Author: Michael C O'Donovan

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Preprints

Genomewide association study identifies 30 loci associated with bipolar disorder

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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

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Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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Psychiatric Genomics: An Update and an Agenda

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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

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Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

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Sex differences in gene expression in the human fetal brain

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Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 10,506
  • In psychiatry and clinical psychology: 35
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 52,083
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The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

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Genetic association study of psychotic experiences in UK Biobank

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Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia

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Association between schizophrenia and both loss of function and missense mutations in paralog conserved sites of voltage-gated sodium channels

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Synaptic protein DLG2 controls neurogenic transcriptional programs disrupted in schizophrenia and related disorders

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Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.

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A Transcriptome Wide Association Study implicates specific pre- and post-synaptic abnormalities in Schizophrenia

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Investigating the potential effect of antihypertensive medication on psychiatric disorders: a mendelian randomisation study

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  • In genetic and genomic medicine: 130
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Genetic association of FMRP targets with psychiatric disorders

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Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

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The independent and combined influence of schizophrenia polygenic risk score and heavy cannabis use on risk for psychotic disorder: A case-control analysis from the EUGEI study.

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Dynamic expression of risk genes for schizophrenia and bipolar disorder across development

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Effects of pathogenic CNVs on physical traits in participants of the UK Biobank

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The role of rare copy number variants in depression

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Meta-analysis of Scandinavian Schizophrenia Exomes

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Schizophrenia polygenic risk score and cannabis use modify psychosis expression in first episode psychosis patients and population controls

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Novel Insight into the Aetiology of Autism Spectrum Disorder Gained by Integrating Expression Data with Genome-wide Association Statistics

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Exome sequencing in bipolar disorder reveals shared risk gene AKAP11 with schizophrenia

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Identifying novel subtypes of irritability using a developmental genetic approach

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Differences in Genetic Liability for Insomnia and Hypersomnia in Bipolar Disorder Subtypes

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The rate of de novo CNVs in healthy controls

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Effects of pathogenic CNVs on biochemical markers: a study on the UK Biobank

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Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

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Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by mutation of the psychiatric risk gene Cacna1c

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Clozapine metabolism is associated with Absolute Neutrophil Count in individuals with treatment-resistant schizophrenia

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Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression

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