Author: Daniel H. Geschwind

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Preprints

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury

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  • Site-wide: 5,551
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A single cell transcriptomic analysis of human neocortical development

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Global changes in patterning, splicing and primate specific lncRNAs in autism brain

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Exome sequencing of 457 autism families recruited online provides evidence for novel ASD genes

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Whole genome sequencing in multiplex families reveals novel inherited and de novo genetic risk in autism

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Atypical neurogenesis in induced pluripotent stem cell (iPSC) from autistic individuals

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De novo mutations in regulatory elements cause neurodevelopmental disorders

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Cell-type specific effects of genetic variation on chromatin accessibility during human neuronal differentiation

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Whole Genome Sequencing in Psychiatric Disorders: the WGSPD Consortium

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Inducible And Reversible Phenotypes In A Novel Mouse Model Of Friedreich's Ataxia

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Correspondence between resting state activity and brain gene expression

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  • Site-wide: 22,010
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Neuronal and glial 3D chromatin architecture illustrates cellular etiology of brain disorders

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Reduced prefrontal synaptic connectivity and disturbed oscillatory population dynamics in the CNTNAP2 model of autism

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  • In neuroscience: 2,828
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Genetic overlap between educational attainment, schizophrenia and autism

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  • Site-wide: 25,197
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  • Site-wide: 120,894
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Widespread RNA editing dysregulation in Autism Spectrum Disorders

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  • Site-wide: 26,833
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  • Site-wide: 85,560
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Genetic correlates of phenotypic heterogeneity in autism

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  • Site-wide: 27,377
  • In genetic and genomic medicine: 127
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Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

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  • Site-wide: 27,663
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Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism

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  • Site-wide: 28,685
  • In genomics: 2,515
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Broad transcriptomic dysregulation across the cerebral cortex in ASD

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  • Site-wide: 38,024
  • In neuroscience: 5,072
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Dissecting the molecular basis of human interneuron migrationin forebrain assembloids from Timothy syndrome

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  • In neuroscience: 5,281
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Synaptic and Gene Regulatory Mechanisms in Schizophrenia, Autism, and 22q11.2 CNV Mediated Risk for Neuropsychiatric Disorders

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  • Site-wide: 40,219
  • In systems biology: 846
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Evolutionary conservation and divergence of human brain co-expression networks

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  • Site-wide: 42,718
  • In genomics: 3,380
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Identification of conserved proteomic networks in neurodegenerative dementia

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  • Site-wide: 43,601
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Gene co-expression network analysis in human spinal cord highlights mechanisms underlying amyotrophic lateral sclerosis susceptibility

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Leveraging genomic diversity for discovery in an EHR-linked biobank: the UCLA ATLAS Community Health Initiative

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  • Site-wide: 53,377
  • In genetic and genomic medicine: 251
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Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder

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  • Site-wide: 68,808
  • In genetic and genomic medicine: 334
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  • Site-wide: 14,801
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  • Site-wide: 33,762

Alterations in retrotransposition, synaptic connectivity, and myelination implicated by transcriptomic changes following maternal immune activation in non-human primates

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  • Site-wide: 81,351
  • In neuroscience: 12,007
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  • Site-wide: 159,886

Functional regulatory variants implicate distinct transcriptional networks in dementia

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  • Site-wide: 81,966
  • In genetics: 3,453
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  • Site-wide: 32,366

Polygenic profiles define aspects of clinical heterogeneity in ADHD

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  • Site-wide: 124,822
  • In psychiatry and clinical psychology: 613
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  • Site-wide: 47,875

Maternal immune activation during pregnancy alters early neurobehavioral development in nonhuman primate offspring

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  • Site-wide: 138,689
  • In neuroscience: 20,765
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  • Site-wide: 96,500

Screening for axon regeneration promoting compounds with human iPSC-derived motor neurons

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  • Site-wide: 142,137
  • In neuroscience: 21,253
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