Author: Lars T. Westlye

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Preprints

The genetic architecture of the human cerebral cortex

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  • Site-wide: 1,580
  • In genetics: 35
• Year to date:
  • Site-wide: 24,054
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  • Site-wide: 27,746

Greater male than female variability in regional brain structure across the lifespan

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  • Site-wide: 4,457
  • In neuroscience: 313
• Year to date:
  • Site-wide: 55,508
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  • Site-wide: 60,831

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

• Downloaded 2,634 times
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  • Site-wide: 7,881
  • In genetics: 339
• Year to date:
  • Site-wide: 8,823
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  • Site-wide: 24,995

A large, open source dataset of stroke anatomical brain images and manual lesion segmentations

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  • Site-wide: 8,881
  • In neuroscience: 788
• Year to date:
  • Site-wide: 53,874
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  • Site-wide: 45,261

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

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  • Site-wide: 13,172
  • In genetics: 498
• Year to date:
  • Site-wide: 124,807
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  • Site-wide: 116,301

The correlation between central and peripheral oxytocin concentrations: a systematic review and meta-analysis

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  • Site-wide: 14,320
  • In physiology: 30
• Year to date:
  • Site-wide: 59,002
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  • Site-wide: 61,633

Cerebellar grey matter volume is associated with cognitive function and psychopathology in adolescence

• Downloaded 1,613 times
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  • Site-wide: 16,304
  • In neuroscience: 1,720
• Year to date:
  • Site-wide: 57,890
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  • Site-wide: 45,103

Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis study

• Downloaded 1,604 times
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  • Site-wide: 16,462
  • In neuroscience: 1,701
• Year to date:
  • Site-wide: 91,999
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  • Site-wide: 115,656

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

• Downloaded 1,552 times
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  • Site-wide: 17,334
  • In neuroscience: 1,787
• Year to date:
  • Site-wide: 134,440
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  • Site-wide: 145,076

Waves of maturation and senescence in micro-structural MRI markers of human cortical myelination over the lifespan

• Downloaded 1,305 times
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  • Site-wide: 22,664
  • In neuroscience: 2,553
• Year to date:
  • Site-wide: 111,343
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  • Site-wide: 65,177

Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years

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  • Site-wide: 23,736
  • In neuroscience: 2,750
• Year to date:
  • Site-wide: 75,617
• Since beginning of last month:
  • Site-wide: 119,204

Vaccination history for diphtheria and tetanus is associated with less severe COVID-19

• Downloaded 1,070 times
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  • Site-wide: 30,710
  • In epidemiology: 1,725
• Year to date:
  • Site-wide: 44,396
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  • Site-wide: 51,651

Phenotypically independent mental health symptom profiles are genetically related

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  • Site-wide: 31,786
  • In psychiatry and clinical psychology: 124
• Year to date:
  • Site-wide: 58,852
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  • Site-wide: 27,903

Predicting cognitive and mental health traits and their polygenic architecture using large-scale brain connectomics

• Downloaded 981 times
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  • Site-wide: 34,960
  • In neuroscience: 4,765
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  • Site-wide: 39,703
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  • Site-wide: 57,081

Data-driven clustering reveals a link between symptoms and functional brain connectivity in depression

• Downloaded 957 times
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  • Site-wide: 36,252
  • In neuroscience: 4,576
• Year to date:
  • Site-wide: 70,273
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  • Site-wide: 65,778

Planar cell polarity pathway and development of the human visual cortex

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  • Site-wide: 36,539
  • In neuroscience: 4,615
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  • Site-wide: 74,888
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  • Site-wide: 50,377

Women’s brain aging: effects of sex-hormone exposure, pregnancies, and genetic risk for Alzheimer’s disease

• Downloaded 938 times
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  • Site-wide: 37,416
  • In neuroscience: 4,682
• Year to date:
  • Site-wide: 93,291
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  • Site-wide: 136,460

Towards an optimised processing pipeline for diffusion MRI data: Effects of artefact corrections on diffusion metrics and their age associations in UK Biobank

• Downloaded 935 times
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  • Site-wide: 37,585
  • In neuroscience: 4,624
• Year to date:
  • Site-wide: 117,233
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  • Site-wide: 178,205

White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction

• Downloaded 931 times
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  • Site-wide: 37,823
  • In neuroscience: 4,854
• Year to date:
  • Site-wide: 75,784
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  • Site-wide: 108,068

Thinner cortex is associated with psychosis onset in individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group mega-analysis

