Author: Mike A Nalls

Downloads per author, site-wide

Preprints

Genetic insights into the biological mechanisms governing human ovarian ageing

No download data for this paper yet.

Expanding Parkinson's disease genetics: novel risk loci, genomic context, causal insights and heritable risk.

• Downloaded 10,259 times
• Download rankings, all-time:
  • Site-wide: 662
  • In genetics: 20
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 5,971

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,027 times
• Download rankings, all-time:
  • Site-wide: 3,510
  • In genetics: 165
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 56,089

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

• Downloaded 2,564 times
• Download rankings, all-time:
  • Site-wide: 4,428
  • In genomics: 533
• Year to date:
  • Site-wide: 2,674
• Since beginning of last month:
  • Site-wide: 1,140

Predicting onset, progression, and clinical subtypes of Parkinson disease using machine learning

• Downloaded 2,564 times
• Download rankings, all-time:
  • Site-wide: 4,424
  • In neuroscience: 410
• Year to date:
  • Site-wide: 10,675
• Since beginning of last month:
  • Site-wide: 7,332

Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms

• Downloaded 1,331 times
• Download rankings, all-time:
  • Site-wide: 11,807
  • In genetics: 613
• Year to date:
  • Site-wide: 19,163
• Since beginning of last month:
  • Site-wide: 31,017

Genome-wide association study of Parkinson’s disease progression biomarkers in 12 longitudinal patients’ cohorts

• Downloaded 1,235 times
• Download rankings, all-time:
  • Site-wide: 13,213
  • In genetics: 693
• Year to date:
  • Site-wide: 12,838
• Since beginning of last month:
  • Site-wide: 36,824

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,224 times
• Download rankings, all-time:
  • Site-wide: 13,390
  • In genomics: 1,473
• Year to date:
  • Site-wide: 31,768
• Since beginning of last month:
  • Site-wide: 69,956

Enrichment of rare protein truncating variants in amyotrophic lateral sclerosis patients

• Downloaded 1,177 times
• Download rankings, all-time:
  • Site-wide: 14,189
  • In genomics: 1,544
• Year to date:
  • Site-wide: 42,539
• Since beginning of last month:
  • Site-wide: 59,990

Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability

• Downloaded 884 times
• Download rankings, all-time:
  • Site-wide: 21,689
  • In genomics: 2,184
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 106,170

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 764 times
• Download rankings, all-time:
  • Site-wide: 26,562
  • In genetics: 1,354
• Year to date:
  • Site-wide: 10,466
• Since beginning of last month:
  • Site-wide: 16,893

The Parkinson's Phenome: Traits Associated with Parkinson's Disease in a Large and Deeply Phenotyped Cohort

• Downloaded 760 times
• Download rankings, all-time:
  • Site-wide: 26,787
  • In epidemiology: 1,352
• Year to date:
  • Site-wide: 35,121
• Since beginning of last month:
  • Site-wide: 77,849

Genetic modifiers of risk and age at onset in GBA associated Parkinson disease and Lewy body dementia

• Downloaded 757 times
• Download rankings, all-time:
  • Site-wide: 26,936
  • In genetics: 1,374
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 53,153

The Parkinson's Disease GWAS Locus Browser

• Downloaded 745 times
• Download rankings, all-time:
  • Site-wide: 27,595
  • In genetics: 1,413
• Year to date:
  • Site-wide: 7,325
• Since beginning of last month:
  • Site-wide: 7,169

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 726 times
• Download rankings, all-time:
  • Site-wide: 28,644
  • In genomics: 2,659
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 107,381

Genetic variability and potential effects on clinical trial outcomes: perspectives in Parkinson's disease

• Downloaded 688 times
• Download rankings, all-time:
  • Site-wide: 30,832
  • In genomics: 2,810
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 94,660

Dopaminergic stimulants and risk of Parkinson's disease

• Downloaded 670 times
• Download rankings, all-time:
  • Site-wide: 31,938
  • In pharmacology and therapeutics: 34
• Year to date:
  • Site-wide: 5,765
• Since beginning of last month:
  • Site-wide: 5,910

Parkinsons disease determinants, prediction and gene-environment interactions in the UK Biobank

• Downloaded 653 times
• Download rankings, all-time:
  • Site-wide: 33,074
  • In genetics: 1,667
• Year to date:
  • Site-wide: 42,979
• Since beginning of last month:
  • Site-wide: 29,128

The genetic architecture of Parkinson disease in Spain: characterizing population-specific risk, differential haplotype structures, and providing etiologic insight

• Downloaded 628 times
• Download rankings, all-time:
  • Site-wide: 34,758
  • In neuroscience: 4,952
• Year to date:
  • Site-wide: 23,632
• Since beginning of last month:
  • Site-wide: 50,421

Predicting Alzheimer’s disease progression trajectory and clinical subtypes using machine learning

• Downloaded 609 times
• Download rankings, all-time:
  • Site-wide: 36,096
  • In neuroscience: 5,173
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 75,308

