Author: Mike A Nalls

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Preprints

Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects

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Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

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Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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Predicting onset, progression, and clinical subtypes of Parkinson disease using machine learning

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  • Site-wide: 4,981
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Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms

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Genome-wide association study of Parkinson’s disease progression biomarkers in 12 longitudinal patients’ cohorts

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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

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Enrichment of rare protein truncating variants in amyotrophic lateral sclerosis patients

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A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease states

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Dopaminergic stimulants and risk of Parkinson's disease

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Genetic insights into the biological mechanisms governing human ovarian ageing

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The Parkinson's Disease GWAS Locus Browser

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Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability

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Genetic modifiers of risk and age at onset in GBA associated Parkinson disease and Lewy body dementia

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Genetic variability and potential effects on clinical trial outcomes: perspectives in Parkinson's disease

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Predicting Alzheimer’s disease progression trajectory and clinical subtypes using machine learning

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The Parkinson's Phenome: Traits Associated with Parkinson's Disease in a Large and Deeply Phenotyped Cohort

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Parkinsons disease determinants, prediction and gene-environment interactions in the UK Biobank

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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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The Foundational data initiative for Parkinsons disease (FOUNDIN-PD): enabling efficient translation from genetic maps to mechanism

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Penetrance of Parkinson’s disease in LRRK2 p.G2019S carriers is modified by a polygenic risk score

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The genetic architecture of Parkinson disease in Spain: characterizing population-specific risk, differential haplotype structures, and providing etiologic insight

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Genetic variation within genes associated with mitochondrial function is significantly associated with later age at onset of Parkinson disease and contributes to disease risk

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Multi-Modality Machine Learning Predicting Parkinsons Disease

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The Parkinsons Disease Mendelian Randomization Research Portal

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Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

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Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

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Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

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  • Site-wide: 65,665
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Regulatory sites for known and novel splicing in human basal ganglia are enriched for disease-relevant information

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Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

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Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

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Comprehensive assessment of PINK1 variants in Parkinson's disease

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  • Site-wide: 108,240

Genome-wide estimates of heritability and genetic correlations in Essential Tremor

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Biomarkers of Parkinson's Disease: Screening Vital Signs and Routine Blood Tests

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Differences in the presentation and progression of Parkinson's disease by sex

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  • Site-wide: 88,131
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Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource

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Evidence for GRN as part of a neuroinflammatory mechanism connecting common neurodegenerative diseases.

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GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

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Investigation of Autosomal Genetic Sex Differences in Parkinsons disease

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The Parkinson's Disease DNA Variant Browser

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Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes

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A population scale analysis of rare SNCA variation in the UK Biobank

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LRRK2 coding variants and the risk of Parkinson's disease

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PhenoExam: an R package and Web application for the examination of phenotypes linked to genes and gene sets

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