• Downloaded 911 times
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  • Site-wide: 39,033
  • In psychiatry and clinical psychology: 160
• Year to date:
  • Site-wide: 41,712
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  • Site-wide: 27,561

Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

• Downloaded 887 times
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  • Site-wide: 40,548
  • In neuroscience: 5,094
• Year to date:
  • Site-wide: 120,730
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  • Site-wide: 133,696

The genetic architecture of human brainstem structures and their involvement in common brain disorders

• Downloaded 837 times
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  • Site-wide: 44,279
  • In neuroscience: 5,573
• Year to date:
  • Site-wide: 128,859
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  • Site-wide: 107,991

Probing brain developmental patterns of myelination and associations with psychopathology in youth using gray/white matter contrast

• Downloaded 787 times
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  • Site-wide: 48,392
  • In neuroscience: 6,179
• Year to date:
  • Site-wide: 139,348
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  • Site-wide: 112,500

Title: Reliability, sensitivity and predictive value of fMRI during multiple object tracking as a marker of cognitive training gain in combination with tDCS in stroke survivors

• Downloaded 786 times
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  • Site-wide: 48,479
  • In neuroscience: 6,334
• Year to date:
  • Site-wide: 81,858
• Since beginning of last month:
  • Site-wide: 141,378

Making the MOSTest of imaging genetics

• Downloaded 781 times
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  • Site-wide: 48,970
  • In neuroscience: 6,243
• Year to date:
  • Site-wide: 137,375
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  • Site-wide: 158,984

A large, curated, open-source stroke neuroimaging dataset to improve lesion segmentation algorithms

• Downloaded 764 times
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  • Site-wide: 50,517
  • In neurology: 483
• Year to date:
  • Site-wide: 3,555
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  • Site-wide: 2,496

Brain scans from 21297 individuals reveal the genetic architecture of hippocampal subfield volumes

• Downloaded 759 times
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  • Site-wide: 51,037
  • In genetics: 1,973
• Year to date:
  • Site-wide: 180,446
• Since beginning of last month:
  • Site-wide: 175,590

Genome-wide association analysis of the human thalamus identifies novel genomic loci and reveals genetic overlap with distinct cortical regions and ten brain disorders

• Downloaded 746 times
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  • Site-wide: 52,280
  • In genetic and genomic medicine: 258
• Year to date:
  • Site-wide: 81,956
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  • Site-wide: 69,182

Patterns of socio-cognitive stratification and perinatal risk in the child brain

• Downloaded 728 times
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  • Site-wide: 54,055
  • In neuroscience: 7,121
• Year to date:
  • Site-wide: 123,873
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  • Site-wide: 127,333

Cortico-genetic mapping links individual brain maturity in youths to cognitive and psychiatric traits

• Downloaded 726 times
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  • Site-wide: 54,317
  • In neuroscience: 6,970
• Year to date:
  • Site-wide: 170,068
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  • Site-wide: 165,089

The genetic architecture of human cortical folding

• Downloaded 723 times
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  • Site-wide: 54,608
  • In genomics: 4,227
• Year to date:
  • Site-wide: 42,908
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  • Site-wide: 12,747

Maturation of cortical microstructure and cognitive development in childhood and adolescence: a T1w/T2w ratio MRI study

• Downloaded 710 times
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  • Site-wide: 55,938
  • In neuroscience: 7,591
• Year to date:
  • Site-wide: 99,105
• Since beginning of last month:
  • Site-wide: 113,138

Multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.

• Downloaded 693 times
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  • Site-wide: 57,919
  • In genetics: 2,378
• Year to date:
  • Site-wide: 76,167
• Since beginning of last month:
  • Site-wide: 36,894

Long-term anabolic androgenic steroid use is associated with deviant brain aging

• Downloaded 682 times
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  • Site-wide: 59,342
  • In psychiatry and clinical psychology: 235
• Year to date:
  • Site-wide: 80,117
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  • Site-wide: 139,036

Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide

• Downloaded 668 times
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  • Site-wide: 61,077
  • In neuroscience: 8,739
• Year to date:
  • Site-wide: 73,040
• Since beginning of last month:
  • Site-wide: 38,747

Federated Multi-Site Normative Modeling using Hierarchical Bayesian Regression

• Downloaded 658 times
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  • Site-wide: 62,306
  • In bioinformatics: 6,974
• Year to date:
  • Site-wide: 18,998
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  • Site-wide: 30,972

Improved prediction of schizophrenia by leveraging genetic overlap with brain morphology

• Downloaded 643 times
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  • Site-wide: 64,119
  • In psychiatry and clinical psychology: 260
• Year to date:
  • Site-wide: 53,690
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  • Site-wide: 87,144

