Author: Sriram Sankararaman

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Preprints

Recovering signals of ghost archaic introgression in African populations

• Downloaded 11,920 times
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  • Site-wide: 1,106
  • In genomics: 69
• Year to date:
  • Site-wide: 9,520
• Since beginning of last month:
  • Site-wide: 2,679

Cross-trait assortative mating is widespread and inflates genetic correlation estimates

• Downloaded 3,008 times
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  • Site-wide: 7,283
  • In genetics: 277
• Year to date:
  • Site-wide: 2,200
• Since beginning of last month:
  • Site-wide: 279

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture

• Downloaded 2,497 times
• Download rankings, all-time:
  • Site-wide: 9,601
  • In genomics: 894
• Year to date:
  • Site-wide: 19,356
• Since beginning of last month:
  • Site-wide: 59,996

Large uncertainty in individual PRS estimation impacts PRS-based risk stratification

• Downloaded 2,401 times
• Download rankings, all-time:
  • Site-wide: 10,208
  • In genomics: 949
• Year to date:
  • Site-wide: 34,684
• Since beginning of last month:
  • Site-wide: 32,111

Widespread allelic heterogeneity in complex traits

• Downloaded 1,972 times
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  • Site-wide: 13,760
  • In genetics: 526
• Year to date:
  • Site-wide: 174,619
• Since beginning of last month:
  • Site-wide: 177,786

Colocalization of GWAS and eQTL Signals Detects Target Genes

• Downloaded 1,834 times
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  • Site-wide: 15,386
  • In genetics: 616
• Year to date:
  • Site-wide: 57,653
• Since beginning of last month:
  • Site-wide: 89,791

Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes

• Downloaded 1,721 times
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  • Site-wide: 16,953
  • In genetics: 690
• Year to date:
  • Site-wide: 58,790
• Since beginning of last month:
  • Site-wide: 177,501

Natural selection interacts with the local recombination rate to shape the evolution of hybrid genomes

• Downloaded 1,677 times
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  • Site-wide: 17,680
  • In evolutionary biology: 505
• Year to date:
  • Site-wide: 141,801
• Since beginning of last month:
  • Site-wide: 15,884

Efficient variance components analysis across millions of genomes

• Downloaded 1,654 times
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  • Site-wide: 18,073
  • In bioinformatics: 1,947
• Year to date:
  • Site-wide: 176,300
• Since beginning of last month:
  • Site-wide: 141,977

Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology

• Downloaded 1,557 times
• Download rankings, all-time:
  • Site-wide: 19,870
  • In bioinformatics: 2,178
• Year to date:
  • Site-wide: 143,020
• Since beginning of last month:
  • Site-wide: 201,425

Fast estimation of genetic correlation for Biobank-scale data

• Downloaded 1,285 times
• Download rankings, all-time:
  • Site-wide: 27,093
  • In bioinformatics: 2,922
• Year to date:
  • Site-wide: 176,214
• Since beginning of last month:
  • Site-wide: 91,031

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals

• Downloaded 1,231 times
• Download rankings, all-time:
  • Site-wide: 28,916
  • In genetic and genomic medicine: 181
• Year to date:
  • Site-wide: 11,617
• Since beginning of last month:
  • Site-wide: 8,015

Scalable probabilistic PCA for large-scale genetic variation data

• Downloaded 1,175 times
• Download rankings, all-time:
  • Site-wide: 31,137
  • In bioinformatics: 3,326
• Year to date:
  • Site-wide: 138,118
• Since beginning of last month:
  • Site-wide: 51,725

Leveraging genomic diversity for discovery in an EHR-linked biobank: the UCLA ATLAS Community Health Initiative

• Downloaded 1,158 times
• Download rankings, all-time:
  • Site-wide: 31,897
  • In genetic and genomic medicine: 200
• Year to date:
  • Site-wide: 29,167
• Since beginning of last month:
  • Site-wide: 27,881

Dating ancient human samples using the recombination clock

• Downloaded 1,116 times
• Download rankings, all-time:
  • Site-wide: 33,800
  • In evolutionary biology: 1,244
• Year to date:
  • Site-wide: 180,296
• Since beginning of last month:
  • Site-wide: 196,726

Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

• Downloaded 969 times
• Download rankings, all-time:
  • Site-wide: 41,972
  • In genomics: 3,218
• Year to date:
  • Site-wide: 93,781
• Since beginning of last month:
  • Site-wide: 85,275

Methylation risk scores are associated with a collection of phenotypes within electronic health record systems

• Downloaded 938 times
• Download rankings, all-time:
  • Site-wide: 44,110
  • In genetic and genomic medicine: 280
• Year to date:
  • Site-wide: 29,959
• Since beginning of last month:
  • Site-wide: 23,594

Accurate modeling of replication rates in genome-wide association studies by accounting for winner's curse and study-specific heterogeneity

• Downloaded 915 times
• Download rankings, all-time:
  • Site-wide: 45,844
  • In bioinformatics: 4,769
• Year to date:
  • Site-wide: 133,348
• Since beginning of last month:
  • Site-wide: 16,423

Preoperative predictions of in-hospital mortality using electronic medical record data

• Downloaded 882 times
• Download rankings, all-time:
  • Site-wide: 48,553
  • In bioinformatics: 4,903
• Year to date:
  • Site-wide: 81,053
• Since beginning of last month:
  • Site-wide: 116,671

Leveraging distant relatedness to quantify human mutation and gene conversion rates

• Downloaded 872 times
• Download rankings, all-time:
  • Site-wide: 49,390
  • In genetics: 1,933
• Year to date:
  • Site-wide: 101,634
• Since beginning of last month:
  • Site-wide: 117,224

The lingering effects of Neanderthal introgression on human complex traits

• Downloaded 847 times
• Download rankings, all-time:
  • Site-wide: 51,700
  • In genetics: 2,141
• Year to date:
  • Site-wide: 8,160
• Since beginning of last month:
  • Site-wide: 18,730

Phenotype integration improves power and preserves specificity in biobank-based genetic studies of MDD

• Downloaded 821 times
• Download rankings, all-time:
  • Site-wide: 54,052
  • In genetics: 2,831
• Year to date:
  • Site-wide: 689
• Since beginning of last month:
  • Site-wide: 12,530

Advancing admixture graph estimation via maximum likelihood network orientation

• Downloaded 758 times
• Download rankings, all-time:
  • Site-wide: 60,918
  • In evolutionary biology: 2,590
• Year to date:
  • Site-wide: 123,626
• Since beginning of last month:
  • Site-wide: 66,918

A scalable method for estimating the regional polygenicity of complex traits

• Downloaded 738 times
• Download rankings, all-time:
  • Site-wide: 63,449
  • In genetics: 2,452
• Year to date:
  • Site-wide: 87,694
• Since beginning of last month:
  • Site-wide: 214,746

Correcting for Background Noise Improves Phenotype Prediction from Human Gut Microbiome Data

• Downloaded 712 times
• Download rankings, all-time:
  • Site-wide: 66,780
  • In bioinformatics: 6,306
• Year to date:
  • Site-wide: 159,202
• Since beginning of last month:
  • Site-wide: 137,347

A Statistical Model for Quantifying the Needed Duration of Social Distancing for the COVID-19 Pandemic

• Downloaded 711 times
• Download rankings, all-time:
  • Site-wide: 66,899
  • In health informatics: 302
• Year to date:
  • Site-wide: 110,423
• Since beginning of last month:
  • Site-wide: 54,194

Haplotype-based eQTL mapping finds evidence for complex gene regulatory regions poorly tagged by marginal SNPs

• Downloaded 650 times
• Download rankings, all-time:
  • Site-wide: 75,605
  • In genetics: 2,925
• Year to date:
  • Site-wide: 80,598
• Since beginning of last month:
  • Site-wide: 151,219

Calling differential DNA methylation at cell-type resolution: addressing misconceptions and best practices

• Downloaded 609 times
• Download rankings, all-time:
  • Site-wide: 82,179
  • In genomics: 5,343
• Year to date:
  • Site-wide: 69,111
• Since beginning of last month:
  • Site-wide: 103,397