Genetic variation within genes associated with mitochondrial function is significantly associated with later age at onset of Parkinson disease and contributes to disease risk

• Downloaded 568 times
• Download rankings, all-time:
  • Site-wide: 39,437
  • In genetics: 1,940
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 89,305

Penetrance of Parkinson’s disease in LRRK2 p.G2019S carriers is modified by a polygenic risk score

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 45,355
  • In genetics: 2,221
• Year to date:
  • Site-wide: 57,359
• Since beginning of last month:
  • Site-wide: 59,840

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 491 times
• Download rankings, all-time:
  • Site-wide: 46,968
  • In genomics: 3,791
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 112,771

The Parkinsons Disease Mendelian Randomization Research Portal

• Downloaded 490 times
• Download rankings, all-time:
  • Site-wide: 47,162
  • In neuroscience: 6,975
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 111,796

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

• Downloaded 489 times
• Download rankings, all-time:
  • Site-wide: 47,254
  • In molecular biology: 1,359
• Year to date:
  • Site-wide: 48,049
• Since beginning of last month:
  • Site-wide: 69,751

Regulatory sites for known and novel splicing in human basal ganglia are enriched for disease-relevant information

• Downloaded 395 times
• Download rankings, all-time:
  • Site-wide: 59,366
  • In bioinformatics: 5,920
• Year to date:
  • Site-wide: 57,056
• Since beginning of last month:
  • Site-wide: 102,002

Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

• Downloaded 387 times
• Download rankings, all-time:
  • Site-wide: 60,585
  • In genetics: 2,911
• Year to date:
  • Site-wide: 31,813
• Since beginning of last month:
  • Site-wide: 37,308

Genome-wide estimates of heritability and genetic correlations in Essential Tremor

• Downloaded 342 times
• Download rankings, all-time:
  • Site-wide: 67,712
  • In genetics: 3,226
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 69,968

Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

• Downloaded 327 times
• Download rankings, all-time:
  • Site-wide: 70,275
  • In genetics: 3,353
• Year to date:
  • Site-wide: 66,319
• Since beginning of last month:
  • Site-wide: 58,565

Unhealthy Behaviours and Parkinsons Disease: A Mendelian Randomisation Study

• Downloaded 299 times
• Download rankings, all-time:
  • Site-wide: 75,344
  • In neurology: 162
• Year to date:
  • Site-wide: 12,970
• Since beginning of last month:
  • Site-wide: 26,318

Comprehensive assessment of PINK1 variants in Parkinson's disease

• Downloaded 288 times
• Download rankings, all-time:
  • Site-wide: 77,651
  • In genetic and genomic medicine: 231
• Year to date:
  • Site-wide: 55,760
• Since beginning of last month:
  • Site-wide: 39,831

Differences in the presentation and progression of Parkinson's disease by sex

• Downloaded 265 times
• Download rankings, all-time:
  • Site-wide: 82,213
  • In neurology: 189
• Year to date:
  • Site-wide: 51,765
• Since beginning of last month:
  • Site-wide: 47,380

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

• Downloaded 254 times
• Download rankings, all-time:
  • Site-wide: 84,502
  • In genetics: 3,937
• Year to date:
  • Site-wide: 41,349
• Since beginning of last month:
  • Site-wide: 94,830

Biomarkers of Parkinson's Disease: Screening Vital Signs and Routine Blood Tests

• Downloaded 215 times
• Download rankings, all-time:
  • Site-wide: 92,538
  • In neurology: 240
• Year to date:
  • Site-wide: 24,556
• Since beginning of last month:
  • Site-wide: 24,621

Evidence for GRN as part of a neuroinflammatory mechanism connecting common neurodegenerative diseases.

• Downloaded 212 times
• Download rankings, all-time:
  • Site-wide: 93,165
  • In neurology: 245
• Year to date:
  • Site-wide: 19,431
• Since beginning of last month:
  • Site-wide: 1,418

Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes

• Downloaded 182 times
• Download rankings, all-time:
  • Site-wide: 99,464
  • In genomics: 5,904
• Year to date:
  • Site-wide: 21,726
• Since beginning of last month:
  • Site-wide: 34,252

The Parkinson's Disease DNA Variant Browser

• Downloaded 171 times
• Download rankings, all-time:
  • Site-wide: 101,492
  • In genetic and genomic medicine: 380
• Year to date:
  • Site-wide: 16,041
• Since beginning of last month:
  • Site-wide: 43,376

Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource

• Downloaded 160 times
• Download rankings, all-time:
  • Site-wide: 103,820
  • In neurology: 324
• Year to date:
  • Site-wide: 20,018
• Since beginning of last month:
  • Site-wide: 10,286

A population scale analysis of rare SNCA variation in the UK Biobank

• Downloaded 141 times
• Download rankings, all-time:
  • Site-wide: 107,151
  • In genetic and genomic medicine: 422
• Year to date:
  • Site-wide: 43,994
• Since beginning of last month:
  • Site-wide: 59,774