Machine Learning for Large-Scale Quality Control of 3D Shape Models in Neuroimaging

• Downloaded 637 times
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  • Site-wide: 64,991
  • In neuroscience: 8,520
• Year to date:
  • Site-wide: 176,629
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  • Site-wide: 176,534

Brain age prediction reveals aberrant brain white matter in schizophrenia and bipolar disorder: A multi-sample diffusion tensor imaging study

• Downloaded 628 times
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  • Site-wide: 66,153
  • In neuroscience: 8,983
• Year to date:
  • Site-wide: 133,618
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  • Site-wide: 117,399

Deep neural networks learn general and clinically relevant representations of the ageingbrain

• Downloaded 627 times
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  • Site-wide: 66,244
  • In neurology: 303
• Year to date:
  • Site-wide: 9,756
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  • Site-wide: 23,837

Functional connectivity directionality between large-scale resting-state networks in children and adolescence from the Healthy Brain Network sample

• Downloaded 622 times
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  • Site-wide: 67,061
  • In radiology and imaging: 145
• Year to date:
  • Site-wide: 23,858
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  • Site-wide: 9,498

Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder

• Downloaded 610 times
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  • Site-wide: 68,633
  • In psychiatry and clinical psychology: 269
• Year to date:
  • Site-wide: 101,122
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  • Site-wide: 84,940

Population-based neuroimaging reveals traces of childbirth in the maternal brain

• Downloaded 604 times
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  • Site-wide: 69,629
  • In neuroscience: 9,373
• Year to date:
  • Site-wide: 149,941
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  • Site-wide: 139,854

The dark side of the mean: brain structural heterogeneity in schizophrenia and its polygenic risk.

• Downloaded 599 times
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  • Site-wide: 70,333
  • In neuroscience: 9,355
• Year to date:
  • Site-wide: 179,236
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  • Site-wide: 146,631

Genetic control of variability in subcortical and intracranial volumes

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  • Site-wide: 72,575
  • In neuroscience: 9,784
• Year to date:
  • Site-wide: 166,381
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  • Site-wide: 141,040

Mind the gap: performance metric evaluation in brain-age prediction

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  • Site-wide: 75,177
  • In neuroscience: 12,679
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  • Site-wide: 30,974
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  • Site-wide: 30,904

Multimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-study

• Downloaded 567 times
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  • Site-wide: 75,305
  • In neuroscience: 10,184
• Year to date:
  • Site-wide: 161,908
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  • Site-wide: 159,625

Genetic overlap between multivariate measures of human functional brain connectivity and psychiatric disorders

• Downloaded 564 times
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  • Site-wide: 75,743
  • In genetic and genomic medicine: 412
• Year to date:
  • Site-wide: 25,340
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  • Site-wide: 56,026

Differences in directed functional brain connectivity related to age, sex and mental health

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  • Site-wide: 76,250
  • In neuroscience: 10,419
• Year to date:
  • Site-wide: 141,958
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  • Site-wide: 101,343

Dissecting the cognitive phenotype of post-stroke fatigue using drift diffusion modeling of sustained attention

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  • Site-wide: 80,285
  • In neuroscience: 11,170
• Year to date:
  • Site-wide: 133,058
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  • Site-wide: 130,953

Reliable longitudinal brain age prediction in stroke patients: Associations with cognitive function and response to cognitive training

• Downloaded 522 times
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  • Site-wide: 83,242
  • In neuroscience: 11,842
• Year to date:
  • Site-wide: 102,089
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  • Site-wide: 94,301

Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories

• Downloaded 510 times
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  • Site-wide: 85,597
  • In neuroscience: 11,714
• Year to date:
  • Site-wide: 154,560
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  • Site-wide: 145,568

Deep Learning for Quality Control of Subcortical Brain 3D Shape Models

• Downloaded 501 times
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  • Site-wide: 87,394
  • In neuroscience: 11,787
• Year to date:
  • Site-wide: 179,260
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  • Site-wide: 172,130

Brain age prediction using fMRI network coupling in youths and associations with psychiatric symptoms

• Downloaded 500 times
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  • Site-wide: 87,612
  • In psychiatry and clinical psychology: 469
• Year to date:
  • Site-wide: 27,854
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  • Site-wide: 8,636

Cardiometabolic risk factors associated with brain age and accelerate brain ageing

• Downloaded 497 times
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  • Site-wide: 88,229
  • In neurology: 326
• Year to date:
  • Site-wide: 64,188
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  • Site-wide: 28,729

