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Author: Mike A Nalls

Rankings

  • All-time downloads: 91,766 (rank: 2,501 )
  • Categories:
    • bioinformatics: 1,178 (rank: 19,391 (tie) )
    • cell biology: 1,143 (rank: 14,167 (tie) )
    • epidemiology: 911 (rank: 17,585 (tie) )
    • genetic and genomic medicine: 4,222 (rank: 1,349 )
    • genetics: 34,240 (rank: 231 )
    • genomics: 17,478 (rank: 1,200 )
    • geriatric medicine: 216 (rank: 958 (tie) )
    • molecular biology: 632 (rank: 18,563 (tie) )
    • neurology: 3,078 (rank: 606 )
    • neuroscience: 21,269 (rank: 621 )
    • pharmacology and therapeutics: 3,212 (rank: 224 (tie) )
    • sexual and reproductive health: 2,565 (rank: 164 (tie) )

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Preprints

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

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Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

genetics more details view paper
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    • Site-wide: 1,061
    • In genetics: 21
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    • Site-wide: 15,791

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

genomics more details view paper
  • Downloaded 6,326 times
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    • Site-wide: 2,542
    • In genomics: 193
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A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

genetics more details view paper
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    • Site-wide: 2,553
    • In genetics: 72
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A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease states

neuroscience more details view paper
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    • Site-wide: 2,856
    • In neuroscience: 154
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A reference induced pluripotent stem cell line for large-scale collaborative studies

neuroscience more details view paper
  • Downloaded 4,793 times
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    • Site-wide: 3,708
    • In neuroscience: 241
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Predicting onset, progression, and clinical subtypes of Parkinson disease using machine learning

neuroscience more details view paper
  • Downloaded 3,627 times
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    • Site-wide: 5,534
    • In neuroscience: 433
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    • Site-wide: 10,154
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    • Site-wide: 26,337

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

genetics more details view paper
  • Downloaded 3,432 times
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    • Site-wide: 6,016
    • In genetics: 198
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A Cellular Taxonomy of the Adult Human Spinal Cord

neuroscience more details view paper
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    • In neuroscience: 522
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Dopaminergic stimulants and risk of Parkinson's disease

pharmacology and therapeutics more details view paper
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    • Site-wide: 6,294
    • In pharmacology and therapeutics: 25
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    • Site-wide: 4,540

Genetic insights into the biological mechanisms governing human ovarian ageing

sexual and reproductive health more details view paper
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    • Site-wide: 9,171
    • In sexual and reproductive health: 13
  • Year to date:
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The Foundational data initiative for Parkinsons disease (FOUNDIN-PD): enabling efficient translation from genetic maps to mechanism

genomics more details view paper
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    • Site-wide: 15,328
    • In genomics: 1,386
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    • Site-wide: None
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Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms

genetics more details view paper
  • Downloaded 1,647 times
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    • Site-wide: 18,219
    • In genetics: 729
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Genome-wide association study of Parkinson’s disease progression biomarkers in 12 longitudinal patients’ cohorts

genetics more details view paper
  • Downloaded 1,629 times
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    • Site-wide: 18,493
    • In genetics: 742
  • Year to date:
    • Site-wide: 78,061
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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

genomics more details view paper
  • Downloaded 1,412 times
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    • Site-wide: 23,273
    • In genomics: 2,011
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    • Site-wide: 103,577
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A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

genomics more details view paper
  • Downloaded 1,408 times
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    • Site-wide: 23,395
    • In genomics: 2,039
  • Year to date:
    • Site-wide: 23,210
  • Since beginning of last month:
    • Site-wide: 28,091

Enrichment of rare protein truncating variants in amyotrophic lateral sclerosis patients

genomics more details view paper
  • Downloaded 1,386 times
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    • Site-wide: 23,987
    • In genomics: 2,063
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    • Site-wide: 103,802
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    • Site-wide: 146,333