A unifying framework for summary statistic imputation

• Downloaded 598 times
• Download rankings, all-time:
  • Site-wide: 84,166
  • In bioinformatics: 7,594
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 143,574

Inferring population structure in biobank-scale genomic data

• Downloaded 578 times
• Download rankings, all-time:
  • Site-wide: 87,959
  • In bioinformatics: 7,992
• Year to date:
  • Site-wide: 120,747
• Since beginning of last month:
  • Site-wide: 71,722

A unifying framework for joint trait analysis under a non-infinitesimal model

• Downloaded 565 times
• Download rankings, all-time:
  • Site-wide: 90,535
  • In bioinformatics: 8,044
• Year to date:
  • Site-wide: 172,797
• Since beginning of last month:
  • Site-wide: 197,631

Robust Mendelian randomization in the presence of residual population stratification, batch effects and horizontal pleiotropy

• Downloaded 561 times
• Download rankings, all-time:
  • Site-wide: 91,370
  • In genetics: 3,496
• Year to date:
  • Site-wide: 136,851
• Since beginning of last month:
  • Site-wide: 121,857

Quantifying the contribution of dominance effects to complex trait variation in biobank-scale data

• Downloaded 517 times
• Download rankings, all-time:
  • Site-wide: 100,531
  • In genetics: 3,808
• Year to date:
  • Site-wide: 152,529
• Since beginning of last month:
  • Site-wide: 81,414

A scalable estimator of SNP heritability for Biobank-scale data

• Downloaded 505 times
• Download rankings, all-time:
  • Site-wide: 103,357
  • In bioinformatics: 8,868
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 153,156

MaLAdapt reveals novel targets of adaptive introgression from Neanderthals and Denisovans in worldwide human populations

• Downloaded 488 times
• Download rankings, all-time:
  • Site-wide: 107,253
  • In evolutionary biology: 5,252
• Year to date:
  • Site-wide: 8,222
• Since beginning of last month:
  • Site-wide: 25,199

A two-step approach to testing overall effect of gene-environment interaction for multiple phenotypes

• Downloaded 466 times
• Download rankings, all-time:
  • Site-wide: 112,584
  • In genetics: 4,293
• Year to date:
  • Site-wide: 51,676
• Since beginning of last month:
  • Site-wide: 79,585

Deep Learning-based Phenotype Imputation on Population-scale Biobank Data Increases Genetic Discoveries

• Downloaded 408 times
• Download rankings, all-time:
  • Site-wide: 128,062
  • In bioinformatics: 10,953
• Year to date:
  • Site-wide: 14,155
• Since beginning of last month:
  • Site-wide: 13,391

Fast Kernel-based Association Testing of non-linear genetic effects for Biobank-scale data

• Downloaded 266 times
• Download rankings, all-time:
  • Site-wide: 170,387
  • In genetics: 6,243
• Year to date:
  • Site-wide: 83,383
• Since beginning of last month:
  • Site-wide: 95,426

Unlocking the microblogging potential for science and medicine

• Downloaded 174 times
• Download rankings, all-time:
  • Site-wide: 193,662
  • In scientific communication and education: 971
• Year to date:
  • Site-wide: 32,283
• Since beginning of last month:
  • Site-wide: 14,686

Leveraging family data to design Mendelian Randomization that is provably robust to population stratification

• Downloaded 173 times
• Download rankings, all-time:
  • Site-wide: 193,885
  • In genetics: None
• Year to date:
  • Site-wide: 565
• Since beginning of last month:
  • Site-wide: None

Personalized Mood Prediction from Patterns of Behavior Collected with Smartphones

• Downloaded 157 times
• Download rankings, all-time:
  • Site-wide: 197,139
  • In psychiatry and clinical psychology: 1,405
• Year to date:
  • Site-wide: 22,933
• Since beginning of last month:
  • Site-wide: 12,092

Phenotypic subtyping via contrastive learning

• Downloaded 83 times
• Download rankings, all-time:
  • Site-wide: 210,963
  • In genomics: None
• Year to date:
  • Site-wide: 1,728
• Since beginning of last month:
  • Site-wide: None