Heritable cognitive and psychopathology factors in youth are predicted by brain fronto-temporal white matter pathway

• Downloaded 486 times
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  • Site-wide: 90,374
  • In neuroscience: 12,251
• Year to date:
  • Site-wide: 187,054
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  • Site-wide: 163,525

Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry

• Downloaded 485 times
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  • Site-wide: 90,449
  • In neuroscience: 12,421
• Year to date:
  • Site-wide: 169,543
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  • Site-wide: 170,321

Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adults

• Downloaded 472 times
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  • Site-wide: 93,423
  • In neurology: 377
• Year to date:
  • Site-wide: 44,467
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  • Site-wide: 17,355

Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank

• Downloaded 467 times
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  • Site-wide: 94,476
  • In genetic and genomic medicine: 495
• Year to date:
  • Site-wide: 103,935
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  • Site-wide: 103,607

Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders

• Downloaded 436 times
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  • Site-wide: 101,506
  • In radiology and imaging: 187
• Year to date:
  • Site-wide: 120,214
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  • Site-wide: 137,058

Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area

• Downloaded 420 times
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  • Site-wide: 105,252
  • In neuroscience: 14,499
• Year to date:
  • Site-wide: 183,195
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  • Site-wide: 157,372

Narcolepsy type 1 patients have abnormal brain activation to neutral-rated movies in humor-paradigm

• Downloaded 402 times
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  • Site-wide: 109,718
  • In neuroscience: 15,271
• Year to date:
  • Site-wide: 134,866
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  • Site-wide: 170,304

Population-based body-brain mapping links brain morphology and body composition

• Downloaded 389 times
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  • Site-wide: 112,979
  • In neuroscience: 15,933
• Year to date:
  • Site-wide: 147,637
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  • Site-wide: 118,375

Cross-sectional and longitudinal brain scans reveal accelerated brain aging in multiple sclerosis

• Downloaded 389 times
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  • Site-wide: 112,877
  • In neuroscience: 15,637
• Year to date:
  • Site-wide: 170,947
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  • Site-wide: 175,153

A history of previous childbirths is linked to women's white matter brain age in midlife and older age

• Downloaded 387 times
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  • Site-wide: 113,531
  • In neuroscience: 17,006
• Year to date:
  • Site-wide: 90,896
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  • Site-wide: 55,539

Functional brain network modeling in sub-acute stroke patients and healthy controls during rest and continuous attentive tracking

• Downloaded 380 times
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  • Site-wide: 115,243
  • In neuroscience: 16,239
• Year to date:
  • Site-wide: 149,169
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  • Site-wide: 130,256

Spatial frequency discrimination in patients with schizophrenia spectrum and bipolar disorders: Evidence of early visual processing deficits and associations with intellectual abilities

• Downloaded 355 times
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  • Site-wide: 122,283
  • In psychiatry and clinical psychology: 609
• Year to date:
  • Site-wide: 37,684
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  • Site-wide: 64,588

Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis

• Downloaded 347 times
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  • Site-wide: 124,328
  • In neuroscience: 17,181
• Year to date:
  • Site-wide: 185,952
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  • Site-wide: 178,445

Longitudinal stability of the brain functional connectome is associated with episodic memory performance in aging

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  • Site-wide: 124,682
  • In neuroscience: 17,159
• Year to date:
  • Site-wide: 188,156
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  • Site-wide: 184,100

Sparse Deep Neural Networks on Imaging Genetics for Schizophrenia Case-Control Classification

• Downloaded 342 times
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  • Site-wide: 125,781
  • In psychiatry and clinical psychology: 578
• Year to date:
  • Site-wide: 168,843
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  • Site-wide: 136,938

Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents

• Downloaded 336 times
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  • Site-wide: 127,505
  • In neuroscience: 17,735
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  • Site-wide: 178,884
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  • Site-wide: 185,972

Genetic overlap between Alzheimer's disease and depression mapped onto the brain

• Downloaded 335 times
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  • Site-wide: 127,830
  • In genetic and genomic medicine: 755
• Year to date:
  • Site-wide: 131,390
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  • Site-wide: 125,067

Experience-dependent modulation of the visual evoked potential: testing effect sizes, retention over time, and associations with age in 415 healthy individuals

• Downloaded 335 times
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  • Site-wide: 127,770
  • In neuroscience: 17,773
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  • Site-wide: 177,613
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  • Site-wide: 156,184

No effect of tDCS on fatigue and depression in chronic stroke patients: an exploratory randomized sham-controlled trial combining tDCS with computerized cognitive training