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

genetics more details view paper
  • Downloaded 1,377 times
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    • Site-wide: 24,233
    • In genetics: 976
  • Year to date:
    • Site-wide: 18,992
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The Parkinson's Disease GWAS Locus Browser

genetics more details view paper
  • Downloaded 1,361 times
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    • Site-wide: 24,681
    • In genetics: 1,002
  • Year to date:
    • Site-wide: 38,263
  • Since beginning of last month:
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A fully automated FAIMS-DIA proteomic pipeline for high-throughput characterization of iPSC-derived neurons

neuroscience more details view paper
  • Downloaded 1,336 times
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    • Site-wide: 25,437
    • In neuroscience: 3,259
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    • Site-wide: 32,180
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    • Site-wide: 6,765

Multi-Modality Machine Learning Predicting Parkinsons Disease

genomics more details view paper
  • Downloaded 1,261 times
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    • Site-wide: 27,871
    • In genomics: 2,364
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    • Site-wide: 119,679
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    • Site-wide: 69,477

Parallel CRISPR-Cas9 screens reveal mechanisms of PLIN2 and lipid droplet regulation

cell biology more details view paper
  • Downloaded 1,245 times
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    • Site-wide: 28,454
    • In cell biology: 1,190
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    • Site-wide: 2,647

Predicting Alzheimer’s disease progression trajectory and clinical subtypes using machine learning

neuroscience more details view paper
  • Downloaded 1,244 times
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    • Site-wide: 28,474
    • In neuroscience: 3,539
  • Year to date:
    • Site-wide: 59,197
  • Since beginning of last month:
    • Site-wide: 30,742

Genetic variability and potential effects on clinical trial outcomes: perspectives in Parkinson's disease

genomics more details view paper
  • Downloaded 1,079 times
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    • Site-wide: 35,490
    • In genomics: 2,851
  • Year to date:
    • Site-wide: 166,378
  • Since beginning of last month:
    • Site-wide: 76,170

Genetic modifiers of risk and age at onset in GBA associated Parkinson disease and Lewy body dementia

genetics more details view paper
  • Downloaded 1,031 times
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    • Site-wide: 38,099
    • In genetics: 1,502
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    • Site-wide: 134,506
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    • Site-wide: 207,006

Penetrance of Parkinson’s disease in LRRK2 p.G2019S carriers is modified by a polygenic risk score

genetics more details view paper
  • Downloaded 1,005 times
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    • Site-wide: 39,672
    • In genetics: 1,577
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    • Site-wide: 101,791
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    • Site-wide: 144,395

Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability

genomics more details view paper
  • Downloaded 1,004 times
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    • Site-wide: 39,691
    • In genomics: 3,066
  • Year to date:
    • Site-wide: 138,919
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    • Site-wide: 210,375

The Parkinson's Phenome: Traits Associated with Parkinson's Disease in a Large and Deeply Phenotyped Cohort

epidemiology more details view paper
  • Downloaded 916 times
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    • Site-wide: 45,746
    • In epidemiology: 2,338
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    • Site-wide: 100,951
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    • Site-wide: 152,036

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

genomics more details view paper
  • Downloaded 883 times
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    • Site-wide: 48,497
    • In genomics: 3,575
  • Year to date:
    • Site-wide: 198,183
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    • Site-wide: 92,257

Parkinsons disease determinants, prediction and gene-environment interactions in the UK Biobank

genetics more details view paper
  • Downloaded 877 times
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    • Site-wide: 48,938
    • In genetics: 1,902
  • Year to date:
    • Site-wide: 131,020
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The genetic architecture of Parkinson disease in Spain: characterizing population-specific risk, differential haplotype structures, and providing etiologic insight

neuroscience more details view paper
  • Downloaded 862 times
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    • Site-wide: 50,192
    • In neuroscience: 6,729
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    • Site-wide: 59,472
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    • Site-wide: 94,317

