP3 axis

• Downloaded 74 times
• Download rankings, all-time:
  • Site-wide: 147,738
  • In immunology: 4,417
• Year to date:
  • Site-wide: 82,061
• Since beginning of last month:
  • Site-wide: 66,974

Sex-specific effects of aging on the humoral immune response to repeat vaccination with the high-dose seasonal influenza vaccine in older adults

• Downloaded 37 times
• Download rankings, all-time:
  • Site-wide: 151,024
  • In infectious diseases: 5,881
• Year to date:
  • Site-wide: 124,040
• Since beginning of last month:
  • Site-wide: 62,134

Genetic Analysis of Bphse: a Novel Gene Complementing Resistance to Bordetella pertussis-Induced Histamine Sensitization

• Downloaded 7 times
• Download rankings, all-time:
  • Site-wide: 153,047
  • In genetics: 5,913
• Year to date:
  • Site-wide: 152,955
• Since beginning of last month:
  • Site-wide: 12,920

Mapping genetic determinants of 184 circulating proteins in 26,494 individuals to connect proteins and disease.

• Downloaded 3 times
• Download rankings, all-time:
  • Site-wide: 153,844
  • In genetic and genomic medicine: 937
• Year to date:
  • Site-wide: 153,830
• Since beginning of last month:
  • Site-wide: 30,424