• Downloaded 328 times
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  • Site-wide: 129,874
  • In rehabilitation medicine and physical therapy: 172
• Year to date:
  • Site-wide: 72,393
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  • Site-wide: 68,888

History of childbirths relates to region-specific brain aging patterns in middle and older-aged women

• Downloaded 327 times
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  • Site-wide: 130,032
  • In neuroscience: 19,301
• Year to date:
  • Site-wide: 86,912
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  • Site-wide: 79,410

Brain disconnectome mapping and serum neurofilament light levels in multiple sclerosis

• Downloaded 320 times
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  • Site-wide: 132,233
  • In neurology: 631
• Year to date:
  • Site-wide: 84,293
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  • Site-wide: 89,471

Brain age estimation is a sensitive marker of processing speed in the early course of multiple sclerosis

• Downloaded 317 times
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  • Site-wide: 132,876
  • In neuroscience: 19,148
• Year to date:
  • Site-wide: 134,620
• Since beginning of last month:
  • Site-wide: 114,937

Linking objective measures of physical activity and capability with brain structure in healthy community dwelling older adults

• Downloaded 291 times
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  • Site-wide: 140,784
  • In neurology: 655
• Year to date:
  • Site-wide: 122,623
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  • Site-wide: 110,267

Structural disconnectome mapping of cognitive function in post-stroke patients

• Downloaded 281 times
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  • Site-wide: 143,859
  • In radiology and imaging: 374
• Year to date:
  • Site-wide: 37,630
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  • Site-wide: 55,878

White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging

• Downloaded 274 times
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  • Site-wide: 145,833
  • In neuroscience: 20,323
• Year to date:
  • Site-wide: 185,130
• Since beginning of last month:
  • Site-wide: 146,504

Fast qualitY conTrol meThod foR derIved diffUsion Metrics (YTTRIUM) in big data analysis: UK Biobank 18608 example

• Downloaded 273 times
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  • Site-wide: 146,120
  • In neuroscience: 20,513
• Year to date:
  • Site-wide: 172,247
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  • Site-wide: 153,085

The role of liver fat in cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition

• Downloaded 262 times
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  • Site-wide: 149,352
  • In genomics: None
• Year to date:
  • Site-wide: 13,181
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  • Site-wide: 35,597

Five years functional connectivity reorganization without clinical or cognitive decline in MS

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  • Site-wide: 151,531
  • In neurology: 753
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  • Site-wide: 151,493
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  • Site-wide: 136,988

Distributed genetic architecture across the hippocampal formation implies common neuropathology across major brain disorders

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  • Site-wide: 154,726
  • In genetic and genomic medicine: 1,008
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  • Site-wide: 80,048

Feasibility of axon density metrics for brain asymmetry evaluation in the UK Biobank subsample

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  • Site-wide: 155,863
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  • Site-wide: 182,333

Evidence for reduced long-term potentiation-like visual cortical plasticity in schizophrenia and bipolar disorder

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  • Site-wide: 156,018
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  • Site-wide: 133,551

Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis

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  • Site-wide: 157,220
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  • Site-wide: 172,858

Sleep and sleep deprivation differentially alter white matter microstructure: a mixed model design utilising advanced diffusion modelling

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  • Site-wide: 159,242
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Brain disconnectivity mapping of post-stroke fatigue

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Evidence for widespread alterations in cortical microstructure after 32 hours of sleep deprivation

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  • Site-wide: 160,321
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Genetic and phenotypic associations between brain imaging, psychopathology and educational attainment in children aged 9-11

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  • Site-wide: 161,260
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  • Site-wide: 37,146

TVA-based modeling of short-term memory capacity, speed of processing and perceptual threshold in chronic stroke patients: Case-control differences, reliability, and sensitivity to cognitive training

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Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages

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Longitudinal brain age prediction and cognitive function after stroke

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  • Site-wide: 171,750
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A comparison of intracranial volume estimation methods and their cross-sectional and longitudinal associations with age

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  • Site-wide: 179,868
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  • Site-wide: 22,885

Global brain health modulates the impact of lesion damage on post-stroke sensorimotor outcomes

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  • Site-wide: 180,178
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Chronic stroke sensorimotor impairment is related to smaller hippocampal volumes: An ENIGMA analysis

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  • Site-wide: 182,690
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  • Site-wide: 64,172

Linking brain maturation and puberty during early adolescence using longitudinal brain age prediction in the ABCD cohort

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  • Site-wide: 187,670
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  • Site-wide: 11,360