Genetic variation within genes associated with mitochondrial function is significantly associated with later age at onset of Parkinson disease and contributes to disease risk

genetics more details view paper
  • Downloaded 715 times
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    • Site-wide: 66,288
    • In genetics: 2,538
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    • Site-wide: 176,608
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Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects

genetic and genomic medicine more details view paper
  • Downloaded 689 times
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    • Site-wide: 69,885
    • In genetic and genomic medicine: 456
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    • Site-wide: 32,892
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Biomarkers of Parkinson's Disease: Screening Vital Signs and Routine Blood Tests

neurology more details view paper
  • Downloaded 656 times
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    • Site-wide: 74,763
    • In neurology: 295
  • Year to date:
    • Site-wide: 54,643
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Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

molecular biology more details view paper
  • Downloaded 637 times
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    • Site-wide: 77,612
    • In molecular biology: 2,214
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    • Site-wide: 110,249
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    • Site-wide: 159,399

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

genomics more details view paper
  • Downloaded 634 times
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    • Site-wide: 78,155
    • In genomics: 5,105
  • Year to date:
    • Site-wide: 139,600
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    • Site-wide: 205,712

Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

genetics more details view paper
  • Downloaded 628 times
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    • Site-wide: 79,031
    • In genetics: 3,032
  • Year to date:
    • Site-wide: 136,036
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    • Site-wide: 190,718

Investigation of Autosomal Genetic Sex Differences in Parkinsons disease

genetic and genomic medicine more details view paper
  • Downloaded 621 times
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    • Site-wide: 80,174
    • In genetic and genomic medicine: 514
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    • Site-wide: 186,890
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    • Site-wide: 110,445

The Parkinsons Disease Mendelian Randomization Research Portal

neuroscience more details view paper
  • Downloaded 599 times
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    • Site-wide: 83,931
    • In neuroscience: 11,864
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Genome-wide analysis of Structural Variants in Parkinson's Disease using Short-Read Sequencing data

genetics more details view paper
  • Downloaded 585 times
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    • Site-wide: 86,635
    • In genetics: 3,599
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    • Site-wide: 7,272

Comprehensive assessment of PINK1 variants in Parkinson's disease

genetic and genomic medicine more details view paper
  • Downloaded 566 times
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    • Site-wide: 90,371
    • In genetic and genomic medicine: 582
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    • Site-wide: 93,682
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Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

neurology more details view paper
  • Downloaded 542 times
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    • Site-wide: 95,243
    • In neurology: 402
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    • Site-wide: 129,106
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    • Site-wide: 82,236

Regulatory sites for known and novel splicing in human basal ganglia are enriched for disease-relevant information

bioinformatics more details view paper
  • Downloaded 530 times
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    • Site-wide: 97,637
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LRRK2 coding variants and the risk of Parkinson's disease

neurology more details view paper
  • Downloaded 529 times
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    • Site-wide: 98,011
    • In neurology: 429
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Differences in the presentation and progression of Parkinson's disease by sex

neurology more details view paper
  • Downloaded 515 times
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    • Site-wide: 101,107
    • In neurology: 436
  • Year to date:
    • Site-wide: 185,224
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    • Site-wide: 132,147

Genome-wide estimates of heritability and genetic correlations in Essential Tremor

genetics more details view paper
  • Downloaded 488 times
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    • Site-wide: 107,279
    • In genetics: 4,060
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    • Site-wide: 139,776
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    • Site-wide: 147,638

Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

genetics more details view paper
  • Downloaded 485 times
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    • Site-wide: 107,893
    • In genetics: 4,075
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    • Site-wide: 167,275
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    • Site-wide: 149,750

Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource

neurology more details view paper
  • Downloaded 466 times
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    • Site-wide: 112,578
    • In neurology: 521
  • Year to date:
    • Site-wide: 110,944
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    • Site-wide: 77,565

Multi-ancestry meta-analysis and fine-mapping in Alzheimer's Disease

genetic and genomic medicine more details view paper
  • Downloaded 455 times
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    • Site-wide: 115,197
    • In genetic and genomic medicine: 870
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    • Site-wide: 6,478
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    • Site-wide: 8,462

Multi-ancestry genome-wide meta-analysis in Parkinson's disease

genetic and genomic medicine more details view paper
  • Downloaded 448 times
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    • Site-wide: 117,194
    • In genetic and genomic medicine: 833
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    • Site-wide: 15,825
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    • Site-wide: 13,911

Evidence for GRN as part of a neuroinflammatory mechanism connecting common neurodegenerative diseases.

