Author: Michael C O'Donovan

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Preprints

Genomewide association study identifies 30 loci associated with bipolar disorder

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Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

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  • Site-wide: 1,782
  • In genetic and genomic medicine: 8
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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,436
  • In genomics: 237
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Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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  • Site-wide: 3,708
  • In genomics: 386
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  • Site-wide: 93,877
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Psychiatric Genomics: An Update and an Agenda

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  • Site-wide: 66,538
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Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 5,170
  • In psychiatry and clinical psychology: 20
• Year to date:
  • Site-wide: 1,660
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  • Site-wide: 33,980

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

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  • Site-wide: 5,963
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Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection

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Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

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Sex differences in gene expression in the human fetal brain

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  • Site-wide: 9,633
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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 105,822
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  • Site-wide: 72,381

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

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  • Site-wide: 14,320
  • In genetics: 658
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  • Site-wide: 86,987
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Synaptic protein DLG2 controls neurogenic transcriptional programs disrupted in schizophrenia and related disorders

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  • Site-wide: 29,305
  • In genetics: 1,336
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  • Site-wide: 14,886
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  • Site-wide: 93,846

Genetic association study of psychotic experiences in UK Biobank

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  • Site-wide: 32,073
  • In genetics: 1,479
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  • Site-wide: 81,774
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Association between schizophrenia and both loss of function and missense mutations in paralog conserved sites of voltage-gated sodium channels

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  • Site-wide: 33,272
  • In genetics: 1,530
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  • Site-wide: 78,315
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The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

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  • Site-wide: 33,714
  • In genetics: 1,546
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  • Site-wide: 124,547
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Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia

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  • Site-wide: 34,409
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Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.

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  • Site-wide: 37,255
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Investigating the potential effect of antihypertensive medication on psychiatric disorders: a mendelian randomisation study

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  • Site-wide: 40,055
  • In genetic and genomic medicine: 155
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  • Site-wide: 29,355
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  • Site-wide: 32,663

Exome sequencing in bipolar disorder reveals shared risk gene AKAP11 with schizophrenia

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  • Site-wide: 43,369
  • In genetic and genomic medicine: 171
• Year to date:
  • Site-wide: 5,693
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  • Site-wide: 16,602

A Transcriptome Wide Association Study implicates specific pre- and post-synaptic abnormalities in Schizophrenia

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  • Site-wide: 43,792
  • In genetics: 1,959
• Year to date:
  • Site-wide: 114,986
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  • Site-wide: 64,295

Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

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  • Site-wide: 48,802
  • In genetics: 2,167
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  • Site-wide: 40,320
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The independent and combined influence of schizophrenia polygenic risk score and heavy cannabis use on risk for psychotic disorder: A case-control analysis from the EUGEI study.

• Downloaded 598 times
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  • Site-wide: 49,258
  • In genetics: 2,183
• Year to date:
  • Site-wide: 55,682
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Genetic association of FMRP targets with psychiatric disorders

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  • Site-wide: 51,836
  • In neuroscience: 7,446
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  • Site-wide: 75,226
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Dynamic expression of risk genes for schizophrenia and bipolar disorder across development

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  • Site-wide: 60,298
  • In neuroscience: 8,862
• Year to date:
  • Site-wide: 130,903
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  • Site-wide: 40,445

Meta-analysis of Scandinavian Schizophrenia Exomes

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  • Site-wide: 62,157
  • In genetics: 2,755
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  • Site-wide: 72,174
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  • Site-wide: 91,585

The role of rare copy number variants in depression

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  • Site-wide: 63,229
  • In neuroscience: 9,311
• Year to date:
  • Site-wide: 100,359
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  • Site-wide: 42,269

Schizophrenia polygenic risk score and cannabis use modify psychosis expression in first episode psychosis patients and population controls

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  • Site-wide: 64,667
  • In psychiatry and clinical psychology: 230
• Year to date:
  • Site-wide: 58,778
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Effects of pathogenic CNVs on physical traits in participants of the UK Biobank

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  • Site-wide: 65,071
  • In genetics: 2,867
• Year to date:
  • Site-wide: 104,034
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Novel Insight into the Aetiology of Autism Spectrum Disorder Gained by Integrating Expression Data with Genome-wide Association Statistics

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  • Site-wide: 75,898
  • In genomics: 5,104
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  • Site-wide: 148,481
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  • Site-wide: 82,115

Differences in Genetic Liability for Insomnia and Hypersomnia in Bipolar Disorder Subtypes

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  • Site-wide: 77,202
  • In genomics: 5,163
• Year to date:
  • Site-wide: 104,063
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Identifying novel subtypes of irritability using a developmental genetic approach

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  • Site-wide: 78,892
  • In genetics: 3,437
• Year to date:
  • Site-wide: 130,029
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  • Site-wide: 81,109

The rate of de novo CNVs in healthy controls

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  • Site-wide: 83,223
  • In genomics: 5,422
• Year to date:
  • Site-wide: 112,618
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  • Site-wide: 92,337

Effects of pathogenic CNVs on biochemical markers: a study on the UK Biobank

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  • Site-wide: 91,082
  • In genomics: 5,710
• Year to date:
  • Site-wide: 95,268
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  • Site-wide: 42,699

Clozapine metabolism is associated with Absolute Neutrophil Count in individuals with treatment-resistant schizophrenia

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  • Site-wide: 92,634
  • In pharmacology and therapeutics: 97
• Year to date:
  • Site-wide: 16,065
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  • Site-wide: 111,975

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

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  • Site-wide: 93,230
  • In genetic and genomic medicine: 415
• Year to date:
  • Site-wide: 43,389
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  • Site-wide: 34,186

Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by mutation of the psychiatric risk gene Cacna1c

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  • Site-wide: 112,581
  • In neuroscience: 17,275
• Year to date:
  • Site-wide: 94,412
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Characterization of Age and Polarity at Onset in Bipolar Disorder

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  • Site-wide: 114,703
  • In psychiatry and clinical psychology: 498
• Year to date:
  • Site-wide: 25,467
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  • Site-wide: 103,177

Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression

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  • Site-wide: 125,053
  • In psychiatry and clinical psychology: 588
• Year to date:
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  • Site-wide: 49,137