Author: Sriram Sankararaman

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Preprints

Recovering signals of ghost archaic introgression in African populations

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  • Site-wide: 928
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• Year to date:
  • Site-wide: 1,974
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  • Site-wide: 34,784

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture

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  • Site-wide: 8,028
  • In genomics: 814
• Year to date:
  • Site-wide: 39,246
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  • Site-wide: 71,079

Large uncertainty in individual PRS estimation impacts PRS-based risk stratification

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  • Site-wide: 10,367
  • In genomics: 1,020
• Year to date:
  • Site-wide: 3,619
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  • Site-wide: 4,734

Widespread allelic heterogeneity in complex traits

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  • Site-wide: 10,764
  • In genetics: 458
• Year to date:
  • Site-wide: 125,262
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  • Site-wide: 130,743

Colocalization of GWAS and eQTL Signals Detects Target Genes

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  • Site-wide: 12,556
  • In genetics: 541
• Year to date:
  • Site-wide: 100,385
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  • Site-wide: 83,386

Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes

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  • Site-wide: 13,301
  • In genetics: 579
• Year to date:
  • Site-wide: 147,244
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  • Site-wide: 158,162

Natural selection interacts with the local recombination rate to shape the evolution of hybrid genomes

• Downloaded 1,580 times
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  • Site-wide: 14,112
  • In evolutionary biology: 439
• Year to date:
  • Site-wide: 112,072
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  • Site-wide: 136,253

Efficient variance components analysis across millions of genomes

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  • Site-wide: 14,659
  • In bioinformatics: 1,649
• Year to date:
  • Site-wide: 53,344
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  • Site-wide: 66,697

Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology

• Downloaded 1,490 times
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  • Site-wide: 15,528
  • In bioinformatics: 1,757
• Year to date:
  • Site-wide: 135,649
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  • Site-wide: 138,282

Fast estimation of genetic correlation for Biobank-scale data

• Downloaded 1,115 times
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  • Site-wide: 24,118
  • In bioinformatics: 2,711
• Year to date:
  • Site-wide: 31,673
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  • Site-wide: 39,938

Scalable probabilistic PCA for large-scale genetic variation data

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  • Site-wide: 25,514
  • In bioinformatics: 2,851
• Year to date:
  • Site-wide: 56,163
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  • Site-wide: 131,754

Dating ancient human samples using the recombination clock

• Downloaded 1,058 times
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  • Site-wide: 26,189
  • In evolutionary biology: 1,046
• Year to date:
  • Site-wide: 141,178
• Since beginning of last month:
  • Site-wide: 159,552

Preoperative predictions of in-hospital mortality using electronic medical record data

• Downloaded 819 times
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  • Site-wide: 38,055
  • In bioinformatics: 4,082
• Year to date:
  • Site-wide: 106,097
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  • Site-wide: 141,417

Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

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  • Site-wide: 38,989
  • In genomics: 3,164
• Year to date:
  • Site-wide: 7,443
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  • Site-wide: 12,428

Leveraging distant relatedness to quantify human mutation and gene conversion rates

• Downloaded 803 times
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  • Site-wide: 39,191
  • In genetics: 1,699
• Year to date:
  • Site-wide: 153,701
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  • Site-wide: 147,892

A scalable method for estimating the regional polygenicity of complex traits

• Downloaded 686 times
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  • Site-wide: 48,875
  • In genetics: 2,101
• Year to date:
  • Site-wide: 93,257
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  • Site-wide: 75,438

Leveraging genomic diversity for discovery in an EHR-linked biobank: the UCLA ATLAS Community Health Initiative

• Downloaded 626 times
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  • Site-wide: 55,408
  • In genetic and genomic medicine: 256
• Year to date:
  • Site-wide: 11,104
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  • Site-wide: 2,791

Advancing admixture graph estimation via maximum likelihood network orientation

• Downloaded 596 times
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  • Site-wide: 58,996
  • In evolutionary biology: 2,901
• Year to date:
  • Site-wide: 11,997
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  • Site-wide: 21,709

Haplotype-based eQTL mapping finds evidence for complex gene regulatory regions poorly tagged by marginal SNPs

• Downloaded 592 times
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  • Site-wide: 59,509
  • In genetics: 2,522
• Year to date:
  • Site-wide: 125,322
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  • Site-wide: 103,451

A Statistical Model for Quantifying the Needed Duration of Social Distancing for the COVID-19 Pandemic

• Downloaded 588 times
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  • Site-wide: 60,007
  • In health informatics: 243
• Year to date:
  • Site-wide: 54,321
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  • Site-wide: 50,261

A unifying framework for summary statistic imputation

• Downloaded 550 times
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  • Site-wide: 65,098
  • In bioinformatics: 6,245
• Year to date:
  • Site-wide: 133,382
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  • Site-wide: 99,217

Accurate modeling of replication rates in genome-wide association studies by accounting for winner's curse and study-specific heterogeneity

• Downloaded 546 times
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  • Site-wide: 65,708
  • In bioinformatics: 6,295
• Year to date:
  • Site-wide: 35,255
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  • Site-wide: 17,951

A unifying framework for joint trait analysis under a non-infinitesimal model

• Downloaded 530 times
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  • Site-wide: 68,043
  • In bioinformatics: 6,472
• Year to date:
  • Site-wide: 163,234
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  • Site-wide: 161,524

A scalable estimator of SNP heritability for Biobank-scale data

• Downloaded 461 times
• Download rankings, all-time:
  • Site-wide: 79,704
  • In bioinformatics: 7,252
• Year to date:
  • Site-wide: 163,014
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  • Site-wide: 154,583

Correcting for Background Noise Improves Phenotype Prediction from Human Gut Microbiome Data

• Downloaded 459 times
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  • Site-wide: 80,046
  • In bioinformatics: 7,284
• Year to date:
  • Site-wide: 17,936
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  • Site-wide: 35,957

Robust Mendelian randomization in the presence of residual population stratification, batch effects and horizontal pleiotropy

• Downloaded 448 times
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  • Site-wide: 82,101
  • In genetics: 3,459
• Year to date:
  • Site-wide: 56,948
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  • Site-wide: 49,730

Quantifying the contribution of dominance effects to complex trait variation in biobank-scale data

• Downloaded 447 times
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  • Site-wide: 82,371
  • In genetics: 3,467
• Year to date:
  • Site-wide: 73,609
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  • Site-wide: 90,014

Calling differential DNA methylation at cell-type resolution: addressing misconceptions and best practices

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  • Site-wide: 101,439
  • In genomics: 6,096
• Year to date:
  • Site-wide: 26,206
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  • Site-wide: 42,978

A two-step approach to testing overall effect of gene-environment interaction for multiple phenotypes

• Downloaded 355 times
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  • Site-wide: 102,256
  • In genetics: 4,232
• Year to date:
  • Site-wide: 56,831
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  • Site-wide: 60,905

Inferring population structure in biobank-scale genomic data

• Downloaded 338 times
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  • Site-wide: 106,480
  • In bioinformatics: 8,948
• Year to date:
  • Site-wide: 28,592
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  • Site-wide: 23,663