neurology more details view paper
  • Downloaded 420 times
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    • Site-wide: 124,485
    • In neurology: 616
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    • Site-wide: 132,678
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    • Site-wide: 168,433

The Parkinson's Disease DNA Variant Browser

genetic and genomic medicine more details view paper
  • Downloaded 398 times
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    • Site-wide: 130,925
    • In genetic and genomic medicine: 905
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    • Site-wide: 94,560
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    • Site-wide: 103,876

Identification and prediction of Parkinson's disease subtypes and progression using machine learning in two cohorts.

bioinformatics more details view paper
  • Downloaded 380 times
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    • Site-wide: 136,056
    • In bioinformatics: 11,477
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    • Site-wide: 12,483

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

genetics more details view paper
  • Downloaded 375 times
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    • Site-wide: 137,654
    • In genetics: 5,111
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    • Site-wide: 174,396
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A population scale analysis of rare SNCA variation in the UK Biobank

genetic and genomic medicine more details view paper
  • Downloaded 357 times
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    • Site-wide: 142,885
    • In genetic and genomic medicine: 1,001
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    • Site-wide: 182,478
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    • Site-wide: 141,157

Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes

genomics more details view paper
  • Downloaded 348 times
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    • Site-wide: 145,806
    • In genomics: 7,710
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    • Site-wide: 126,348
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PhenoExam: an R package and Web application for the examination of phenotypes linked to genes and gene sets

bioinformatics more details view paper
  • Downloaded 338 times
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    • Site-wide: 148,847
    • In bioinformatics: 12,193
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    • Site-wide: 12,150

Large-scale Rare Variant Burden Testing in Parkinson's Disease Identifies Novel Associations with Genes Involved in Neuro-inflammation

genetic and genomic medicine more details view paper
  • Downloaded 319 times
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    • Site-wide: 154,582
    • In genetic and genomic medicine: 1,142
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    • Site-wide: 8,543

Analysis of Y Chromosome Haplogroups in Parkinson's Disease

genetic and genomic medicine more details view paper
  • Downloaded 310 times
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    • Site-wide: 157,258
    • In genetic and genomic medicine: 1,154
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    • Site-wide: 26,930
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Virus exposure and neurodegenerative disease risk across national biobanks.

geriatric medicine more details view paper
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    • Site-wide: 177,103
    • In geriatric medicine: 137
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    • Site-wide: 21,012

The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson's disease data

genetics more details view paper
  • Downloaded 182 times
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    • Site-wide: 191,842
    • In genetics: 6,820
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    • Site-wide: 121,881
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    • Site-wide: 33,350

Genome-wide epistasis analysis in Parkinson's disease between populations with different genetic ancestry reveals significant variant-variant interactions

genetic and genomic medicine more details view paper
  • Downloaded 170 times
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    • Site-wide: 194,433
    • In genetic and genomic medicine: 1,487
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    • Site-wide: 160,794
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    • Site-wide: 41,392

Application of Aligned-UMAP to longitudinal biomedical studies

bioinformatics more details view paper
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    • Site-wide: 203,891
    • In bioinformatics: None
  • Year to date:
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Global Parkinson's Genetics Program (GP2) Complex Network Protocol: Defining the causes of sporadic Parkinson's disease

genetic and genomic medicine more details view paper
  • Downloaded 119 times
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    • Site-wide: 204,434
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    • Site-wide: 14,730
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    • Site-wide: 5,614

Global Parkinson's Genetics Program (GP2) Monogenic Network Protocol: Elucidating causative gene variants in hereditary Parkinson's disease

genetic and genomic medicine more details view paper
  • Downloaded 94 times
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    • Site-wide: 208,810
    • In genetic and genomic medicine: 1,748
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    • Site-wide: 7,667
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    • Site-wide: 4,999

Polygenic Parkinson's disease genetic risk score as risk modifier of parkinsonism in Gaucher disease

genetic and genomic medicine more details view paper
  • Downloaded 66 times
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    • Site-wide: 214,027
    • In genetic and genomic medicine: None
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    • Site-wide: 16,299
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    • Site-wide: 7,431

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